bradykinin B2 antagonist
Icatibant clinical trials
Answer
Icatibant has 37 registered trials: 2 running, 28 completed, 3 stopped early. 15 posted results.
Trial registerClinicalTrials.gov and EU CTIS, read 2026-10-03
| Trial | Title | Status | Phase | Registered | Results |
|---|---|---|---|---|---|
| NCT04113109 Trial register | Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2 | completed | - | 2019-10-02 | Posted |
| NCT05509569 Trial register | A Survey of Icatibant in Pediatric Participants With Hereditary Angioedema | completed | - | 2022-08-22 | - |
| 2024-516247-62-00 Trial register | A Phase 3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Orally Administered Deucrictibant Extended-release Tablet f | Not stated | 3 | - | - |
| 2023-505766-28-00 Trial register | A Phase II/III, Extension Study of Orally Administered PHA-022121 for Acute Treatment of Angioedema Attacks in Patients with Hereditary Angioedema | Not stated | 2/3 | - | - |
| NCT05834777 Trial register | Prevention of Intradialytic Hypotension by Inhibiting Bradykinin B2 Receptor | currently recruiting participants | - | 2023-04-28 | - |
| NCT04488081 Trial register | I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients | running, but no longer enrolling | - | 2020-07-27 | - |
| NCT06346899 Trial register | A Study of Lanadelumab (Takhzyro) and Icatibant (Firazyr®) in Persons With HAE in China | completed | - | 2024-04-04 | - |
| NCT07009262 Trial register | A Study Observing US Patients With HAE Type I or II Who Take Icatibant to Treat HAE Attacks | completed | - | 2025-06-06 | - |
| NCT07290855 Trial register | A Study to Evaluate the Safety and Efficacy of Icatibant in Patients With Bradykinin Induced Angioedema | completed | - | 2025-12-18 | - |
| 2023-507268-37-00 Trial register | A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Crossover Study of Oral Deucrictibant Soft Capsule for On-Demand Treatment of Attacks in Adolescents an | Not stated | 3 | - | - |
| 2025-521354-42-00 Trial register | A randomized, double-blind crossover study to investigate the analgesic efficacy of the bradykinin (B2) antagonist icatibant for propofol injection pain in heal | Not stated | 2 | - | - |
| NCT04057131 Trial register | FIRAZYR General Drug Use-Results Survey (Japan) | completed | - | 2019-08-13 | Posted |
| NCT06587464 Trial register | A Study to Explore Hereditary Angioedema (HAE) Symptoms and Treatment Patterns in Korean People | completed | - | 2024-09-04 | - |
| NCT01034969 Trial register | Firazyr® Patient Registry (Icatibant Outcome Survey - IOS) | completed | - | 2009-12-18 | - |
| NCT05489640 Trial register | A Study in Adults With Hereditary Angioedema (HAE) Who Currently Receive Icatibant at Home | completed | - | 2022-08-05 | - |
| NCT05407597 Trial register | Inhibition of Bradykinin in COVID-19 Infection With Icatibant | completed | - | 2022-06-07 | - |
| NCT05010876 Trial register | Evaluation of the Effects of Bradykinin Antagonists on Pulmonary Manifestations of COVID-19 Infections (AntagoBrad-Cov Study). | completed | - | 2021-08-18 | - |
| NCT04978051 Trial register | Investigating the Efficacy and Safety ICATIBANT For The Treatment of Patients With SARS-CoV-2 (COVID-19) Infection | completed | - | 2021-07-27 | - |
| NCT04654351 Trial register | A Study of Icatibant (TAK-667) in Japanese Children and Teenagers With Acute Attacks of Hereditary Angioedema | completed | - | 2020-12-04 | Posted |
| NCT00912093 Trial register | A Study of Icatibant in Patients With Acute Attacks of Hereditary Angioedema (FAST-3) | completed | - | 2009-06-03 | Posted |
| NCT00997204 Trial register | EASSI - Evaluation of the Safety of Self-Administration With Icatibant | completed | - | 2009-10-19 | Posted |
| NCT00097695 Trial register | Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema | completed | - | 2004-11-29 | Posted |
| NCT00500656 Trial register | Subcutaneous Treatment With Icatibant for Acute Attacks of Hereditary Angioedema (HAE) | completed | - | 2007-07-13 | Posted |
| NCT01386658 Trial register | A Pharmacokinetic, Tolerability and Safety Study of Icatibant in Children and Adolescents With Hereditary Angioedema | completed | - | 2011-07-01 | Posted |
| NCT01919801 Trial register | Blinded Safety & Efficacy Placebo Controlled Study of Icatibant for Angiotensin Converting Enzyme Inhibitor Induced Angioedema | completed | - | 2013-08-09 | Posted |
| NCT02045264 Trial register | Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers | completed | - | 2014-01-24 | Posted |
| NCT03888755 Trial register | A Study of Icatibant for Acute Attacks of Hereditary Angioedema in Japanese Participants | completed | - | 2019-03-25 | Posted |
| NCT03177798 Trial register | Mitochondria and Chronic Kidney Disease | completed | - | 2017-06-06 | Posted |
| NCT03005184 Trial register | Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2 | withdrawn before enrolling anyone | - | 2016-12-29 | - |
| NCT01574248 Trial register | Effect of Bradykinin Receptor Antagonism on ACE Inhibitor-associated Angioedema | terminated before completion | - | 2012-04-10 | Posted |
| NCT01457430 Trial register | Efficacy, Safety and Tolerability of Icatibant for the Treatment of HAE | completed | - | 2011-10-24 | Posted |
| NCT00517582 Trial register | Bradykinin Receptor Blocker in ACE Inhibitor-associated Angioedema | terminated before completion | - | 2007-08-15 | - |
| NCT00223704 Trial register | Bradykinin Receptor Antagonism During Cardiopulmonary Bypass | completed | - | 2005-09-19 | Posted |
| NCT00303056 Trial register | Efficacy and Safety Study of Intra-articular Multiple Doses of Icatibant in Patients With Painful Knee Osteoarthritis | completed | - | 2006-03-15 | - |
| NCT01154361 Trial register | AMelioration of Angiotensin Converting Enzyme Inhibitor Induced Angioedema Study | completed | - | 2010-06-30 | - |
| NCT00965120 Trial register | The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway | completed | - | 2009-08-21 | - |
| NCT00965393 Trial register | The Effect of Ischaemic-Reperfusion and Remote Ischaemic Preconditioning in Man - A Bradykinin Dependent Pathway | completed | - | 2009-08-19 | - |
Source: ClinicalTrials.gov and EU CTIS, read 2026-10-03. Not medical advice.
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