cyclic polypeptide antibiotic

Colistin clinical trials

Answer

Colistin has 130 registered trials: 23 running, 58 completed, 12 stopped early. 9 posted results.

Trial registerClinicalTrials.gov and EU CTIS, read 2026-10-03

TrialTitleStatusPhaseRegisteredResults
2022-501575-12-00
Trial register
C3601008 - A PHASE 2A MULTICENTER, OBSERVER-BLINDED, RANDOMIZED 2 ARM STUDY TO INVESTIGATE PHARMACOKINETICS, SAFETY, TOLERABILITY AND EFFICACY OF INTRAVENOUS AZNot stated2--
NCT06819462
Trial register
Inhaled Colistin to Prevent Ventilator-Associated Pneumonia in Patients With Acute Brain Injurycurrently recruiting participants-2025-02-11-
2025-524657-14-00
Trial register
Comparative bioavailability study of Colistin Cyclops® administered as 3 different dosesNot stated1--
NCT07082465
Trial register
Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailandrunning, but no longer enrolling-2025-07-02-
2024-519748-34-00
Trial register
A Randomized controlled open-label phase II trial assessing the efficacy and safety of two-dosing regimens of frozen encapsulated fecal microbiota transfer prodNot stated2--
NCT07512596
Trial register
Study on the Safety and Efficacy of Polymyxin E2 Methanesulfonate for Injection in the Treatment of Hospital-Acquired Bacterial Pneumonia/Ventilator-Associated not yet recruiting participants-2026-03-27-
NCT07694700
Trial register
Colistin and Meropenem Versus Amikacin and Meropenem for MDR Gram Negative Bacteria Regarding Efficacy and Safety.running, but no longer enrolling-2026-07-10-
NCT06087536
Trial register
A Clinical Trial to Assess the Safety and PK of OMN6 in HABP or VABP Caused by Acinetobacter Baumannii Complexcurrently recruiting participants-2023-07-25-
NCT07671755
Trial register
Colistin Versus Colistin Combined With Cefoperazone-sulbactam for Multiresistant Acinetobactor Baumannii Ventilator-associated Pneumonia Treatmentcompleted-2026-06-26-
NCT07668141
Trial register
Colistin Nephrotoxicity and Role of Alpha Lipoic Acidnot yet recruiting participants-2026-06-25-
NCT04764500
Trial register
Developing Microbials to Fight Extended-spectrum Beta-lactamase (ESBL)-Producing Escherichia Colicompleted-2021-02-17-
2025-524092-23-00
Trial register
A Phase 3 prospective, randomized, multicenter, active-controlled study to evaluate the efficacy and safety of BV100 plus low-dose polymyxin B compared with colNot stated3--
NCT06834971
Trial register
Colistin Methanesulfonate Sodium Inhalation for Prophylaxis of Ventilator-Associated Pneumonia (CIVAP): A Prospective, Multicentre, Double-Blind, Randomized, Plcurrently recruiting participants-2025-02-19-
NCT07326540
Trial register
Efficacy and Safety of BV100 Plus Low Dose Polymyxin B Versus Colistin Plus High-dose Ampicillin/Sulbactam in Patients With Hospital-acquired or Ventilator-assocurrently recruiting participants-2026-01-08-
NCT02918409
Trial register
IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacycompleted-2016-09-29Posted
NCT07524920
Trial register
Comparing Efficacy and Safety of (Meropenem + Colistin) Versus (Imipenem/Cilastatin + Tigecycline) on Eradication of Multi-Drug Resistance Bacterianot yet recruiting participants-2026-04-13-
NCT07503600
Trial register
The Effect of Adjunctive Melatonin With Colistin in Patients With Multidrug-Resistant Gram-Negative Bacterial Infectionsnot yet recruiting participants-2026-03-31-
NCT07487116
Trial register
Phenotypic and Genotypic Detection of Colistin Resistancenot yet recruiting participants-2026-03-23-
NCT06966284
Trial register
A Post-Marketing Study to Assess the Efficacy and Safety of Intravenous Polymyxin B and Colistin Methanesulfonate in Patients With Carbapenem-Resistant Gram-Negcurrently recruiting participants-2025-05-11-
NCT06230614
Trial register
Effect of Diluent Volume on Colistin Inhalation Therapycurrently recruiting participants-2024-01-30-
NCT06488794
Trial register
Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonianot yet recruiting participants-2024-06-15-
2023-504755-26-00
Trial register
Comparison of Two Antibiotic Regimens for the Treatment of Early Airways Infection With PA in Adults With Bronchiectasis (ANTEIPA)Not stated2--
NCT06650384
Trial register
Efficacy and Safety of N-Acetylcysteine Versus Alpha-Lipoic Acid in Colistin-Induced Nephrotoxicitycompleted-2024-10-21-
NCT06440304
Trial register
Therapeutic Options for CRABcurrently recruiting participants-2024-05-21-
NCT03477292
Trial register
7-days Versus 14 Days of Antibiotics Therapy for Ventilator Associated Pneumoniacompleted-2018-03-20-
2024-516232-10-00
Trial register
Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether conNot stated4--
2025-520940-14-00
Trial register
TIME-TO-LIA : Optimal Duration of Antibiotic Therapy in Drained Pyogenic Liver Abscess: 3 weeks versus 6 weeks, a non-inferiority trialNot stated4--
NCT07172932
Trial register
ANTIBIOTIC-RESISTANT ENTEROBACTERALES BLOODSTREAM INFECTIONS AND RISK FACTORS IN PATIENTS ADMITTED TO THE INTENSIVE CARE UNITcompleted-2025-09-08-
NCT06472271
Trial register
Colistin Dosage Prsonalization Approachcurrently recruiting participants-2024-06-25-
NCT05922124
Trial register
Cefiderocol and Ampicillin-sulbactam vs. Colistin +/- Meropenem for Carbapenem Resistant A. Baumanniicurrently recruiting participants-2023-06-28-
NCT07089186
Trial register
Study to Assess the Efficacy and Safety of Meropenem and Pralurbactam in Carbapenem-Resistant Enterobacteriaceae Infectionscurrently recruiting participants-2025-07-28-
NCT06843668
Trial register
Different Dosing Strategies of Colistin in Multidrug-Resistant Gram-Negative Bacilli Infectionscurrently recruiting participants-2025-02-25-
2024-515180-56-00
Trial register
A Phase 3, Multi-Center, Randomized, Single-Blind Study to Assess the Efficacy and Safety of Cefepime/Nacubactam and Aztreonam/Nacubactam Versus Best Available Not stated3--
NCT07004049
Trial register
Optimising TREATment for Severe Gram-Negative Bacterial Infectionscurrently recruiting participants-2025-06-04-
NCT06051513
Trial register
Efficacy and Safety of Colistimethate Sodium for Injection in The Treatment of Carbapenem-Resistant Enterobacteriaceae Infectioncurrently recruiting participants-2023-09-25-
NCT06893835
Trial register
Comparative Study of Clinical Outcomes and Safety Between Colistin and Tigecyclinerunning, but no longer enrolling-2025-03-25-
NCT05865743
Trial register
Perioperative SDD to Prevent Infectious Complications After Esophagectomycurrently recruiting participants-2023-04-25-
NCT06827756
Trial register
Comparative Study of Secondary Prophylaxis for SBPcompleted-2025-02-14-
NCT05685615
Trial register
PK of BV100 in Patients VABP Suspected or Confirmed to Be Due to CRABcompleted-2023-01-04-
NCT03329092
Trial register
A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for thcompleted-2017-11-01Posted
NCT06419296
Trial register
Mortality of MBL-producing Enterobacteriaceae Bacteremias with the Combined Use of Ceftazidime-avibactam and Aztreonam Vs. Other Active Antibiotics. a Multicentcompleted-2024-05-14-
NCT04882085
Trial register
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adultscompleted-2021-04-27Posted
NCT06570850
Trial register
Colistin Monotherapy vs Colsitin-fosfomycine in CRAB Infectionlast verified some time ago; the register no longer confirms its status-2024-08-26-
NCT05258851
Trial register
Ceftazidime-Avibactam Use in Critically Ill Patients With Carbapenem-Resistant Enterobacteriaceae Infectionsterminated before completion-2022-02-28-
NCT05542446
Trial register
Pharmacokinetics of Colistin in Critically Ill Patients With Extracorporeal Membrane Oxygenationterminated before completion-2022-09-15-
NCT06198764
Trial register
A Clinical Trial for the Treatment of Carbapenem Resistant Gram-negative Bacterial Infection With Colistimethate Sodium for Injectionlast verified some time ago; the register no longer confirms its status-2023-12-27-
NCT03460704
Trial register
Trial in Non-cystic Fibrosis Bronchiectasis Patients With Chronic Lung Infections Treated With Colistimethate Sodium.terminated before completion-2018-02-14Posted
NCT03093974
Trial register
Efficacy and Safety of Inhaled CMS in Bronchiectasis Subjects With Chronic P. Aeruginosa Infection. (PROMIS-I)completed-2017-03-09Posted
NCT05613361
Trial register
The Effect of Curcumin Against Colistin-induced Nephrotoxicitylast verified some time ago; the register no longer confirms its status-2022-11-14-
NCT02389036
Trial register
Selective Decontamination of the Digestive Tract in Intensive Care Unit Patientscompleted-2015-03-02-
NCT05960084
Trial register
Impact of Reducing Colistin Use on Colistin Resistance in Humans and Poultry in Indonesialast verified some time ago; the register no longer confirms its status-2023-07-25-
NCT04633317
Trial register
Aerosolized Colistin to Mechanical Ventilated Patients With Pneumoniacompleted-2020-11-18-
NCT05862402
Trial register
Dose Optimization by Pharmacokinetic/Pharmacodynamic of Antibiotics to Improve Clinical Outcome of Carbapenem Resistant Klebsiella Pneumoniae Bloodstream Infectlast verified some time ago; the register no longer confirms its status-2023-04-26-
NCT05850871
Trial register
Drug Resistance Mechanism of Enterobacteriaceae and Its Strategieslast verified some time ago; the register no longer confirms its status-2023-04-06-
NCT05833412
Trial register
Molecular Early Sepsis Identification Studylast verified some time ago; the register no longer confirms its status-2023-04-17-
NCT03894046
Trial register
Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoacompleted-2019-03-28Posted
NCT05689229
Trial register
Aerosolized Versus Intravenous Colistin-based Antimicrobial Regimens in Hospitalized COVID-19 Patients With Bacterial Coinfection: A Randomized Controlled Trialcompleted-2023-01-19-
NCT05586815
Trial register
Efficacy of Colistin Monotherapy Versus Colistin Plus Minocycline for Carbapenem-Resistant A. Baumannii Infectionlast verified some time ago; the register no longer confirms its status-2022-10-19-
NCT05586438
Trial register
Pharmacokinetics of Colistin in Critically-ill Patients With AKI Who Receive SLEDcompleted-2022-10-19-
NCT01597973
Trial register
Trial for the Treatment of Extensively Drug-Resistant Gram-negative Bacilli (OVERCOME)completed-2012-05-15Posted
NCT05279586
Trial register
Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhotic Patientslast verified some time ago; the register no longer confirms its status-2022-03-15-
NCT03971877
Trial register
Detection of Colistin-resistant Isolates From Patients of Intensive Care Units and Oncohaematology Wards.completed-2019-06-03-
NCT04995133
Trial register
Colistin Intravenous Administration in Critically Ill Patients Suffering From Hospital Infections Caused by Multi-antibiotic-resistant Germs.last verified some time ago; the register no longer confirms its status-2021-08-06-
NCT02099240
Trial register
Patients Response to Early Switch To Oral:Osteomyelitis Studyterminated before completion-2014-03-18-
NCT04764058
Trial register
Efficacy and Safety of Colistin Based Antibiotic Therapylast verified some time ago; the register no longer confirms its status-2021-02-21-
NCT04208763
Trial register
A Randomized Controlled Trial Comparing Imipenem and Tigecycline Versus Imipenem and Tigecycline With GM-CSF for the Management of Spontaneous Bacterial Peritonlast verified some time ago; the register no longer confirms its status-2019-12-23-
NCT03397914
Trial register
Effect of Different Colistin Doses on Clinical Outcome of Pediatric Cancer Patients With Gram Negative Infectionscompleted-2018-01-12-
NCT01793012
Trial register
Drug Monitoring of Antibiotics in Critical Care Patientscompleted-2013-01-24-
NCT04489459
Trial register
Comparative Clinical Study Between Colistin-Tigecycline Combined Therapy Versus Colistin-Meropenem Combined Therapy in Treatment of Blood Stream Infections Withlast verified some time ago; the register no longer confirms its status-2020-07-28-
NCT03190421
Trial register
Expanded Quantitative Urinary Culture (EQUC) vs Standard Culture (SUC) Techniques in the Clinical Carecompleted-2017-06-14-
NCT01863719
Trial register
Aerosolized and Intravenous Colistin in Healthy Adultsterminated before completion-2013-05-29-
NCT04208945
Trial register
Nebulized Colistin for Gram Negative VAP Prevention.last verified some time ago; the register no longer confirms its status-2019-12-23-
NCT02134106
Trial register
Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteriawithdrawn before enrolling anyone-2014-05-04-
NCT02894684
Trial register
Aztreonam for Inhalation Solution (AZLI) for the Treatment of Exacerbations of Cystic Fibrosiscompleted-2016-09-01-
NCT03409679
Trial register
Pivotal Study in VAP Suspected or Confirmed to be Due to Pseudomonas Aeruginosaterminated before completion-2018-01-08-
NCT03597841
Trial register
Turkish Prospective Cohort Study on Carbapenem Resistant Klebsiella Pneumonia Bacteremiacompleted-2018-07-09-
NCT02288429
Trial register
Evaluation of Pharmacokinetic and Pharmacodynamic Properties of Intravenous Colistimethate Sodiumcompleted-2014-09-15-
NCT01740947
Trial register
Does Administration of Antibiotics in Patients Undergoing Surgery for Colorectal Cancer Result in Less Complications and Better Prognosis?terminated before completion-2012-12-04-
NCT02452047
Trial register
Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) Versus Colistimethate Sodium+Imipenem+Cilastatin in Imipenem-Resistant Bacterial Infection (MK-completed-2015-05-20Posted
NCT01970371
Trial register
A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)completed-2013-10-28Posted
NCT02906722
Trial register
Nebulized and Intravenous Colistin in Ventilator Associated-pneumoniaterminated before completion-2016-09-20-
NCT03622450
Trial register
The Effect of Colistin Inhalation on Ventilator Associated Pneumoniacompleted-2018-08-09-
NCT03622918
Trial register
Colistin-rifampin Combination and Colistin Monotherapy in Extensively Drug-resistant Acinetobacter Baumanniicompleted-2018-08-09-
NCT02806141
Trial register
Aerosolized Plus Intravenous vs. Intravenous Colistin for VAP Due to Pandrugs-resistant A. Baumannii in Neonatesterminated before completion-2016-06-20-
NCT02482961
Trial register
Impact of Plasma Levels of Colistin in Patients With Carbapenem Resistant Acinetobacter Baumannii Infectioncompleted-2015-06-26-
NCT03007290
Trial register
Clinical Usefulness of Therapeutic Drug Monitoring of Colistin in Patients Treated With Colistin.completed-2017-01-02-
NCT02117986
Trial register
Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patientslast verified some time ago; the register no longer confirms its status-2014-04-21-
NCT02966457
Trial register
A Study of DEcolonization in Patients With HAematological Malignancies (DEHAM)completed-2016-11-15-
NCT02472600
Trial register
Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapylast verified some time ago; the register no longer confirms its status-2015-06-16-
NCT03341741
Trial register
Combined Dry Powder Tobramycin and Nebulized Colistin Inhalation in CF Patientscompleted-2017-11-14-
NCT02208154
Trial register
Ecological Effects of Decolonisation Strategies in Intensive Carecompleted-2014-07-22-
NCT01449838
Trial register
Phase I Study of Colistin Methanesulfonate Sodiumcompleted-2011-10-10-
NCT01931592
Trial register
Controling Intestinal Colonization With Extended Spectrum ß-Lactamase Producing Enterobacteriaceae ESBL-Eterminated before completion-2013-08-26-
NCT01266499
Trial register
A Study Evaluating the Role of Oral Antibiotics in an Aim to Eradicate Carrier State of Carbapenem- Resistant Klebsiella Pneumonia (KPC).completed-2010-12-24-
NCT01732250
Trial register
Multicenter Open-label Randomized Controlled Trial (RCT) to Compare Colistin Alone Versus Colistin Plus Meropenemcompleted-2012-11-22-
NCT01845246
Trial register
Multicentric Study About the Usefulness of Monitoring Plasma Levels of Colistin and Sodium Colistimethate in Patients With Infections Due to Multi-drug Resistancompleted-2013-05-03-
NCT03045692
Trial register
Assessment of Kidney Function for Drug Dosage Adjustments in Critically Ill Patientslast verified some time ago; the register no longer confirms its status-2017-02-05-
NCT02156323
Trial register
A Phase 1 Clinical Study in Healthy Volunteers to Investigate the Drug-drug Interaction Between Multiple Doses of RO7033877 and Multiple Doses of Colistin Methacompleted-2014-06-05-
NCT01060891
Trial register
Population Pharmacokinetic Study of Colistin in Patients Infected With Multiresistant Gram-negative Bacteriacompleted-2010-02-02-
NCT01537614
Trial register
Pharmacokinetic Study of Aerosolized Colimycin in Cystic Fibrosiscompleted-2012-02-17-
NCT02556190
Trial register
Colistin Pharmacokinetics in Critically Ill Patients During Extended Dialysiscompleted-2015-09-22-
NCT01894347
Trial register
Prospective Observational Pilot-study for the Evaluation of the Nephro- an Neurotoxicity in the Anti-infectious Therapy With Inhalative Colistin Therapy for Patcompleted-2013-07-10-
NCT01631968
Trial register
Incidence of Infection After Total Knee Arthroplasty Using an Erythromycin and Colistin Loaded Cement or a Standard Cementcompleted-2012-06-29-
NCT02683603
Trial register
Effect of Aerosolised Colistin in Ventilator Associated Pneumoniacompleted-2016-02-17-
NCT01292031
Trial register
Trial of Colistin Versus Meropenem in Ventilator-associated Pneumonia (VAP) (CR-GNB)completed-2011-02-09-
NCT02408185
Trial register
Optimization Dose Study on Pharmacokinetics and Pharmacodynamics of Colistin in Critically Ill Patientscompleted-2015-04-03-
NCT00235690
Trial register
Optimizing Dosing of Colistin for Infections Resistant to All Other Antibiotics, Approved NIH Protocol Dated 12.06.07(DMID Protocol #07-0036)completed-2005-10-10-
NCT02619786
Trial register
Therapy of Ventilator-associated Tracheobronchitis Caused by Gram Negative Bacteria With Nebulized Colistinlast verified some time ago; the register no longer confirms its status-2015-12-02-
NCT02604849
Trial register
Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistincompleted-2015-11-13-
NCT02573064
Trial register
Impact of Treatment With Colistin on Mortality Bacteremia Multiresistant Acinetobacter Baumannii Sensitive Colistin in Patients Criticalcompleted-2015-10-09-
NCT02162966
Trial register
Safety and Efficacy Study of High Dose Colistinlast verified some time ago; the register no longer confirms its status-2014-06-13-
NCT00411736
Trial register
Scandinavian Cystic Fibrosis Azithromycin Studycompleted-2006-12-14-
NCT02081560
Trial register
Colistin Pharmacokinetics in Continuous Renal Replacement Therapylast verified some time ago; the register no longer confirms its status-2014-03-07-
NCT01025921
Trial register
Tracheobronchitis Prevention Trialcompleted-2009-12-04-
NCT01035853
Trial register
Sino-nasal Inhalation of Colistin in Patients With Cystic Fibrosis and Pseudomonas Aeruginosa Colonizationcompleted-2009-12-21-
NCT01798537
Trial register
Simplified Selective Digestive Tract Decontamination for the Prevention of Intensive Care Unit Acquired Infectionslast verified some time ago; the register no longer confirms its status-2013-02-26-
NCT01761487
Trial register
SDD for Eradicating CRKP Carriagelast verified some time ago; the register no longer confirms its status-2013-01-03-
NCT00826670
Trial register
Enterobacteriaceae Producing Extended-spectrum β-lactamases (ESBL) Decolonization Studycompleted-2009-01-20-
NCT01577862
Trial register
Colistin and Rifampicin for MDR-Acinetobactercompleted-2012-04-16-
NCT01511224
Trial register
A Prospective Observational Study of Patients With Drug Resistant Acinetobacter Baumannii Bacteremialast verified some time ago; the register no longer confirms its status-2012-01-12-
NCT01297855
Trial register
Colistin Plus Rifampicin in MDR P. Aeruginosa and A. Baumaniilast verified some time ago; the register no longer confirms its status-2011-02-17-
NCT01501968
Trial register
Efficacy of Ascorbic Acid for Prevention of Colistin-Associated Nephrotoxicitylast verified some time ago; the register no longer confirms its status-2011-12-30-
NCT01297894
Trial register
Colistin Versus Colistin Plus Fosfomycin for Infections Caused by MDR Acinetobacter Baumanniilast verified some time ago; the register no longer confirms its status-2011-02-17-
NCT01400750
Trial register
Comparison of 2 Treatment Regimens for Eradication of P Aeruginosa Infection in Children With Cystic Fibrosiscompleted-2011-07-22-
NCT01023087
Trial register
Renal Impairment Associated With Colistin Levelscompleted-2009-12-02-
NCT00753558
Trial register
Selective Digestive Decontamination in Carriers of Carbapenem-resistant Klebsiella Pneumoniaecompleted-2008-09-02-
NCT00645723
Trial register
Intravenous Colistin Versus Intravenous Colistin Plus Nebulized Colistin in VAP Due MDR Acinetobacter Baumanniilast verified some time ago; the register no longer confirms its status-2008-03-28-
NCT00920270
Trial register
Nebulized Colistin for Hospital-Acquired Pneumonialast verified some time ago; the register no longer confirms its status-2009-06-15-
NCT00250133
Trial register
Microbiologic Effect of Selective Decontamination of the Digestive Tract With Colistin, Gentamicin and Nystatinterminated before completion-2005-11-07-
NCT00300560
Trial register
Efficacy and Safety of Colistin for Therapy of Infections Caused by ESBL Producing K.Pneumoniae or E.Colilast verified some time ago; the register no longer confirms its status-2006-03-09-

Source: ClinicalTrials.gov and EU CTIS, read 2026-10-03. Not medical advice.

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