melanocortin-1 receptor agonist
Afamelanotide clinical trials
Answer
Afamelanotide has 28 registered trials: 1 running, 18 completed, 0 stopped early. 12 posted results.
Trial registerClinicalTrials.gov and EU CTIS, read 2026-10-03
| Trial | Title | Status | Phase | Registered | Results |
|---|---|---|---|---|---|
| NCT06388642 Trial register | Pharmacokinetics of Afamelanotide in Erythropoietic Protoporphyria Patients | completed | - | 2024-04-29 | Posted |
| 2023-505907-21-00 Trial register | A Mechanistic Study to Evaluate Impact of Afamelanotide in Aqueous Solution on Ultraviolet Radiation-Induced DNA Damage and DNA Repair Capacity in Healthy Volun | Not stated | 2 | - | - |
| NCT06109649 Trial register | A Study to Compare the Efficacy and Safety of SCENESSE and Narrow-Band Ultraviolet (NB-UVB) Light Versus NB-UVB Light Alone in Patients With Vitiligo | running, but no longer enrolling | - | 2023-10-31 | - |
| NCT05854784 Trial register | Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Variegate Porphyria (VP) | completed | - | 2023-05-11 | Posted |
| 2023-507311-35-00 Trial register | A Study to Evaluate the Pharmacokinetics of Afamelanotide in Patients with Erythropoietic Protoporphyria (EPP). | Not stated | 1/2 | - | - |
| 2022-500919-40-01 Trial register | A Phase IIa, Open Label, Proof of Concept Study to Evaluate the Safety of Aqueous Afamelanotide Solution in Patients with acute Arterial Ischaemic Stroke (AIS) | Not stated | 2 | - | - |
| 2022-502207-30-01 Trial register | A Proof of Concept, Phase IIa, Open Label Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients with Early Parkinson's Disease | Not stated | 2 | - | - |
| NCT04525157 Trial register | Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Phototherapy in the Treatment of Nonsegmental Vitiligo (NSV) | completed | - | 2020-08-25 | Posted |
| NCT05370235 Trial register | A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum C and V | last verified some time ago; the register no longer confirms its status | - | 2022-05-11 | - |
| 2022-502207-30-00 Trial register | A Phase IIa, Open Label Study to Evaluate the Safety of Afamelanotide in Patients with Early Parkinson's Disease | Not stated | 2 | - | - |
| NCT05159752 Trial register | A Study to Evaluate the Safety and Efficacy of Afamelanotide in Patients With Xeroderma Pigmentosum (XP) | last verified some time ago; the register no longer confirms its status | - | 2021-12-16 | - |
| NCT04962503 Trial register | A Proof of Concept Study to Evaluate the Safety of Afamelanotide in Patients With Acute Arterial Ischaemic Stroke (AIS) | completed | - | 2021-07-15 | Posted |
| NCT05210582 Trial register | A Study to Assess the Changes in Pigmentation and Safety of Afamelanotide in Patients With Vitiligo on the Face | last verified some time ago; the register no longer confirms its status | - | 2022-01-27 | - |
| NCT05368857 Trial register | DNA Repair Capacity of Afamelanotide on Ultraviolet Radiation-induced DNA Damage in Healthy Volunteers | completed | - | 2022-05-10 | - |
| NCT04943159 Trial register | Afamelanotide in Patients Suffering With Acne Vulgaris | completed | - | 2021-06-29 | Posted |
| NCT00979745 Trial register | Phase III Confirmatory Study in Erythropoietic Protoporphyria (EPP) | completed | - | 2009-09-18 | Posted |
| NCT04425746 Trial register | Afamelanotide as Adjunctive Therapy in Patients Undergoing Photodynamic Therapy (PDT) Utilising Porfimer Sodium | completed | - | 2020-06-11 | Posted |
| NCT04704713 Trial register | Afamelanotide in Patients Suffering From Polymorphic Light Eruption (PLE) | completed | - | 2021-01-12 | Posted |
| NCT04578496 Trial register | A Safety Extension Study in Patients With Erythropoietic Protoporphyria (EPP) | completed | - | 2020-10-08 | Posted |
| NCT01097044 Trial register | Phase II Confirmatory Study in Erythropoietic Protoporphyria (EPP) | completed | - | 2010-04-01 | Posted |
| NCT04053270 Trial register | Multicentre Phase III Erythropoietic Protoporphyria Study | completed | - | 2019-08-12 | Posted |
| NCT01605136 Trial register | Phase III Confirmatory Study in Erythropoietic Protoporphyria | completed | - | 2012-05-24 | Posted |
| NCT03634137 Trial register | Implant Pharmacokinetic and Pharmacodynamic Study | completed | - | 2018-08-16 | - |
| NCT01382589 Trial register | Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental Vitiligo | completed | - | 2011-06-27 | - |
| NCT01430195 Trial register | Afamelanotide and Narrow-Band Ultraviolet B (NB-UVB) Light in the Treatment of Nonsegmental Vitiligo (NSV) | completed | - | 2011-09-08 | - |
| NCT00472901 Trial register | Phase III Trial of CUV1647 in Polymorphic Light Eruption (PLE) | completed | - | 2007-05-14 | - |
| NCT00829192 Trial register | Phase II AK Study in Organ Transplant Patients | last verified some time ago; the register no longer confirms its status | - | 2009-01-26 | - |
| NCT00859534 Trial register | Phase II Solar Urticaria (SU) Pilot Study | completed | - | 2009-03-11 | - |
Source: ClinicalTrials.gov and EU CTIS, read 2026-10-03. Not medical advice.
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