COMPARISON
Exenatide vs Retatrutide
5 attributes held for at least one of the two. 5 differ. Each value carries the register it came from and the date that register was read.
Answer
Exenatide is authorised or registered in 5 and Retatrutide in 0 of the 10 registers read. Exenatide: highest phase Phase 2. Retatrutide: highest phase Phase 3 (20 phase 3 trials, 0 with posted results). 0 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Exenatide | Retatrutide | |
|---|---|---|
| Registered trials differs | 383 clinicaltrials.gov · 2026-10-03 | 41 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: Byetta openfda · 2026-10-03T17:23:44.062Z | Not checked no record of "fdaLabel" for retatrutide |
| EU authorisation differs | Withdrawn ema · 2026-10-03 | Nothing on record ema read 2026-08-31 |
| EU withdrawn on differs | 2024-11-20 ema · 2026-10-03 | Not checked no record of "withdrawnOn" for retatrutide |
| ATC code differs | A10BJ01 ema · 2026-10-03 | Not checked no record of "atcCode" for retatrutide |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Exenatide | placebo | Retatrutide | placebo |
|---|---|---|---|---|
| Constipation | 0.8% | 0.3% | 10.7% | 2.6% |
| Fatigue | 0.6% | 0.1% | 6.6% | 2.6% |
| Headache | 1.9% | 1.3% | - | - |
| Non-cardiac chest pain | 1.1% | 1.0% | - | - |
| Osteoarthritis | 0.9% | 1.0% | - | - |
| Dizziness | 0.8% | 0.4% | - | - |
| Dyspepsia | 0.8% | 0.3% | - | - |
| Chronic obstructive pulmonary disease | 0.7% | 0.7% | - | - |
| Back pain | 0.5% | 0.6% | - | - |
| Sinusitis | 0.5% | 0.2% | - | - |
| Nausea | - | - | 26.0% | 8.7% |
| Decreased appetite | - | - | 17.9% | 5.2% |
| Covid-19 | - | - | 14.9% | 14.8% |
| Diarrhoea | - | - | 14.2% | 8.7% |
| Vomiting | - | - | 10.1% | 1.7% |
| Lipase increased | - | - | 5.5% | 3.5% |
| Hypertension | - | - | 5.2% | 2.9% |
| Gastrooesophageal reflux disease | - | - | 4.9% | 1.4% |
Trial register Exenatide: 24 placebo-controlled trials; Retatrutide: 2. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Exenatide side effects · Retatrutide side effects
LEGAL STATUS
Approval in each country read
| Country | Exenatide | Retatrutide | Register |
|---|---|---|---|
| United States | FDA-approved | Not on the register | Regulator FDA |
| European Union | Withdrawn | Not on the register | Regulator EMA |
| United Kingdom | Authorised | Not on the register | Regulator MHRA |
| Canada | Authorised | Not on the register | Regulator Health Canada |
| Australia | Status unknown | Status unknown | TGA |
| Switzerland | Not on the register | Not on the register | Regulator Swissmedic |
| Brazil | Registado | Not on the register | Regulator ANVISA |
| Serbia | Not on the register | Not on the register | Regulator ALIMS |
| Singapore | Not on the register | Not on the register | Regulator HSA |
| Turkey | Ruhsatli | Not on the register | Regulator TITCK |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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