COMPARISON
Dulaglutide vs Lixisenatide
6 attributes held for at least one of the two. 5 differ. Each value carries the register it came from and the date that register was read.
Answer
Dulaglutide is authorised or registered in 10 and Lixisenatide in 8 of the 10 registers read. Dulaglutide: highest phase Phase 4 (after approval). Lixisenatide: No trial states a phase. 8 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Dulaglutide | Lixisenatide | |
|---|---|---|
| Registered trials differs | 144 clinicaltrials.gov · 2026-10-03 | 75 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: TRULICITY openfda · 2026-10-03T17:23:44.062Z | FDA-approved: Soliqua 100/33 openfda · 2026-10-03T17:23:44.062Z |
| EU authorisation | Authorised ema · 2026-10-03 | Authorised ema · 2026-10-03 |
| EU authorised on differs | 2014-11-21 ema · 2026-10-03 | 2017-01-11 ema · 2026-10-03 |
| EU withdrawn on differs | Not checked no record of "withdrawnOn" for dulaglutide | 2024-08-27 ema · 2026-10-03 |
| ATC code differs | A10BJ05 ema · 2026-10-03 | A10AE54 ema · 2026-10-03 |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Dulaglutide | placebo | Lixisenatide | placebo |
|---|---|---|---|---|
| Nausea | 14.5% | 5.5% | 24.8% | 6.5% |
| Diarrhoea | 12.8% | 8.5% | 10.1% | 8.1% |
| Nasopharyngitis | 11.2% | 10.4% | 9.1% | 9.0% |
| Hypoglycaemia | 7.5% | 6.6% | 18.4% | 16.4% |
| Urinary tract infection | 10.2% | 9.8% | - | - |
| Back pain | 8.4% | 7.9% | - | - |
| Bronchitis | 7.9% | 8.3% | - | - |
| Arthralgia | 7.3% | 7.6% | - | - |
| Constipation | 7.2% | 4.1% | - | - |
| Decreased appetite | 7.1% | 2.2% | - | - |
| Vomiting | - | - | 10.3% | 2.6% |
| Headache | - | - | 9.6% | 6.8% |
| Dizziness | - | - | 8.3% | 6.3% |
| Hypertension | - | - | 4.6% | 4.9% |
| Influenza | - | - | 4.4% | 2.4% |
| Angina pectoris | - | - | 4.3% | 5.5% |
Trial register Dulaglutide: 11 placebo-controlled trials; Lixisenatide: 11. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Dulaglutide side effects · Lixisenatide side effects
LEGAL STATUS
Approval in each country read
| Country | Dulaglutide | Lixisenatide | Register |
|---|---|---|---|
| United States | FDA-approved | FDA-approved | Regulator FDA |
| European Union | Authorised | Authorised | Regulator EMA |
| United Kingdom | Authorised | Not on the register | Regulator MHRA |
| Canada | Authorised | Authorised | Regulator Health Canada |
| Australia | Registered | Status unknown | Regulator TGA |
| Switzerland | Authorised | Authorised | Regulator Swissmedic |
| Brazil | Registado | Registado | Regulator ANVISA |
| Serbia | Authorised | Authorised | Regulator ALIMS |
| Singapore | Registered | Registered | Regulator HSA |
| Turkey | Ruhsatli | Ruhsatli | Regulator TITCK |
HEAD TO HEAD
8 registered trials include both
| NCT05220917 | Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study ACTIVE_NOT_RECRUITING · updated 2026-08-13 |
|---|---|
| NCT07188545 | Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Rea ACTIVE_NOT_RECRUITING · updated 2025-09-23 |
| NCT03492580 | A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants COMPLETED · updated 2025-06-25 |
| NCT06449235 | Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh UNKNOWN · updated 2024-07-16 |
| NCT05136287 | SEMAGLUTIDE VERSUS GLP-1 RECEPTOR AGONISTS. EFFECTIVENESS , SAFETY AND QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUS 2. OBSERVATIONAL, PROSPECTIVE AND MULT COMPLETED · updated 2024-02-28 |
| NCT02787551 | Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, With a FR COMPLETED · updated 2022-03-25 |
| NCT04184947 | Cardiovascular Outcomes SGLT-2 Inhibitors Versus GLP-1 Receptor Agonists COMPLETED · updated 2020-03-11 |
| NCT03959865 | GLP-1 REceptor Agonists and Real World EvIdeNce UNKNOWN · updated 2019-05-22 |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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