COMPARISON
Retatrutide vs Semaglutide
5 attributes held for at least one of the two. 5 differ. Each value carries the register it came from and the date that register was read.
Answer
Retatrutide is authorised or registered in 0 and Semaglutide in 10 of the 10 registers read. Retatrutide: highest phase Phase 3 (20 phase 3 trials, 0 with posted results). Semaglutide: highest phase Phase 4 (after approval). 2 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Retatrutide | Semaglutide | |
|---|---|---|
| Registered trials differs | 41 clinicaltrials.gov · 2026-10-03 | 861 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | Not checked no record of "fdaLabel" for retatrutide | FDA-approved: OZEMPIC openfda · 2026-10-03T17:23:44.062Z |
| EU authorisation differs | Nothing on record ema read 2026-08-31 | Authorised ema · 2026-10-03 |
| EU authorised on differs | Not checked no record of "authorisedOn" for retatrutide | 2018-02-08 ema · 2026-10-03 |
| ATC code differs | Not checked no record of "atcCode" for retatrutide | A10BJ06 ema · 2026-10-03 |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Retatrutide | placebo | Semaglutide | placebo |
|---|---|---|---|---|
| Nausea | 26.0% | 8.7% | 19.5% | 4.5% |
| Decreased appetite | 17.9% | 5.2% | 6.3% | 1.3% |
| Covid-19 | 14.9% | 14.8% | 17.0% | 17.8% |
| Diarrhoea | 14.2% | 8.7% | 11.8% | 4.5% |
| Constipation | 10.7% | 2.6% | 8.9% | 2.8% |
| Vomiting | 10.1% | 1.7% | 8.6% | 1.6% |
| Fatigue | 6.6% | 2.6% | - | - |
| Lipase increased | 5.5% | 3.5% | - | - |
| Hypertension | 5.2% | 2.9% | - | - |
| Gastrooesophageal reflux disease | 4.9% | 1.4% | - | - |
| Nasopharyngitis | - | - | 7.5% | 6.1% |
| Dyspepsia | - | - | 5.3% | 1.2% |
| Headache | - | - | 4.0% | 2.1% |
| Upper respiratory tract infection | - | - | 2.7% | 1.9% |
Trial register Retatrutide: 2 placebo-controlled trials; Semaglutide: 50. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Retatrutide side effects · Semaglutide side effects
LEGAL STATUS
Approval in each country read
| Country | Retatrutide | Semaglutide | Register |
|---|---|---|---|
| United States | Not on the register | FDA-approved | Regulator FDA |
| European Union | Not on the register | Authorised | Regulator EMA |
| United Kingdom | Not on the register | Authorised | Regulator MHRA |
| Canada | Not on the register | Authorised | Regulator Health Canada |
| Australia | Status unknown | Registered | TGA |
| Switzerland | Not on the register | Authorised | Regulator Swissmedic |
| Brazil | Not on the register | Registado | Regulator ANVISA |
| Serbia | Not on the register | Authorised | Regulator ALIMS |
| Singapore | Not on the register | Registered | Regulator HSA |
| Turkey | Not on the register | Ruhsatli | Regulator TITCK |
HEAD TO HEAD
2 registered trials include both
| NCT06260722 | Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 ACTIVE_NOT_RECRUITING · updated 2026-09-28 |
|---|---|
| NCT06982859 | A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus ACTIVE_NOT_RECRUITING · updated 2026-07-16 |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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