COMPARISON
Exenatide vs Tirzepatide
6 attributes held for at least one of the two. 6 differ. Each value carries the register it came from and the date that register was read.
Answer
Exenatide is authorised or registered in 5 and Tirzepatide in 10 of the 10 registers read. Exenatide: highest phase Phase 2. Tirzepatide: highest phase Phase 4 (after approval). 3 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Exenatide | Tirzepatide | |
|---|---|---|
| Registered trials differs | 383 clinicaltrials.gov · 2026-10-03 | 309 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: Byetta openfda · 2026-10-03T17:23:44.062Z | FDA-approved: MOUNJARO openfda · 2026-10-03T17:23:44.062Z |
| EU authorisation differs | Withdrawn ema · 2026-10-03 | Authorised ema · 2026-10-03 |
| EU authorised on differs | Not checked no record of "authorisedOn" for exenatide | 2022-09-15 ema · 2026-10-03 |
| EU withdrawn on differs | 2024-11-20 ema · 2026-10-03 | Not checked no record of "withdrawnOn" for tirzepatide |
| ATC code differs | A10BJ01 ema · 2026-10-03 | A10BX16 ema · 2026-10-03 |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Exenatide | placebo | Tirzepatide | placebo |
|---|---|---|---|---|
| Headache | 1.9% | 1.3% | 6.6% | 6.2% |
| Constipation | 0.8% | 0.3% | 13.7% | 4.5% |
| Dyspepsia | 0.8% | 0.3% | 7.9% | 2.7% |
| Non-cardiac chest pain | 1.1% | 1.0% | - | - |
| Osteoarthritis | 0.9% | 1.0% | - | - |
| Dizziness | 0.8% | 0.4% | - | - |
| Chronic obstructive pulmonary disease | 0.7% | 0.7% | - | - |
| Fatigue | 0.6% | 0.1% | - | - |
| Back pain | 0.5% | 0.6% | - | - |
| Sinusitis | 0.5% | 0.2% | - | - |
| Nausea | - | - | 25.6% | 8.1% |
| Diarrhoea | - | - | 21.2% | 8.3% |
| Covid-19 | - | - | 15.5% | 16.0% |
| Decreased appetite | - | - | 11.6% | 2.9% |
| Vomiting | - | - | 11.4% | 2.6% |
| Abdominal pain | - | - | 6.0% | 2.7% |
| Upper respiratory tract infection | - | - | 5.7% | 6.2% |
Trial register Exenatide: 24 placebo-controlled trials; Tirzepatide: 19. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Exenatide side effects · Tirzepatide side effects
LEGAL STATUS
Approval in each country read
| Country | Exenatide | Tirzepatide | Register |
|---|---|---|---|
| United States | FDA-approved | FDA-approved | Regulator FDA |
| European Union | Withdrawn | Authorised | Regulator EMA |
| United Kingdom | Authorised | Authorised | Regulator MHRA |
| Canada | Authorised | Authorised | Regulator Health Canada |
| Australia | Status unknown | Registered | TGA |
| Switzerland | Not on the register | Authorised | Regulator Swissmedic |
| Brazil | Registado | Registado | Regulator ANVISA |
| Serbia | Not on the register | Authorised | Regulator ALIMS |
| Singapore | Not on the register | Registered | Regulator HSA |
| Turkey | Ruhsatli | Ruhsatli | Regulator TITCK |
HEAD TO HEAD
3 registered trials include both
| NCT07702461 | Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists RECRUITING · updated 2026-07-24 |
|---|---|
| NCT07309094 | Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD RECRUITING · updated 2025-12-30 |
| NCT07188545 | Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Rea ACTIVE_NOT_RECRUITING · updated 2025-09-23 |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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