long-acting insulin analogue

Insulin degludec updates

Answer

10 changes for Insulin degludec in the last 12 months. Latest: 2026-06-11.

DateTypeWhat changedSource
2026-06-11TrialNew trial registered: CGM-guided Patch Pump vs Basal-Bolus Injection for Steroid-Induced Hyperglycemia in Sudden Sensorineural Hearing Loss: SHIP TrialTrial register ClinicalTrials.gov
2026-06-05TrialNew trial registered: A Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Subcutaneous UBT38006 Injection in Healthy Adult MalesTrial register ClinicalTrials.gov
2026-04-14TrialNew trial registered: Evaluate the Efficacy and Safety of GZR33 Injection in Patients With Type 2 DiabetesTrial register ClinicalTrials.gov
2026-03-04ResultsResults posted: The Effect and Safety of a Novel CGM-Based Titration Algorithm for Basal Insulin in T2DM Participants.Trial register ClinicalTrials.gov
2026-02-23TrialNew trial registered: Comparing the Safety and Efficacy of Insulin GLARGINE and DEGLUDEC in Glucocorticoid Induced HYPERGLYCEMIA in Hospitalized Patients".Trial register ClinicalTrials.gov
2026-02-04TrialNew trial registered: Evaluate the Efficacy and Safety of GZR101-80 Injection in Patients With Type 2 DiabetesTrial register ClinicalTrials.gov
2026-01-14TrialNew trial registered: Single-ascending Dose Study of HEC-151 InjectionTrial register ClinicalTrials.gov
2025-11-21TrialNew trial registered: Clamp Study to Estimate the Relative Potency of GZR33 Versus Insulin Degludec at Steady StateTrial register ClinicalTrials.gov
2025-10-14LabelFDA label revised: Xultophy 100/3.6 (BLA208583)Regulator FDA drug label register
2025-10-09TrialNew trial registered: A Study of LY3938577 in Participants With Type 2 Diabetes Previously Treated With Basal InsulinTrial register ClinicalTrials.gov
2025-09-15TrialNew trial registered: Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 DiabetesTrial register ClinicalTrials.gov
2025-08-28TrialNew trial registered: Comparison Study of Insulin GZR4 With Insulin DegludecTrial register ClinicalTrials.gov
2025-08-26ResultsResults posted: A Research Study to Compare a New Weekly Insulin, Insulin Icodec Used With DoseGuide App, and Daily Insulins in People With Type 2 Diabetes Who Have Not UTrial register ClinicalTrials.gov
2025-06-24ResultsResults posted: A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily Injection TheTrial register ClinicalTrials.gov
2025-06-24TrialNew trial registered: A Clinical Study to Evaluate the Pharmacokinetic and Pharmacodynamics Properties of of SHR-3167 in Subjects With Type 2 DiabetesTrial register ClinicalTrials.gov
2025-06-12ResultsResults posted: A Research Study to Compare a New Weekly Insulin, Insulin Icodec, and an Available Daily Insulin, Insulin Degludec, Both in Combination With Mealtime InsuTrial register ClinicalTrials.gov
2025-06-12TrialNew trial registered: A Study Comparing SHR-3167 and Insulin Degludec in Type 2 Diabetic Subjects Treated With Basal Insulin With or Without Oral Antidiabetic DrugsTrial register ClinicalTrials.gov
2025-06-03ResultsResults posted: A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 2 Diabetes Currently Treated With Basal InsulinTrial register ClinicalTrials.gov
2025-05-16ResultsResults posted: A Study of Insulin Efsitora Alfa (LY3209590) Compared to Degludec in Adults With Type 2 Diabetes Who Are Starting Basal Insulin for the First TimeTrial register ClinicalTrials.gov
2025-04-18TrialNew trial registered: A Study of LY4057996 in Healthy Participants and Participants With Type 1 and Type 2 DiabetesTrial register ClinicalTrials.gov
2025-04-13TrialNew trial registered: A Study Comparing Degu Insulin Liraglutide Injection With Premixed Insulin on the Prognosis of Diabetes MellitusTrial register ClinicalTrials.gov
2025-02-20ResultsResults posted: A Research Study to Compare Two Types of Insulin, a New Weekly Insulin, Insulin Icodec and an Available Daily Insulin, Insulin Degludec, in People With TyTrial register ClinicalTrials.gov
2025-01-10TrialNew trial registered: A Phase III Clinical Study to Assess the Efficacy and Safety of GZR4 in Subjects With Type 2 Diabetes Mellitus Treated With Basal InsulinTrial register ClinicalTrials.gov
2024-12-04ResultsResults posted: A Research Study to Compare Two Types of Insulin, a New Insulin, Insulin Icodec and an Available Insulin, Insulin Degludec, in People With Type 2 DiabetesTrial register ClinicalTrials.gov
2024-11-12TrialNew trial registered: A Research Study of a New Medicine NNC0363-1063 in Healthy Participants and Participants With Type 1 DiabetesTrial register ClinicalTrials.gov
2024-10-30ResultsResults posted: iGlarLixi vs IDegAsp in Chinese Participants After OAD(s)Trial register ClinicalTrials.gov
2024-10-18ResultsResults posted: Afrezza With Basal Combination (ABC): Afrezza® Combined With AID Pump or Insulin Degludec in Adults With Type 1 DiabetesTrial register ClinicalTrials.gov
2024-09-05ResultsResults posted: Gla-300 and IDeg-100 in Insulin-Naïve People With Type 2 Diabetes Mellitus and Renal ImpairmentTrial register ClinicalTrials.gov
2024-08-19TrialNew trial registered: A Trial Investigating the Efficacy and Safety of Insulin Degludec/Liraglutide Injection in Subjects With Type 2 DiabetesTrial register ClinicalTrials.gov
2024-08-16TrialNew trial registered: A Clinical Study of GZR33 and GZR101 in Healthy SubjectsTrial register ClinicalTrials.gov
2024-08-14TrialNew trial registered: A Trial Investigating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GZR4 in Subjects With Type 2 DiabetesTrial register ClinicalTrials.gov
2024-07-29ResultsResults posted: Transition From Basal/Bolus to Once-weekly Subcutaneous Semaglutide and Basal Insulin in Patients With T2DTrial register ClinicalTrials.gov
2024-06-10TrialNew trial registered: A Trial to Investigate the Single Dose Pharmacokinetics of Insulin Degludec/Liraglutide in Healthy Chinese SubjectsTrial register ClinicalTrials.gov
2024-06-03LabelFDA label revised: Insulin Degludec (BLA203314)Regulator FDA drug label register
2024-05-31LabelFDA label revised: Insulin Degludec (BLA203314)Regulator FDA drug label register
2024-05-10TrialNew trial registered: The Efficacy and Safety of Insulin Degludec/Liraglutide Combination (IDegLira) in Patients With Type 2 DiabetesTrial register ClinicalTrials.gov
2024-03-20ResultsResults posted: Research Study to Compare a New Medicine "Fast-acting Insulin Aspart" to Another Medicine "Insulin Aspart" in Chinese People With DiabetesTrial register ClinicalTrials.gov
2024-03-01TrialNew trial registered: A Study to Test How a New Long-acting Insulin Works in the Body of Patients With Type 2 Diabetes During Exercise and Prolonged FastingTrial register ClinicalTrials.gov
2024-02-28ResultsResults posted: Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine DoseTrial register ClinicalTrials.gov
2024-02-28TrialNew trial registered: A Study of LY3938577 in Healthy Participants and Participants With Type 1 Diabetes Mellitus (T1DM)Trial register ClinicalTrials.gov
2024-02-22LabelFDA label revised: TRESIBA (BLA203314)Regulator FDA drug label register
2024-02-02TrialNew trial registered: Phase 2b Trial Comparing HDV-Insulin Lispro to Insulin Lispro in Adults With Type 1 Diabetes Receiving Insulin DegludecTrial register ClinicalTrials.gov
2024-01-11TrialNew trial registered: A Trial Comparing the Efficacy and Safety of GZR4 Injection Versus Insulin Degludec in Subjects with Type 2 Diabetes MellitusTrial register ClinicalTrials.gov
2023-12-28TrialNew trial registered: A Trial Comparing Efficacy and Safety of GZR101 and IDegAsp in Insulin Naïve or Insulin Treated Subjects with T2DMTrial register ClinicalTrials.gov
2023-12-21TrialNew trial registered: Insulin Degludec vs Insulin Glargine for Glycemic Control in Critical Illness HyperglycemiaTrial register ClinicalTrials.gov
2023-12-12LabelFDA label revised: Tresiba (BLA203314)Regulator FDA drug label register
2023-12-01TrialNew trial registered: A Research Study in Saudi Arabia to Understand How the Dose Check App Used With Tresiba Treatment Helps to Control Blood Sugar LevelTrial register ClinicalTrials.gov
2023-11-15TrialNew trial registered: A Study to Investigate the Safety and Tolerability of LY3938577 in Healthy Participants and Participants With Type 2 Diabetes MellitusTrial register ClinicalTrials.gov
2023-10-26TrialNew trial registered: The Effect and Safety of a Novel CGM-Based Titration Algorithm for Basal Insulin in T2DM Participants.Trial register ClinicalTrials.gov
2023-09-28TrialNew trial registered: Semaglutide GLP1 Agonists With Degludec Basal-bolus Insulin in Early Type 1 Diabetes to Basal-bolusTrial register ClinicalTrials.gov
2023-09-13TrialNew trial registered: Degludec Insulin Use in Critically Ill PatientsTrial register ClinicalTrials.gov
2023-09-08ResultsResults posted: IDegLira HIGH TrialTrial register ClinicalTrials.gov
2023-06-15TrialNew trial registered: INHALE-3: Afrezza® Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 DiabetesTrial register ClinicalTrials.gov
2023-04-07TrialNew trial registered: A Study of Insulin Degludec/Insulin Aspart Biosimilar (22011) Compared With Insulin Degludec/Insulin Aspart(Ryzodeg) in Participants With Type 2 DiaTrial register ClinicalTrials.gov
2023-03-14TrialNew trial registered: Risk of Hypoglycemia in the Transition From Inpatient to Outpatient Setting. Comparative Study of Basal-bolus Insulin Versus Basal Insulin Plus GLP-Trial register ClinicalTrials.gov
2023-02-08ResultsResults posted: A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 1 DiabetesTrial register ClinicalTrials.gov
2022-12-07TrialNew trial registered: Research on Optimal Strategy of Hypoglycemic Therapy for Cirrhosis With DiabetesTrial register ClinicalTrials.gov
2022-11-14ResultsResults posted: Comparison of Glucose Values and Variability Between TOUJEO and TRESIBA During Continuous Glucose Monitoring in Type 1 Diabetes PatientsTrial register ClinicalTrials.gov
2022-11-02ResultsResults posted: A Phase 2 Study of LY3209590 in Participants With Type 2 Diabetes MellitusTrial register ClinicalTrials.gov
2022-10-27ResultsResults posted: A Study of LY3209590 in Participants With Type 1 DiabetesTrial register ClinicalTrials.gov
2022-10-12TrialNew trial registered: A Clinical Study Comparing the Pharmacokinetics and Pharmacodynamic Characteristics of Insulin Degludec Injection (RD15003) and Insulin Degludec InjTrial register ClinicalTrials.gov
2022-09-23TrialNew trial registered: Gla-300 and IDeg-100 in Insulin-Naïve People With Type 2 Diabetes Mellitus and Renal ImpairmentTrial register ClinicalTrials.gov
2022-09-15TrialNew trial registered: Efficacy and Safety Of Different Regimens In Patients With Type 2 Diabetes Receiving Intensive Insulin TherapyTrial register ClinicalTrials.gov
2022-07-29TrialNew trial registered: A Research Study Looking at Blood Sugar Control in People With Type 2 Diabetes Previously Treated With Premix Insulin and Initiating Treatment With Trial register ClinicalTrials.gov
2022-07-21ResultsResults posted: Sensor-augmented Pump Versus Multiple Daily Injections With Degludec as Basal Insulin for Insulin Therapy in Type 1 DiabetesTrial register ClinicalTrials.gov
2022-07-19TrialNew trial registered: A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 1 Diabetes Treated With Multiple Daily InjectiTrial register ClinicalTrials.gov
2022-07-01LabelFDA label revised: Tresiba (BLA203314)Regulator FDA drug label register
2022-07-01LabelFDA label revised: Insulin Degludec (BLA203314)Regulator FDA drug label register
2022-06-28TrialNew trial registered: Evaluation of Glycemic Control in Adults With Type 1 Diabetes When Switching to Insulin DegludecTrial register ClinicalTrials.gov
2022-06-17TrialNew trial registered: cArdiopulmonary exerCise Test Assessing Multiple biOmarkers and Hormones iN Type 1 diabetEs Under Different CircumstancesTrial register ClinicalTrials.gov
2022-06-14TrialNew trial registered: Safety and Efficacy of Insulin Degludec/Insulin Aspart in Patients With T2DMTrial register ClinicalTrials.gov
2022-06-10TrialNew trial registered: iGlarLixi vs IDegAsp in Chinese Participants After OAD(s)Trial register ClinicalTrials.gov
2022-06-03ResultsResults posted: A Study of LY900014 and Insulin Degludec in Participants With Type 1 DiabetesTrial register ClinicalTrials.gov
2022-06-02ResultsResults posted: Comparison of Insulin Degludec With Insulin Glargine U100 for Adults With Type 1 Diabetes Crossing Multiple Time Zones.Trial register ClinicalTrials.gov
2022-05-05TrialNew trial registered: A Study of Insulin Efsitora Alfa (LY3209590) Compared to Degludec in Adults With Type 2 Diabetes Who Are Starting Basal Insulin for the First TimeTrial register ClinicalTrials.gov
2022-05-04TrialNew trial registered: Effects of Degludec/Liraglutide on Time in Range, Inflammation and Endothelial Function vs Insulin Basal Bolus in Diabetic InpatientsTrial register ClinicalTrials.gov
2022-04-27ResultsResults posted: Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 DiabetesTrial register ClinicalTrials.gov
2022-03-31ResultsResults posted: Insulin Degludec and Glargine U100 for Management of Hospitalized and Discharged Patients With Type 2 DiabetesTrial register ClinicalTrials.gov
2022-03-11TrialNew trial registered: A Study of Insulin Efsitora Alfa (LY3209590) Compared With Insulin Degludec in Participants With Type 2 Diabetes Currently Treated With Basal InsuliTrial register ClinicalTrials.gov
2022-02-17TrialNew trial registered: Afrezza With Basal Combination (ABC): Afrezza® Combined With AID Pump or Insulin Degludec in Adults With Type 1 DiabetesTrial register ClinicalTrials.gov
2022-02-08ResultsResults posted: A Study of LY900014 Compared to Insulin Lispro (Humalog) in Adults With Type 2 DiabetesTrial register ClinicalTrials.gov
2022-02-01TrialNew trial registered: Basal Plus GLP1-ra on Glycemic Variability in CKDTrial register ClinicalTrials.gov
2022-01-24ResultsResults posted: A Study Comparing LY900014 to Insulin Lispro (Humalog) in Children and Adolescents With Type 1 DiabetesTrial register ClinicalTrials.gov
2022-01-19ResultsResults posted: A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 DiabetesTrial register ClinicalTrials.gov
2022-01-12TrialNew trial registered: China Research of IDEgAsp Treatment in Real-world Clinical practicE (CREATE)Trial register ClinicalTrials.gov
2021-12-22TrialNew trial registered: Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes StudyTrial register ClinicalTrials.gov
2021-11-24TrialNew trial registered: Endotherapy for Painless Chronic PancreatitisTrial register ClinicalTrials.gov
2021-11-23TrialNew trial registered: BESTMED: Observational Evaluation of Second Line Therapy Medications in DiabetesTrial register ClinicalTrials.gov
2021-11-01TrialNew trial registered: Empagliflozin-based Quadruple Therapy vs Basal Insulin-based TherapyTrial register ClinicalTrials.gov
2021-10-06TrialNew trial registered: A Research Study Looking at How the Use of NovoPen® 6 for Treatment With Tresiba® & Fiasp® Affects the Blood Sugar Level in Patients With Type 1 DiaTrial register ClinicalTrials.gov
2021-09-13ResultsResults posted: Insulin Pump to Multiple Daily Injection Transition Clinical TrialTrial register ClinicalTrials.gov
2021-08-27TrialNew trial registered: Degludec Glargine U300 Hospital StudyTrial register ClinicalTrials.gov
2021-07-16TrialNew trial registered: Safety and Efficacy of Insulin Degludec/Insulin Aspart in Patients With T1DMTrial register ClinicalTrials.gov
2021-07-09TrialNew trial registered: A Clinical Study of Insulin Degludec Injection in Subjects With Type 2 DiabetesTrial register ClinicalTrials.gov
2021-07-07TrialNew trial registered: Regulatory Post Marketing Surveillance (rPMS) Study of Xultophy® (Insulin Degludec/Liraglutide) to Evaluate Safety and Effectiveness in Patients WitTrial register ClinicalTrials.gov
2021-06-22TrialNew trial registered: Afrezza® INHALE-1 Study in PediatricsTrial register ClinicalTrials.gov
2021-05-19TrialNew trial registered: Investigating the Effect of Ryzodeg® in Adult Patients With Type 2 Diabetes in LebanonTrial register ClinicalTrials.gov
2021-04-21RecallFDA recall, Class I: Novo Nordisk Inc. Temperature Abuse: product samples were stored at temperatures below 32* F which is not in accordance with storage requirements thaRegulator FDA enforcement reports
2021-04-21RecallFDA recall, Class I: Novo Nordisk Inc. Temperature Abuse: product samples were stored at temperatures below 32* F which is not in accordance with storage requirements thaRegulator FDA enforcement reports
2021-04-21RecallFDA recall, Class I: Novo Nordisk Inc. Temperature Abuse: product samples were stored at temperatures below 32* F which is not in accordance with storage requirements thaRegulator FDA enforcement reports

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