long-acting insulin analogue

Insulin degludec clinical trials

Answer

Insulin degludec has 255 registered trials: 17 running, 206 completed, 7 stopped early. 98 posted results.

Trial registerClinicalTrials.gov and EU CTIS, read 2026-10-03

TrialTitleStatusPhaseRegisteredResults
NCT07630233
Trial register
A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Subcutaneous UBT38006 Injection in Healthy Adult Malescurrently recruiting participants-2026-06-05-
NCT05220917
Trial register
Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Studyrunning, but no longer enrolling-2021-12-22-
NCT04760626
Trial register
A Research Study to Compare a New Weekly Insulin, Insulin Icodec Used With DoseGuide App, and Daily Insulins in People With Type 2 Diabetes Who Have Not Used Incompleted-2021-02-18Posted
NCT06238778
Trial register
Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin Degludeccompleted-2024-02-02-
NCT07652528
Trial register
CGM-guided Patch Pump vs Basal-Bolus Injection for Steroid-Induced Hyperglycemia in Sudden Sensorineural Hearing Loss: SHIP Trialnot yet recruiting participants-2026-06-11-
NCT07215312
Trial register
A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal Insulinrunning, but no longer enrolling-2025-10-09-
NCT07527078
Trial register
Evaluate the Efficacy and Safety of GZR33 Injection in Patients With Type 2 Diabetescurrently recruiting participants-2026-04-14-
NCT04795531
Trial register
A Research Study to Compare Two Types of Insulin, a New Insulin, Insulin Icodec and an Available Insulin, Insulin Degludec, in People With Type 2 Diabetes Who Hcompleted-2021-03-12Posted
NCT06288412
Trial register
A Study to Test How a New Long-acting Insulin Works in the Body of Patients With Type 2 Diabetes During Exercise and Prolonged Fastingcompleted-2024-03-01-
NCT07599891
Trial register
Comparing the Safety and Efficacy of Insulin GLARGINE and DEGLUDEC in Glucocorticoid Induced HYPERGLYCEMIA in Hospitalized Patients".completed-2026-02-23-
NCT05802862
Trial register
A Study of Insulin Degludec/Insulin Aspart Biosimilar (22011) Compared With Insulin Degludec/Insulin Aspart(Ryzodeg) in Participants With Type 2 Diabetes in Chicompleted-2023-04-07-
NCT07376200
Trial register
Single-ascending Dose Study of HEC-151 Injectioncurrently recruiting participants-2026-01-14-
NCT07032688
Trial register
A Clinical Study to Evaluate the Pharmacokinetic and Pharmacodynamics Properties of of SHR-3167 in Subjects With Type 2 Diabetescurrently recruiting participants-2025-06-24-
NCT07387003
Trial register
Evaluate the Efficacy and Safety of GZR101-80 Injection in Patients With Type 2 Diabetesnot yet recruiting participants-2026-02-04-
NCT06685185
Trial register
A Research Study of a New Medicine NNC0363-1063 in Healthy Participants and Participants With Type 1 Diabetescompleted-2024-11-12-
NCT06945406
Trial register
A Study of LY4057996 in Healthy Participants and Participants With Type 1 and Type 2 Diabetescurrently recruiting participants-2025-04-18-
NCT06111508
Trial register
The Effect and Safety of a Novel CGM-Based Titration Algorithm for Basal Insulin in T2DM Participants.completed-2023-10-26Posted
NCT07173712
Trial register
Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetesnot yet recruiting participants-2025-09-15-
2025-521150-42-00
Trial register
A 40-week study comparing the efficacy, safety and patient-reported outcomes of once weekly IcoSema and once or twice daily insulin degludec/insulin aspart 100 Not stated3--
2022-502679-43-00
Trial register
Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4 mg/2.4 mg and 1.0 mg/1.0 mg once weekly versus placebo in partNot stated3--
NCT06280703
Trial register
A Study of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus (T1DM)currently recruiting participants-2024-02-28-
NCT06153537
Trial register
A Research Study in Saudi Arabia to Understand How the Dose Check App Used With Tresiba Treatment Helps to Control Blood Sugar Levelcompleted-2023-12-01-
NCT04952779
Trial register
Regulatory Post Marketing Surveillance (rPMS) Study of Xultophy® (Insulin Degludec/Liraglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diacompleted-2021-07-07-
NCT05069545
Trial register
A Research Study Looking at How the Use of NovoPen® 6 for Treatment With Tresiba® & Fiasp® Affects the Blood Sugar Level in Patients With Type 1 Diabetes as Parcompleted-2021-10-06-
NCT04770532
Trial register
A Research Study to Compare Two Types of Insulin, a New Weekly Insulin, Insulin Icodec and an Available Daily Insulin, Insulin Degludec, in People With Type 2 Dcompleted-2021-02-25Posted
2025-521748-39-00
Trial register
SGLT-2i, Heart, Improvement of Cardiovascular Autonomic NeuropathyNot stated4--
2025-522662-67-00
Trial register
A Trial to Evaluate Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Insulin GZR4 Compared with Insulin Degludec and Insulin Icodec in ParticipanNot stated1--
NCT04588259
Trial register
Research Study to Compare a New Medicine "Fast-acting Insulin Aspart" to Another Medicine "Insulin Aspart" in Chinese People With Diabetescompleted-2020-10-19Posted
NCT04848480
Trial register
A Research Study to Compare a New Weekly Insulin, Insulin Icodec, and an Available Daily Insulin, Insulin Degludec, Both in Combination With Mealtime Insulin incompleted-2021-04-19Posted
NCT05417841
Trial register
Safety and Efficacy of Insulin Degludec/Insulin Aspart in Patients With T2DMcompleted-2022-06-14-
NCT06767748
Trial register
A Phase III Clinical Study to Assess the Efficacy and Safety of GZR4 in Subjects With Type 2 Diabetes Mellitus Treated With Basal Insulinrunning, but no longer enrolling-2025-01-10-
NCT07242664
Trial register
Clamp Study to Estimate the Relative Potency of GZR33 Versus Insulin Degludec at Steady Statecurrently recruiting participants-2025-11-21-
NCT07018453
Trial register
A Study Comparing SHR-3167 and Insulin Degludec in Type 2 Diabetic Subjects Treated With Basal Insulin With or Without Oral Antidiabetic Drugsrunning, but no longer enrolling-2025-06-12-
2025-523052-32-00
Trial register
A Trial to Evaluate the Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of Insulin GZR33 Compared with Insulin Degludec at steady state in participNot stated1--
NCT05413369
Trial register
iGlarLixi vs IDegAsp in Chinese Participants After OAD(s)completed-2022-06-10Posted
NCT05552859
Trial register
Gla-300 and IDeg-100 in Insulin-Naïve People With Type 2 Diabetes Mellitus and Renal Impairmentterminated before completion-2022-09-23Posted
NCT07146347
Trial register
Comparison Study of Insulin GZR4 With Insulin Degludeccurrently recruiting participants-2025-08-28-
NCT05463744
Trial register
A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection Therapycompleted-2022-07-19Posted
NCT05275400
Trial register
A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 2 Diabetes Currently Treated With Basal Insulincompleted-2022-03-11Posted
NCT05362058
Trial register
A Study of Insulin Efsitora Alfa (LY3209590) Compared to Degludec in Adults With Type 2 Diabetes Who Are Starting Basal Insulin for the First Timecompleted-2022-05-05Posted
NCT04974528
Trial register
Afrezza® INHALE-1 Study in Pediatricscompleted-2021-06-22-
NCT06925334
Trial register
A Study Comparing Degu Insulin Liraglutide Injection With Premixed Insulin on the Prognosis of Diabetes Mellitusenrolling by invitation only-2025-04-13-
NCT05243628
Trial register
Afrezza With Basal Combination (ABC): Afrezza® Combined With AID Pump or Insulin Degludec in Adults With Type 1 Diabetescompleted-2022-02-17Posted
NCT04538352
Trial register
Transition From Basal/Bolus to Once-weekly Subcutaneous Semaglutide and Basal Insulin in Patients With T2Dcompleted-2020-09-04Posted
NCT06202079
Trial register
A Trial Comparing the Efficacy and Safety of GZR4 Injection Versus Insulin Degludec in Subjects with Type 2 Diabetes Mellituscompleted-2024-01-11-
NCT06199505
Trial register
A Trial Comparing Efficacy and Safety of GZR101 and IDegAsp in Insulin Naïve or Insulin Treated Subjects with T2DMcompleted-2023-12-28-
NCT05036876
Trial register
Degludec Glargine U300 Hospital Studycompleted-2021-08-27-
NCT05218915
Trial register
Basal Plus GLP1-ra on Glycemic Variability in CKDcompleted-2022-02-01-
NCT04042441
Trial register
A Research Study, Looking at How Ryzodeg® (Insulin Degludec/Insulin Aspart) Works in People With Type 2 Diabetes in Local Clinical Practicecompleted-2019-08-02-
NCT06559722
Trial register
A Trial Investigating the Efficacy and Safety of Insulin Degludec/Liraglutide Injection in Subjects With Type 2 Diabeteslast verified some time ago; the register no longer confirms its status-2024-08-19-
NCT06556641
Trial register
A Clinical Study of GZR33 and GZR101 in Healthy Subjectscompleted-2024-08-16-
NCT06553248
Trial register
A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GZR4 in Subjects With Type 2 Diabetescompleted-2024-08-14-
NCT05904743
Trial register
INHALE-3: Afrezza® Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 Diabetescompleted-2023-06-15-
NCT06178874
Trial register
Insulin Degludec vs Insulin Glargine for Glycemic Control in Critical Illness Hyperglycemiacompleted-2023-12-21-
NCT06132126
Trial register
A Study to Investigate the Safety and Tolerability of LY3938577 in Healthy Participants and Participants With Type 2 Diabetes Mellituscompleted-2023-11-15-
NCT05221580
Trial register
China Research of IDEgAsp Treatment in Real-world Clinical practicE (CREATE)completed-2022-01-12-
NCT06056167
Trial register
Degludec Insulin Use in Critically Ill Patientscompleted-2023-09-13-
NCT06449703
Trial register
A Trial to Investigate the Single Dose Pharmacokinetics of Insulin Degludec/Liraglutide in Healthy Chinese Subjectslast verified some time ago; the register no longer confirms its status-2024-06-10-
NCT06408532
Trial register
The Efficacy and Safety of Insulin Degludec/Liraglutide Combination (IDegLira) in Patients With Type 2 Diabeteslast verified some time ago; the register no longer confirms its status-2024-05-10-
NCT04666987
Trial register
A Research Study Looking at Long-term Blood Sugar Control in People With Type 2 Diabetes Being Treated With Xultophy® in a Real-world Setting in Italycompleted-2020-12-14-
NCT04227431
Trial register
A Research Study, Looking at How Tresiba® Works in People With Type 2 Diabetes in Local Clinical Practice in Chinacompleted-2020-01-13-
NCT04623086
Trial register
Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dosecompleted-2020-11-10Posted
NCT05360537
Trial register
Effects of Degludec/Liraglutide on Time in Range, Inflammation and Endothelial Function vs Insulin Basal Bolus in Diabetic Inpatientscompleted-2022-05-04-
NCT03862716
Trial register
Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IDegLiracompleted-2019-03-05-
NCT06057077
Trial register
Semaglutide GLP1 Agonists With Degludec Basal-bolus Insulin in Early Type 1 Diabetes to Basal-boluslast verified some time ago; the register no longer confirms its status-2023-09-28-
NCT03737240
Trial register
IDegLira HIGH Trialcompleted-2018-11-09Posted
NCT04569994
Trial register
A Study to Look at the Safety of NNC0363-0845 in Healthy People and People With Type 1 Diabetescompleted-2020-09-30-
NCT05161429
Trial register
BESTMED: Observational Evaluation of Second Line Therapy Medications in Diabeteslast verified some time ago; the register no longer confirms its status-2021-11-23-
NCT03387787
Trial register
Evaluation of Glycaemic Control Using GlucoTab® With Insulin Degludec in Hospitalized Patients With Diabetes Mellitus Type 2completed-2018-01-02-
NCT04671043
Trial register
Caffeine Ingestion to Counter the Exercise-mediated Fall in Glycaemia in Type 1 Diabetescompleted-2020-12-10-
NCT05767255
Trial register
Risk of Hypoglycemia in the Transition From Inpatient to Outpatient Setting. Comparative Study of Basal-bolus Insulin Versus Basal Insulin Plus GLP-1 Analoguelast verified some time ago; the register no longer confirms its status-2023-03-14-
NCT03952130
Trial register
A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 1 Diabetescompleted-2019-05-16Posted
NCT03377699
Trial register
Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetescompleted-2017-12-19Posted
NCT04663282
Trial register
A Trial of INS068 in Patients With Type 2 Diabetes Not Adequately Controlled With One or Two Oral Antidiabeticscompleted-2020-12-10-
NCT05434559
Trial register
Evaluation of Glycemic Control in Adults With Type 1 Diabetes When Switching to Insulin Degludeccompleted-2022-06-28-
NCT03172494
Trial register
A Trial Comparing Insulin Degludec/Liraglutide, Insulin Degludec, and Liraglutide in Chinese Subjects With Type 2 Diabetes Inadequately Controlled on Oral Antidcompleted-2017-06-01Posted
NCT05641337
Trial register
Research on Optimal Strategy of Hypoglycemic Therapy for Cirrhosis With Diabeteslast verified some time ago; the register no longer confirms its status-2022-12-07-
NCT04075513
Trial register
Comparison of Glucose Values and Variability Between TOUJEO and TRESIBA During Continuous Glucose Monitoring in Type 1 Diabetes Patientscompleted-2019-08-30Posted
NCT04892069
Trial register
Investigating the Effect of Ryzodeg® in Adult Patients With Type 2 Diabetes in Lebanoncompleted-2021-05-19-
NCT04450394
Trial register
A Phase 2 Study of LY3209590 in Participants With Type 2 Diabetes Mellituscompleted-2020-06-29Posted
NCT03668808
Trial register
Comparison of Insulin Degludec With Insulin Glargine U100 for Adults With Type 1 Diabetes Crossing Multiple Time Zones.completed-2018-09-13Posted
NCT05479591
Trial register
A Research Study Looking at Blood Sugar Control in People With Type 2 Diabetes Previously Treated With Premix Insulin and Initiating Treatment With Insulin Deglwithdrawn before enrolling anyone-2022-07-29-
NCT04450407
Trial register
A Study of LY3209590 in Participants With Type 1 Diabetescompleted-2020-06-29Posted
NCT05576298
Trial register
A Clinical Study Comparing the Pharmacokinetics and Pharmacodynamic Characteristics of Insulin Degludec Injection (RD15003) and Insulin Degludec Injection (Trescompleted-2022-10-12-
NCT05545800
Trial register
Efficacy and Safety Of Different Regimens In Patients With Type 2 Diabetes Receiving Intensive Insulin Therapylast verified some time ago; the register no longer confirms its status-2022-09-15-
NCT05429359
Trial register
cArdiopulmonary exerCise Test Assessing Multiple biOmarkers and Hormones iN Type 1 diabetEs Under Different Circumstanceslast verified some time ago; the register no longer confirms its status-2022-06-17-
NCT03557892
Trial register
Sensor-augmented Pump Versus Multiple Daily Injections With Degludec as Basal Insulin for Insulin Therapy in Type 1 Diabetescompleted-2018-06-05Posted
NCT05103306
Trial register
Empagliflozin-based Quadruple Therapy vs Basal Insulin-based Therapylast verified some time ago; the register no longer confirms its status-2021-11-01-
NCT04585776
Trial register
A Study of LY900014 and Insulin Degludec in Participants With Type 1 Diabetescompleted-2020-10-14Posted
NCT02967211
Trial register
A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulin in Patients Already Using Basal Insulincompleted-2016-11-18-
NCT02967224
Trial register
A "Real World" Trial to Determine Efficacy and Health Outcomes of Toujeo Compared to "Standard of Care" Basal Insulins in Insulin Naïve Patients Initiating Insucompleted-2016-11-18-
NCT03336528
Trial register
Insulin Degludec and Glargine U100 for Management of Hospitalized and Discharged Patients With Type 2 Diabetescompleted-2017-11-08Posted
NCT05261997
Trial register
Endotherapy for Painless Chronic Pancreatitislast verified some time ago; the register no longer confirms its status-2021-11-24-
NCT03952143
Trial register
A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 2 Diabetescompleted-2019-05-16Posted
NCT03740919
Trial register
A Study Comparing LY900014 to Insulin Lispro (Humalog) in Children and Adolescents With Type 1 Diabetescompleted-2018-11-14Posted
NCT03882970
Trial register
A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 Diabetescompleted32019-03-20Posted
NCT03078478
Trial register
A Trial Comparing the Efficacy and Safety of Insulin Degludec and Insulin Glargine 300 Units/mL in Subjects With Type 2 Diabetes Mellitus Inadequately Treated Wcompleted-2017-03-13Posted
NCT03268005
Trial register
Research Study Comparing a New Medicine "Fast-acting Insulin Aspart" to Another Already Available Medicine "NovoRapid"/"NovoLog" in People With Type 2 Diabetescompleted-2017-08-31Posted
NCT03328845
Trial register
Impact on the Oxidative Stress of the Different Analogues of Insulin in People With Type 1 Diabetes. (Ineox Study)completed-2017-10-29-
NCT03416855
Trial register
A Regulatory Post Marketing Surveillance (rPMS) Study of Ryzodeg® FlexTouch® (Insulin Degludec /Insulin Aspart) to Evaluate Safety and Effectiveness in Patientscompleted-2018-01-31-
NCT03400501
Trial register
Reducing the Risk of Metabolic Decompensation in Diabetic Adolescents by Supervised School Administration of Insulincompleted-2018-01-17-
NCT04656106
Trial register
A Study Investigating the Clinical Parameters Associated With the Use of Ryzodeg® (Insulin Degludec/Insulin Aspart) in a Real-world Adult Population With Type 2completed-2020-12-07-
NCT03823339
Trial register
A Research Study, Looking at How Xultophy® Works in People With Type 2 Diabetes in Local Clinical Practice in United Arab Emiratescompleted-2019-01-30-
NCT04955834
Trial register
A Clinical Study of Insulin Degludec Injection in Subjects With Type 2 Diabeteslast verified some time ago; the register no longer confirms its status-2021-07-09-
NCT03987191
Trial register
Insulin Pump to Multiple Daily Injection Transition Clinical Trialcompleted-2019-06-14Posted
NCT02964104
Trial register
A Trial Investigating the Safety, Tolerability, Pharmacokinetics (the Exposure of the Trial Drug in the Body) and Pharmacodynamics (the Effect of the Investigatcompleted-2016-11-15-
NCT04315688
Trial register
A Research Study, Looking at How Tresiba® Works in People With Type 2 Diabetes in Local Clinical Practice in Russiacompleted-2020-03-19-
NCT04190160
Trial register
Quality of Life and Fixed-ratio Combination of Insulin Degludec and Liraglutide (iDegLira)completed-2019-12-09-
NCT04965051
Trial register
Safety and Efficacy of Insulin Degludec/Insulin Aspart in Patients With T1DMlast verified some time ago; the register no longer confirms its status-2021-07-16-
NCT03785522
Trial register
A Research Study, Looking at How Tresiba® Works in People With Type 2 Diabetes in Local Clinical Practice in Saudi Arabiacompleted-2018-12-24-
NCT03001323
Trial register
Insulin Degludec for the Management of Patient With Recurrent Diabetic Ketoacidosisterminated before completion-2016-12-23-
NCT02607306
Trial register
A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Japanese Subjects With Type 2 Diabetes Mellitus.completed-2015-11-18Posted
NCT02911948
Trial register
A Double-blinded Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide and Insulin Degludec Both in Combination With Metformin in Japanese Subcompleted-2016-09-23Posted
NCT04027023
Trial register
Evaluation of the Impact of Intensive Short-Term Drug Therapy in Patients With Type 2 Diabetes Mellituslast verified some time ago; the register no longer confirms its status-2019-07-11-
NCT02148861
Trial register
A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneously Administered NNC0148-0287 (Insulin 287) in Subjects Withcompleted-2014-05-28-
NCT03736785
Trial register
A Study of LY3209590 in Participants With Type 2 Diabetes Mellituscompleted-2018-11-09Posted
NCT04409587
Trial register
Basal Insulin Glycemic ControL With DEglugec vs Aspart Via Pumpcompleted-2018-07-30-
NCT04664764
Trial register
Intermediate and Long Acting Insulin Young Children Type 1 Diabetes.last verified some time ago; the register no longer confirms its status-2020-12-01-
NCT03687827
Trial register
A Research Study to Compare the Effect of Insulin Degludec and Insulin Glargine on Blood Sugar Levels in People With Type 2 Diabetes - the SWITCH PRO Studycompleted-2018-09-27Posted
NCT04692415
Trial register
Insulin Glargine U300 vs Insulin Degludec U100 in Impact on the Glycaemic and Cardiovascular Factorscompleted-2020-12-31-
NCT04276428
Trial register
A Study of LY3209590 in Japanese Participants With Type 2 Diabetes Mellituscompleted-2020-02-19-
NCT04196231
Trial register
Durability of Combination of Insulin and GLP-1 Receptor Agonist or SGLT-2 Inhibitors Versus Basal Bolus Insulin Regimen in Type 2 Diabetes (BEYOND)completed-2019-12-06-
NCT02680457
Trial register
Effect of Insulin Degludec Versus Insulin Glargine on Glycemic Variability in Patients With Type 2 Diabetes Mellituscompleted-2016-02-11Posted
NCT02773368
Trial register
A Clinical Trial Comparing Glycaemic Control and Safety of Insulin Degludec/Liraglutide (IDegLira) Versus Insulin Glargine (IGlar) as add-on Therapy to SGLT2i icompleted-2016-05-16Posted
NCT01984372
Trial register
Post-marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Tresiba®completed-2013-11-14-
NCT04034524
Trial register
Cardiovascular Outcomes and HbA1c Among Patients With Type 2 Diabetes Newly Initiating GLP1RAs vs Basal Insulinlast verified some time ago; the register no longer confirms its status-2019-07-24-
NCT03349840
Trial register
Randomised Open Label Study of Insulin Degludec Versus Insulin Glargine U100 in Ramadanterminated before completion-2017-11-22-
NCT03214367
Trial register
A Study of LY900014 in Participants With Type 1 Diabetescompleted-2017-07-11Posted
NCT02779413
Trial register
A Study to Evaluate Safety and Effectiveness in Patients of All Age Groups Excluding Less Than 12 Months Old Infants With Diabetes Mellitus in Routine Clinical completed-2016-05-20-
NCT03938740
Trial register
Comparison of Different Insulin Dosing Algorithms Using Hepatic Directed Vesicle-Insulin Lispro and Insulin Degludeccompleted-2019-05-06-
NCT03214380
Trial register
A Study of LY900014 Compared to Insulin Lispro in Participants With Type 2 Diabetescompleted-2017-07-11Posted
NCT03175120
Trial register
A Trial Comparing Insulin Degludec/Liraglutide and Insulin Degludec in Combination With Metformin in Chinese Subjects With Type 2 Diabetes Mellitus Inadequatelycompleted-2017-06-05Posted
NCT03091712
Trial register
Insulin Degludec Titration Using Mobile Insulin Dosing Systemcompleted-2017-03-27-
NCT02844790
Trial register
A Trial Investigating the Pharmacokinetic Properties of Insulin Degludec/Insulin Aspart in Healthy Chinese Subjectscompleted-2016-07-26-
NCT03745157
Trial register
RESILIENT: A Research Study, Looking at How Ryzodeg® Works in People With Type 2 Diabetes in Local Clinical Practice in Japancompleted-2018-11-19-
NCT03674866
Trial register
A Canadian Study of the Effectiveness of Tresiba® (Insulin Degludec) After Switching Basal Insulin in a Population With Type 1 or Type 2 Diabetes Mellituscompleted-2018-09-18-
NCT02501161
Trial register
A 104 Week Clinical Trial Comparing Long Term Glycaemic Control of Insulin Degludec/Liraglutide (IDegLira) Versus Insulin Glargine Therapy in Subjects With Typecompleted-2015-07-17Posted
NCT03292185
Trial register
A Trial to Investigate the Single Dose Pharmacokinetics of Insulin Degludec/Liraglutide Compared With Insulin Degludec and Liraglutide in Healthy Chinese Subjeccompleted-2017-09-25-
NCT02906917
Trial register
A 38 Week Trial Comparing Effect and Safety of Insulin Degludec/Insulin Aspart vs. Insulin Glargine Plus Insulin Aspart in Subjects With Type 2 Diabetes Treatedcompleted-2016-09-20Posted
NCT03726125
Trial register
A Study of LY3374849 in Healthy Participantscompleted-2018-10-31-
NCT02821052
Trial register
Post-marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Ryzodeg®completed-2016-07-01-
NCT02392117
Trial register
Investigating the Safety and Effectiveness of Insulin Degludec in a Real World Population With Type 1 and 2 Diabetes Mellituscompleted-2015-03-18-
NCT03497260
Trial register
Fructose in Exercising Individuals With Type 1 Diabetes Using Insulin Degludeccompleted-2018-04-13-
NCT01959529
Trial register
A Trial Comparing Cardiovascular Safety of Insulin Degludec Versus Insulin Glargine in Subjects With Type 2 Diabetes at High Risk of Cardiovascular Eventscompleted-2013-10-10Posted
NCT02192450
Trial register
Insulin Degludec and Symptomatic Nocturnal Hypoglycaemiacompleted-2014-07-16-
NCT01513473
Trial register
A Trial Investigating the Efficacy and Safety of Insulin Degludec in Children and Adolescents With Type 1 Diabetes Mellituscompleted-2012-01-20Posted
NCT02500706
Trial register
Efficacy and Safety of Faster-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec in Adults With Type 1 Diabetescompleted-2015-07-16Posted
NCT01835431
Trial register
A Trial Investigating the Efficacy and Safety of Insulin Degludec/Insulin Aspart Once Daily Plus Insulin Aspart for the Remaining Meals Versus Insulin Detemir Ocompleted-2013-04-19Posted
NCT02670915
Trial register
Efficacy and Safety of Faster-acting Insulin Aspart Compared to NovoRapid® Both in Combination With Insulin Degludec in Children and Adolescents With Type 1 Diacompleted-2016-02-02Posted
NCT01437592
Trial register
Investigating the Pharmacokinetic Properties of NN1250 in Healthy Chinese Subjectscompleted-2011-09-21-
NCT03959865
Trial register
GLP-1 REceptor Agonists and Real World EvIdeNcelast verified some time ago; the register no longer confirms its status-2019-05-20-
NCT02030600
Trial register
A Trial Comparing the Safety and Efficacy of Insulin Degludec and Insulin Glargine, With or Without OADs in Subjects With Type 2 Diabetescompleted-2014-01-08Posted
NCT02662114
Trial register
Investigating the Effectiveness of Tresiba® (Insulin Degludec) After Switching Basal Insulin in a Population With Type 1 or Type 2 Diabetes Mellituscompleted-2016-01-25-
NCT02536859
Trial register
Comparing Pharmacodynamic and Pharmacokinetic Properties of Insulin Degludec and Insulin Glargine 300 U/mL at Steady-state Conditions in Subjects With Type 1 Dicompleted-2015-09-01-
NCT03908762
Trial register
mHealth Titration and Managementlast verified some time ago; the register no longer confirms its status-2019-04-08-
NCT02762578
Trial register
Comparing Efficacy and Safety of Insulin Degludec/Insulin Aspart and BIAsp 30 in Subjects With Type 2 Diabetescompleted-2016-05-05Posted
NCT01513590
Trial register
A Trial Comparing Efficacy and Safety of Insulin Degludec/Insulin Aspart and BIAsp 30 in Insulin naïve Subjects With Type 2 Diabetescompleted-2012-01-20Posted
NCT03838783
Trial register
Flexible Insulin Therapy Untethered Insulin Regimen in Avidly Exercising Patients With Type 1 Diabetes: FIT Untetheredlast verified some time ago; the register no longer confirms its status-2019-02-12-
NCT01392573
Trial register
A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide and Insulin Degludec in Subjects With Type 2 Diabetescompleted-2011-07-12Posted
NCT01676116
Trial register
The Efficacy of Insulin Degludec/Liraglutide in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on GLP-1 Receptor Agonist and OAD Tcompleted-2012-08-30Posted
NCT01952145
Trial register
A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide Versus Insulin Glargine in Subjects With Type 2 Diabetes Mellituscompleted-2013-09-27Posted
NCT02034513
Trial register
A Trial Comparing the Safety and Efficacy of Insulin Degludec and Insulin Glargine, Both With Insulin Aspart as Mealtime Insulin in Subjects With Type 1 Diabetecompleted-2014-01-13Posted
NCT01059812
Trial register
A Pan Asian Trial Comparing Efficacy and Safety of NN5401 and Biphasic Insulin Aspart 30 in Type 2 Diabetescompleted-2010-02-01Posted
NCT01009580
Trial register
Comparison of NN5401 With Biphasic Insulin Aspart 30 in Type 2 Diabetescompleted-2009-11-06Posted
NCT02738151
Trial register
Efficacy and Safety of Toujeo® Versus Tresiba® in Insulin-Naive Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Oral Antihyperglycemic Drug(completed-2016-04-14Posted
NCT02648217
Trial register
Comparing Efficacy and Safety of Insulin Degludec/Insulin Aspart Twice Daily and Biphasic Insulin Aspart Twice Daily in Subjects With Type 2 Diabetes Mellitus Bcompleted-2016-01-06Posted
NCT02033889
Trial register
A Study To Evaluate The Efficacy And Safety Of Ertugliflozin In Participants With Type 2 Diabetes Mellitus And Inadequate Glycemic Control On Metformin Monothercompleted-2014-01-09Posted
NCT01680341
Trial register
Comparison of the Efficacy and Safety of Two Different Dose Adjustment Regimens for Insulin Degludec/Insulin Aspart in Subjects With Type 2 Diabetes Mellitus Prcompleted-2012-09-07Posted
NCT01713530
Trial register
A 26-week Trial Comparing Efficacy and Safety of Insulin Degludec/Insulin Aspart BID and Insulin Degludec OD Plus Insulin Aspart in Subjects With Type 2 Diabetecompleted-2012-10-24Posted
NCT02420262
Trial register
A Clinical Trial Comparing Efficacy and Safety of Insulin Degludec/Liraglutide (IDegLira) Versus Basal-bolus Therapy in Subjects With Type 2 Diabetes Mellituscompleted-2015-04-17Posted
NCT03463564
Trial register
Insulin Pump vs Multiple Daily Injections of Insulin and Glyco-metabolic Control in Type 1 Diabetic Patientscurrently recruiting participants-2018-02-19-
NCT02230618
Trial register
Post Marketing Surveillance (PMS) Study of Ryzodeg™ (Insulin Degludec/Insulin Aspart) in Patients With Diabetes Mellitus in Routine Clinical Practice in Indiacompleted-2014-09-03-
NCT01336023
Trial register
Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec completed-2011-04-15Posted
NCT02754817
Trial register
A Study of the Effectiveness of Xultophy® (Insulin Degludec/Liraglutide) in an Adult Real-world Population With Type 2 Diabetes Mellituscompleted-2016-04-28-
NCT01618162
Trial register
The Efficacy of Insulin Degludec/Liraglutide as add-on Therapy in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on Sulphonylurea completed-2012-06-13Posted
NCT00961324
Trial register
A Trial Investigating the Within-subject Variability of NN1250 in Subjects With Type 1 Diabetescompleted-2009-08-18-
NCT01114542
Trial register
A Trial Evaluating the Effect of NN1250 at Steady State Conditions in Subjects With Type 1 Diabetescompleted-2010-05-03-
NCT01664247
Trial register
The Effect of Insulin Degludec in Combination With Liraglutide and Metformin in Subjects With Type 2 Diabetes Qualifying for Treatment Intensificationcompleted-2012-08-14Posted
NCT03070704
Trial register
Non-interventional, Post Marketing Surveillance Study of Xultophy™ (Insulin Degludec/Liraglutide) to Evaluate Long Term Safety and Efficacy in Patients With Typwithdrawn before enrolling anyone-2017-03-03-
NCT03244241
Trial register
Basal-bolus Insulin Therapy Versus Standard Therapy for the Inpatient Management of Type 2 Diabetes: the IDA2 Studylast verified some time ago; the register no longer confirms its status-2017-08-09-
NCT02117622
Trial register
A Non-interventional, Post Marketing Surveillance (PMS) Study of Tresiba® (Insulin Degludec) to Evaluate Long Term Safety and Efficacy in Patients With Diabetescompleted-2014-04-21-
NCT02298192
Trial register
A Clinical Trial Comparing Efficacy and Safety of Insulin Degludec/Liraglutide (IDegLira) in Subjects With Type 2 Diabetes Mellitus Using Two Different Titratiocompleted-2014-11-21Posted
NCT01849289
Trial register
A Trial Comparing Efficacy and Safety of Insulin Degludec and Insulin Glargine in Insulin naïve Subjects With Type 2 Diabetescompleted-2013-05-08Posted
NCT02767596
Trial register
Evaluation of Lixisenatide Efficacy in Diabetes Mellitus Type 2 With Failure of Other GLP-1 Analogterminated before completion-2016-05-10-
NCT00972283
Trial register
Comparison of NN1250 With Insulin Glargine Plus Insulin Aspart With/Without Metformin and With/Without Pioglitazone in Type 2 Diabetescompleted-2009-09-04Posted
NCT00982228
Trial register
Comparison of NN1250 Plus Insulin Aspart With Insulin Glargine Plus Insulin Aspart in Type 1 Diabetescompleted-2009-09-23Posted
NCT01059799
Trial register
Comparison of NN1250 Versus Insulin Glargine in Subjects With Type 2 Diabetescompleted-2010-02-01Posted
NCT01814137
Trial register
A Randomised Trial Comparing Efficacy and Safety After Intensification With Either Insulin Aspart Once Daily as add-on or Changing to Basal Bolus Treatment Withcompleted-2013-03-19Posted
NCT00613951
Trial register
Comparison of Two NN5401 Formulations Versus Biphasic Insulin Aspart 30, All in Combination With Metformin in Subjects With Type 2 Diabetescompleted-2008-02-13Posted
NCT00614055
Trial register
Comparison of Two NN5401 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetescompleted-2008-02-13Posted
NCT00978627
Trial register
Comparison of NN5401 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetescompleted-2009-09-17Posted
NCT01045447
Trial register
Comparison of NN5401 With Insulin Glargine, Both in Combination With Oral Antidiabetic Drugs, in Subjects With Type 2 Diabetescompleted-2010-01-11Posted
NCT01272193
Trial register
Comparison of NN5401 With Insulin Glargine in Insulin Naive Subjects With Type 2 Diabetescompleted-2011-01-07Posted
NCT01365507
Trial register
Efficacy and Safety of Insulin Degludec/Insulin Aspart in Insulin-naïve Subjects With Type 2 Diabetes Using Two Dosing Regimenscompleted-2011-06-03Posted
NCT01570751
Trial register
A Trial Comparing the Efficacy, Patient-reported Outcomes and Safety of Insulin Degludec 200 U/mL vs Insulin Glargine in Subjects With Type 2 Diabetes Mellitus completed-2012-04-04Posted
NCT01068665
Trial register
Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 Diabetescompleted-2010-02-15Posted
NCT01068678
Trial register
Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 Diabetescompleted-2010-02-15Posted
NCT01074268
Trial register
Comparison of NN1250 Plus Insulin Aspart With Insulin Detemir Plus Insulin Aspart in Type 1 Diabetescompleted-2010-02-24Posted
NCT01076647
Trial register
Comparison of NN1250 With Insulin Glargine in Subjects With Type 2 Diabetescompleted-2010-02-26Posted
NCT01326026
Trial register
Comparing the Efficacy and Safety of NN1250 Once Daily When Titrated Using 2 Different Algorithms in Insulin naïve Subjects With Type 2 Diabetes Mellituscompleted-2011-03-30Posted
NCT01364428
Trial register
Comparison of Two Insulin Degludec Formulations in Subjects With Type 2 Diabetes Mellituscompleted-2011-06-02Posted
NCT01388361
Trial register
Comparison of the Efficacy and Safety of Two Intensification Strategies in Subjects With Type 2 Diabetes Inadequately Controlled on Basal Insulin and Metformincompleted-2011-07-06Posted
NCT00611884
Trial register
Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetescompleted-2008-02-11Posted
NCT00612040
Trial register
Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Insulin Aspart in Subjects With Type 1 Diabetescompleted-2008-02-11Posted
NCT00841087
Trial register
Comparison of NN1250 Versus Insulin Detemir, Both Combined With Insulin Aspart in Subjects With Type 1 Diabetescompleted-2009-02-11Posted
NCT01046110
Trial register
Comparison of NN1250 With Sitagliptin in Subjects With Type 2 Diabetes Never Treated With Insulincompleted-2010-01-11Posted
NCT00993096
Trial register
Investigation of the Response Relationship of NN5401 in Type 1 Diabeticscompleted-2009-10-09-
NCT01051102
Trial register
Effect of NN5401 in Japanese Subjects With Type 1 Diabetescompleted-2010-01-18-
NCT01138488
Trial register
A Trial Investigating the Total Exposure of NN5401 (Insulin Degludec/Insulin Aspart) in Children, Adolescents and Adult Subjects With Type 1 Diabetescompleted-2010-06-07-
NCT01174303
Trial register
A Trial Investigating the Exposure of NN5401 in Young Adults and Elderly Subjects With Type 1 Diabetescompleted-2010-08-03-
NCT01590836
Trial register
A Trial Investigating the Pharmacodynamic Properties of NN5401 in Subjects With Type 1 Diabetescompleted-2012-05-03-
NCT01880736
Trial register
A Trial Investigating the Efficacy and Safety of Flexible vs. Fixed Dosing and Simple vs. Stepwise Titration With Once Daily (OD) Insulin Degludec in Inadequatecompleted-2013-06-19Posted
NCT00842361
Trial register
Comparison of NN5401 Versus Biphasic Insulin Aspart 30 on a Twice Daily Regimen in Subjects With Type 2 Diabetes Mellituscompleted-2009-02-12Posted
NCT00982644
Trial register
Comparison of NN1250 Versus Insulin Glargine in Subjects With Type 2 Diabetescompleted-2009-09-23Posted
NCT01006291
Trial register
Comparison of NN1250 With Insulin Glargine in Type 2 Diabetescompleted-2009-11-02Posted
NCT01079234
Trial register
Comparison of NN1250 With Insulin Glargine in Type 1 Diabetescompleted-2010-03-03Posted
NCT00983021
Trial register
Safety and Tolerability of NN9068 in Healthy Male Volunteerscompleted-2009-09-23-
NCT01043510
Trial register
The Effect of NN1250 in Subjects With Type 2 Diabetes of Different Race and/or Ethnic Origincompleted-2010-01-06-
NCT01076634
Trial register
Comparison of Two NN1250 Formulations in Subjects With Type 1 Diabetescompleted-2010-02-26-
NCT00964418
Trial register
A Trial Investigating the Effect of NN1250 in Young and Elderly Subjects With Type 1 Diabetescompleted-2009-08-25-
NCT00976326
Trial register
A Trial Investigating the Pharmacokinetic (Mode of Action in the Body) and Safety Profiles of NN1250 (Insulin Degludec) in Subjects With Various Degrees of Impacompleted-2009-09-14-
NCT01002768
Trial register
Comparison of Hypoglycaemic Response Between NN1250 and Insulin Glargine in Type 1 Diabeticscompleted-2009-10-27-
NCT01006057
Trial register
A Trial Investigating the NN1250 Concentration-time Curve in Subjects With Various Degrees of Renal Impairment and in Subjects With Normal Renal Functioncompleted-2009-11-02-
NCT01030926
Trial register
A Trial Investigating the Concentration in the Blood of NN1250 in Children, Adolescents and Adults With Type 1 Diabetescompleted-2009-12-14-
NCT01135927
Trial register
A Trial Investigating the Effect of NN1250 in Japanese Subjects With Type 1 Diabetescompleted-2010-06-03-
NCT01151072
Trial register
A Trial Comparing the Effect of NN1250 After Different Routes of Injection in Healthy Subjectscompleted-2010-06-25-
NCT01154881
Trial register
A Trial Evaluating the Blood Glucose-lowering Effect of NN1250 in Subjects With Type 2 Diabetescompleted-2010-07-01-
NCT02100475
Trial register
A Trial Comparing Sequential Addition of Insulin Aspart Versus Further Dose Increase With Insulin Degludec/Liraglutide in Subjects With Type 2 Diabetes Mellituscompleted-2014-04-01Posted
NCT01704417
Trial register
A Trial Comparing the Effect of Exercise on Blood Glucose in Subjects With Type 1 Diabetes, Who Are Treated With Either Insulin Degludec or Insulin Glarginecompleted-2012-10-11-
NCT01045707
Trial register
Comparison of NN5401 Versus Insulin Glargine, Both Combined With Metformin Treatment, in Subjects With Type 2 Diabetescompleted-2010-01-11Posted
NCT02360254
Trial register
Effects of Shifting From Twice Daily Insulin Glargine or Detemir to Once Daily Insulin Degludec in Type 1 Diabetescompleted-2015-02-10-
NCT01569841
Trial register
A Trial Comparing the Efficacy of Insulin Degludec With Insulin Glargine on Glycaemic Control Using Continuous Glucose Monitoring in Patients With Type 1 Diabetcompleted-2012-04-03Posted
NCT01135992
Trial register
Switching From Insulin Glargine to Insulin Degludec in Subjects With Type 2 Diabetes Mellitus (BEGIN™)completed-2010-06-03Posted
NCT01865331
Trial register
Safety, Tolerability and Pharmacokinetic and Pharmacodynamic Characteristics of Explorative Formulations of Insulin Degludec and IDegAsp 50 in Healthy Japanese completed-2013-05-30-
NCT01868581
Trial register
Bioequivalence Between Two Explorative Insulin Degludec Formulations and Between Two Explorative IDegAsp Formulations in Healthy Subjectscompleted-2013-06-04-
NCT01865279
Trial register
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Explorative Formulation of Insulin Degludeccompleted-2013-05-30-
NCT01865305
Trial register
Comparison of Explorative Formulation of Insulin Degludec and Insulin Aspart Co-formulation Versus Explorative Formulation of Insulin Degludec and Insulin Asparcompleted-2013-05-30-
NCT01865318
Trial register
Investigation of Pharmacodynamic Characteristics of Explorative Formulation of Insulin Degludec in Male Subjects With Type 1 Diabetescompleted-2013-05-30-
NCT01868555
Trial register
Safety, Pharmacokinetics and Pharmacodynamics of Two IDegAsp (One Explorative) Preparations and Two Insulin Degludec (One Explorative) Preparations in Japanese completed-2013-06-04-
NCT01868568
Trial register
Comparison of IDegAsp (Inclusive Three Explorative Formulations) With Insulin Degludec and Insulin Aspart Separately Injected in Subjects With Type 1 Diabetescompleted-2013-06-04-
NCT01865292
Trial register
Comparing the Pharmacodynamics and Pharmacokinetics of Explorative Formulation of Insulin Degludec With Insulin Glargine in Subjects With Type 1 and Type 2 Diabcompleted-2013-05-30-
NCT01319240
Trial register
Safety and Tolerability of Insulin Degludec/Liraglutide (A3) in Healthy Subjectscompleted-2011-03-21-
NCT00966368
Trial register
Comparison of Two NN1250 Formulations in Healthy Volunteerscompleted-2009-08-26-
NCT01868529
Trial register
Comparison of Insulin Degludec With Insulin Glargine in Subjects With Type 1 Diabetes Mellituscompleted-2013-06-04-
NCT01125553
Trial register
A Comparison Between Two Formulations of NN5401 in Healthy Subjectscompleted-2010-05-18-
NCT01773798
Trial register
A Trial Investigating the Pharmacodynamic and Pharmacokinetic Properties of Insulin Degludec/Insulin Aspart 15 in Subjects With Type 1 Diabetescompleted-2013-01-23-
NCT01455142
Trial register
A Trial to Test for Bioequivalence Between NN1045 and NN5401 in Subjects With Type 1 Diabetescompleted-2011-10-19-
NCT01623375
Trial register
A Trial Investigating the Absolute Bioavailability of Insulin Degludec in Healthy Subjectscompleted-2012-06-20-
NCT00964964
Trial register
A Trial Assessing Changes in Blood Sugar and the Number of Periods Where Supplementation of Carbohydrate is Needed to Treat Low Blood Sugar, During Two Differencompleted-2009-08-25-
NCT00992537
Trial register
Comparison of the Effect of NN5401 With the Effect of NN1250 and Insulin Aspart in Type 1 Diabeticscompleted-2009-10-09-
NCT01134224
Trial register
A Trial Investigating the Effect of NN5401 in Subjects With Type 2 Diabetescompleted-2010-05-31-
NCT01173926
Trial register
Comparison of the Effect of NN5401 With the Effect of NN1250 and Insulin Aspart in Subjects With Type 1 Diabetescompleted-2010-08-02-
NCT01193387
Trial register
Comparison of Two Identical NN1250 Formulations in Healthy Volunteerscompleted-2010-09-01-
NCT01467414
Trial register
A Trial Investigating the Effect of NN1250 in Japanese Subjects With Type 2 Diabetesterminated before completion-2011-11-08-
NCT01916174
Trial register
A Trial to Demonstrate Bioequivalence Between Two Insulin Degludec/Liraglutide Formulations, B5 and V2 in Healthy Subjectscompleted-2013-08-05-

Source: ClinicalTrials.gov and EU CTIS, read 2026-10-03. Not medical advice.

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