What is the half-life of Desmopressin?

2.8 hours, per the FDA label (section 12.3).

What doses of Desmopressin were studied?

50 μg (3 trials, 727 people); 100 μg (3 trials, 714 people); 25 μg (3 trials, 655 people); 10 μg (2 trials, 493 people); 75 μg (1 trial, 224 people). Source: ClinicalTrials.gov posted results.

vasopressin analogue

Desmopressin dose

Answer

FDA label for Desmopressin Acetate: The recommended dosage is 0.3 mcg/kg actual body weight (to a maximum of 20 mcg) administered by intravenous infusion over 15 minutes to 30 minutes. Half-life on the label: 2.8 hours. Trials with posted results tested 10 doses, most often 50 μg, 100 μg, 25 μg.

Not dosing advice.

FDA LABEL

What the approved labels state

Desmopressin Acetate ANDA210223 · label of 2026-08-27 Regulator

The recommended dosage is 0.3 mcg/kg actual body weight (to a maximum of 20 mcg) administered by intravenous infusion over 15 minutes to 30 minutes.

Full label, section 2, on DailyMed

Stimate NDA020355 · label of 2026-07-22 Regulator

The recommended dosage for patients weighing at least 50 kg is 300 mcg intranasal spray (one spray in each nostril).

Half-life: 2.8 hours (section 12.3).

Full label, section 2, on DailyMed

DESMODA NDA219873 · label of 2026-03-02 Regulator

Recommended starting dosage of DESMODA for adults and pediatric patients is 0.05 mg orally twice daily.

Half-life: 3.6 hours (section 12.3).

Full label, section 2, on DailyMed

DDAVP NDA018938 · label of 2022-09-28 Regulator

The recommended starting dose of DDAVP Injection is 1/10 th the daily maintenance intranasal dose administered by subcutaneous or intravenous injection as one or two divided doses Hemophilia A and von Willebrand's Disease (Type I): The recommended dosage is 0.3 mcg/kg actual body weight (to a maximum of 20 mcg) administered by intravenous infusion over 15 minutes to 30 minutes.

Half-life: 2.8 hours (section 12.3).

Full label, section 2, on DailyMed

IN TRIALS

Doses tested in 18 trials with posted results

Dose in the arm title	Trials	People on it	Phases
50 μg	3	727	3
100 μg	3	714	3
25 μg	3	655	3
10 μg	2	493	3
75 μg	1	224	3
0.1 mg	1	137	-
25 mcg	2	70	2
10 mcg	1	48	2
100 mcg	1	47	2
50 mcg	1	44	2

Trial register Read from the titles of arms that received Desmopressin (n ≥ 20). An arm naming several doses counts under each; a schedule or escalation is on the trial record. All trials.

WEEKLY

Register Watch, weekly

New trials, approvals and enforcement actions. One email a week.