GLP-1 receptor agonist

Exenatide updates

Answer

9 changes for Exenatide in the last 12 months. Latest: 2026-08-20.

DateTypeWhat changedSource
2026-08-20Federal RegisterFederal Register notice: Advisory Committee; Endocrinologic and Metabolic Drugs Advisory Committee; RenewalRegulator Federal Register
2026-07-14TrialNew trial registered: Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor AgonistsTrial register ClinicalTrials.gov
2026-05-27LabelFDA label revised: Exenatide (ANDA206697)Regulator FDA drug label register
2026-03-27TrialNew trial registered: Targeting Agonists of Glucagon-like Peptide-1 Receptor for Multiple SclerosisTrial register ClinicalTrials.gov
2026-03-09Federal RegisterFederal Register notice: Aspen Global Inc. c/o Lachman Consultant Services, Inc., et al.; Withdrawal of Approval of 46 New Drug ApplicationsRegulator Federal Register
2026-01-16TrialNew trial registered: A Single-Center, Open-Label, Single Ascending Dose Study of Exenatide Circular RNA-Lipid Nanoparticle Injection (CR059) in Chinese Subjects With TypTrial register ClinicalTrials.gov
2026-01-06TrialNew trial registered: Clinical Study of 18F-Exendin-4 in InsulinomaTrial register ClinicalTrials.gov
2025-12-30TrialNew trial registered: Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKDTrial register ClinicalTrials.gov
2025-11-21ResultsResults posted: Comparison of Type 2 Diabetes Pharmacotherapy RegimensTrial register ClinicalTrials.gov
2025-10-02Federal RegisterFederal Register notice: Pediatric Advisory Committee (PAC); Notice of Meeting; Establishment of a Public Docket; Request for CommentsRegulator Federal Register
2025-09-16TrialNew trial registered: Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) OutTrial register ClinicalTrials.gov
2025-09-02LabelFDA label revised: Byetta (NDA021773)Regulator FDA drug label register
2025-08-04Federal RegisterFederal Register notice: Teva Branded Pharmaceutical Products R&D, Inc., et al.; Withdrawal of Approval of 39 New Drug ApplicationsRegulator Federal Register
2025-07-01ResultsResults posted: Pharmacogenomics of GLP1 Receptor AgonistsTrial register ClinicalTrials.gov
2025-06-27ResultsResults posted: Exenatide Once-weekly as a Treatment for Multiple System AtrophyTrial register ClinicalTrials.gov
2025-03-10TrialNew trial registered: Food (Poly)Phenol Metabotypes and Beta-cell Mass and Function.Trial register ClinicalTrials.gov
2024-12-10TrialNew trial registered: Glucagon-like Peptide-1 Receptor PET/CT in GLP-1R Related DiseaseTrial register ClinicalTrials.gov
2024-09-05ResultsResults posted: Durability of Combination Therapy With Exenatide/Pioglitazone/Metformin vs. Conventional Therapy in New Onset T2DMTrial register ClinicalTrials.gov
2024-08-23Federal RegisterFederal Register notice: Final Decision on the Proposal To Refuse To Approve a New Drug Application for ITCA 650Regulator Federal Register
2024-06-07TrialNew trial registered: Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in BangladeshTrial register ClinicalTrials.gov
2024-06-04ResultsResults posted: Liver and Fat Regulation in Overweight Adolescent GirlsTrial register ClinicalTrials.gov
2024-04-24ResultsResults posted: A Trial to Determine the Efficacy and Safety of Presendin in IIHTrial register ClinicalTrials.gov
2024-04-16ResultsResults posted: GLP-1 Receptor Agonist Therapy and Albuminuria in Patients With Type 2 DiabetesTrial register ClinicalTrials.gov
2024-02-29ResultsResults posted: An Investigation Into the Effect of Dapagliflozin on Ketogenesis in Type 1 DiabetesTrial register ClinicalTrials.gov
2024-02-14TrialNew trial registered: A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With MetforminTrial register ClinicalTrials.gov
2024-02-13TrialNew trial registered: Association of Gene Polymorphism With Susceptibility to T2DM and the Therapeutic Responses to Exenatide in Chinese Patients With T2DMTrial register ClinicalTrials.gov
2024-02-12TrialNew trial registered: Exenatide For Reducing the Reinforcing Effects of CocaineTrial register ClinicalTrials.gov
2024-02-03TrialNew trial registered: A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Placebo in T2DM PatientsTrial register ClinicalTrials.gov
2024-01-22TrialNew trial registered: Influence of JY09 on Pharmacokinetics of Metformin , Rosuvastatin , and Digoxin and the QT Interval Study in Overweight Chinese SubjectsTrial register ClinicalTrials.gov
2023-12-29ResultsResults posted: FLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR)Trial register ClinicalTrials.gov
2023-12-04ResultsResults posted: The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOSTrial register ClinicalTrials.gov
2023-08-24Federal RegisterFederal Register notice: Endocrinologic and Metabolic Drugs Advisory Committee; Notice of Alternative Form of HearingRegulator Federal Register
2023-08-24Federal RegisterFederal Register notice: Endocrinologic and Metabolic Drugs Advisory Committee; Notice of Meeting; Establishment of a Public Docket; Request for CommentsRegulator Federal Register
2023-07-24ResultsResults posted: Can Exenatide Prevent Increase in EGP in Response to Dapagliflozin-induced Increase in GlucosuriaTrial register ClinicalTrials.gov
2023-07-20ResultsResults posted: Effect of Chronic Exenatide Therapy on Beta Cell Function and Insulin Sensitivity in T2DMTrial register ClinicalTrials.gov
2023-05-17ResultsResults posted: Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal SyndromeTrial register ClinicalTrials.gov
2023-03-10TrialNew trial registered: Pharmacogenomics of GLP1 Receptor AgonistsTrial register ClinicalTrials.gov
2023-01-04TrialNew trial registered: Assessment of Safety, Tolerability and Drug Levels of Exenatide ImplantTrial register ClinicalTrials.gov
2022-12-23TrialNew trial registered: A Pan-European Post-Authorisation Safety Study: Risk of Pancreatic Cancer Among Type 2 Diabetes Patients Who Initiated Exenatide as Compared With ThTrial register ClinicalTrials.gov
2022-12-01TrialNew trial registered: Assessment of Pancreatic Beta Cell Mass and Function by Positron Emission Tomography Imaging in Human Diabetes MellitusTrial register ClinicalTrials.gov
2022-11-09TrialNew trial registered: Exenatide for Smoking Cessation and Prevention of Weight GainTrial register ClinicalTrials.gov
2022-11-08TrialNew trial registered: BetaFIT Study: Beta Cell Imaging After Faecal mIcrobiota TransplantationTrial register ClinicalTrials.gov
2022-10-28ResultsResults posted: Assess the Efficacy and Safety of Exenatide SR for the Prevention of Diabetes After Kidney TransplantationTrial register ClinicalTrials.gov
2022-10-06ResultsResults posted: Exeantide in Type 2 Diabetes on InsulinTrial register ClinicalTrials.gov
2022-08-01TrialNew trial registered: Exenatide Pharmacokinetics and Pharmacodynamics in Gestational DiabetesTrial register ClinicalTrials.gov
2022-06-27ResultsResults posted: Exenatide for Treating Cocaine Use DisorderTrial register ClinicalTrials.gov
2022-06-02TrialNew trial registered: Exendin PET/CT for Imaging of ParagangliomasTrial register ClinicalTrials.gov
2022-05-20Federal RegisterFederal Register notice: Product-Specific Guidances; Draft and Revised Draft Guidances for Industry; AvailabilityRegulator Federal Register
2022-05-05ResultsResults posted: Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic ObesityTrial register ClinicalTrials.gov
2022-04-20TrialNew trial registered: A Trial to Determine the Efficacy and Safety of Presendin in IIHTrial register ClinicalTrials.gov
2022-04-14TrialNew trial registered: Study to Evaluate the Pharmacokinetic Characteristics of Pegylated Exenatide Injection (PB-119) in Subjects With Different Degrees of Renal InsufficTrial register ClinicalTrials.gov
2022-04-08TrialNew trial registered: GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD)Trial register ClinicalTrials.gov
2022-02-09ResultsResults posted: The Effects of Exenatide, a GLP-1 Agonist, on Alcohol Self-Administration in Heavy DrinkersTrial register ClinicalTrials.gov
2022-01-21ResultsResults posted: Intravenous Exenatide (Byetta) During SurgeryTrial register ClinicalTrials.gov
2022-01-03ResultsResults posted: Enhancing Weight Loss Maintenance With GLP-1RA (BYDUREON™) in Adolescents With Severe ObesityTrial register ClinicalTrials.gov
2021-12-22TrialNew trial registered: Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes StudyTrial register ClinicalTrials.gov
2021-11-29TrialNew trial registered: SEMAGLUTIDE VERSUS GLP-1 RECEPTOR AGONISTS. EFFECTIVENESS , SAFETY AND QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUS 2. OBSERVATIONAL, PROSPECTTrial register ClinicalTrials.gov
2021-11-23TrialNew trial registered: BESTMED: Observational Evaluation of Second Line Therapy Medications in DiabetesTrial register ClinicalTrials.gov
2021-10-11TrialNew trial registered: Comparison of Type 2 Diabetes Pharmacotherapy RegimensTrial register ClinicalTrials.gov
2021-09-02Federal RegisterFederal Register notice: Proposal To Refuse To Approve a New Drug Application for ITCA 650 (Exenatide in DUROS Device); Opportunity for a HearingRegulator Federal Register
2021-09-02TrialNew trial registered: [68Ga]Ga-HBED-CC-exendin-4 and [68Ga]Ga-NOTA-exendin-4 PET/CT Imaging in the Same Group of Insulinoma PatientsTrial register ClinicalTrials.gov
2021-08-04ResultsResults posted: New Onset Type 1 Diabetes: Role of ExenatideTrial register ClinicalTrials.gov
2021-07-27TrialNew trial registered: The Clinical Application of 68Ga-NOTA-exendin-4 PET/CT in Detecting InsulinomaTrial register ClinicalTrials.gov
2021-07-21TrialNew trial registered: Effects of GLP-1 Analogue Combined With Metformin and Metformin on Gonadal and Metabolic Profiles in Chinese Overweight/Obese PCOS Patients With HypTrial register ClinicalTrials.gov
2021-06-28TrialNew trial registered: Exenatide for Treating Cocaine Use DisorderTrial register ClinicalTrials.gov
2021-06-15ResultsResults posted: Exenatide Weekly Injections as an Adjunctive Treatment in Patients With SchizophreniaTrial register ClinicalTrials.gov
2021-06-01TrialNew trial registered: Exenatide-test for Diagnosing Endogenous Hyperinsulinemic HypoglycemiaTrial register ClinicalTrials.gov
2021-05-28ResultsResults posted: Bexagliflozin Drug/Drug Interaction Study With Exenatide InjectionTrial register ClinicalTrials.gov
2021-05-24TrialNew trial registered: Identification and Clinical Relevance of an Oxytocin Deficient State (GLP1 Study)Trial register ClinicalTrials.gov
2021-04-14ResultsResults posted: A Study to Compare a New Drug for Type 2 Diabetes to Placebo and to a Treatment Already Available for Type 2 DiabetesTrial register ClinicalTrials.gov
2021-04-06ResultsResults posted: Islet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) ProtocolTrial register ClinicalTrials.gov
2021-02-02TrialNew trial registered: Glucagon Like Peptide 1 Receptor (GLP1R) Expression and Beta-cell Mass in Patients With Type 2 DiabetesTrial register ClinicalTrials.gov
2021-01-29ResultsResults posted: EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS)Trial register ClinicalTrials.gov
2021-01-28ResultsResults posted: Exenatide Once Weekly for Smoking CessationTrial register ClinicalTrials.gov
2020-12-03ResultsResults posted: Safety and Efficacy Study of Exenatide Once Weekly in Adolescents With Type 2 DiabetesTrial register ClinicalTrials.gov
2020-12-01ResultsResults posted: Safety and Efficacy of Exenatide as Monotherapy and Adjunctive Therapy to Oral Antidiabetic Agents in Adolescents With Type 2 DiabetesTrial register ClinicalTrials.gov
2020-10-22TrialNew trial registered: A GLP-1 Receptor PET Imaging Substudy Within the VER-A-T1D Trial Investigating the Effects on Beta Cell MassTrial register ClinicalTrials.gov
2020-08-24ResultsResults posted: A Study Comparing the Effect of Albiglutide With Exenatide on Regional Brain Activity Related to Nausea in Healthy SubjectsTrial register ClinicalTrials.gov
2020-08-20TrialNew trial registered: Brain Activation and Satiety in Children 2Trial register ClinicalTrials.gov
2020-08-05TrialNew trial registered: Safety and Efficacy of Pegylated Exenatine Injection (PB-119) in Drug-naïve T2DM SubjectsTrial register ClinicalTrials.gov
2020-08-05TrialNew trial registered: Safety and Efficacy of PB-119 in Subjects With Type 2 Diabetes and Not Well-controlled by Metformin MonotherapyTrial register ClinicalTrials.gov
2020-06-16TrialNew trial registered: Exenatide Once-weekly as a Treatment for Multiple System AtrophyTrial register ClinicalTrials.gov
2020-04-02TrialNew trial registered: Proof of Concept Study in Patients With Short Bowel SyndromeTrial register ClinicalTrials.gov
2020-03-31ResultsResults posted: Effects of Obesity Treatments on Food Preferences and MetabolismTrial register ClinicalTrials.gov
2020-03-13TrialNew trial registered: Effect of Glucagon and Glucagon-like Peptide-1 Co-agonism on Cardiac Function and Metabolism in Overweight Participants with Type 2 DiabetesTrial register ClinicalTrials.gov
2020-03-12TrialNew trial registered: Exenatide Treatment in Parkinson's DiseaseTrial register ClinicalTrials.gov
2020-03-11TrialNew trial registered: The Effect of Exenatide on Fasting Bile AcidsTrial register ClinicalTrials.gov
2020-02-17TrialNew trial registered: SR-Exenatide (PT320) to Eveluate Efficacy and Safety in Patients With Early Parkinson's DiseaseTrial register ClinicalTrials.gov
2020-02-12ResultsResults posted: Weight Loss With Exenatide TreatmentTrial register ClinicalTrials.gov
2020-01-18TrialNew trial registered: Exenatide Once Weekly Over 2 Years as a Potential Disease Modifying Treatment for Parkinson's DiseaseTrial register ClinicalTrials.gov
2019-12-01TrialNew trial registered: Cardiovascular Outcomes SGLT-2 Inhibitors Versus GLP-1 Receptor AgonistsTrial register ClinicalTrials.gov
2019-12-01TrialNew trial registered: Clinical Evaluation of 68Ga-NOTA-MAL-Cys39-exendin-4 Positron Emission Tomography in the Detection of InsulinomaTrial register ClinicalTrials.gov
2019-11-06TrialNew trial registered: A Study With NLY01 in Subjects With Type 2 DiabetesTrial register ClinicalTrials.gov
2019-11-04TrialNew trial registered: A Clinical Study of NLY01 in Patient's With Early Parkinson's DiseaseTrial register ClinicalTrials.gov
2019-10-22ResultsResults posted: A Phase II Trial to Examine the Effect of Subcutaneous Exenatide (Bydureon®) on Glucose Control in Patients With Type I DiabetesTrial register ClinicalTrials.gov
2019-07-23TrialNew trial registered: Metformin vs Metformin Combined With GLP-1RA (Glucagon-like Peptide 1 Receptor Agonist) on Overweight/Obese PCOS PatientsTrial register ClinicalTrials.gov
2019-07-11TrialNew trial registered: Evaluation of the Impact of Intensive Short-Term Drug Therapy in Patients With Type 2 Diabetes MellitusTrial register ClinicalTrials.gov
2019-06-28TrialNew trial registered: Study of Exenatide Once-Weekly Suspension in Chinese Patients With Type 2 Diabetes MellitusTrial register ClinicalTrials.gov
2019-06-20ResultsResults posted: Exenatide Inpatient Trial: A Randomized Controlled Pilot Trial on the Safety and Efficacy of Exenatide (Byetta®) Therapy for the Inpatient Management of PTrial register ClinicalTrials.gov
2019-06-12ResultsResults posted: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, WitTrial register ClinicalTrials.gov

The 100 newest of 517 are listed.

From ClinicalTrials.gov, EU CTIS, FDA labels, recalls, shortages and warning letters, the Federal Register, and regulators' published actions. Not medical advice.

WEEKLY

Register Watch, weekly

New trials, approvals and enforcement actions. One email a week.