GnRH antagonist
Degarelix dose
Answer
Half-life on the label: approximately 53 days. Trials with posted results tested 12 doses, most often 240 mg, 80 mg, 480 mg.
Not dosing advice.
FDA LABEL
What the approved labels state
FIRMAGON NDA022201 · label of 2024-01-30 Regulator
Half-life: approximately 53 days (section 12.3).
IN TRIALS
Doses tested in 57 trials with posted results
| Dose in the arm title | Trials | People on it | Phases |
|---|---|---|---|
| 240 mg | 7 | 1,913 | 3 |
| 80 mg | 10 | 1,325 | 2/3 |
| 480 mg | 3 | 1,196 | 2/3 |
| 160 mg | 3 | 369 | 2/3 |
| 7.5 mg | 1 | 135 | 3 |
| 30 mg | 1 | 105 | 2 |
| 10 mg | 1 | 101 | 2 |
| 20 mg | 1 | 100 | 2 |
| 360 mg | 1 | 67 | 2 |
| 2.5 mg | 1 | 63 | 2 |
| 120 mg | 1 | 48 | 2/3 |
| 60 mg | 1 | 30 | 2/3 |
Trial register Read from the titles of arms that received Degarelix (n ≥ 20). An arm naming several doses counts under each; a schedule or escalation is on the trial record. All trials.
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