COMPARISON
Plecanatide vs SS-31 (elamipretide)
3 attributes held for at least one of the two. 2 differ. Each value carries the register it came from and the date that register was read.
Answer
Plecanatide is authorised or registered in 2 and SS-31 (elamipretide) in 0 of the 10 registers read. Plecanatide: No trial states a phase. SS-31 (elamipretide): No trial states a phase. 0 registered trials include both.
States no view on which is preferable, safer or more effective. Not medical advice.
| Plecanatide | SS-31 (elamipretide) | |
|---|---|---|
| Registered trials differs | 15 clinicaltrials.gov · 2026-10-03 | 30 clinicaltrials.gov · 2026-10-03 |
| FDA label differs | FDA-approved: Trulance Immediate release openfda · 2026-10-03T17:23:44.062Z | Not checked no record of "fdaLabel" for ss-31 |
| EU authorisation | Nothing on record ema read 2026-08-31 | Nothing on record ema read 2026-08-31 |
SIDE EFFECTS
Most common side effects, each beside its own placebo
| Side effect | Plecanatide | placebo | SS-31 (elamipretide) | placebo |
|---|---|---|---|---|
| Headache | 2.3% | 1.6% | 4.4% | 3.4% |
| Diarrhoea | 5.8% | 1.2% | - | - |
| Injection site erythema | - | - | 63.8% | 44.7% |
| Injection site pain | - | - | 29.4% | 21.8% |
| Nasopharyngitis | - | - | 5.5% | 2.4% |
| Nausea | - | - | 4.8% | 4.7% |
| Fall | - | - | 4.3% | 4.7% |
| Hypertension | - | - | 3.7% | 2.7% |
| Dizziness | - | - | 3.1% | 2.5% |
| Cough | - | - | 3.0% | 2.2% |
| Urinary Tract Infection | - | - | 2.9% | 2.3% |
Trial register Plecanatide: 8 placebo-controlled trials; SS-31 (elamipretide): 5. Each peptide is compared with placebo in its own trials, not with the other: a dash means the event is not in that peptide's top list. Plecanatide side effects · SS-31 (elamipretide) side effects
LEGAL STATUS
Approval in each country read
| Country | Plecanatide | SS-31 (elamipretide) | Register |
|---|---|---|---|
| United States | FDA-approved | Not on the register | Regulator FDA |
| European Union | Not on the register | Not on the register | Regulator EMA |
| United Kingdom | Not on the register | Not on the register | Regulator MHRA |
| Canada | Authorised | Not on the register | Regulator Health Canada |
| Australia | Status unknown | Status unknown | TGA |
| Switzerland | Not on the register | Not on the register | Regulator Swissmedic |
| Brazil | Not on the register | Not on the register | Regulator ANVISA |
| Serbia | Not on the register | Not on the register | Regulator ALIMS |
| Singapore | Not on the register | Not on the register | Regulator HSA |
| Turkey | Not on the register | Not on the register | Regulator TITCK |
Values reproduce public registers on the dates shown. This comparison states no view on which compound is preferable, safer or more effective. Not medical, legal or regulatory advice.
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