COMPARISON
Dulaglutide vs Retatrutide
5 attributes held for at least one of the two. 5 differ. Each value carries the register it came from and the date that register was read.
Answer
Dulaglutide is authorised or registered in 10 and Retatrutide in 0 of the 10 registers read. Dulaglutide: highest phase Phase 4 (after approval). Retatrutide: highest phase Phase 3 (20 phase 3 trials, 0 with posted results). 2 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Dulaglutide | Retatrutide | |
|---|---|---|
| Registered trials differs | 144 clinicaltrials.gov · 2026-10-03 | 41 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: TRULICITY openfda · 2026-10-03T17:23:44.062Z | Not checked no record of "fdaLabel" for retatrutide |
| EU authorisation differs | Authorised ema · 2026-10-03 | Nothing on record ema read 2026-08-31 |
| EU authorised on differs | 2014-11-21 ema · 2026-10-03 | Not checked no record of "authorisedOn" for retatrutide |
| ATC code differs | A10BJ05 ema · 2026-10-03 | Not checked no record of "atcCode" for retatrutide |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Dulaglutide | placebo | Retatrutide | placebo |
|---|---|---|---|---|
| Nausea | 14.5% | 5.5% | 26.0% | 8.7% |
| Diarrhoea | 12.8% | 8.5% | 14.2% | 8.7% |
| Constipation | 7.2% | 4.1% | 10.7% | 2.6% |
| Decreased appetite | 7.1% | 2.2% | 17.9% | 5.2% |
| Nasopharyngitis | 11.2% | 10.4% | - | - |
| Urinary tract infection | 10.2% | 9.8% | - | - |
| Back pain | 8.4% | 7.9% | - | - |
| Bronchitis | 7.9% | 8.3% | - | - |
| Hypoglycaemia | 7.5% | 6.6% | - | - |
| Arthralgia | 7.3% | 7.6% | - | - |
| Covid-19 | - | - | 14.9% | 14.8% |
| Vomiting | - | - | 10.1% | 1.7% |
| Fatigue | - | - | 6.6% | 2.6% |
| Lipase increased | - | - | 5.5% | 3.5% |
| Hypertension | - | - | 5.2% | 2.9% |
| Gastrooesophageal reflux disease | - | - | 4.9% | 1.4% |
Trial register Dulaglutide: 11 placebo-controlled trials; Retatrutide: 2. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Dulaglutide side effects · Retatrutide side effects
LEGAL STATUS
Approval in each country read
| Country | Dulaglutide | Retatrutide | Register |
|---|---|---|---|
| United States | FDA-approved | Not on the register | Regulator FDA |
| European Union | Authorised | Not on the register | Regulator EMA |
| United Kingdom | Authorised | Not on the register | Regulator MHRA |
| Canada | Authorised | Not on the register | Regulator Health Canada |
| Australia | Registered | Status unknown | Regulator TGA |
| Switzerland | Authorised | Not on the register | Regulator Swissmedic |
| Brazil | Registado | Not on the register | Regulator ANVISA |
| Serbia | Authorised | Not on the register | Regulator ALIMS |
| Singapore | Registered | Not on the register | Regulator HSA |
| Turkey | Ruhsatli | Not on the register | Regulator TITCK |
HEAD TO HEAD
2 registered trials include both
| NCT04867785 | A Study of LY3437943 in Participants With Type 2 Diabetes COMPLETED · updated 2023-07-03 |
|---|---|
| NCT04143802 | A Study of LY3437943 in Participants With Type 2 Diabetes Mellitus (T2DM) COMPLETED · updated 2021-01-20 |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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