GIP/GLP-1 receptor agonist
Tirzepatide clinical trials
Answer
Tirzepatide has 309 registered trials: 191 running, 91 completed, 5 stopped early. 47 posted results.
Trial registerClinicalTrials.gov and EU CTIS, read 2026-10-03
| Trial | Title | Status | Phase | Registered | Results |
|---|---|---|---|---|---|
| NCT06861439 Trial register | GLP-1s to Enhance Lasting Optimal Weight | running, but no longer enrolling | 4 | 2025-03-06 | - |
| NCT07065552 Trial register | Tirzepatide in Obesity-Driven Endometrial Cancer | currently recruiting participants | EARLY_1 | 2025-07-15 | - |
| NCT07734792 Trial register | Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial | not yet recruiting participants | 2/3 | 2026-07-29 | - |
| NCT06854614 Trial register | Sequential Therapy Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial) | running, but no longer enrolling | 4 | 2025-03-03 | - |
| NCT06603571 Trial register | A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight W | completed | 2 | 2024-09-19 | - |
| NCT07527910 Trial register | A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD | currently recruiting participants | 2 | 2026-04-14 | - |
| NCT07845500 Trial register | A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity | not yet recruiting participants | 3 | 2026-09-29 | - |
| NCT07846865 Trial register | Tirzepatide Versus Positive Airway Pressure for the Treatment of Obstructive Sleep Apnoea: A Randomised Comparative Effectiveness Trial | not yet recruiting participants | 2 | 2026-09-29 | - |
| NCT07847515 Trial register | Effects of Tirzepatide on Gut Microbiota and Gastrointestinal Function After Drug Withdrawal in Obese Patients | not yet recruiting participants | - | 2026-09-29 | - |
| NCT06745128 Trial register | Tirzepatide for Obesity and Meth Use Disorder | completed | 2 | 2024-12-20 | - |
| NCT07078838 Trial register | Tirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer | not yet recruiting participants | 2 | 2025-07-22 | - |
| NCT06700538 Trial register | A First-In-Human Study of ARO-INHBE in Adults With Obesity With and Without Type 2 Diabetes Mellitus | currently recruiting participants | 1/2 | 2024-11-22 | - |
| NCT06759701 Trial register | Pre-Surgical Tirzepatide-Assisted Weight Loss in Overweight and Obese Men With Intermediate Risk Prostate Cancer: A Pilot Feasibility Study | currently recruiting participants | EARLY_1 | 2025-01-06 | - |
| NCT07817875 Trial register | Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus Placebo in Pediatric Participants 6 to Less Than 12 Years of Age Who Have O | not yet recruiting participants | 3 | 2026-09-14 | - |
| NCT07842640 Trial register | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC35 Injection in Participants With Obesity or Overweight | currently recruiting participants | 1 | 2026-09-25 | - |
| NCT06439277 Trial register | A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2) | currently recruiting participants | 3 | 2024-06-03 | - |
| NCT06937086 Trial register | Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: | currently recruiting participants | 3 | 2025-04-22 | - |
| NCT06937099 Trial register | Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight | currently recruiting participants | 3 | 2025-04-22 | - |
| NCT07265752 Trial register | Tirzepatide for the Treatment of Cannabis Use Disorder | not yet recruiting participants | 2 | 2025-12-05 | - |
| NCT07734870 Trial register | Tirzepatide for Treatment of CCCA | currently recruiting participants | 2 | 2026-07-29 | - |
| NCT07803744 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Type 1 Diabetes Mellitus and Overweight or Obesity | currently recruiting participants | 1 | 2026-09-04 | - |
| NCT07825857 Trial register | Randomized Controlled Trial of Tirzepatide for Methamphetamine Use Disorder | not yet recruiting participants | 2 | 2026-09-17 | - |
| 2026-527062-72-00 Trial register | A multicentre, single-arm, open-label, non-randomised pilot clinical trial to assess the dose-dependent effect of tirzepatide on gastric emptying in adult patie | Not stated | 1 | - | - |
| NCT05556512 Trial register | A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity | running, but no longer enrolling | 3 | 2022-09-27 | - |
| NCT07165028 Trial register | A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes) | currently recruiting participants | 3 | 2025-09-10 | - |
| NCT07834398 Trial register | Weekly GLP-1 Receptor Agonists in Obese Individuals Without Diabetes | completed | 3 | 2026-09-22 | - |
| 2025-522674-36-00 Trial register | N1T-MC-MALO: A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Pharmacologic Agents in Adult Participants With Metabolic Dysfunction-A | Not stated | 3 | - | - |
| NCT06734273 Trial register | Randomized Control Trial of Sleeve Gastrectomy With Tirzepatide in Maximizing Weight Loss | running, but no longer enrolling | EARLY_1 | 2024-12-16 | - |
| NCT06864026 Trial register | A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity | running, but no longer enrolling | 4 | 2025-03-07 | - |
| NCT07468552 Trial register | Trial of Tirzepatide for the Treatment of Cannabis Use Disorder | not yet recruiting participants | 2 | 2026-03-12 | - |
| NCT06779929 Trial register | Comparative Study of Tirzepatide Versus Dulaglutide (SURPASS CVOT) or Semaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes | completed | - | 2025-01-17 | - |
| NCT07829198 Trial register | Efficacy of Tirzepatide for Weight Management in Patients With Suboptimal Weight Loss After Bariatric Surgery: A Randomized, Double-Blind, Placebo-Controlled Cl | not yet recruiting participants | 3 | 2026-09-18 | - |
| NCT07777575 Trial register | Resistance Training to Prevent Muscle Loss During Treatment With Tirzepatide | currently recruiting participants | 4 | 2026-08-20 | - |
| 2024-515982-32-00 Trial register | A Clinical Trial of Tirzepatide (LY3298176) in Subjects With Overweight or Obesity and PCOS-related Ovarian Dysfunction (PERIODS) | Not stated | 4 | - | - |
| 2024-518608-28-00 Trial register | Effect of tirzepatide on alcohol intake and reward processing in patients diagnosed with schizophrenia and alcohol use disorder | Not stated | 2 | - | - |
| NCT06820281 Trial register | Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes | currently recruiting participants | 2 | 2025-02-11 | - |
| NCT07463846 Trial register | A Study to Evaluate ALN-2232 in Participants With Obesity | currently recruiting participants | 1/2 | 2026-03-11 | - |
| NCT07191873 Trial register | Tirzepatide in Idiopathic Intracranial Hypertension Trial | currently recruiting participants | 4 | 2025-09-25 | - |
| NCT07820111 Trial register | Comparative Study of Different Weekly GLP-1 Receptor Agonists Among Diabetic and Non-Diabetic Patients: Clinical Trial | completed | 3 | 2026-09-15 | - |
| NCT06897475 Trial register | A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide | currently recruiting participants | 2 | 2025-03-27 | - |
| NCT07728318 Trial register | Efficacy, Safety, and Treatment Satisfaction of Once-Weekly Tirzepatide in Obese Type 2 Diabetic Patients | not yet recruiting participants | NA | 2026-07-27 | - |
| NCT05536804 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes | completed | 2 | 2022-09-13 | - |
| NCT07622992 Trial register | Preoperative Optimization With Tirzepatide, Ketogenic Diet, or Standard Care Before One Anastomosis Gastric Bypass Surgery | not yet recruiting participants | - | 2026-06-03 | - |
| NCT07812636 Trial register | Tirzepatide and Levonorgestrel IUD Therapy for EIN and Early-Stage Endometrial Cancer | not yet recruiting participants | EARLY_1 | 2026-09-10 | - |
| NCT06534411 Trial register | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGL | completed | 3 | 2024-08-02 | - |
| NCT06847399 Trial register | Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder | currently recruiting participants | 2 | 2025-02-26 | - |
| NCT06965413 Trial register | A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants W | running, but no longer enrolling | 2 | 2025-05-11 | - |
| NCT07247084 Trial register | A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK) | currently recruiting participants | 4 | 2025-11-25 | - |
| NCT07809568 Trial register | Real-World Outcomes of Tirzepatide in Pakistani Adults With Obesity, Prediabetes, and Type 2 Diabetes | not yet recruiting participants | - | 2026-09-09 | - |
| NCT06143956 Trial register | A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight | currently recruiting participants | 2 | 2023-11-22 | - |
| 2024-519561-22-00 Trial register | A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial to Assess Efficacy, Safety, and Tolerability of RO7204239 in Combination with Tirzepatide in Partic | Not stated | 2 | - | - |
| NCT06221969 Trial register | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With | completed | 3 | 2024-01-24 | - |
| NCT06857942 Trial register | A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaqu | currently recruiting participants | 4 | 2025-03-05 | - |
| NCT06934642 Trial register | Effect of Tirzepatide on Markers of MASLD in Patients With Obesity | currently recruiting participants | EARLY_1 | 2025-04-18 | - |
| NCT06803888 Trial register | Bariatric Surgery vs. Semaglutide vs. Tirzepatide | running, but no longer enrolling | 4 | 2025-01-31 | - |
| NCT07387796 Trial register | Clinical and Neurobehavioral Changes With Weight Loss Drug Discontinuation and Reinitiation | currently recruiting participants | NA | 2026-02-04 | - |
| NCT07796477 Trial register | A Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or Metformin | not yet recruiting participants | 2 | 2026-09-01 | - |
| NCT07154719 Trial register | GLP-1R Actions on Muscle and the Skeleton | currently recruiting participants | 4 | 2025-09-04 | - |
| NCT07349641 Trial register | A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer | not yet recruiting participants | 2 | 2026-01-20 | - |
| NCT07787936 Trial register | GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry | not yet recruiting participants | - | 2026-08-18 | - |
| NCT07554638 Trial register | Incretin Therapies in Obesity-related HFpEF | currently recruiting participants | 4 | 2026-04-28 | - |
| NCT07782359 Trial register | Impact of Using a GLP1 on Treatment Related Side Effects of Lung Cancer Patients Receiving Lorlatinib | not yet recruiting participants | 1 | 2026-08-24 | - |
| NCT05822544 Trial register | Phase 1/1b Study of TLC-6740 in Healthy Subjects and Subjects With Obesity, With or Without Diabetes | running, but no longer enrolling | 1 | 2023-04-20 | - |
| NCT07438444 Trial register | A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or Obesity | running, but no longer enrolling | 4 | 2026-02-27 | - |
| NCT07693608 Trial register | An Open-Label Tirzepatide Trial for Comorbid Obesity and Stimulant Use Disorder | enrolling by invitation only | 2 | 2026-07-09 | - |
| NCT07213323 Trial register | Probiotic Intervention for Digestive Health in Obese Patients Initiating GLP-RA Treatment | currently recruiting participants | NA | 2025-09-18 | - |
| 2023-507655-30-00 Trial register | I8F-MC-GPIX: Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo for the Treatment of Obesity and Weight-Related Comorbidities in Adolescents: A Rando | Not stated | 3 | - | - |
| NCT07218445 Trial register | The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity | currently recruiting participants | 4 | 2025-10-20 | - |
| NCT07202247 Trial register | Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients Du | currently recruiting participants | 2 | 2025-10-01 | - |
| 2024-511450-49-00 Trial register | J1I-MC-GZBP: A Phase 3, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Retatrutide Compared to Tirzepatide in Adults Who Have Obesity | Not stated | 3 | - | - |
| NCT06326047 Trial register | A Research Study Comparing How Well Different Doses of the Medicine NN0519-0130 Lower Blood Sugar in People With Type 2 Diabetes | completed | 2 | 2024-03-16 | - |
| NCT07046819 Trial register | Tirzepatide in MetALD | currently recruiting participants | 2 | 2025-07-02 | - |
| NCT07760532 Trial register | Comparing Facial Aging Between Identical Twins With 3D Imaging | not yet recruiting participants | - | 2026-08-07 | - |
| NCT06651177 Trial register | Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder | currently recruiting participants | 2 | 2024-10-21 | - |
| NCT07758231 Trial register | Impact of GLP-1 Receptor Agonist Therapy on Alcohol Pharmacokinetics | not yet recruiting participants | 1 | 2026-08-05 | - |
| NCT07756359 Trial register | Tirzepatide for Ileal Pouch-anal Anastomosis (IPAA) and Chronic High Bowel Frequency (I8F-NS-X008) | not yet recruiting participants | 4 | 2026-08-10 | - |
| NCT07747805 Trial register | GLP-1 Agonists for Lung Function Improvement and Muscle Restoration in COPD | not yet recruiting participants | 2 | 2026-08-05 | - |
| 2024-520210-21-00 Trial register | I6T-MC-AMCE: A Phase 3b, Randomized, Multicenter, Controlled Study of Mirikizumab and Placebo or Mirikizumab Concomitantly Administered with Tirzepatide in Adul | Not stated | 3 | - | - |
| 2026-526200-69-00 Trial register | A Phase IV, Randomized Controlled Trial to Evaluate the Effects of Resistance Training Versus Usual Care on Thigh Muscle Volume During Treatment with the Dual G | Not stated | 4 | - | - |
| NCT06162715 Trial register | GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial | running, but no longer enrolling | 2/3 | 2023-12-08 | - |
| 2023-509600-15-00 Trial register | Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) 1.0 mg/1.0 mg s.c. once weekly versus tirzepatide 5 mg s.c. once weekly in parti | Not stated | 3 | - | - |
| NCT07738276 Trial register | Evaluation of the Efficacy and Safety of Tirzepatide, a Dual GLP-1/GIP Agonist, on Functional Capacity in Reduced Ejection Fraction Heart Failure Patients With | not yet recruiting participants | 3 | 2026-07-31 | - |
| NCT06374875 Trial register | Fibrosis Lessens After Metabolic Surgery | currently recruiting participants | 4 | 2024-04-16 | - |
| NCT07619989 Trial register | Transcutaneous Auricular Vagus Nerve Stimulation for Poor Weight-Loss Response to Incretin Receptor Agonists | currently recruiting participants | NA | 2026-05-18 | - |
| NCT07740291 Trial register | Tirzepatide Impact Assessment Study | currently recruiting participants | NA | 2026-07-31 | - |
| NCT07573163 Trial register | Tirzepatide Following Adrenalectomy in Mild Autonomous Cortisol Secretion | currently recruiting participants | 2 | 2026-05-07 | - |
| NCT07559500 Trial register | Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD) | currently recruiting participants | 1 | 2026-04-30 | - |
| NCT07728812 Trial register | Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity Pharmacotherapy | not yet recruiting participants | NA | 2026-07-10 | - |
| NCT07702461 Trial register | Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists | currently recruiting participants | - | 2026-07-14 | - |
| NCT07257484 Trial register | Tirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors | currently recruiting participants | 4 | 2025-12-02 | - |
| NCT07720414 Trial register | Effects of GLP-1 RAs on Human Lactation Outcomes | currently recruiting participants | - | 2026-07-17 | - |
| NCT07720466 Trial register | Salivary Function and Dental Changes During GLP-1 Therapy | not yet recruiting participants | - | 2026-07-14 | - |
| NCT07715929 Trial register | Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients | not yet recruiting participants | 4 | 2026-07-21 | - |
| NCT06662383 Trial register | A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity | running, but no longer enrolling | 3 | 2024-10-28 | - |
| NCT07057310 Trial register | Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women | enrolling by invitation only | 4 | 2025-07-09 | - |
| NCT07707778 Trial register | Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV | enrolling by invitation only | 4 | 2026-07-16 | - |
| NCT07602699 Trial register | Multi-Site Trial of Tirzepatide for Smoking Cessation | currently recruiting participants | 2 | 2026-05-22 | - |
| NCT06737042 Trial register | Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight Participants | completed | 2 | 2024-12-17 | - |
| NCT06575738 Trial register | Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents | currently recruiting participants | 1 | 2024-08-28 | - |
| NCT07262762 Trial register | Spartina® (Tirzepatide) Effectiveness and Safety Evaluation | completed | - | 2025-12-04 | - |
| NCT07701005 Trial register | Non-Invasive Hepatic and Metabolic Index Changes After Incretin Therapy in Overweight/Obesity | completed | - | 2026-07-14 | - |
| NCT07706088 Trial register | Effect of Tirzepatide on Diabetic Peripheral Sensorimotor Neuropathy | not yet recruiting participants | 4 | 2026-07-15 | - |
| NCT07115069 Trial register | Comparison of Body Composition Changes With Weight Loss Interventions | running, but no longer enrolling | - | 2025-07-25 | - |
| NCT07697391 Trial register | AI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 Diabetes | not yet recruiting participants | 4 | 2026-07-13 | - |
| NCT07700030 Trial register | High-protein plUs reSistance Training in gLucagon-like pEptide 1 Receptor Agonist Users (HUSTLE) | not yet recruiting participants | NA | 2026-07-13 | - |
| NCT07653412 Trial register | Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists. | currently recruiting participants | - | 2026-06-17 | - |
| NCT06727331 Trial register | Study of Tirzepatide for Recovery and Alcohol Use Management | currently recruiting participants | 2 | 2024-12-10 | - |
| NCT07417618 Trial register | INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD) | completed | - | 2026-02-18 | - |
| NCT07619508 Trial register | Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes. | completed | - | 2026-06-02 | - |
| NCT04255433 Trial register | A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes | completed | 3 | 2020-02-05 | Posted |
| NCT06935838 Trial register | Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV | completed | 2 | 2025-04-20 | - |
| NCT06937203 Trial register | A First-In-Human Study of ARO-ALK7 in Adults With Obesity With and Without Type 2 Diabetes Mellitus | currently recruiting participants | 1/2 | 2025-04-15 | - |
| NCT07574723 Trial register | Tirzepatide Titration to Reduce Side Effects in Individuals With Obesity | currently recruiting participants | NA | 2026-05-08 | - |
| NCT07685834 Trial register | Evaluation of Facial and Neck Skin Laxity With SofWave Treatment in Adults Initiating Tirzepatide for Weight Loss | running, but no longer enrolling | NA | 2026-07-06 | - |
| 2024-520328-27-00 Trial register | J1R-MC-GZFD: A Parallel-Group Treatment, Phase 2, Double-Blind study of Once-Weekly Subcutaneous LY3457263 Compared to Placebo in Participants with Type 2 Diabe | Not stated | 2 | - | - |
| NCT06893211 Trial register | Effect of Tirzepatide on Brown Adipose Tissue in Obesity | completed | 2 | 2025-03-25 | - |
| NCT07676331 Trial register | Clinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA Trial | not yet recruiting participants | 2 | 2026-06-30 | - |
| NCT06640972 Trial register | Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 Agonists | completed | 2 | 2024-10-08 | Posted |
| NCT07444073 Trial register | Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock | not yet recruiting participants | - | 2026-02-12 | - |
| NCT07671248 Trial register | Tirzepatide in the Treatment of Cannabis Use Disorder | not yet recruiting participants | 3 | 2026-06-26 | - |
| NCT07677865 Trial register | GLP-1 Receptor Agonists and Alzheimer's Disease: A Multi-National Target Trial Emulation | completed | - | 2026-06-24 | - |
| 2026-525500-10-00 Trial register | ObStructive Sleep Apnoea ManageMent in Older AdUlts with Overweight or ObEsity: A Randomized ClinicaL Trial (SAMUEL study) | Not stated | 4 | - | - |
| NCT06075667 Trial register | A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities | running, but no longer enrolling | 3 | 2023-10-10 | - |
| NCT07671391 Trial register | A Randomized, Double-blind, Placebo-controlled Study Evaluating the Effect of LAE102 Injection in Combination With Tirzepatide on Body in Obese Participants | not yet recruiting participants | 2 | 2026-06-26 | - |
| NCT07668765 Trial register | GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity | not yet recruiting participants | - | 2026-06-04 | - |
| NCT06588283 Trial register | Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight | completed | 3 | 2024-09-19 | - |
| NCT07650149 Trial register | Genetic, Microbiological and Behavioral Factors in Obesity | currently recruiting participants | - | 2026-06-10 | - |
| NCT07382024 Trial register | Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial Fibrillation | not yet recruiting participants | NA | 2026-02-02 | - |
| NCT07638592 Trial register | Tirzepatide-Based Prehabilitation Before Elective Ventral and Incisional Hernia Repair in Patients With Obesity | completed | - | 2026-06-10 | - |
| NCT07640139 Trial register | Estimating the Impact of Obesity Medications on Clinical and Economic Outcomes | enrolling by invitation only | - | 2026-06-03 | - |
| NCT07635953 Trial register | New Triple Combination Therapy in Newly Diagnosed Type 2 Diabetes | not yet recruiting participants | 3 | 2026-06-03 | - |
| NCT07107334 Trial register | A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients Wit | currently recruiting participants | 2 | 2025-08-06 | - |
| NCT07633639 Trial register | GLP-1 Therapy After Bariatric Surgery in Chinese Patients With Obesity | currently recruiting participants | NA | 2026-06-08 | - |
| NCT06976853 Trial register | Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease | currently recruiting participants | 2 | 2025-05-16 | - |
| NCT07630454 Trial register | Tirzepatide on Atrial Fibrillation Recurrence After Catheter Ablation in Patients With Obesity and HFpEF | not yet recruiting participants | 4 | 2026-06-05 | - |
| NCT06584916 Trial register | A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MA | completed | 3 | 2024-09-03 | - |
| NCT07228741 Trial register | Resistance Exercise and Incretin Mimetic for Cardiometabolic Health in Survivors of ALL With Obesity | currently recruiting participants | 2 | 2025-11-14 | - |
| NCT07609160 Trial register | Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and | not yet recruiting participants | NA | 2026-04-28 | - |
| NCT06485089 Trial register | Effects of Tirzepatide on Blood, Imaging and Breast Tissue Biomarkers | completed | - | 2024-07-03 | - |
| NCT07284511 Trial register | A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar | currently recruiting participants | 2/3 | 2025-12-16 | - |
| NCT06643728 Trial register | A Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight | running, but no longer enrolling | 2 | 2024-10-16 | - |
| NCT06635057 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During Ramadan | completed | 4 | 2024-10-10 | - |
| NCT07605247 Trial register | Tirzepatide in the Treatment of Endometrial Cancer | not yet recruiting participants | 2 | 2026-05-22 | - |
| NCT07299084 Trial register | A Study to Evaluate the Effect of Fasting Duration and Tirzepatide Withholding on the Amount of Food and Fluid in the Stomach in Participants With Type 2 Diabet | running, but no longer enrolling | 1 | 2025-12-23 | - |
| NCT07588438 Trial register | Efficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay. | currently recruiting participants | 4 | 2026-05-14 | - |
| NCT06790160 Trial register | Study of Patients Being Treated With Anti-obesity Medication | currently recruiting participants | - | 2025-01-17 | - |
| NCT06980623 Trial register | Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction | running, but no longer enrolling | - | 2025-05-20 | - |
| NCT07588984 Trial register | GLP-1 Medication & Behavioral Health Programs on Weight & Metabolic Outcomes: FLOURISH and THRIVE Prospective Cohort Study | not yet recruiting participants | - | 2026-05-15 | - |
| NCT07589322 Trial register | Comparative Observation of Metabolic and Pharmacologic Adipose Remodeling With Enhanced Incretin AgonisTs | currently recruiting participants | NA | 2026-05-15 | - |
| NCT06721507 Trial register | 2024 Tirzepatide-Bariatric Surgery | currently recruiting participants | 4 | 2024-12-06 | - |
| NCT06588296 Trial register | Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Psoriatic Arthritis and Obesity or Overweight | completed | 3 | 2024-09-19 | - |
| NCT06914895 Trial register | A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight | running, but no longer enrolling | 3 | 2025-04-06 | - |
| NCT07567378 Trial register | CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry | not yet recruiting participants | - | 2026-05-05 | - |
| NCT06373146 Trial register | A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity | completed | 2 | 2024-04-18 | - |
| NCT07298915 Trial register | The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED) | not yet recruiting participants | 3 | 2025-12-23 | - |
| NCT07041983 Trial register | 24-h Energy Expenditure and Anti-obesity Medication | enrolling by invitation only | - | 2025-05-28 | - |
| NCT07443956 Trial register | Combination of Biologic and Anti-obesity Therapies in Psoriatic Arthritis | currently recruiting participants | NA | 2026-03-02 | - |
| NCT07203677 Trial register | Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT) | completed | - | 2025-10-02 | - |
| NCT07555730 Trial register | AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN) | not yet recruiting participants | 4 | 2026-04-29 | - |
| NCT07229170 Trial register | Changes in Taste and Eating Habits Associated With GLP-1 Agonists in Weight Loss Patients | currently recruiting participants | - | 2025-11-13 | - |
| NCT06885736 Trial register | LEAN Mass Preservation With Resistance Exercise and Protein During Semaglutide/Tirzepatide Therapy | currently recruiting participants | NA | 2025-03-20 | - |
| NCT06657209 Trial register | Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide | currently recruiting participants | 4 | 2024-10-24 | - |
| NCT07096908 Trial register | Tirzepatide Use in People With Obesity and Type 1 Diabetes | currently recruiting participants | 4 | 2025-07-31 | - |
| NCT07027969 Trial register | Metabolic Surgery for Atrial Fibrillation Elimination | not yet recruiting participants | 4 | 2025-06-11 | - |
| NCT06326060 Trial register | A Research Study Comparing How Well Different Doses of the Medicine NN0519-0130 Help People With Excess Body Weight Lose Weight | completed | 2 | 2024-03-22 | - |
| NCT06467604 Trial register | CRAVE Study: Comparing Craving Responses and Diet Quality of GLP1 Receptor Agonist Users | running, but no longer enrolling | - | 2024-06-11 | - |
| NCT06811324 Trial register | Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults | currently recruiting participants | 2 | 2025-02-06 | - |
| NCT06605703 Trial register | A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepat | completed | 4 | 2024-09-20 | - |
| NCT06751589 Trial register | A Study of a Weight Loss Intervention in People With Endometrial Cancer | currently recruiting participants | EARLY_1 | 2024-12-30 | - |
| NCT07521631 Trial register | Efficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without Diabetes | currently recruiting participants | 2 | 2026-04-13 | - |
| 2023-505270-15-00 Trial register | The effects of tirzepatIDE on coronAry pLaque lipid content and myocardial microvascular function in people with overweight or obesity and CORonary disease | Not stated | 3 | - | - |
| 2025-523877-40-00 Trial register | TREAT-EC (Tirzepatide in the treatment of endometrial cancer) - a clinical trial | Not stated | 2 | - | - |
| NCT07504172 Trial register | Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity | not yet recruiting participants | - | 2026-03-31 | - |
| NCT06774079 Trial register | Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) and Diet in Inflammatory Bowel Disease (IBD) Patients | currently recruiting participants | 4 | 2025-01-14 | - |
| NCT05933499 Trial register | Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity | currently recruiting participants | 2 | 2023-07-06 | - |
| NCT06732245 Trial register | Safety and Efficacy of NA-931 and Tirzepatide in Adults Who Are Overweight or Obese | not yet recruiting participants | 2 | 2024-12-13 | - |
| NCT07457437 Trial register | Function and Lean Mass Preservation With Resistance Exercise During a GLP-1RA Treatment | currently recruiting participants | NA | 2026-02-19 | - |
| 2022-500311-39-00 Trial register | Prevention of postoperative endoscopic recurrence with endoscopy-driven versus systematic biological therapy: a randomized, multicentre, parallel group pragmati | Not stated | 4 | - | - |
| NCT06047548 Trial register | A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities | completed | 3 | 2023-09-21 | - |
| NCT07492563 Trial register | Safety and Effectiveness of Tirzepatide in Patients With Obesity at Hospital de Clínicas, Paraguay | not yet recruiting participants | - | 2026-03-25 | - |
| NCT07220473 Trial register | Tirzepatide to Slow Biological Aging | currently recruiting participants | 2 | 2025-10-24 | - |
| NCT06037252 Trial register | A Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity | running, but no longer enrolling | 2 | 2023-09-14 | - |
| NCT07481747 Trial register | Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1) | currently recruiting participants | 3 | 2026-03-19 | - |
| NCT07483801 Trial register | DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies | not yet recruiting participants | 4 | 2026-03-19 | - |
| NCT06246799 Trial register | Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes | currently recruiting participants | 3 | 2024-02-07 | - |
| NCT06484114 Trial register | Evaluation of the Safety and Efficacy of Revita® DMR on Body Weight Maintenance in Subjects With Obesity Who Have Achieved at Least 15% Weight Loss on Tirzepati | running, but no longer enrolling | NA | 2024-07-03 | - |
| NCT07095517 Trial register | Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors | currently recruiting participants | 1 | 2025-07-31 | - |
| NCT07423247 Trial register | Tirzepatide (Spartina) in Obese Kidney Transplant Recipients | currently recruiting participants | 4 | 2026-02-20 | - |
| NCT06962280 Trial register | A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight | running, but no longer enrolling | 3 | 2025-05-08 | - |
| NCT06517212 Trial register | Tirzepatide Weight Loss for MRD+ Early Breast Cancer | currently recruiting participants | 2 | 2024-07-24 | - |
| 2024-514909-64-00 Trial register | Towards a personalized precision medicine in rare disease: tirzepatide (a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor | Not stated | 2 | - | - |
| NCT06939088 Trial register | Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder | currently recruiting participants | 2 | 2025-04-22 | - |
| NCT07398222 Trial register | Gastric Content in Fasting Volunteers and in Tirzepatide Users: an Observational and Cross-sectional Study | currently recruiting participants | - | 2026-02-09 | - |
| NCT06131437 Trial register | A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight | completed | 3 | 2023-11-14 | - |
| NCT07382180 Trial register | Real-World Tirzepatide Therapy in Post-Bariatric Weight Regain and Preoperative Obesity Patients | completed | - | 2026-02-02 | - |
| NCT07382388 Trial register | A Real-World Study on the Impact of Weight Loss on Treatment Efficacy in Overweight/Obese Patients With Plaque Psoriasis | not yet recruiting participants | - | 2026-01-20 | - |
| NCT06914141 Trial register | Comparative Effectiveness of Tirzepatide Versus Semaglutide in Individuals With Heart Failure With Preserved Ejection Fraction | completed | - | 2025-04-06 | - |
| NCT06914154 Trial register | Emulation of the SUMMIT Heart Failure Trial in Healthcare Claims Data | completed | - | 2025-04-06 | - |
| NCT06916065 Trial register | A Study of Eloralintide (LY3841136) and Eloralintide With Tirzepatide in Participants With Overweight or Obesity | completed | 1 | 2025-04-08 | - |
| NCT07364175 Trial register | A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in | currently recruiting participants | NA | 2026-01-23 | - |
| NCT07303556 Trial register | Improving Cardiovascular Disease Diagnosis and Treatment in Kazakhstan Using Metabolic Correction With GLP-1 Drugs | running, but no longer enrolling | NA | 2025-12-26 | - |
| NCT07373834 Trial register | Tirzepatide and Muscle Outcomes in Obesity | currently recruiting participants | NA | 2026-01-28 | - |
| NCT06630585 Trial register | GIP/GLP-1RA as Adjunctive to Automated Insulin Delivery in Adults With Type 1 Diabetes | currently recruiting participants | 3 | 2024-10-08 | - |
| NCT06445075 Trial register | Efficacy and Safety of Apitegromab for the Treatment of Adults Who Are Overweight or Obese | completed | 2 | 2024-06-06 | - |
| NCT06518837 Trial register | Tirzepatide for Weight Loss Intervention in Early-Stage Hormone Receptor Positive/HER2 Negative Breast Cancer | currently recruiting participants | 2 | 2024-07-24 | - |
| NCT07094568 Trial register | Tirzepatide vs Liraglutide in Bone | currently recruiting participants | - | 2025-07-30 | - |
| NCT07354880 Trial register | Effect of Tirzepatide on Cardiovascular and Metabolic Parameters in Obese Adult Patients With Congenital Heart Disease | not yet recruiting participants | 4 | 2026-01-21 | - |
| NCT06297616 Trial register | A Study of LY3841136 in Japanese Participants With Obesity or Overweight | completed | 1 | 2024-03-07 | - |
| NCT06802081 Trial register | TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation | currently recruiting participants | 2 | 2025-01-30 | - |
| NCT06648031 Trial register | Comparison of the Safety, Efficacy and Pharmacokinetics of DehydraTECH -CBD and DehydraTECH-GLP1 Agonists Alone or in Combination, in Overweight or Obese, Pre- | completed | 1 | 2024-10-18 | - |
| NCT07326111 Trial register | A Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese | currently recruiting participants | 4 | 2026-01-08 | - |
| NCT07319975 Trial register | Effect of Semaglutide and Tirzepatide Combined With Exercise in Obesity | not yet recruiting participants | NA | 2026-01-06 | - |
| NCT07309094 Trial register | Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD | currently recruiting participants | - | 2025-12-30 | - |
| NCT06801015 Trial register | Effects of Long-Acting GLP-1 (Glucagon-like Peptide-1) or Dual Incretin (GLP-1 and GIP [Glucose-dependent Insulinotropic Peptide]) Modulation on Gastric Motor F | running, but no longer enrolling | 4 | 2025-01-30 | - |
| NCT07058155 Trial register | Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease | currently recruiting participants | 4 | 2025-06-27 | - |
| NCT07128082 Trial register | The Long COVID Treatment Trial | running, but no longer enrolling | 2 | 2025-08-17 | - |
| NCT07293325 Trial register | Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity | currently recruiting participants | NA | 2025-12-19 | - |
| NCT07292519 Trial register | Tirzepatide Combined With Cognitive-Behavioural Therapy (CBT) for Adults With Alcohol Use Disorder (AUD) and Overweight/Obesity (OOB) | not yet recruiting participants | 2 | 2025-12-18 | - |
| NCT07000955 Trial register | Tolerance and Pharmacokinetic/Pharmacokinetic Study of IBI362 15mg in Patients With Moderate to Severe Obesity | running, but no longer enrolling | 1/2 | 2025-06-03 | - |
| NCT07176663 Trial register | Efficacy and Safety of Tirzepatide (Spartina) in Chronic Kidney Failure | not yet recruiting participants | NA | 2025-09-16 | - |
| NCT05433584 Trial register | A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes | running, but no longer enrolling | 4 | 2022-06-27 | - |
| NCT06533527 Trial register | Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy | completed | 4 | 2024-06-27 | Posted |
| NCT05822830 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities | completed | 3 | 2023-04-21 | Posted |
| NCT07245771 Trial register | Phase 1/2a Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effect on Body Weight of RN3161 as Monotherapy and in Combination | currently recruiting participants | 1/2 | 2025-11-24 | - |
| NCT07223242 Trial register | Tailored Exercise Training Study Among Adults With HFpEF | currently recruiting participants | 2/3 | 2025-10-06 | - |
| NCT06911203 Trial register | A Study of BGM0504 in Participants With Obesity | currently recruiting participants | 2 | 2025-04-04 | - |
| NCT05963022 Trial register | A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO) | completed | 3 | 2023-07-27 | Posted |
| NCT06345066 Trial register | A Study of LY3841136 in Overweight and Obese Participants | completed | 1 | 2024-04-03 | - |
| NCT07088718 Trial register | Prediction of the SURPASS-CVOT Cardiovascular Outcome Trial in Healthcare Claims Data | completed | - | 2025-07-28 | - |
| NCT07096063 Trial register | Comparative Effectiveness of Tirzepatide and Semaglutide in Individuals at Cardiovascular Risk | completed | - | 2025-07-31 | - |
| NCT06994338 Trial register | Tirzepatide for Alcohol Use Disorder | currently recruiting participants | 2 | 2025-05-29 | - |
| NCT06890611 Trial register | A Study of Bimagrumab Alone (LY3985863) and Bimagrumab With Tirzepatide (LY900042) in Healthy Participants | completed | 1 | 2025-03-24 | - |
| NCT05260021 Trial register | A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Bas | completed | 3 | 2022-03-02 | Posted |
| NCT06901349 Trial register | A Study of Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Participants With Obesity or Overweight With Type 2 Diabetes | withdrawn before enrolling anyone | 2 | 2025-03-28 | - |
| NCT07188545 Trial register | Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Rea | running, but no longer enrolling | - | 2025-09-16 | - |
| NCT07179120 Trial register | Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health | not yet recruiting participants | 2 | 2025-09-17 | - |
| NCT06901245 Trial register | Tirzepatide in PWS, HO and GNSO | currently recruiting participants | 4 | 2025-03-28 | - |
| NCT07042672 Trial register | Behavioral Therapy and GLP-1 Analogue Effects on Binge Eating, Weight, and Coping in Obesity | currently recruiting participants | - | 2025-04-03 | - |
| NCT05756764 Trial register | Anti-obesity Pharmacotherapy and Inflammation | running, but no longer enrolling | - | 2023-03-06 | - |
| NCT07091734 Trial register | Tirzepatide for Partial Lipodystrophy Treatment: A New Horizon in 2024 | currently recruiting participants | 2 | 2025-07-29 | - |
| NCT07156331 Trial register | Research on Effects of Drugs on Body Composition and Function With Imaging in Diabetes | not yet recruiting participants | - | 2025-08-07 | - |
| NCT05696847 Trial register | A Study of Tirzepatide (LY3298176) in Pediatric Participants With Obesity | completed | 1 | 2023-01-25 | Posted |
| NCT04847557 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Obesity: The SUMMIT Trial | completed | 3 | 2021-04-19 | Posted |
| NCT05691712 Trial register | A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes | completed | 3 | 2023-01-20 | Posted |
| NCT05564039 Trial register | A Study of Tirzepatide (LY3298176) in Adult Participants With Type 2 Diabetes Switching From Dulaglutide (SURPASS-SWITCH) | completed | 4 | 2022-10-03 | Posted |
| NCT07099742 Trial register | Effectiveness and Safety of Tirzepatide Among Participants With Obesity With or Without Type 2 Diabetes Mellitus (T2DM) | not yet recruiting participants | - | 2025-08-01 | - |
| NCT06180616 Trial register | Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity | not yet recruiting participants | 2 | 2023-12-22 | - |
| NCT04184622 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight | completed | 3 | 2019-12-03 | Posted |
| NCT06073184 Trial register | Weight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Low-grade Cancer of the Endometrium | not yet recruiting participants | 2 | 2023-09-12 | - |
| NCT06606821 Trial register | The Effects of Tirzepatide in People With Overweight/Obesity and Coronary Artery Disease | currently recruiting participants | 4 | 2024-09-23 | - |
| NCT06582875 Trial register | Glucagon-Like Peptide-1 Receptor Agonist in ADPKD | currently recruiting participants | 2 | 2024-09-03 | - |
| NCT05412004 Trial register | Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea | completed | 3 | 2022-06-09 | Posted |
| NCT06191848 Trial register | Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA) | currently recruiting participants | 4 | 2024-01-05 | - |
| NCT05978713 Trial register | A Study of Tirzepatide (LY3298176) in Healthy Lactating Females | completed | 1 | 2023-08-07 | Posted |
| NCT06918405 Trial register | Efficacy and Safety of Tirzepatide for Weight Management | running, but no longer enrolling | 3 | 2025-04-09 | - |
| NCT06734312 Trial register | MAINTAIN (Mucosal AblatIoN Therapy After INcretins) | currently recruiting participants | NA | 2024-12-10 | - |
| NCT06515418 Trial register | Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared with Tirzepatide Alone in Participants with Obesity Aged 55 Years and Over | terminated before completion | 2 | 2024-07-23 | - |
| NCT06565611 Trial register | A Phase 2 Study Evaluating the Co-Administration of Bremelanotide With Tirzepatide for the Treatment of Obesity | running, but no longer enrolling | 2 | 2024-08-22 | - |
| NCT06856928 Trial register | Impact of Antiobesity Medications on Appetite and Appetite-related Hormones and Metabolites. | not yet recruiting participants | - | 2025-02-13 | - |
| NCT06009653 Trial register | Effects of Tirzepatide Plus Intensive Lifestyle Therapy on Body Weight and Metabolic Health in Latinos With Obesity | withdrawn before enrolling anyone | 4 | 2023-08-24 | - |
| NCT06400615 Trial register | Study That Tests AD109 in Patients Taking GLP-1 Drugs | completed | 2 | 2024-04-12 | - |
| NCT05812183 Trial register | Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity | withdrawn before enrolling anyone | 4 | 2023-03-31 | - |
| NCT04166773 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH) | completed | 2 | 2019-11-18 | Posted |
| NCT06761703 Trial register | A Study to Determine the Feasibility of Online Recruitment of People Using an Anti-Obesity Medication for Weight Loss | completed | - | 2025-01-01 | - |
| NCT05706506 Trial register | A Study of Tirzepatide (LY3298176) in Adults With Type 2 Diabetes Switching From a GLP-1 RA (SURPASS-SWITCH-2) | completed | 4 | 2023-01-31 | Posted |
| NCT05912621 Trial register | Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity | currently recruiting participants | 2 | 2023-06-22 | - |
| NCT05708859 Trial register | Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT | currently recruiting participants | 4 | 2023-02-01 | - |
| NCT05810597 Trial register | A Research Study Looking at Similarity Between Tirzepatide Versions for Different Injection Devices | completed | 1 | 2023-04-12 | Posted |
| 2022-500101-41-00 Trial register | A Phase 4, Randomized, Open-Label, Active-Controlled Study to Investigate the Efficacy and Safety of Switching From Weekly Dulaglutide to Weekly Tirzepatide in | Not stated | 4 | - | - |
| NCT04844918 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Obesity Disease | completed | 3 | 2021-04-14 | Posted |
| NCT05766358 Trial register | Role Of Metabolic Adaptation In Weight Regain | completed | - | 2023-03-13 | - |
| NCT04311411 Trial register | A Study of Tirzepatide in Overweight and Very Overweight Participants | completed | 1 | 2020-03-17 | Posted |
| NCT04660643 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight for the Maintenance of Weight Loss | completed | 3 | 2020-12-09 | Posted |
| NCT04050553 Trial register | A Study of Tirzepatide in Participants With Type 2 Diabetes Mellitus | completed | 1 | 2019-08-08 | Posted |
| NCT04657016 Trial register | A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program | completed | 3 | 2020-12-07 | Posted |
| NCT06354101 Trial register | The Purpose of This Registry Study is to Learn More About Metabolic Health: Approximately 15,000 Participants Who Are Overweight or Have Obesity With or Without | withdrawn before enrolling anyone | - | 2024-04-09 | - |
| NCT04657003 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Who Have Obesity or Are Overweight | completed | 3 | 2020-12-07 | Posted |
| NCT06301256 Trial register | Evaluate the Efficacy of TIRZEPATIDE for the Treatment of Moderate to Severe HS Hidradenitis Suppurativa | last verified some time ago; the register no longer confirms its status | NA | 2024-03-08 | - |
| NCT05659368 Trial register | Tirzepatide Monotherapy in Patients With Wolfram Syndrome Type 1 | last verified some time ago; the register no longer confirms its status | 2 | 2022-12-21 | - |
| NCT04081337 Trial register | A Study to Measure Energy Expenditure and Food Intake in Participants With Obesity Using Tirzepatide | completed | 1 | 2019-09-09 | Posted |
| NCT03375463 Trial register | A Study of Tirzepatide (LY3298176) in Healthy Participants | completed | 1 | 2017-12-18 | Posted |
| NCT05024032 Trial register | A Study of Tirzepatide (LY3298176) in Chinese Participants Without Type 2 Diabetes Who Have Obesity or Overweight (SURMOUNT-CN) | completed | 3 | 2021-08-27 | Posted |
| NCT02759107 Trial register | A Study of Tirzepatide (LY3298176) in Healthy Participants and Participants With Type 2 Diabetes (T2DM) | completed | 1 | 2016-05-03 | Posted |
| NCT05751720 Trial register | Effect on Non-Alcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus With Gastric Inhibitory Polypeptide/Glucagon Like Peptide-1 Analogue | last verified some time ago; the register no longer confirms its status | 1/2 | 2023-03-02 | - |
| NCT04407234 Trial register | A Study to Measure Stomach Emptying in Overweight Non-diabetic and Diabetic Participants Using Tirzepatide | completed | 1 | 2020-05-29 | Posted |
| NCT04537923 Trial register | A Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or | completed | 3 | 2020-09-03 | Posted |
| NCT05990374 Trial register | Therapeutic Effects and Effects on Body Fat of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes for 1-4 Years | last verified some time ago; the register no longer confirms its status | NA | 2023-08-14 | - |
| NCT05582096 Trial register | A Study of LY3457263 in Obese Participants | completed | 1 | 2022-10-17 | - |
| NCT04235959 Trial register | A Study of Tirzepatide in Chinese Participants With Type 2 Diabetes Mellitus | completed | 1 | 2020-01-22 | Posted |
| NCT04050670 Trial register | A Study of Tirzepatide at Different Injection Sites in Participants With Different Body Sizes | completed | 1 | 2019-08-08 | Posted |
| NCT04004988 Trial register | A Study of Tirzepatide Administered by Two Different Devices in Healthy Participants | completed | 1 | 2019-07-02 | Posted |
| NCT04172987 Trial register | A Study of the Effect of Tirzepatide on How the Body Handles Birth Control Pills in Healthy Female Participants | completed | 1 | 2019-11-21 | Posted |
| NCT03940742 Trial register | A Study of Tirzepatide in Participants With Impaired Liver Function | completed | 1 | 2019-05-07 | Posted |
| NCT04311424 Trial register | Study of Tirzepatide in Healthy Participants | completed | 1 | 2020-03-17 | Posted |
| NCT03322631 Trial register | A Study of Tirzepatide (LY3298176) in Japanese Participants With Type 2 Diabetes | completed | 1 | 2017-10-26 | Posted |
| NCT03482024 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Impaired Kidney Function | completed | 1 | 2018-03-29 | Posted |
| NCT03951753 Trial register | A Study of Tirzepatide in Participants With Type 2 Diabetes Mellitus (T2DM) | completed | 1 | 2019-05-15 | Posted |
| 2022-501106-35-00 Trial register | I8F-MC-GPHJ: A Phase 3b, Randomized Controlled Study to Evaluate the Efficacy and Safety of Tirzepatide Compared to Semaglutide 2.4 mg in Adults Who Have Obesit | Not stated | 3 | - | - |
| NCT04093752 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes on Metformin With or Without Sulfonylurea (SURPASS-AP-Combo) | completed | 3 | 2019-09-18 | Posted |
| NCT05553093 Trial register | Effects of Tirzepatide and Insulin Glargine on Glucolipid Metabolism and Brain Function in Patients With Type 2 Diabetes | currently recruiting participants | 4 | 2022-09-23 | - |
| NCT03861052 Trial register | A Study of Tirzepatide (LY3298176) Compared to Dulaglutide in Participants With Type 2 Diabetes | completed | 3 | 2019-03-04 | Posted |
| NCT03730662 Trial register | A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participants With Type 2 Diabetes and Increased Cardiovascular Risk | completed | 3 | 2018-11-05 | Posted |
| NCT03861039 Trial register | A Long-term Safety Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes | completed | 3 | 2019-03-04 | Posted |
| NCT03987919 Trial register | A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes | completed | 3 | 2019-06-17 | Posted |
| NCT03882970 Trial register | A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 Diabetes | completed | 3 | 2019-03-20 | Posted |
| NCT04039503 Trial register | A Study of Tirzepatide (LY3298176) Versus Placebo in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine With or Without Metformin | completed | 3 | 2019-07-31 | Posted |
| NCT03954834 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone | completed | 3 | 2019-05-17 | Posted |
| NCT03311724 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes | completed | 2 | 2017-10-17 | Posted |
| NCT03131687 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Mellitus | completed | 2 | 2017-04-27 | Posted |
Source: ClinicalTrials.gov and EU CTIS, read 2026-10-03. Not medical advice.
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