cyclic lipopeptide antibiotic

Daptomycin clinical trials

Answer

Daptomycin has 132 registered trials: 11 running, 59 completed, 33 stopped early. 41 posted results.

Trial registerClinicalTrials.gov and EU CTIS, read 2026-10-03

TrialTitleStatusPhaseRegisteredResults
NCT00967941
Trial register
Vancomycin and Daptomycin Plus Cefazolin for Preoperative Vascular Surgery Prophylaxiscompleted-2009-08-28Posted
NCT06637332
Trial register
Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremiacurrently recruiting participants-2024-10-15-
NCT07376889
Trial register
Combination Antibiotic Therapy for Staphylococcus Aureus Bacteremiacurrently recruiting participants-2026-01-21-
2024-514952-34-00
Trial register
Randomized open-label controlled trial evaluating a single-dose intravenous Dalbavancin versus standard antibiotic therapy during catheterrelated bloodstream inNot stated3--
2023-508442-18-00
Trial register
Efficacy and safety of different antimicrobial DURATions for the treatment of Infections associated with Osteosynthesis Material implanted after long bone fractNot stated3--
2026-526149-91-00
Trial register
Efficacy and safety of Dalbavancin in the treatment of infective Endocarditis caused by gram-positive cocciNot stated3--
NCT07058415
Trial register
Impact of Three Probabilistic Antibiotic Therapy on Digestive Microbiota and Colonization With Multi-resistant Bacterianot yet recruiting participants-2025-03-10-
2024-519186-21-01
Trial register
Efficacy of seven and fourteen days of antibiotic treatment in uncomplicated Staphylococcus aureus bacteremia: A randomized, non-blinded, non-inferiority intervNot stated4--
2023-503582-35-00
Trial register
Staphylococcus aureus Network Adaptive Platform trial (SNAP)Not stated4--
NCT05137119
Trial register
Staphylococcus Aureus Network Adaptive Platform Trialcurrently recruiting participants-2021-11-30-
NCT05156437
Trial register
Postoperative Antibiotic Management Duration Following Surgery for Intravenous Drug Abuse (IVDA) Endocarditis (OPTIMAL)terminated before completion-2021-12-14Posted
NCT07230041
Trial register
In Vivo Antibiotics Removal During Hemoadsorption Cartridges and Continuous Renal Replacement Therapy in the Intensive Care Unitcurrently recruiting participants-2025-08-23-
NCT04434300
Trial register
Subcutaneous Daptomycin in Healthy Volunteers (DAPTOSC)completed-2020-06-16-
NCT04983901
Trial register
PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONINcompleted-2021-07-30Posted
NCT02539407
Trial register
Population Pharmacokinetics of Anti-infectives in Critically Ill Childrencurrently recruiting participants-2015-07-02-
2024-513298-29-00
Trial register
Osteoarticular infections on equipment: impact of three probabilistic antibiotic therapy strategies on the digestive microbiota and gastrointestinal colonizatioNot stated2--
2024-516232-10-00
Trial register
Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether conNot stated4--
2025-520940-14-00
Trial register
TIME-TO-LIA : Optimal Duration of Antibiotic Therapy in Drained Pyogenic Liver Abscess: 3 weeks versus 6 weeks, a non-inferiority trialNot stated4--
NCT07148960
Trial register
Does Staphylococcus Aureus Bacteremia Early Dual Therapy Improve Outcomes?enrolling by invitation only-2025-08-22-
NCT05977868
Trial register
Comparing Oral Versus Parenteral Antimicrobial Therapyterminated before completion-2023-08-07Posted
2023-508456-18-00
Trial register
Ramdomized non-inferiority clinical trial to evaluate the safety and efficacy of short duration therapy for non complicated enterococcal bacteremia.Not stated4--
NCT06423898
Trial register
Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.currently recruiting participants-2024-05-13-
NCT07072923
Trial register
Antibiotic Impregnated Beads in Osteomyelitisnot yet recruiting participants-2025-03-07-
NCT05225558
Trial register
A Phase 2a Study, Effect of Vancomycin With vs Without Delpazolid (LCB01-0371) in Patients With MRSA Bacteremiaterminated before completion-2022-02-04Posted
NCT06959667
Trial register
Comparative Analysis of Nemonoxacin and Other Anti-methicillin Resistant Staphylococcus Aureus (Anti-MRSA) Antimicrobial Therapy in Patients With Complicated Skrunning, but no longer enrolling-2025-04-28-
NCT04775953
Trial register
DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremiacompleted-2021-03-01Posted
NCT06695832
Trial register
Adjunctive Fosfomycin for Treatment of Staphylococcus Aureus Bacteraemiarunning, but no longer enrolling-2024-11-18-
NCT03480191
Trial register
Adjunction of Daptomycin for the Treatment of Pneumococcal Meningitiscompleted-2018-03-29-
NCT01199783
Trial register
Application of Daptomycin in MRSA Infected Diabetic Foot in Comparison to Vancomycin Treatmentterminated before completion-2010-09-13Posted
2023-504480-17-00
Trial register
Clinical impact of pharmacokinetic monitoring of antibiotics in critically ill patientsNot stated4--
NCT06189885
Trial register
Preoperative Daptomycin Prophylaxis in Two-Stage Exchange Arthroplasty: A Prospective, Randomized, Double-Blinded Triallast verified some time ago; the register no longer confirms its status-2024-01-05-
NCT03138733
Trial register
Ceftobiprole in the Treatment of Patients With Staphylococcus Aureus Bacteremiacompleted-2017-05-03Posted
NCT04033029
Trial register
Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®)completed-2019-02-20-
NCT03426761
Trial register
Dalbavancin For The Treatment of Gram Positive Osteoarticular Infectionscompleted-2018-02-08-
NCT01734694
Trial register
Safety and Efficacy of Strategy to Prevent Drug-Induced Nephrotoxicity in High-Risk Patientsterminated before completion-2012-11-28Posted
NCT03588637
Trial register
Real-world Daptomycin Use in Chinese ICUscompleted-2018-07-17-
NCT03643952
Trial register
Safety, Efficacy, and Pharmacokinetics (PK) of Daptomycin (MK-3009) in Japanese Pediatric Subjects With Complicated Skin and Soft Tissue Infections (cSSTI) and completed-2018-08-23Posted
NCT04933344
Trial register
Pharmacokinetics and Toxicodynamics of Daptomycin in Bone and Joint Infectionslast verified some time ago; the register no longer confirms its status-2021-06-21-
NCT04298463
Trial register
Retrospective Effectiveness Study of Dalbavancin and Other Standard of Care of the Same Class in Patients With ABSSSIcompleted-2020-03-06-
NCT05224687
Trial register
Utility Assessment of a Pharmacy-to-Dose Daptomycinlast verified some time ago; the register no longer confirms its status-2022-02-04-
NCT00261807
Trial register
Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infectionscompleted-2005-12-05Posted
NCT04132115
Trial register
Optimized Antibiotic Therapy in Patients With Subarachnoid Haemorrhage (ES) and Cerebral Haemorrhage (EC)last verified some time ago; the register no longer confirms its status-2019-10-18-
NCT00467272
Trial register
Catheter Related - Gram Positive Bloodstream Infectionscompleted-2007-04-30Posted
NCT00638157
Trial register
Phase 4 Efficacy and Safety Study of Cubicin® With and Without Combination Therapy in S. Aureus Infective Endocarditis (SAIE)terminated before completion-2008-03-18Posted
NCT04277143
Trial register
A Pharmacokinetics Study of Daptomycin in Critically Ill Patients and Effects of Daptomycin on Kidneylast verified some time ago; the register no longer confirms its status-2020-02-20-
NCT04414137
Trial register
Description of Eosinophilic Pneumonia in BJI/PJI Treated by Daptomycinlast verified some time ago; the register no longer confirms its status-2020-06-04-
NCT02972983
Trial register
Daptomycin as Adjunctive Therapy for Staphylococcus Aureus Bacteremiacompleted-2016-11-25-
NCT04546815
Trial register
The Efficacy and Safety of Daptomycin in the Treatment of Gram-positive Bacterial Infection.last verified some time ago; the register no longer confirms its status-2020-09-14-
NCT01792804
Trial register
Staphylococcus Aureus Bacteremia Antibiotic Treatment Optionscompleted-2013-02-15-
NCT00136292
Trial register
Study of Single Dose Daptomycin in Pediatric Patients With Gram-positive Infection for Which They Are Receiving Standard Antibioticscompleted-2005-08-29-
NCT02208063
Trial register
A Phase 3 Telavancin Staphylococcus Aureus (S. Aureus) Bacteremia Trialterminated before completion-2014-08-04Posted
NCT00538694
Trial register
Comparative Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumoniacompleted-2007-10-03-
NCT00540072
Trial register
Study of Cidecin™ (Daptomycin) to Rocephin® (Ceftriaxone) in the Treatment of Moderate to Severe Community-Acquired Acute Bacterial Pneumonia Due to S. Pneumonicompleted-2007-10-05-
NCT00679835
Trial register
PK and Safety Evaluation of Daptomycin in Children Ages 2-6 With Proven or Suspected Gram-positive Infectionscompleted-2008-05-19-
NCT01019395
Trial register
Pharmacokinetics (PK) and Safety Evaluation of Daptomycin in Children Ages 3-24 Months With Proven or Suspected Gram-positive Infections or Peri-Operative Subjecompleted-2009-11-25-
NCT04141787
Trial register
Ceftriaxone as Home IV for Staph Infectionslast verified some time ago; the register no longer confirms its status-2019-10-28-
NCT03961503
Trial register
Retrospective Analysis of Nephrotoxicity During Daptomycin Versus Vancomycin Treatments in High Risk Patientscompleted-2019-05-23-
NCT01756924
Trial register
Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infectionterminated before completion-2012-12-18-
NCT03004066
Trial register
Daptomycin Concentration in Drainage Fluid and Blood Samples of ICU Patientscompleted-2016-12-28-
NCT01175707
Trial register
Study Comparing Cubicin With Vancomycin in Treatment of Participants With Complicated Skin and Skin Structure Infections in a Home Infusion Settingterminated before completion-2010-08-05Posted
NCT00695903
Trial register
Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremiaterminated before completion-2008-06-12Posted
NCT02365493
Trial register
Combination Antibiotic Therapy for Methicillin Resistant Staphylococcus Aureus Infectionterminated before completion-2015-02-11-
NCT01522105
Trial register
Daptomycin in Pediatric Patients With Bacterial Meningitisterminated before completion-2012-01-31-
NCT02052388
Trial register
Efficacy and Safety Study of Brilacidin to Treat Serious Skin Infectionscompleted-2014-02-03-
NCT00711802
Trial register
Safety and Efficacy Study of Daptomycin in Pediatric Participants (1 to 17 Years-old) With Skin and Skin Structure Infectionscompleted-2008-07-09Posted
NCT01104662
Trial register
Study of Daptomycin Safety and Efficacy for Complicated Skin and Skin Structure Infections (cSSSI) and Bacteremia in Renal Impairmentterminated before completion-2010-04-15Posted
NCT01419184
Trial register
Daptomycin Versus Vancomycin in Participants With Skin Infections Due to MRSAcompleted-2011-08-18Posted
NCT01728376
Trial register
Safety & Efficacy of Daptomycin Versus Standard of Care (SOC) in 1 - 17 Year Olds With Staphylococcus Aureus Bacteremia (MK-3009-005)completed-2012-11-19Posted
NCT01922011
Trial register
Safety and Efficacy Study of Daptomycin Compared to Active Comparator in Pediatric Participants With Acute Hematogenous Osteomyelitis (AHO) (MK-3009-006)completed-2013-08-14Posted
NCT00296049
Trial register
Daptomycin or Vancomycin in Treating Bacteria in the Blood in Patients With Neutropenia Caused By Chemotherapywithdrawn before enrolling anyone-2006-02-24-
NCT02168816
Trial register
Efficacy of Oral Antibiotic Therapy Compared to Intravenous Antibiotic Therapy for Osteomyelitisterminated before completion-2014-06-10Posted
NCT01012089
Trial register
Study of the Pharmacokinetics of Daptomycin in Children With Renal Diseasecompleted-2009-11-11Posted
NCT00882557
Trial register
Study to Evaluate Daptomycin Given During Dialysis and After Dialysiscompleted-2009-04-16Posted
NCT02660346
Trial register
IL-10 Stratifying Tool for Towards Antibiotic Selection for MRSaBcompleted-2016-01-21-
NCT00428844
Trial register
Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococcicompleted-2007-01-30Posted
NCT02000414
Trial register
Pharmacokinetics Study of Intraperitoneal Administration of Daptomycin in Peritoneal Infectioncompleted-2013-12-04-
NCT01898338
Trial register
Efficacy of Daptomycin Plus Fosfomycin Versus Daptomycin for Treatment of MRSA Bacteremiacompleted-2013-07-12-
NCT00490737
Trial register
Safety Study to Evaluate Daptomycin in Non-infected Adults Who Are Either on Hemodialysis or Continuous Ambulatory Peritoneal Dialysis (MK-3009-021)completed-2007-06-25-
NCT01191840
Trial register
Treatment Algorithm to Reduce the Use of Vancomycin in Adults With Blood Stream Infectioncompleted-2010-08-31Posted
NCT00295178
Trial register
Study Comparing CUBICIN® (Daptomycin for Injection) With Vancomycin in Cellulitis or Erysipelascompleted-2006-02-23-
NCT00651131
Trial register
Cubicin(R) for Complicated Post-surgical Wound Infectionsterminated before completion-2008-04-02-
NCT03245879
Trial register
Antibiotic Stewardship in Small Hospitalscompleted-2017-08-03-
NCT03209921
Trial register
Pharmacokinetic Variability of Daptomycin During Prolonged Therapy for Bone and Joint Infectionscompleted-2017-07-06-
NCT03209934
Trial register
Daptomycin > 6 mg/kg/Day as Salvage Therapy in Patients With Complex Bone and Joint Infection: Cohort Study in a Regionalreference Centercompleted-2017-07-06-
NCT00055198
Trial register
Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteriaterminated before completion-2003-02-21-
NCT03134521
Trial register
Population Pharmacokinetic Analysis of Daptomycin in Patients With Osteoarticular Infectionslast verified some time ago; the register no longer confirms its status-2017-05-01-
NCT00335478
Trial register
Daptomycin in Treating Neutropenia and Fever in Patients With Cancercompleted-2006-06-12Posted
NCT00401960
Trial register
Daptomycin as an Adjuvant Agent in the Treatment of Enterococcal Native Valve Endocarditis.terminated before completion-2006-11-22Posted
NCT00770341
Trial register
A Study of MK-3009 in Japanese Patients With Skin or Blood Stream Infections Caused by Methicillin-resistant Staphylococcus Aureus (MK-3009-002)completed-2008-10-10Posted
NCT00093067
Trial register
Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureuscompleted-2004-10-01-
NCT02097953
Trial register
Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycincompleted-2014-03-27-
NCT02241941
Trial register
Evaluation of Single-dose Pharmacokinetics of Intravenous Daptomycin in Patients With Thermal Injurywithdrawn before enrolling anyone-2014-09-16-
NCT02142075
Trial register
Population Pharmacokinetic (PK) Study of Multiple Doses of Cubicin® (Daptomycin) 10 mg/kg in Critical Care Patients Having Bacteremia, Endocarditis or Skin Softcompleted-2014-05-20-
NCT00701636
Trial register
Pharmacokinetics of Daptomycin During Cardiopulmonary Bypass Surgerycompleted-2008-06-19Posted
NCT00102947
Trial register
Daptomycin in the Treatment of Patients With Renal Insufficiency and Complicated Skin and Skin Structure Infectionsterminated before completion-2005-02-07-
NCT00507247
Trial register
Daptomycin in the Treatment of Catheter-Related Staphylococcus Aureuscompleted-2007-07-26-
NCT01975662
Trial register
Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremiaterminated before completion-2013-11-05-
NCT00663403
Trial register
Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD)completed-2008-04-22Posted
NCT02508350
Trial register
The Pharmacokinetics/Pharmacodynamics of High-dose Daptomycin in Patients With Septic Shocklast verified some time ago; the register no longer confirms its status-2015-07-24-
NCT01306825
Trial register
Clinical Evaluation of Daptomycin Bone Penetrationlast verified some time ago; the register no longer confirms its status-2011-03-02-
NCT01626560
Trial register
The Effects of Daptomycin and Cytokines Production in Comparison With Vancomycincompleted-2012-06-22-
NCT00772447
Trial register
China Registration Study in Patients With Skin Infectionscompleted-2008-10-15Posted
NCT01592032
Trial register
Concentration of Antimicrobials in Catheter-lock Solutionslast verified some time ago; the register no longer confirms its status-2012-05-04-
NCT01455246
Trial register
Daptomycin + Meropenem Versus Ceftazidime in the Treatment of Nosocomial Spontaneous Bacterial Peritonitisterminated before completion-2011-10-19-
NCT01515020
Trial register
Daptomycin Versus Vancomycin in the Treatment of Nosocomial or Healthcare-associated MRSA Bacteremiaterminated before completion-2012-01-23-
NCT01549613
Trial register
Evaluation of Daptomycin for the Emergency Department Treatment of Complicated Skin and Skin Structure Infectionscompleted-2012-03-09Posted
NCT01701219
Trial register
Safety and Efficacy Study of Ceftaroline in Subjects With Staphylococcus Aureus Bacteremia or With Persistent Methicillin-Resistant Staphylococcus Aureus Bactercompleted-2012-10-03-
NCT00572260
Trial register
A Pilot Study of Daptomycin for Antimicrobial Prophylaxisterminated before completion-2007-12-13Posted
NCT01216241
Trial register
Daptomycin Versus Placebo in Patients With Neutropenia and Feverterminated before completion-2010-10-07Posted
NCT01287832
Trial register
Vancomycin Versus Daptomycin for the Treatment of Methicillin-resistant Staphylococcus Aureus Bacteremia Due to Isolates With High Vancomycin Minimum Inhibitoryterminated before completion-2011-02-01Posted
NCT01196169
Trial register
Daptomycin Use for Antimicrobial Prophylaxis in Methicillin Resistant Staphylococcus Aureus (MRSA) Colonized Adult Patients Undergoing Primary Elective Hip, Kneterminated before completion-2010-09-08-
NCT01133600
Trial register
Outpatient Treatment of Gram Positive Wound Infections in the Diabetic Foot: A Pharmaco-economic Comparison of Daptomycin vs. Vancomycin Based Regimensterminated before completion-2010-05-31-
NCT01025271
Trial register
Cerebrospinal Fluid Pharmacokinetics of Daptomycinterminated before completion-2009-12-03Posted
NCT00942149
Trial register
An Open Label Study to Describe the Pharmacokinetics of Daptomycin in Infantscompleted-2009-07-20Posted
NCT01612052
Trial register
Vascular Surgical Antibiotic Prophylaxis Study (VSAPS 2)last verified some time ago; the register no longer confirms its status-2011-09-01-
NCT01551719
Trial register
Clinical Usefulness of Mic/Breakpoint Ratio and Penetration in Tissues. A Prospective Study of Clinical Validationwithdrawn before enrolling anyone-2012-02-29-
NCT01212601
Trial register
Collect Clinical Data in Chinese Patients Received CUBICIN Treatment for Actual Usage in Clinical Practicecompleted-2010-09-16-
NCT00430937
Trial register
Efficacy and Safety of Daptomycin Versus Vancomycin or Teicoplanin for Treatment of Complicated Skin and Soft Tissue Infectionsterminated before completion-2007-02-02Posted
NCT01184872
Trial register
Study to Compare Efficacy and Safety of Daptomycin in Elderly Patients With Complicated Skin and Soft Tissue Infectionscompleted-2010-08-19Posted
NCT01144000
Trial register
Daptomycin With Rifampin for Treatment of Staphylococcal Prosthetic Joint Infectionlast verified some time ago; the register no longer confirms its status-2010-06-15-
NCT01211470
Trial register
Initial Treatment for Acute Bacterial Skin Infections (ABSSSI) Caused by Staphylococcus Aureuscompleted-2010-09-29-
NCT01080963
Trial register
Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infectionscompleted-2010-03-05-
NCT01219114
Trial register
Safety and Efficacy Study of CUBICIN (Daptomycin) Under Conditions of Actual Usewithdrawn before enrolling anyone-2010-10-13-
NCT00463801
Trial register
Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin-structure Infectionsterminated before completion-2007-04-20Posted
NCT01314053
Trial register
Retrospective Evaluation of Safety and Efficacy of Daptomycin Used in Patients With Serious Gram-positive Infectionslast verified some time ago; the register no longer confirms its status-2011-03-14-
NCT01301638
Trial register
Retrospective Evaluation of Safety and Efficacy of Daptomycin Used in Patients With Serious Gram-positive Infectionslast verified some time ago; the register no longer confirms its status-2011-02-23-
NCT00573898
Trial register
Daptomycin Study - Collection of Pharmacokinetic Samples in Patients With Renal Failurecompleted-2007-12-14-
NCT01212432
Trial register
Daptomycin Pharmacokinetics in Critically Ill Patients Undergoing Continuous Veno-venous Hemodiafiltration, a Dose Finding Studylast verified some time ago; the register no longer confirms its status-2010-09-30-
NCT00426933
Trial register
Phase 2 Safety and Efficacy Study of Daptomycin in Complicated Skin and Skin Structure Infectionscompleted-2007-01-25-
NCT01171547
Trial register
Daptomycin Pharmacokinetics in Continuous Veno-venous Hemodiafiltrationlast verified some time ago; the register no longer confirms its status-2010-07-28-
NCT00858325
Trial register
Pharmacokinetic Study of Daptomycin in Healthy Chinese Subjects Living in Chinacompleted-2009-03-09-
NCT00451373
Trial register
Acute Renal Failure in the Surgical Intense Care Units - NTUH-SICU-ARF (NSARF) Studylast verified some time ago; the register no longer confirms its status-2007-03-23-

Source: ClinicalTrials.gov and EU CTIS, read 2026-10-03. Not medical advice.

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