guanylate cyclase-C agonist
Linaclotide clinical trials
Answer
Linaclotide has 62 registered trials: 7 running, 41 completed, 6 stopped early. 24 posted results.
Trial registerClinicalTrials.gov and EU CTIS, read 2026-10-03
| Trial | Title | Status | Phase | Registered | Results |
|---|---|---|---|---|---|
| NCT07780344 Trial register | MRI Parameters as Biomarkers in Cystic Fibrosis (FEMPTO) | not yet recruiting participants | - | 2026-08-21 | - |
| NCT05796388 Trial register | A Study of Virtual Reality and Linaclotide for IBS-C | currently recruiting participants | - | 2023-04-03 | - |
| NCT03796884 Trial register | Linaclotide in Treating Patients With Stages 0-3 Colorectal Cancer | running, but no longer enrolling | - | 2019-01-08 | - |
| NCT05652205 Trial register | A Study to Assess Adverse Events and Change in Symptoms With Linaclotide Versus Placebo in Pediatric Subjects, Ages 2 to 5 Years, With Functional Constipation | completed | - | 2022-12-15 | Posted |
| NCT07569419 Trial register | Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis | currently recruiting participants | - | 2026-05-06 | - |
| NCT05107219 Trial register | GCC Agonist Signal in the Small Intestine | completed | - | 2021-11-04 | - |
| NCT03119584 Trial register | Efficacy of Linaclotide in Type II Diabetics With Chronic Constipation | running, but no longer enrolling | - | 2017-04-18 | - |
| NCT07431957 Trial register | "Efficacy and Safety of Linaclotide in Chronic Constipation" | not yet recruiting participants | - | 2026-02-25 | - |
| NCT06692673 Trial register | Linaclotide for Colonoscopy Bowel Prep | currently recruiting participants | - | 2024-11-18 | - |
| NCT04166058 Trial register | Long-term Safety of Linaclotide in Pediatric Participants With FC or IBS-C | completed | - | 2019-11-18 | Posted |
| NCT05760313 Trial register | A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treate | completed | - | 2023-03-08 | Posted |
| NCT06989268 Trial register | Effect to Linaclotide on Colonic Motility | completed | - | 2025-05-25 | - |
| 2022-501946-31-00 Trial register | A Phase 3, Multicenter, Randomized, Double-blind, Parallel-group, Safety and Efficacy Study of Linaclotide versus Placebo in Pediatric Subjects, Ages 2 to 5 Yea | Not stated | 3 | - | - |
| 2022-501947-34-00 Trial register | A Phase 2 Dose Finding Study Evaluating the Safety and Efficacy of Linaclotide in Pediatric Subjects 6 Months to Less Than 2 Years of Age with Functional Consti | Not stated | 2 | - | - |
| NCT06748638 Trial register | Clinical Study on the Application of Lactulose Combined with Linaclotide in Bowel Preparation for Colonoscopy | last verified some time ago; the register no longer confirms its status | - | 2024-12-27 | - |
| NCT06091735 Trial register | Clinical Study of Bowel Preparation Before Colonoscopy | completed | - | 2023-10-16 | - |
| NCT01950403 Trial register | Linaclotide Acetate in Preventing Colorectal Cancer in Healthy Volunteers | completed | - | 2013-09-25 | - |
| NCT04026113 Trial register | Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipat | completed | - | 2019-07-19 | Posted |
| NCT01714843 Trial register | A Study to Evaluate the Effect of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndrome | completed | - | 2012-10-26 | - |
| NCT02316899 Trial register | Phase III Study to Evaluate the Efficacy and Safety of ASP0456 in Patients With Constipation Predominant Irritable Bowel Syndrome | completed | - | 2014-12-15 | - |
| NCT02425722 Trial register | A Study to Evaluate Dose Responses of Efficacy and Safety of ASP0456 in Patient With Chronic Constipation | completed | - | 2015-04-07 | - |
| NCT02809105 Trial register | A Study of Oral Dosing of ASP0456 in Patients With Chronic Constipation | completed | - | 2016-06-22 | - |
| NCT03471728 Trial register | Post-marketing Surveillance of Linaclotide Tablet in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation (Excluding Constipation Du | completed | - | 2018-03-21 | - |
| NCT05291325 Trial register | Application of Linaclotide Capsule in Bowel Preparation for Colonoscopy | completed | - | 2022-03-22 | - |
| NCT05379491 Trial register | Application of Linaclotide Capsule in Bowel Preparation for Patients at High Risk of Inadequate Bowel Preparation | completed | - | 2022-05-18 | - |
| NCT04462900 Trial register | Evaluate the Safety of Linaclotide in IBS-C Patients in China | completed | - | 2020-07-08 | - |
| NCT02970591 Trial register | A Comparison of Three Different Treatment Options for Irritable Bowel Syndrome | completed | - | 2016-11-18 | - |
| NCT03336034 Trial register | Assessment of Responsiveness to Treatment by Experience Sampling Method | terminated before completion | - | 2017-10-25 | - |
| NCT04110145 Trial register | Linaclotide Safety and Efficacy in 2 to 5-Year-Old Participants With Functional Constipation | completed | - | 2019-10-01 | Posted |
| NCT05134584 Trial register | Efficacy of Linaclotide in Patients With Overlapping Functional Gastrointestinal Disorders | last verified some time ago; the register no longer confirms its status | - | 2021-11-26 | - |
| NCT02837783 Trial register | A Study of the Effect of Linaclotide on Abdominal Girth in Participants With Irritable Bowel Syndrome With Constipation (IBS-C) | terminated before completion | - | 2016-07-20 | Posted |
| NCT05137145 Trial register | Effect and Safety of Polyethylene Glycol Combined With Linaclotide on Colon Cleansing for Patients With Chronic Constipation | last verified some time ago; the register no longer confirms its status | - | 2021-11-30 | - |
| NCT04532879 Trial register | HygiRelief Procedure and HygiSample Evaluation for Functional Constipation | withdrawn before enrolling anyone | - | 2020-08-20 | - |
| NCT03342287 Trial register | Cognitive and Psychiatric Effects of Linaclotide on Patients With Constipation | withdrawn before enrolling anyone | - | 2017-11-14 | - |
| NCT04804267 Trial register | Evaluation of Clinical Equivalence Between Two Linaclotide Products in the Treatment of Chronic Idiopathic Constipation | last verified some time ago; the register no longer confirms its status | - | 2021-03-18 | - |
| NCT02559817 Trial register | A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With Constipation | terminated before completion | - | 2015-09-24 | Posted |
| NCT02220348 Trial register | A Lactation Study in Women Who Are Breastfeeding or Pumping and Are Receiving Linaclotide Therapeutically | completed | - | 2014-08-19 | - |
| NCT03573908 Trial register | A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation (IBS-C) | completed | - | 2018-06-29 | Posted |
| NCT02559206 Trial register | Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C) | completed | - | 2015-09-24 | Posted |
| NCT02590432 Trial register | An Open-Label, Long-term Study to Assess the Immunogenicity of LINZESS® (Linaclotide) Administered Orally to Adult Participants With Irritable Bowel Syndrome Wi | completed | - | 2015-10-29 | Posted |
| NCT02239510 Trial register | Efficacy of Linaclotide to Senna for CIC | terminated before completion | - | 2014-09-12 | Posted |
| NCT02559570 Trial register | A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 6-17 Years Who Fulfill Modified Rome III Criteria for Child/Ado | completed | - | 2015-09-24 | Posted |
| NCT02270983 Trial register | Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Ch | completed | - | 2014-10-22 | Posted |
| NCT00765999 Trial register | An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation | completed | - | 2008-10-03 | Posted |
| NCT02078323 Trial register | Investigation of Linaclotide's Effect on the Bi-directional Brain and Gut Axis in IBS-C Patients | completed | - | 2014-03-05 | - |
| NCT00730171 Trial register | An Open-label, Long-term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation | completed | - | 2008-08-08 | Posted |
| NCT02291679 Trial register | Trial of Linaclotide in Patients With Chronic Idiopathic Constipation | completed | - | 2014-11-14 | Posted |
| NCT02360384 Trial register | Caecal pH as a Biomarker for Irritable Bowel Syndrome | last verified some time ago; the register no longer confirms its status | - | 2015-02-10 | - |
| NCT01880424 Trial register | A Phase 3, International, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Efficacy and Safety Trial of Linaclotide Administered Orally | completed | - | 2013-06-19 | Posted |
| NCT02465385 Trial register | Single-dose Linaclotide for Capsule Endoscopy Preparation | completed | - | 2015-06-08 | - |
| NCT02781493 Trial register | Efficacy of Prucalopride Plus Polyethylene Glycol in Bowel Preparation for Colonoscopy | last verified some time ago; the register no longer confirms its status | - | 2016-05-21 | - |
| NCT01642914 Trial register | Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating | completed | - | 2012-07-17 | Posted |
| NCT00938717 Trial register | Trial of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation (IBS-C) | completed | - | 2009-07-14 | Posted |
| NCT00402337 Trial register | Dose-range-finding, Phase 2 Trial of Oral Linaclotide Acetate Administered to Patients With Chronic Constipation | completed | - | 2006-11-22 | Posted |
| NCT00460811 Trial register | Randomized, Double-blind, Dose-range-finding, Phase 2 Study of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation (IBS-C) | completed | - | 2007-04-16 | Posted |
| NCT00730015 Trial register | Trial of Linaclotide in Patients With Chronic Constipation | completed | - | 2008-08-08 | Posted |
| NCT00765882 Trial register | Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic Constipation | completed | - | 2008-10-03 | Posted |
| NCT00948818 Trial register | Trial of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation | completed | - | 2009-07-29 | Posted |
| NCT01427387 Trial register | A Study to Evaluate Safety of Multiple Dose of ASP0456 in Healthy Subjects | completed | - | 2011-08-31 | - |
| NCT01279915 Trial register | A Safety and Pharmacokinetics Study of ASP0456 in Healthy Subjects | completed | - | 2011-01-18 | - |
| NCT00306748 Trial register | Phase 2 Study of MD-1100 Acetate Administered for 14 Days to Patients Meeting Criteria for Chronic Constipation | completed | - | 2006-03-20 | - |
| NCT00258193 Trial register | Phase 2 Study of MD-1100 Acetate on Gastrointestinal Transit in Patients With C-IBS | completed | - | 2005-11-22 | - |
Source: ClinicalTrials.gov and EU CTIS, read 2026-10-03. Not medical advice.
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