What is the starting dose of Vancomycin?

The recommended dose is 125 mg administered orally 4 times daily for 10 days. Source: FDA label for Vancomycin Hydrochloride (ANDA210729).

What is the half-life of Vancomycin?

7.5 days, per the FDA label (section 12.3).

What doses of Vancomycin were studied?

125 mg (2 trials, 447 people); 25 mg/kg (1 trial, 20 people). Source: ClinicalTrials.gov posted results.

glycopeptide antibiotic

Vancomycin dose

Answer

FDA label for Vancomycin Hydrochloride: The recommended dose is 125 mg administered orally 4 times daily for 10 days. Half-life on the label: 7.5 days. Trials with posted results tested 2 doses, most often 125 mg, 25 mg/kg.

Not dosing advice.

FDA LABEL

What the approved labels state

TYZAVAN NDA211962 · label of 2026-08-19 Regulator

Half-life: 7.5 days (section 12.3).

Full label, section 2, on DailyMed

Vancomycin Hydrochloride ANDA210729 · label of 2026-08-17 Regulator

The recommended dose is 125 mg administered orally 4 times daily for 10 days.

Full label, section 2, on DailyMed

Vancomycin Hydrochloride for Oral Solution NDA208910 · label of 2026-07-14 Regulator

The recommended dose is 125 mg administered orally 4 times daily for 10 days.

Full label, section 2, on DailyMed

FIRVANQ NDA208910 · label of 2026-07-14 Regulator

The recommended dose is 125 mg administered orally 4 times daily for 10 days.

Full label, section 2, on DailyMed

IN TRIALS

Doses tested in 175 trials with posted results

Dose in the arm title	Trials	People on it	Phases
125 mg	2	447	2/3
25 mg/kg	1	20	4

Trial register Read from the titles of arms that received Vancomycin (n ≥ 20). An arm naming several doses counts under each; a schedule or escalation is on the trial record. All trials.

WEEKLY

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New trials, approvals and enforcement actions. One email a week.