COMPARISON
Octreotide vs Terlipressin
6 attributes held for at least one of the two. 6 differ. Each value carries the register it came from and the date that register was read.
Answer
Octreotide is authorised or registered in 10 and Terlipressin in 8 of the 10 registers read. Octreotide: highest phase Phase 4 (after approval). Terlipressin: highest phase Phase 3 (2 phase 3 trials, 0 with posted results). 10 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Octreotide | Terlipressin | |
|---|---|---|
| Registered trials differs | 344 clinicaltrials.gov · 2026-10-03 | 118 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: Octreotide Acetate openfda · 2026-10-03T17:23:44.062Z | FDA-approved: Terlivaz openfda · 2026-10-03T17:23:44.062Z |
| EU authorisation differs | Authorised ema · 2026-10-03 | Nothing on record ema read 2026-08-31 |
| EU authorised on differs | 2025-06-30 ema · 2026-10-03 | Not checked no record of "authorisedOn" for terlipressin |
| EU withdrawn on differs | 2022-12-02 ema · 2026-10-03 | Not checked no record of "withdrawnOn" for terlipressin |
| ATC code differs | H01CB02 ema · 2026-10-03 | Not checked no record of "atcCode" for terlipressin |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Octreotide | placebo | Terlipressin | placebo |
|---|---|---|---|---|
| Diarrhoea | 46.2% | 31.7% | 16.4% | 5.7% |
| Nausea | 30.8% | 21.2% | 15.0% | 11.3% |
| Dyspnoea | 25.9% | 9.1% | 12.3% | 6.7% |
| Oedema peripheral | 34.9% | 19.6% | - | - |
| Asthenia | 33.3% | 20.9% | - | - |
| Fatigue | 29.8% | 27.7% | - | - |
| Rash | 28.8% | 14.1% | - | - |
| Decreased appetite | 28.5% | 15.2% | - | - |
| Hypertension | 26.5% | 19.4% | - | - |
| Anaemia | 24.3% | 9.1% | - | - |
| Abdominal pain | - | - | 21.8% | 13.4% |
| Hypotension | - | - | 11.3% | 6.7% |
| Respiratory failure | - | - | 10.5% | 3.0% |
| Vomiting | - | - | 8.9% | 7.2% |
| Hypokalaemia | - | - | 8.9% | 6.2% |
| Hepatic encephalopathy | - | - | 8.5% | 11.3% |
| Fluid overload | - | - | 8.2% | 4.1% |
Trial register Octreotide: 5 placebo-controlled trials; Terlipressin: 2. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Octreotide side effects · Terlipressin side effects
LEGAL STATUS
Approval in each country read
| Country | Octreotide | Terlipressin | Register |
|---|---|---|---|
| United States | FDA-approved | FDA-approved | Regulator FDA |
| European Union | Authorised | Not on the register | Regulator EMA |
| United Kingdom | Authorised | Authorised | Regulator MHRA |
| Canada | Authorised | Not on the register | Regulator Health Canada |
| Australia | Registered | Registered | Regulator TGA |
| Switzerland | Authorised | Authorised | Regulator Swissmedic |
| Brazil | Registado | Registado | Regulator ANVISA |
| Serbia | Authorised | Authorised | Regulator ALIMS |
| Singapore | Registered | Registered | Regulator HSA |
| Turkey | Ruhsatli | Ruhsatli | Regulator TITCK |
HEAD TO HEAD
10 registered trials include both
| NCT07460908 | Comparison of Terlipressin Versus Octreotide in Patients With Hepatorenal Syndrome COMPLETED · updated 2026-03-10 |
|---|---|
| NCT04028323 | Functional MRI-based Assessment of Terlipressin vs. Octreotide on Renal Function in Cirrhotic Patients With Acute Variceal Bleeding (CHESS1903) UNKNOWN · updated 2021-08-17 |
| NCT04353193 | Hemodynamic Profile of Terlipressin and Octreotide in Patients With Cirrhosis and Portal Hypertension. A Randomised, Single Blinded Clinical Trial. UNKNOWN · updated 2020-04-20 |
| NCT03846180 | Terlipressin on Effect of Renal Function in Cirrhotic Patients With Acute Gastrointestinal Hemorrhage COMPLETED · updated 2019-07-05 |
| NCT01370161 | Early TIPS With Polytetrafluoroethylene (PTFE) Covered Stents for Acute Variceal Bleeding in Patients With Advanced Cirrhosis COMPLETED · updated 2019-01-17 |
| NCT00966355 | Comparison of Terlipressin, Somatostatin, and Octreotide for Control of Variceal Bleeding COMPLETED · updated 2018-03-19 |
| NCT02119884 | Hemodynamic Effects of Terlipressin and High Dose Octreotide COMPLETED · updated 2016-06-13 |
| NCT02311608 | Effects of Terlipressin When Usual Somatostatin or Octreotide Dose Fails UNKNOWN · updated 2014-12-08 |
| NCT00742339 | Terlipressin + Albumin Versus Midodrine + Octreotide in the Treatment of Hepatorenal Syndrome TERMINATED · updated 2014-10-15 |
| NCT00534677 | The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed COMPLETED · updated 2007-12-05 |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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