COMPARISON
Pramlintide vs Semaglutide
5 attributes held for at least one of the two. 5 differ. Each value carries the register it came from and the date that register was read.
Answer
Pramlintide is authorised or registered in 1 and Semaglutide in 10 of the 10 registers read. Pramlintide: highest phase Phase 3 (1 phase 3 trial, 0 with posted results). Semaglutide: highest phase Phase 4 (after approval). 2 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Pramlintide | Semaglutide | |
|---|---|---|
| Registered trials differs | 65 clinicaltrials.gov · 2026-10-03 | 861 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: SymlinPen openfda · 2026-10-03T17:23:44.062Z | FDA-approved: OZEMPIC openfda · 2026-10-03T17:23:44.062Z |
| EU authorisation differs | Nothing on record ema read 2026-08-31 | Authorised ema · 2026-10-03 |
| EU authorised on differs | Not checked no record of "authorisedOn" for pramlintide | 2018-02-08 ema · 2026-10-03 |
| ATC code differs | Not checked no record of "atcCode" for pramlintide | A10BJ06 ema · 2026-10-03 |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Pramlintide | placebo | Semaglutide | placebo |
|---|---|---|---|---|
| nausea | 28.5% | 4.7% | 19.5% | 4.5% |
| Upper respiratory tract infection | 12.1% | 10.4% | 2.7% | 1.9% |
| nasopharyngitis | 6.6% | 7.5% | 7.5% | 6.1% |
| injection site pruritus | 14.7% | 0.7% | - | - |
| injection site erythema | 14.5% | 0.9% | - | - |
| injection site bruising | 11.2% | 12.3% | - | - |
| injection site hemorrhage | 11.2% | 3.8% | - | - |
| injection site rash | 8.9% | 0.0% | - | - |
| injection site urticaria | 8.3% | 0.0% | - | - |
| injection site nodule | 5.9% | 3.8% | - | - |
| COVID-19 | - | - | 17.0% | 17.8% |
| Diarrhoea | - | - | 11.8% | 4.5% |
| Constipation | - | - | 8.9% | 2.8% |
| Vomiting | - | - | 8.6% | 1.6% |
| Decreased appetite | - | - | 6.3% | 1.3% |
| Dyspepsia | - | - | 5.3% | 1.2% |
| Headache | - | - | 4.0% | 2.1% |
Trial register Pramlintide: 5 placebo-controlled trials; Semaglutide: 50. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Pramlintide side effects · Semaglutide side effects
LEGAL STATUS
Approval in each country read
| Country | Pramlintide | Semaglutide | Register |
|---|---|---|---|
| United States | FDA-approved | FDA-approved | Regulator FDA |
| European Union | Not on the register | Authorised | Regulator EMA |
| United Kingdom | Not on the register | Authorised | Regulator MHRA |
| Canada | Not on the register | Authorised | Regulator Health Canada |
| Australia | Status unknown | Registered | TGA |
| Switzerland | Not on the register | Authorised | Regulator Swissmedic |
| Brazil | Not on the register | Registado | Regulator ANVISA |
| Serbia | Not on the register | Authorised | Regulator ALIMS |
| Singapore | Not on the register | Registered | Regulator HSA |
| Turkey | Not on the register | Ruhsatli | Regulator TITCK |
HEAD TO HEAD
2 registered trials include both
| NCT06619015 | Tailoring Obesity Treatment Trial WITHDRAWN · updated 2026-04-17 |
|---|---|
| 2024-510802-10-00 | The impact of pramlintide on top of semaglutide in obese people with prediabetes Not stated · updated 2024-12-03 |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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