guanylate cyclase-C agonist
Linaclotide dose
Answer
FDA label for Linzess: The recommended dosage of LINZESS is:. Trials with posted results tested 11 doses, most often 145 μg, 290 mcg, 290 μg.
Not dosing advice.
FDA LABEL
What the approved labels state
Linzess NDA202811 · label of 2026-05-21 Regulator
The recommended dosage of LINZESS is:.
IN TRIALS
Doses tested in 24 trials with posted results
| Dose in the arm title | Trials | People on it | Phases |
|---|---|---|---|
| 145 μg | 5 | 1,337 | 2/3/4 |
| 290 mcg | 4 | 810 | 2/3 |
| 290 μg | 5 | 806 | 2/3/4 |
| 72 μg | 3 | 636 | 2/3 |
| 145 mcg | 3 | 390 | 2/3 |
| 72 mcg | 2 | 289 | 2/3 |
| 30 μg | 1 | 134 | 2 |
| 100 μg | 1 | 133 | 2 |
| 300 μg | 1 | 133 | 2 |
| 579 mcg | 1 | 89 | 2 |
| 579 μg | 1 | 63 | 2 |
Trial register Read from the titles of arms that received Linaclotide (n ≥ 20). An arm naming several doses counts under each; a schedule or escalation is on the trial record. All trials.
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New trials, approvals and enforcement actions. One email a week.