guanylate cyclase-C agonist
Plecanatide
Answer
Plecanatide is authorised or registered in the US and Canada: 2 of the 10 registers read. No trial states a phase. It has 15 registered trials, 1 of them running. Brand names on the FDA label register: Trulance Immediate Release.
RegulatorTrial register10 regulators' registers, read 2026-08-31 to 2026-10-03 · ClinicalTrials.gov, read 2026-10-03
Not medical, legal or regulatory advice.
15 trials by status
Trial registerClinicalTrials.gov · read 2026-10-03 · 10 trials have posted results
Trials first submitted per year
Trial registerClinicalTrials.gov first-submitted date, last 10 years · read 2026-10-03. 2026 is not complete. 1 trial carries no first-submitted date (EU CTIS publishes none, or the year is outside this range).
Status by jurisdiction
World map| Where | Status | Register | Read |
|---|---|---|---|
| United States | FDA-approved | FDA, openfda | 2026-10-03 |
| European Union | Not on the register | EMA, ema | 2026-08-31 |
| United Kingdom | Not on the register | MHRA, uk-mhra | 2026-09-03 |
| Canada | Authorised | Health Canada, ca-dpd | 2026-10-03 |
| Australia | Status unknown | TGA, au-artg | not read |
| Switzerland | Not on the register | Swissmedic, ch-swissmedic | 2026-09-03 |
| Brazil | Not on the register | ANVISA, br-anvisa | 2026-09-03 |
| Serbia | Not on the register | ALIMS, rs-alims | 2026-09-03 |
| Singapore | Not on the register | HSA, sg-hsa | 2026-09-03 |
| Turkey | Not on the register | TITCK, tr-titck | 2026-09-03 |
An EU decision applies in the 30 territories the EU register covers: its member states, and Iceland, Liechtenstein and Norway. A dashed tile has no register read for this peptide.
Side effects
Trial registerCHANGE ALERTS
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One email when the status of Plecanatide changes on the register. You confirm your address first.
REGISTERED TRIALS
Newest 10 of 15 trials
| NCT07723924 | This is a Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study of the Efficacy and Safety of 2 Weight-b currently recruiting participants · register updated 2026-10-02 |
|---|---|
| NCT05107219 | GCC Agonist Signal in the Small Intestine completed · register updated 2026-04-07 |
| NCT03596905 | Efficacy and Safety of Plecanatide in Children 6 to <18 Years With Irritable Bowel Syndrome With Constipation (IBS-C) completed · register updated 2025-12-31 |
| NCT05151328 | Efficacy and Safety of Plecanatide Comparing With Placebo in the Treatment of Functional Constipation completed · register updated 2024-07-11 |
| NCT02706483 | Long Term Safety Study of Plecanatide completed · register updated 2020-08-18 |
| NCT01053962 | SP-304 Dose Ranging Study in Patients With Chronic Idiopathic Constipation completed · register updated 2020-01-02 |
| NCT01982240 | 12-Week Study of Plecanatide for CIC (The CIC3 Study) completed · register updated 2019-12-26 |
| NCT03551873 | A Postmarketing Study of Plecanatide in Breast Milk of Lactating Women Treated With TRULANCE® completed · register updated 2019-11-22 |
| NCT03120520 | An Efficacy and Safety Study of Plecanatide in Adolescents 12 to <18 Years of Age With Chronic Idiopathic Constipation completed · register updated 2019-10-04 |
| NCT01919697 | Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC) completed · register updated 2019-07-02 |
WEEKLY
Register Watch, weekly
New trials, approvals and enforcement actions. One email a week.