COMPARISON
Octreotide vs Vosoritide
6 attributes held for at least one of the two. 5 differ. Each value carries the register it came from and the date that register was read.
Answer
Octreotide is authorised or registered in 10 and Vosoritide in 7 of the 10 registers read. Octreotide: highest phase Phase 4 (after approval). Vosoritide: highest phase Phase 3 (3 phase 3 trials, 0 with posted results). 0 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Octreotide | Vosoritide | |
|---|---|---|
| Registered trials differs | 344 clinicaltrials.gov · 2026-10-03 | 23 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: Octreotide Acetate openfda · 2026-10-03T17:23:44.062Z | FDA-approved: VOXZOGO 0.4mg openfda · 2026-10-03T17:23:44.062Z |
| EU authorisation | Authorised ema · 2026-10-03 | Authorised ema · 2026-10-03 |
| EU authorised on differs | 2025-06-30 ema · 2026-10-03 | 2021-08-26 ema · 2026-10-03 |
| EU withdrawn on differs | 2022-12-02 ema · 2026-10-03 | Not checked no record of "withdrawnOn" for vosoritide |
| ATC code differs | H01CB02 ema · 2026-10-03 | M05BX ema · 2026-10-03 |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Octreotide | placebo | Vosoritide | placebo |
|---|---|---|---|---|
| Diarrhoea | 46.2% | 31.7% | - | - |
| Oedema peripheral | 34.9% | 19.6% | - | - |
| Asthenia | 33.3% | 20.9% | - | - |
| Nausea | 30.8% | 21.2% | - | - |
| Fatigue | 29.8% | 27.7% | - | - |
| Rash | 28.8% | 14.1% | - | - |
| Decreased appetite | 28.5% | 15.2% | - | - |
| Hypertension | 26.5% | 19.4% | - | - |
| Dyspnoea | 25.9% | 9.1% | - | - |
| Anaemia | 24.3% | 9.1% | - | - |
| Injection site reaction | - | - | 79.1% | 40.6% |
| Injection site erythema | - | - | 76.7% | 40.6% |
| Viral infection | - | - | 18.6% | 12.5% |
| Injection site swelling | - | - | 18.6% | 6.3% |
| Fall | - | - | 16.3% | 9.4% |
| Injection site urticaria | - | - | 14.0% | 3.1% |
| Arthropod bite | - | - | 14.0% | 6.3% |
| Injection site induration | - | - | 11.6% | 0.0% |
| Constipation | - | - | 11.6% | 6.3% |
| Rhinitis | - | - | 9.3% | 0.0% |
Trial register Octreotide: 5 placebo-controlled trials; Vosoritide: 1. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Octreotide side effects · Vosoritide side effects
LEGAL STATUS
Approval in each country read
| Country | Octreotide | Vosoritide | Register |
|---|---|---|---|
| United States | FDA-approved | FDA-approved | Regulator FDA |
| European Union | Authorised | Authorised | Regulator EMA |
| United Kingdom | Authorised | Not on the register | Regulator MHRA |
| Canada | Authorised | Authorised | Regulator Health Canada |
| Australia | Registered | Registered | Regulator TGA |
| Switzerland | Authorised | Authorised | Regulator Swissmedic |
| Brazil | Registado | Registado | Regulator ANVISA |
| Serbia | Authorised | Not on the register | Regulator ALIMS |
| Singapore | Registered | Not on the register | Regulator HSA |
| Turkey | Ruhsatli | Ruhsatli | Regulator TITCK |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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