TRIAL RESULTS · SIDE EFFECTS
Vasopressin side effects
ANSWER
3 placebo-controlled trials of Vasopressin posted side-effect results, but no side effect was reported for at least half of the 453 people on Vasopressin, so no pooled comparison is shown. Read from ClinicalTrials.gov on 2026-10-03. Not medical advice.
Trial register
Trials with posted results
8
with an arm on Vasopressin, of 449 registered
Against placebo
3
placebo-controlled trials
People in those trials
453
on Vasopressin · 599 on placebo
Read
2026-10-03
ClinicalTrials.gov
ALL TRIALS
The 100 most reported of 190 side effects reported
Every trial with posted results and an arm on Vasopressin (n ≥ 20), all phases, by people affected. Placebo is shown where placebo-controlled trials reported the same event. Comparator arms are not counted.
| Side effect | Organ system | Vasopressin | Placebo | Trials |
|---|---|---|---|---|
| ARDS | Respiratory, thoracic and mediastinal disorders | 65.9% (29 of 44) | - | 1 |
| Minor adverse events | Nervous system disorders | 23.7% (27 of 114) | - | 1 |
| Aggression | Psychiatric disorders | 18.7% (14 of 75) | 20.9% | 1 |
| Nasal Congestion | Respiratory, thoracic and mediastinal disorders | 18.7% (14 of 75) | 22.2% | 1 |
| Pneumonia | Respiratory, thoracic and mediastinal disorders | 11.9% (10 of 84) | - | 2 |
| Constipation | Gastrointestinal disorders | 7.8% (9 of 115) | 5.7% | 2 |
| Skin Breakdown | Skin and subcutaneous tissue disorders | 20.0% (8 of 40) | - | 1 |
| Wound Infection | Infections and infestations | 7.1% (6 of 84) | - | 2 |
| Agitation | Nervous system disorders | 5.2% (6 of 115) | 7.0% | 2 |
| Hyperglycemia | Endocrine disorders | 15.0% (6 of 40) | - | 1 |
| Death | General disorders | 14.3% (6 of 42) | - | 1 |
| Headache | Nervous system disorders | 8.0% (6 of 75) | 10.1% | 1 |
| Hyponatremia | Endocrine disorders | 6.0% (5 of 84) | - | 2 |
| Anemia | Blood and lymphatic system disorders | 12.5% (5 of 40) | - | 1 |
| Deep Venous Thrombosis | Blood and lymphatic system disorders | 11.4% (5 of 44) | - | 1 |
| Pharyngeal Pain | Gastrointestinal disorders | 6.7% (5 of 75) | 4.4% | 1 |
| Hypokalemia | Endocrine disorders | 10.0% (4 of 40) | - | 1 |
| Multiple Organ Failure | General disorders | 10.0% (4 of 40) | - | 1 |
| Traumatic Brain Injury (TBI) | Nervous system disorders | 10.0% (4 of 40) | - | 1 |
| Pyrexia | General disorders | 5.3% (4 of 75) | 6.3% | 1 |
| Depressed Mood | Psychiatric disorders | 5.3% (4 of 75) | 3.2% | 1 |
| Nasal Discomfort | Respiratory, thoracic and mediastinal disorders | 5.3% (4 of 75) | 1.9% | 1 |
| Hypotension | Cardiac disorders | 7.5% (3 of 40) | - | 1 |
| Hypocalcemia | Endocrine disorders | 7.5% (3 of 40) | - | 1 |
| Nausea | Gastrointestinal disorders | 7.5% (3 of 40) | - | 1 |
| Bacteremia | Infections and infestations | 7.5% (3 of 40) | - | 1 |
| Multiorgan failure | General disorders | 7.5% (3 of 40) | - | 1 |
| Cardiopulmonary Arrest | General disorders | 7.5% (3 of 40) | - | 1 |
| Hemorrhagic Shock | General disorders | 7.5% (3 of 40) | - | 1 |
| Deep Vein Thrombosis | Vascular disorders | 7.5% (3 of 40) | - | 1 |
| high blood pressure or heart rate post-drug administration | Vascular disorders | 2.1% (3 of 141) | 5.6% | 1 |
| Cough | Respiratory, thoracic and mediastinal disorders | 4.0% (3 of 75) | 10.1% | 1 |
| Sneezing | Respiratory, thoracic and mediastinal disorders | 4.0% (3 of 75) | 4.4% | 1 |
| Bug Bite | Skin and subcutaneous tissue disorders | 4.0% (3 of 75) | 1.9% | 1 |
| Diarrhea | Gastrointestinal disorders | 1.7% (2 of 115) | 5.1% | 2 |
| Urinary Tract Infection | Renal and urinary disorders | 2.4% (2 of 84) | - | 2 |
| Arrhythmia | Cardiac disorders | 5.0% (2 of 40) | - | 1 |
| hypoglycemia | Endocrine disorders | 5.0% (2 of 40) | - | 1 |
| Hypophosphatemia | Endocrine disorders | 5.0% (2 of 40) | - | 1 |
| Dysphagia | Metabolism and nutrition disorders | 5.0% (2 of 40) | - | 1 |
| Elevated gastric residuals | Gastrointestinal disorders | 5.0% (2 of 40) | - | 1 |
| Elevated Temperature | Infections and infestations | 5.0% (2 of 40) | - | 1 |
| Wound Dehiscence | Skin and subcutaneous tissue disorders | 5.0% (2 of 40) | - | 1 |
| Acidosis | Metabolism and nutrition disorders | 5.0% (2 of 40) | - | 1 |
| Pain | General disorders | 5.0% (2 of 40) | - | 1 |
| Hemothorax | Respiratory, thoracic and mediastinal disorders | 5.0% (2 of 40) | - | 1 |
| desaturation | Respiratory, thoracic and mediastinal disorders | 5.0% (2 of 40) | - | 1 |
| Hypertenson | Cardiac disorders | 5.0% (2 of 40) | - | 1 |
| Cardiac Arrhythmia | Cardiac disorders | 5.0% (2 of 40) | - | 1 |
| Acute Respiratory Distress Syndrome (ARDS) | Respiratory, thoracic and mediastinal disorders | 5.0% (2 of 40) | - | 1 |
| Pulmonary Emboli | Respiratory, thoracic and mediastinal disorders | 5.0% (2 of 40) | - | 1 |
| Respiratory Distress | Respiratory, thoracic and mediastinal disorders | 5.0% (2 of 40) | - | 1 |
| Sepsis | Infections and infestations | 4.5% (2 of 44) | - | 1 |
| Acute Renal Failure | Renal and urinary disorders | 4.5% (2 of 44) | - | 1 |
| Somnolence | Nervous system disorders | 2.7% (2 of 75) | 5.1% | 1 |
| Rash | Skin and subcutaneous tissue disorders | 2.7% (2 of 75) | 6.3% | 1 |
| Hypertension | Cardiac disorders | 2.5% (1 of 40) | - | 1 |
| Diabetes Insipidus | Endocrine disorders | 2.5% (1 of 40) | - | 1 |
| Hypomagnesemia | Endocrine disorders | 2.5% (1 of 40) | - | 1 |
| Hyperkalemia | Endocrine disorders | 2.5% (1 of 40) | - | 1 |
| Otorrhea | Ear and labyrinth disorders | 2.5% (1 of 40) | - | 1 |
| Acute Choleycystitis | Gastrointestinal disorders | 2.5% (1 of 40) | - | 1 |
| Cholelithiasis | Gastrointestinal disorders | 2.5% (1 of 40) | - | 1 |
| vomiting | Gastrointestinal disorders | 2.5% (1 of 40) | - | 1 |
| incontinence stool | Gastrointestinal disorders | 2.5% (1 of 40) | - | 1 |
| Dilitional Thrombocytopenia | Blood and lymphatic system disorders | 2.5% (1 of 40) | - | 1 |
| Elevated INR | Blood and lymphatic system disorders | 2.5% (1 of 40) | - | 1 |
| Cephalic Vein Thrombosis | Vascular disorders | 2.5% (1 of 40) | - | 1 |
| Leukocytosis | Blood and lymphatic system disorders | 2.5% (1 of 40) | - | 1 |
| Hives | Skin and subcutaneous tissue disorders | 2.5% (1 of 40) | - | 1 |
| Infiltration, skin | Skin and subcutaneous tissue disorders | 2.5% (1 of 40) | - | 1 |
| Myoglobinuria | General disorders | 2.5% (1 of 40) | - | 1 |
| Edema | Vascular disorders | 2.5% (1 of 40) | - | 1 |
| anorexia | Metabolism and nutrition disorders | 2.5% (1 of 40) | - | 1 |
| Delirium Tremors | Nervous system disorders | 2.5% (1 of 40) | - | 1 |
| Hyper-reflexia | Nervous system disorders | 2.5% (1 of 40) | - | 1 |
| Hyperthermia | General disorders | 2.5% (1 of 40) | - | 1 |
| insomia | Nervous system disorders | 2.5% (1 of 40) | - | 1 |
| Impaired Renal Function | Renal and urinary disorders | 2.5% (1 of 40) | - | 1 |
| Acute Respiratory Failure | Respiratory, thoracic and mediastinal disorders | 2.5% (1 of 40) | - | 1 |
| Pleural Effusions | Respiratory, thoracic and mediastinal disorders | 2.5% (1 of 40) | - | 1 |
| Laryngeal Edema | Respiratory, thoracic and mediastinal disorders | 2.5% (1 of 40) | - | 1 |
| Pulmonary Edema | Respiratory, thoracic and mediastinal disorders | 2.5% (1 of 40) | - | 1 |
| Cardiac Dysrhythmia | Cardiac disorders | 2.5% (1 of 40) | - | 1 |
| exsanguination | General disorders | 2.5% (1 of 40) | - | 1 |
| Myocardial Infarction | Cardiac disorders | 2.5% (1 of 40) | - | 1 |
| reperfusion syndrome | Vascular disorders | 2.5% (1 of 40) | - | 1 |
| Ogilvies Syndrome | Gastrointestinal disorders | 2.5% (1 of 40) | - | 1 |
| Upper GI bleed | Gastrointestinal disorders | 2.5% (1 of 40) | - | 1 |
| Heparin induced thrombocytopenia | Vascular disorders | 2.5% (1 of 40) | - | 1 |
| Sepsis, abdominal | General disorders | 2.5% (1 of 40) | - | 1 |
| Ischemic Necrosis Bilateral Lower Extremities | Vascular disorders | 2.5% (1 of 40) | - | 1 |
| Cellutlitis | Skin and subcutaneous tissue disorders | 2.5% (1 of 40) | - | 1 |
| Compartment Syndrome | Vascular disorders | 2.5% (1 of 40) | - | 1 |
| Pulmonary Hemorrhage | General disorders | 2.5% (1 of 40) | - | 1 |
| Renal Insufficiency, worsening | Renal and urinary disorders | 2.5% (1 of 40) | - | 1 |
| nose bleed | General disorders | 0.7% (1 of 141) | 0.0% | 1 |
| Urticaria | Skin and subcutaneous tissue disorders | 2.3% (1 of 44) | - | 1 |
| Rhabdomyolysis | Musculoskeletal and connective tissue disorders | 2.3% (1 of 44) | - | 1 |
| Dizziness | Cardiac disorders | 1.3% (1 of 75) | 1.3% | 1 |
Source: ClinicalTrials.gov posted results, read 2026-10-03. A trial lists events above its own reporting threshold, so a rare event may be missing from some trials. Not medical advice.
FDA LABEL
What the FDA label says
Vasostrict NDA204485 · label of 2026-04-21 Regulator
The most common adverse reactions include decreased cardiac output, bradycardia, tachyarrhythmias, hyponatremia and ischemia (coronary, mesenteric, skin, digital).
VASOPRESSIN ANDA214314 · label of 2025-12-18 Regulator
The most common adverse reactions include decreased cardiac output, bradycardia, tachyarrhythmias, hyponatremia and ischemia (coronary, mesenteric, skin, digital).
Vasopressin in 0.9% Sodium Chloride NDA217766 · label of 2025-06-17 Regulator
The most common adverse reactions include decreased cardiac output, bradycardia, tachyarrhythmias, hyponatremia and ischemia (coronary, mesenteric, skin, digital).
REGISTERED STUDIES
449 registered clinical trials of Vasopressin
The 10 most recently updated are listed.
| NCT07102615 | Intracervical Vasopressin Status: RECRUITING · Updated 2026-10-02 |
|---|---|
| NCT05958342 | CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial Status: RECRUITING · Updated 2026-09-29 |
| NCT07838493 | Oromucosal Oxytocin and Vasopressin Modulation of Emotional Face Attention Status: RECRUITING · Updated 2026-09-24 |
| NCT04501861 | Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients: Status: COMPLETED · Updated 2026-09-01 |
| NCT06635629 | Desmopressin Stimulation Test Performance in ACTH-Dependent Cushing Syndrome Status: RECRUITING · Updated 2026-08-31 |
| NCT06709573 | Early Versus Late Adjunctive Vasopressin in Septic Shock Status: RECRUITING · Updated 2026-08-31 |
| NCT07252401 | Terlipressin vs. Somatostatin in Cirrhotic Patients With Acute Variceal Bleeding and Renal Dysfunction Status: NOT_YET_RECRUITING · Updated 2026-08-27 |
| NCT07576036 | International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia Status: ENROLLING_BY_INVITATION · Updated 2026-08-26 |
| NCT07776977 | Bedtime Device Restriction and Desmopressin in PMNE. Status: RECRUITING · Updated 2026-08-24 |
| NCT07568509 | Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease Status: RECRUITING · Updated 2026-08-21 |
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