COMPARISON
Linaclotide vs TB-500
5 attributes held for at least one of the two. 5 differ. Each value carries the register it came from and the date that register was read.
Answer
Linaclotide is authorised or registered in 5 and TB-500 in 0 of the 10 registers read. Linaclotide: highest phase Phase 3 (1 phase 3 trial, 0 with posted results). TB-500: highest phase Phase 2. 0 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Linaclotide | TB-500 | |
|---|---|---|
| Registered trials differs | 62 clinicaltrials.gov · 2026-10-03 | 1 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: Linzess openfda · 2026-10-03T17:23:44.062Z | Not checked no record of "fdaLabel" for tb-500 |
| EU authorisation differs | Authorised ema · 2026-10-03 | Nothing on record ema read 2026-08-31 |
| EU authorised on differs | 2012-11-26 ema · 2026-10-03 | Not checked no record of "authorisedOn" for tb-500 |
| ATC code differs | A06AX04 ema · 2026-10-03 | Not checked no record of "atcCode" for tb-500 |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Linaclotide | placebo | TB-500 | placebo |
|---|---|---|---|---|
| Diarrhea | 14.0% | 4.6% | - | - |
Trial register Linaclotide: 14 placebo-controlled trials; TB-500: 0. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Linaclotide side effects · TB-500 side effects
LEGAL STATUS
Approval in each country read
| Country | Linaclotide | TB-500 | Register |
|---|---|---|---|
| United States | FDA-approved | Not on the register | Regulator FDA |
| European Union | Authorised | Not on the register | Regulator EMA |
| United Kingdom | Authorised | Not on the register | Regulator MHRA |
| Canada | Authorised | Not on the register | Regulator Health Canada |
| Australia | Status unknown | Status unknown | TGA |
| Switzerland | Authorised | Not on the register | Regulator Swissmedic |
| Brazil | Not on the register | Not on the register | Regulator ANVISA |
| Serbia | Not on the register | Not on the register | Regulator ALIMS |
| Singapore | Not on the register | Not on the register | Regulator HSA |
| Turkey | Not on the register | Not on the register | Regulator TITCK |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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