COMPARISON
Dulaglutide vs Semaglutide
5 attributes held for at least one of the two. 4 differ. Each value carries the register it came from and the date that register was read.
Answer
Dulaglutide is authorised or registered in 10 and Semaglutide in 10 of the 10 registers read. Dulaglutide: highest phase Phase 4 (after approval). Semaglutide: highest phase Phase 4 (after approval). 31 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Dulaglutide | Semaglutide | |
|---|---|---|
| Registered trials differs | 144 clinicaltrials.gov · 2026-10-03 | 861 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: TRULICITY openfda · 2026-10-03T17:23:44.062Z | FDA-approved: OZEMPIC openfda · 2026-10-03T17:23:44.062Z |
| EU authorisation | Authorised ema · 2026-10-03 | Authorised ema · 2026-10-03 |
| EU authorised on differs | 2014-11-21 ema · 2026-10-03 | 2018-02-08 ema · 2026-10-03 |
| ATC code differs | A10BJ05 ema · 2026-10-03 | A10BJ06 ema · 2026-10-03 |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Dulaglutide | placebo | Semaglutide | placebo |
|---|---|---|---|---|
| Nausea | 14.5% | 5.5% | 19.5% | 4.5% |
| Diarrhoea | 12.8% | 8.5% | 11.8% | 4.5% |
| Nasopharyngitis | 11.2% | 10.4% | 7.5% | 6.1% |
| Constipation | 7.2% | 4.1% | 8.9% | 2.8% |
| Decreased appetite | 7.1% | 2.2% | 6.3% | 1.3% |
| Urinary tract infection | 10.2% | 9.8% | - | - |
| Back pain | 8.4% | 7.9% | - | - |
| Bronchitis | 7.9% | 8.3% | - | - |
| Hypoglycaemia | 7.5% | 6.6% | - | - |
| Arthralgia | 7.3% | 7.6% | - | - |
| COVID-19 | - | - | 17.0% | 17.8% |
| Vomiting | - | - | 8.6% | 1.6% |
| Dyspepsia | - | - | 5.3% | 1.2% |
| Headache | - | - | 4.0% | 2.1% |
| Upper respiratory tract infection | - | - | 2.7% | 1.9% |
Trial register Dulaglutide: 11 placebo-controlled trials; Semaglutide: 50. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Dulaglutide side effects · Semaglutide side effects
LEGAL STATUS
Approval in each country read
| Country | Dulaglutide | Semaglutide | Register |
|---|---|---|---|
| United States | FDA-approved | FDA-approved | Regulator FDA |
| European Union | Authorised | Authorised | Regulator EMA |
| United Kingdom | Authorised | Authorised | Regulator MHRA |
| Canada | Authorised | Authorised | Regulator Health Canada |
| Australia | Registered | Registered | Regulator TGA |
| Switzerland | Authorised | Authorised | Regulator Swissmedic |
| Brazil | Registado | Registado | Regulator ANVISA |
| Serbia | Authorised | Authorised | Regulator ALIMS |
| Singapore | Registered | Registered | Regulator HSA |
| Turkey | Ruhsatli | Ruhsatli | Regulator TITCK |
HEAD TO HEAD
31 registered trials include both
| NCT06779929 | Comparative Study of Tirzepatide Versus Dulaglutide (SURPASS CVOT) or Semaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes COMPLETED · updated 2026-09-18 |
|---|---|
| NCT07820111 | Comparative Study of Different Weekly GLP-1 Receptor Agonists Among Diabetic and Non-Diabetic Patients: Clinical Trial COMPLETED · updated 2026-09-15 |
| NCT06851962 | Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes. COMPLETED · updated 2026-09-04 |
| NCT07787936 | GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry NOT_YET_RECRUITING · updated 2026-08-26 |
| NCT05220917 | Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study ACTIVE_NOT_RECRUITING · updated 2026-08-13 |
| NCT07702461 | Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists RECRUITING · updated 2026-07-24 |
| NCT07417618 | INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD) COMPLETED · updated 2026-07-09 |
| NCT07619495 | Injectable Semaglutide vs Dulaglutide in Individuals at Cardiovascular Risk COMPLETED · updated 2026-07-09 |
| NCT07027969 | Metabolic Surgery for Atrial Fibrillation Elimination NOT_YET_RECRUITING · updated 2026-04-17 |
| NCT05390892 | PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes RECRUITING · updated 2026-04-13 |
| NCT03498001 | Effects of GLP-1 Agonists on CArdiac Steatosis Evaluated by Magnetic Resonance Imaging COMPLETED · updated 2026-02-04 |
| NCT06500143 | Residual Gastric Content After Holding of Glucagon-like Peptide-1 Receptor Agonists Before Elective Surgery COMPLETED · updated 2026-01-16 |
| NCT07325435 | Beta Cell Function in Type 2 Diabetes: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists ACTIVE_NOT_RECRUITING · updated 2026-01-08 |
| NCT07309094 | Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD RECRUITING · updated 2025-12-30 |
| NCT07276763 | Impact of Discontinuing GLP-1 Receptor Agonists for Two Weeks Prior to Upper Endoscopy on the Risk of Gastric Retention NOT_YET_RECRUITING · updated 2025-12-11 |
| NCT06533527 | Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy COMPLETED · updated 2025-12-05 |
| NCT07096063 | Comparative Effectiveness of Tirzepatide and Semaglutide in Individuals at Cardiovascular Risk COMPLETED · updated 2025-10-15 |
| NCT07188545 | Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Rea ACTIVE_NOT_RECRUITING · updated 2025-09-23 |
| NCT06581120 | GLP_1 RA Ultrasound Study ENROLLING_BY_INVITATION · updated 2024-11-07 |
| NCT06449235 | Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh UNKNOWN · updated 2024-07-16 |
The 20 most recently updated are listed.
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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New trials, approvals and enforcement actions. One email a week.