macrocyclic peptide complement inhibitor
Zilucoplan clinical trials
Answer
Zilucoplan has 24 registered trials: 6 running, 11 completed, 2 stopped early. 12 posted results.
Trial registerClinicalTrials.gov and EU CTIS, read 2026-10-03
| Trial | Title | Status | Phase | Registered | Results |
|---|---|---|---|---|---|
| NCT06055959 Trial register | A Study to Evaluate Subcutaneous Zilucoplan in Pediatric Participants With Generalized Myasthenia Gravis | currently recruiting participants | - | 2023-09-28 | - |
| NCT06435312 Trial register | An Open-label Extension Study to Evaluate Subcutaneous Zilucoplan in Pediatric Participants With Generalized Myasthenia Gravis | enrolling by invitation only | - | 2024-05-30 | - |
| NCT07215949 Trial register | Zilucoplan for Severe gMG Exacerbations | currently recruiting participants | - | 2025-10-14 | - |
| NCT06961747 Trial register | A Study to Assess Zilucoplan Concentration in Breast Milk of Healthy Lactating Women | currently recruiting participants | - | 2025-05-08 | - |
| NCT04225871 Trial register | Open-Label Extension of Zilucoplan in Subjects With Generalized Myasthenia Gravis | completed | - | 2020-01-13 | - |
| NCT04297683 Trial register | HEALEY ALS Platform Trial - Master Protocol | running, but no longer enrolling | - | 2020-03-05 | - |
| 2022-502072-23-00 Trial register | A MULTICENTER OPEN-LABEL, UNCONTROLLED STUDY TO EVALUATE THE PHARMACOKINETICS, PHARMACODYNAMICS, SAFETY, TOLERABILITY, AND ACTIVITY OF ZILUCOPLAN IN PEDIATRIC S | Not stated | 2/3 | - | - |
| 2022-502073-42-00 Trial register | AN OPEN-LABEL EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY, TOLERABILITY, PHARMACOKINETICS, PHARMACODYNAMICS, AND ACTIVITY OF ZILUCOPLAN IN PEDIATRIC STUDY | Not stated | 3 | - | - |
| NCT06471361 Trial register | A Study to Evaluate the Safe and Effective Use of a Zilucoplan Auto-injector by Study Participants With Generalized Myasthenia Gravis | completed | - | 2024-06-24 | Posted |
| NCT06511076 Trial register | A Study to Evaluate Zilucoplan Injected Subcutaneously Either by a Prefilled Syringe or an Auto-injector in Healthy Adult Participants | completed | - | 2024-07-19 | Posted |
| 2024-512399-37-00 Trial register | A Phase 3, Multicenter, Open-Label Extension Study of Zilucoplan in Subjects with Generalized Myasthenia Gravis | Not stated | 3 | - | - |
| NCT06815133 Trial register | Effectiveness and Safety of Zilucoplan Treatment for French Patients With Myasthenia Gravis Over 3 Months | currently recruiting participants | - | 2025-02-07 | - |
| NCT05514873 Trial register | An Open-label Study to Evaluate the Safety, Tolerability, and Efficacy of Subcutaneous Zilucoplan in Participants With Generalized Myasthenia Gravis Who Were Pr | completed | - | 2022-08-25 | Posted |
| NCT04115293 Trial register | Safety, Tolerability, and Efficacy of Zilucoplan in Subjects With Generalized Myasthenia Gravis | completed | - | 2019-10-04 | Posted |
| 2023-508388-64-00 Trial register | A study to learn how zilucoplan moves throughout the body over time when given in 2 different ways in healthy adults | Not stated | 1 | - | - |
| 2023-508287-30-00 Trial register | A MULTICENTER, OPEN-LABEL, OUTPATIENT STUDY TO EVALUATE THE SAFE AND EFFECTIVE USE OF A ZILUCOPLAN AUTO INJECTOR COMBINATION PRODUCT FOR SUBCUTANEOUS SELF-ADMIN | Not stated | 3 | - | - |
| NCT03225287 Trial register | Extension Study of RA101495 for Patients With PNH Who Have Completed a Zilucoplan (RA101495) Clinical Study | terminated before completion | - | 2017-07-21 | Posted |
| NCT04382755 Trial register | Zilucoplan® in Improving Oxygenation, Short-, Longterm Outcome of COVID19 Patients With Acute Hypoxic Respiratory Failure | completed | - | 2020-05-11 | Posted |
| NCT04436497 Trial register | HEALEY ALS Platform Trial - Regimen A Zilucoplan | completed | - | 2020-06-18 | Posted |
| NCT03030183 Trial register | Phase 2 Safety and Efficacy Study of Zilucoplan (RA101495) to Treat PNH Patients Who Have an Inadequate Response to Eculizumab | completed | - | 2017-01-24 | Posted |
| NCT03078582 Trial register | Phase 2 Safety and Efficacy Study of Zilucoplan (RA101495) to Treat PNH Patients | completed | - | 2017-03-13 | Posted |
| NCT03315130 Trial register | Safety and Efficacy Study of RA101495 in Subjects With Generalized Myasthenia Gravis | completed | - | 2017-10-19 | Posted |
| NCT04025632 Trial register | Safety and Efficacy Study of Zilucoplan in Subjects With Immune-Mediated Necrotizing Myopathy | terminated before completion | - | 2019-07-19 | Posted |
| NCT04590586 Trial register | Study of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalized Patients | completed | - | 2020-10-19 | Posted |
Source: ClinicalTrials.gov and EU CTIS, read 2026-10-03. Not medical advice.
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