| 2026-03-18 | Label | FDA label revised: Soliqua 100/33 (BLA208673) | Regulator FDA drug label register |
| 2025-12-29 | Trial | New trial registered: Efficacy and Safety of iGlarLixi Versus Standard of Care in a Real-world Adult China Population With Uncontrolled Type 2 Diabetes on Oral Agents | Trial register ClinicalTrials.gov |
| 2025-09-16 | Trial | New trial registered: Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Out | Trial register ClinicalTrials.gov |
| 2025-09-15 | Trial | New trial registered: Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2025-08-12 | Trial | New trial registered: Evaluation of the Efficacy and Safety of GLP-1 Receptor Agonist Therapy In Steroid-Induced Diabetes | Trial register ClinicalTrials.gov |
| 2024-12-04 | Trial | New trial registered: A Study to Investigate Safety and Efficacy of iGlarLixi in Adult Patients With Type 2 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2024-11-04 | Trial | New trial registered: iGlarLixi CGM Study in Chinese T2D Individuals After OADs | Trial register ClinicalTrials.gov |
| 2024-10-30 | Results | Results posted: iGlarLixi vs IDegAsp in Chinese Participants After OAD(s) | Trial register ClinicalTrials.gov |
| 2024-06-07 | Trial | New trial registered: Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh | Trial register ClinicalTrials.gov |
| 2024-05-24 | Results | Results posted: Effect of Soliqua 100/33 on Time in Range From Continuous Glucose Monitoring in Insulin-naive Patients With Very Uncontrolled Type 2 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2023-04-07 | Trial | New trial registered: The Effect of Lixisenatide on the Effect of Pituitary Hormones | Trial register ClinicalTrials.gov |
| 2022-06-10 | Trial | New trial registered: iGlarLixi vs IDegAsp in Chinese Participants After OAD(s) | Trial register ClinicalTrials.gov |
| 2021-12-22 | Trial | New trial registered: Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study | Trial register ClinicalTrials.gov |
| 2021-11-29 | Trial | New trial registered: SEMAGLUTIDE VERSUS GLP-1 RECEPTOR AGONISTS. EFFECTIVENESS , SAFETY AND QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUS 2. OBSERVATIONAL, PROSPECT | Trial register ClinicalTrials.gov |
| 2021-11-10 | Trial | New trial registered: Effect of Soliqua 100/33 on Time in Range From Continuous Glucose Monitoring in Insulin-naive Patients With Very Uncontrolled Type 2 Diabetes Mellit | Trial register ClinicalTrials.gov |
| 2020-01-13 | Results | Results posted: Efficacy and Safety of Soliqua Versus Lantus in Ethnically/Racially Diverse Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Basal Insuli | Trial register ClinicalTrials.gov |
| 2019-12-06 | Trial | New trial registered: Durability of Combination of Insulin and GLP-1 Receptor Agonist or SGLT-2 Inhibitors Versus Basal Bolus Insulin Regimen in Type 2 Diabetes (BEYOND) | Trial register ClinicalTrials.gov |
| 2019-12-01 | Trial | New trial registered: Cardiovascular Outcomes SGLT-2 Inhibitors Versus GLP-1 Receptor Agonists | Trial register ClinicalTrials.gov |
| 2019-06-12 | Results | Results posted: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabetes, Wit | Trial register ClinicalTrials.gov |
| 2019-05-20 | Trial | New trial registered: GLP-1 REceptor Agonists and Real World EvIdeNce | Trial register ClinicalTrials.gov |
| 2019-03-20 | Trial | New trial registered: Effects of Insulin Glargine and Lixisenatide on the Brain | Trial register ClinicalTrials.gov |
| 2019-01-29 | Trial | New trial registered: The Effect of Soliqua on Glucose Variability in Type 2 Patients Among South Asians | Trial register ClinicalTrials.gov |
| 2019-01-09 | Trial | New trial registered: Evaluation of Insulin Glargine/Lixisenatide Fixed Ratio Combination in Patients With Type 2 Diabetes Insufficiently Controlled With Oral Antidiabeti | Trial register ClinicalTrials.gov |
| 2019-01-09 | Trial | New trial registered: Comparison of the Efficacy and Safety of Insulin Glargine/Lixisenatide Fixed Ratio Combination to Insulin Glargine in Patients With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2018-12-26 | Federal Register | Federal Register notice: Determination of Regulatory Review Period for Purposes of Patent Extension; ADLYXIN | Regulator Federal Register |
| 2018-12-06 | Trial | New trial registered: Study Comparing the Efficacy and Safety of Insulin Glargine (Basal Insulin)/Lixisenatide (GLP-1 Receptor Agonist) Combination (Soliqua™) in Patients | Trial register ClinicalTrials.gov |
| 2018-05-18 | Trial | New trial registered: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination Versus Insulin Glargine in Patients With Type 2 Diabetes (LixiLan-I | Trial register ClinicalTrials.gov |
| 2018-04-10 | Federal Register | Federal Register notice: Notice of Approval of Products Under Voucher: Rare Pediatric Disease Priority Review Vouchers | Regulator Federal Register |
| 2018-04-10 | Trial | New trial registered: A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for | Trial register ClinicalTrials.gov |
| 2018-02-20 | Trial | New trial registered: Study to Evaluate the Effect of Lixisenatide in Patient With Parkinson's Disease | Trial register ClinicalTrials.gov |
| 2018-02-15 | Trial | New trial registered: Efficacy and Safety of Soliqua Versus Lantus in Ethnically/Racially Diverse Patients With Type 2 Diabetes Mellitus Inadequately Controlled on Basal | Trial register ClinicalTrials.gov |
| 2017-04-23 | Trial | New trial registered: Remission Evaluation of a Metabolic Intervention for Type 2 Diabetes With IGlarLixi | Trial register ClinicalTrials.gov |
| 2017-04-04 | Results | Results posted: Feasibility of Once/Daily Administered GLP/1 Receptoragonist (Lixisenatide) in Combination With Basal Insulin | Trial register ClinicalTrials.gov |
| 2017-02-10 | Results | Results posted: Efficacy and Safety of Insulin Glargine/ Lixisenatide Fixed Ratio Combination Compared to Insulin Glargine Alone and Lixisenatide Alone on Top of Metformi | Trial register ClinicalTrials.gov |
| 2017-02-10 | Results | Results posted: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination Versus Insulin Glargine in Patients With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2017-02-10 | Results | Results posted: Efficacy and Safety of Insulin Glargine/Lixisenatide Fixed Combination Versus Insulin Glargine Alone on Top of Metformin in Type 2 Diabetic Patients | Trial register ClinicalTrials.gov |
| 2017-01-04 | Results | Results posted: Efficacy and Safety of Lixisenatide Versus Insulin Glulisine on Top of Insulin Glargine With or Without Metformin in Type 2 Diabetic Patients | Trial register ClinicalTrials.gov |
| 2016-12-21 | Results | Results posted: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation in Monotherapy (GETGOAL-MONO Japan LTS) | Trial register ClinicalTrials.gov |
| 2016-12-15 | Results | Results posted: GLP-1 Receptor Agonist Lixisenatide (Morning or Evening) in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin | Trial register ClinicalTrials.gov |
| 2016-12-14 | Results | Results posted: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Sulfonylurea | Trial register ClinicalTrials.gov |
| 2016-12-14 | Results | Results posted: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin | Trial register ClinicalTrials.gov |
| 2016-12-12 | Results | Results posted: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation in Monotherapy | Trial register ClinicalTrials.gov |
| 2016-10-21 | Trial | New trial registered: Safety Assessment of Lyxumia (Lixisenatide) and Sulfonylurea as Add-on Treatment to Basal Insulin in Uncontrolled Patients With Type 2 Diabetes Mell | Trial register ClinicalTrials.gov |
| 2016-10-14 | Results | Results posted: Efficacy and Safety of Lixisenatide Versus Placebo on Top of Basal Insulin and/or Oral Antidiabetic Treatment in Older Type 2 Diabetic Patients | Trial register ClinicalTrials.gov |
| 2016-10-14 | Results | Results posted: Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 (Lixisenatide) | Trial register ClinicalTrials.gov |
| 2016-10-14 | Results | Results posted: Comparison of Lixisenatide Injected Prior to the Main Meal of the Day Versus Prior to Breakfast in Type 2 Diabetic Patients on Metformin | Trial register ClinicalTrials.gov |
| 2016-10-14 | Results | Results posted: Pharmacodynamic Effects of Lixisenatide Compared to Liraglutide in Patients With Type 2 Diabetes Not Adequately Controlled With Insulin Glargine With or W | Trial register ClinicalTrials.gov |
| 2016-10-13 | Results | Results posted: Efficacy and Safety of Lixisenatide in Patients With Type 2 Diabetes Mellitus Insufficiently Controlled by Metformin | Trial register ClinicalTrials.gov |
| 2016-10-11 | Results | Results posted: GLP-1 Receptor Agonist Lixisenatide Versus Exenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin | Trial register ClinicalTrials.gov |
| 2016-10-11 | Results | Results posted: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Basal Insulin | Trial register ClinicalTrials.gov |
| 2016-10-11 | Results | Results posted: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Pioglitazone | Trial register ClinicalTrials.gov |
| 2016-10-11 | Results | Results posted: Effects of Lixisenatide Compared to Liraglutide on the Postprandial Plasma Glucose in Patients With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2016-10-11 | Results | Results posted: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Basal Insulin +/- Sulfonylurea | Trial register ClinicalTrials.gov |
| 2016-10-11 | Results | Results posted: 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine | Trial register ClinicalTrials.gov |
| 2016-10-11 | Results | Results posted: 24-week Study Comparing Lixisenatide to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 Years | Trial register ClinicalTrials.gov |
| 2016-06-17 | Trial | New trial registered: A Study on Safety, Pharmacokinetics and Pharmacodynamics of Lixisenatide in Pediatric Patients With Type 2 Diabetes Mellitus (T2DM) | Trial register ClinicalTrials.gov |
| 2016-06-01 | Trial | New trial registered: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (FRC) Versus GLP-1 Receptor Agonist in Patients With Type 2 Diabete | Trial register ClinicalTrials.gov |
| 2016-05-10 | Trial | New trial registered: Evaluation of Lixisenatide Efficacy in Diabetes Mellitus Type 2 With Failure of Other GLP-1 Analog | Trial register ClinicalTrials.gov |
| 2016-04-27 | Trial | New trial registered: Efficacy and Safety of LixiLan Versus Insulin Glargine Alone Both With Metformin in Japanese With Type 2 Diabetes Mellitus Inadequately Controlled o | Trial register ClinicalTrials.gov |
| 2016-04-27 | Trial | New trial registered: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (LixiLan) to Insulin Glargine Alone on Top of Oral Anti-diabetic Dr | Trial register ClinicalTrials.gov |
| 2016-04-25 | Trial | New trial registered: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination (LixiLan) to Lixisenatide on Top of Oral Anti-diabetic Drugs (OADs) | Trial register ClinicalTrials.gov |
| 2016-04-20 | Trial | New trial registered: Effects of a GLP-1 Receptor Agonist on Functional Activation and Connectivity of the Brain | Trial register ClinicalTrials.gov |
| 2016-03-18 | Trial | New trial registered: Postprandial Glucodynamic Response to Insulin Glargine/Lixisenatide Fixed Ratio Combination in Japanese Patients With Type 2 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2016-03-16 | Federal Register | Federal Register notice: Endocrinologic and Metabolic Drugs Advisory Committee; Notice of Meeting | Regulator Federal Register |
| 2015-12-28 | Trial | New trial registered: The Impact of Lixisenatide on Postprandial Glucose Tolerance in Pancreatectomised Subjects | Trial register ClinicalTrials.gov |
| 2015-12-22 | Results | Results posted: Efficacy and Safety of Liraglutide Versus Lixisenatide as add-on to Metformin in Subjects With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2015-07-17 | Trial | New trial registered: The Effect of the GLP-1 Receptor Agonists on Blood Levels of Lipoprotein (a) | Trial register ClinicalTrials.gov |
| 2014-12-04 | Trial | New trial registered: Drug Trial of Lixisenatide on Gastric Emptying and Blood Pressure Drops in Type 2 Diabetics and Healthy People | Trial register ClinicalTrials.gov |
| 2014-10-28 | Trial | New trial registered: Effect of LIXIsenatide on the Renal System | Trial register ClinicalTrials.gov |
| 2014-10-24 | Trial | New trial registered: Effect of Lixisenatide on Postprandial Lipid Profile in Obese Type 2 Diabetic Patients | Trial register ClinicalTrials.gov |
| 2014-09-15 | Trial | New trial registered: Pathophysiological Study of the Increase in Pancreatic Volume in Type 2 Diabetes Treatments. | Trial register ClinicalTrials.gov |
| 2014-09-04 | Trial | New trial registered: Effects of Victoza® Versus Lyxumia® on Gastroesophageal Reflux, Gastric Emptying and Gastric Acid Secretion | Trial register ClinicalTrials.gov |
| 2014-07-25 | Trial | New trial registered: Effect of Lixisenatide on Postprandial Plasma Glucose Compared to Sitagliptin in Combination With Insulin Glargine | Trial register ClinicalTrials.gov |
| 2014-06-20 | Trial | New trial registered: Feasibility of Once/Daily Administered GLP/1 Receptoragonist (Lixisenatide) in Combination With Basal Insulin | Trial register ClinicalTrials.gov |
| 2014-02-07 | Trial | New trial registered: Efficacy and Safety of Insulin Glargine/ Lixisenatide Fixed Ratio Combination Compared to Insulin Glargine Alone and Lixisenatide Alone on Top of Me | Trial register ClinicalTrials.gov |
| 2014-02-07 | Trial | New trial registered: Efficacy and Safety of the Insulin Glargine/Lixisenatide Fixed Ratio Combination Versus Insulin Glargine in Patients With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2014-01-29 | Trial | New trial registered: Lixisenatide-The Effects on Glucose and Lipid Metabolism in Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2013-12-25 | Trial | New trial registered: Study on Lixisenatide and Counterregulation to Hypoglycemia | Trial register ClinicalTrials.gov |
| 2013-10-31 | Trial | New trial registered: Efficacy and Safety of Liraglutide Versus Lixisenatide as add-on to Metformin in Subjects With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2013-10-10 | Trial | New trial registered: Safety And Tolerability Of Lixisenatide In Monotherapy In Patients With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2013-09-12 | Trial | New trial registered: Safety and Tolerability of Lixisenatide in Combination With Oral Anti-Diabetic Treatment in Patients With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2013-07-29 | Trial | New trial registered: Impact of Combined of Lantus(Insulin Glargine) and Lyxumia (Lixisenatide) on Insulin Secretion and Gastric Emptying | Trial register ClinicalTrials.gov |
| 2013-02-26 | Trial | New trial registered: Efficacy and Safety of Lixisenatide Versus Placebo on Top of Basal Insulin and/or Oral Antidiabetic Treatment in Older Type 2 Diabetic Patients | Trial register ClinicalTrials.gov |
| 2013-01-15 | Trial | New trial registered: Efficacy and Safety of Lixisenatide Versus Insulin Glulisine on Top of Insulin Glargine With or Without Metformin in Type 2 Diabetic Patients | Trial register ClinicalTrials.gov |
| 2012-07-02 | Trial | New trial registered: Assessment of the Efficacy and Safety of Lixisenatide in Patients With Type 2 Diabetes Insufficiently Controlled With Basal Insulin +/- Metformin | Trial register ClinicalTrials.gov |
| 2012-05-11 | Trial | New trial registered: Pharmacodynamic Effects of Lixisenatide Compared to Liraglutide in Patients With Type 2 Diabetes Not Adequately Controlled With Insulin Glargine Wit | Trial register ClinicalTrials.gov |
| 2012-04-06 | Trial | New trial registered: Evaluation of the Blood Levels of the Drug (Lixisenatide), the Plasma Glucose Levels and Safety in Paediatric and Adult Patients With Type 2 Diabete | Trial register ClinicalTrials.gov |
| 2012-01-25 | Trial | New trial registered: Comparison of Lixisenatide Injected Prior to the Main Meal of the Day Versus Prior to Breakfast in Type 2 Diabetic Patients on Metformin | Trial register ClinicalTrials.gov |
| 2011-11-22 | Trial | New trial registered: Efficacy and Safety of Insulin Glargine/Lixisenatide Fixed Combination Versus Insulin Glargine Alone on Top of Metformin in Type 2 Diabetic Patients | Trial register ClinicalTrials.gov |
| 2010-08-04 | Trial | New trial registered: Effects of Lixisenatide Compared to Liraglutide on the Postprandial Plasma Glucose in Patients With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2010-07-26 | Trial | New trial registered: Efficacy and Safety of Lixisenatide in Patients With Type 2 Diabetes Mellitus Insufficiently Controlled by Metformin | Trial register ClinicalTrials.gov |
| 2010-06-22 | Trial | New trial registered: Evaluation of Cardiovascular Outcomes in Patients With Type 2 Diabetes After Acute Coronary Syndrome During Treatment With AVE0010 (Lixisenatide) | Trial register ClinicalTrials.gov |
| 2010-06-17 | Trial | New trial registered: Relative Bioavailability and Activity of Different Formulations of Insulin Glargine and Lixisenatide in Patients With Diabetes Mellitus Type 1 | Trial register ClinicalTrials.gov |
| 2009-09-15 | Trial | New trial registered: 24-week Study Comparing Lixisenatide to Sitagliptin as add-on to Metformin in Obese Type 2 Diabetic Patients Younger Than 50 Years | Trial register ClinicalTrials.gov |
| 2009-09-11 | Trial | New trial registered: 24-week Treatment With Lixisenatide in Type 2 Diabetes Insufficiently Controlled With Metformin and Insulin Glargine | Trial register ClinicalTrials.gov |
| 2009-07-02 | Trial | New trial registered: Lixisenatide for Restoration of Insulin Release in Subjects With Diabetes Mellitus Type 2 | Trial register ClinicalTrials.gov |
| 2009-05-20 | Trial | New trial registered: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation in Monotherapy (GETGOAL-MONO Japan L | Trial register ClinicalTrials.gov |
| 2009-03-20 | Trial | New trial registered: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Basal Insulin +/- Sulfony | Trial register ClinicalTrials.gov |
| 2008-10-01 | Trial | New trial registered: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin | Trial register ClinicalTrials.gov |
| 2008-10-01 | Trial | New trial registered: GLP-1 Receptor Agonist Lixisenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Pioglitazone | Trial register ClinicalTrials.gov |