COMPARISON
Motixafortide vs Plecanatide
3 attributes held for at least one of the two. 2 differ. Each value carries the register it came from and the date that register was read.
Answer
Motixafortide is authorised or registered in 2 and Plecanatide in 2 of the 10 registers read. Motixafortide: highest phase Phase 3 (1 phase 3 trial, 0 with posted results). Plecanatide: No trial states a phase. 0 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Motixafortide | Plecanatide | |
|---|---|---|
| Registered trials differs | 11 clinicaltrials.gov · 2026-10-03 | 15 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: APHEXDA openfda · 2026-10-03T17:23:44.062Z | FDA-approved: Trulance Immediate release openfda · 2026-10-03T17:23:44.062Z |
| EU authorisation | Nothing on record ema read 2026-08-31 | Nothing on record ema read 2026-08-31 |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Motixafortide | placebo | Plecanatide | placebo |
|---|---|---|---|---|
| Leukocytosis | 98.6% | 0.0% | - | - |
| Injection site pain | 93.2% | 27.8% | - | - |
| Injection site erythema | 78.1% | 11.1% | - | - |
| Pruritus | 61.6% | 0.0% | - | - |
| Urticaria | 49.3% | 0.0% | - | - |
| Injection site pruritus | 46.6% | 8.3% | - | - |
| Flushing | 42.5% | 0.0% | - | - |
| Injection site induration | 37.0% | 13.9% | - | - |
| Feeling hot | 35.6% | 0.0% | - | - |
| Paraesthesia | 27.4% | 0.0% | - | - |
| Diarrhoea | - | - | 5.8% | 1.2% |
| Headache | - | - | 2.3% | 1.6% |
Trial register Motixafortide: 1 placebo-controlled trials; Plecanatide: 8. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Motixafortide side effects · Plecanatide side effects
LEGAL STATUS
Approval in each country read
| Country | Motixafortide | Plecanatide | Register |
|---|---|---|---|
| United States | FDA-approved | FDA-approved | Regulator FDA |
| European Union | Not on the register | Not on the register | Regulator EMA |
| United Kingdom | Not on the register | Not on the register | Regulator MHRA |
| Canada | Not on the register | Authorised | Regulator Health Canada |
| Australia | Status unknown | Status unknown | TGA |
| Switzerland | Not on the register | Not on the register | Regulator Swissmedic |
| Brazil | Not on the register | Not on the register | Regulator ANVISA |
| Serbia | Not on the register | Not on the register | Regulator ALIMS |
| Singapore | Registered | Not on the register | Regulator HSA |
| Turkey | Not on the register | Not on the register | Regulator TITCK |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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