guanylate cyclase-C agonist

Plecanatide updates

Name: Plecanatide updates
Creator: Global Peptide Index
License: https://globalpeptideindex.com/methodology

Answer

2 changes for Plecanatide in the last 12 months. Latest: 2026-07-23.

Date	Type	What changed	Source
2026-07-23	Trial	New trial registered: This is a Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study of the Efficacy and Safety of 2 Weight-based Treatment Gro	Trial register ClinicalTrials.gov
2025-12-31	Results	Results posted: Efficacy and Safety of Plecanatide in Children 6 to <18 Years With Irritable Bowel Syndrome With Constipation (IBS-C)	Trial register ClinicalTrials.gov
2024-04-04	Label	FDA label revised: Trulance Immediate release (NDA208745)	Regulator FDA drug label register
2021-12-09	Trial	New trial registered: Efficacy and Safety of Plecanatide Comparing With Placebo in the Treatment of Functional Constipation	Trial register ClinicalTrials.gov
2021-11-04	Trial	New trial registered: GCC Agonist Signal in the Small Intestine	Trial register ClinicalTrials.gov
2020-08-18	Results	Results posted: Long Term Safety Study of Plecanatide	Trial register ClinicalTrials.gov
2020-01-02	Results	Results posted: SP-304 Dose Ranging Study in Patients With Chronic Idiopathic Constipation	Trial register ClinicalTrials.gov
2019-09-19	Results	Results posted: An Efficacy and Safety Study of Plecanatide in Adolescents 12 to <18 Years of Age With Chronic Idiopathic Constipation	Trial register ClinicalTrials.gov
2019-09-17	Federal Register	Federal Register notice: Product-Specific Guidances; Draft and Revised Draft Guidances for Industry; Availability	Regulator Federal Register
2019-07-02	Results	Results posted: Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC)	Trial register ClinicalTrials.gov
2019-06-14	Results	Results posted: The Plecanatide Irritable Bowel Syndrome With Constipation Study (IBS-C)	Trial register ClinicalTrials.gov
2019-06-14	Results	Results posted: Second Plecanatide Study In Irritable Bowel Syndrome With Constipation (IBS-C)	Trial register ClinicalTrials.gov
2019-03-21	Results	Results posted: 12-Week Study of Plecanatide for CIC (The CIC3 Study)	Trial register ClinicalTrials.gov
2019-03-14	Results	Results posted: 12-Week Study of Plecanatide for CIC (The National CIC3 Study)	Trial register ClinicalTrials.gov
2018-12-04	Federal Register	Federal Register notice: Determination of Regulatory Review Period for Purposes of Patent Extension; TRULANCE	Regulator Federal Register
2018-11-29	Federal Register	Federal Register notice: Product-Specific Guidances; Draft and Revised Draft Guidances for Industry; Availability	Regulator Federal Register
2018-09-17	Results	Results posted: The Plecanatide Irritable Bowel Syndrome With Constipation Study (IBS-C)	Trial register ClinicalTrials.gov
2018-07-24	Trial	New trial registered: Efficacy and Safety of Plecanatide in Children 6 to <18 Years With Irritable Bowel Syndrome With Constipation (IBS-C)	Trial register ClinicalTrials.gov
2018-06-11	Trial	New trial registered: A Postmarketing Study of Plecanatide in Breast Milk of Lactating Women Treated With TRULANCE®	Trial register ClinicalTrials.gov
2017-11-29	Results	Results posted: The Plecanatide Chronic Idiopathic Constipation (CIC) Study	Trial register ClinicalTrials.gov
2017-04-19	Trial	New trial registered: An Efficacy and Safety Study of Plecanatide in Adolescents 12 to <18 Years of Age With Chronic Idiopathic Constipation	Trial register ClinicalTrials.gov
2016-03-11	Trial	New trial registered: Long Term Safety Study of Plecanatide	Trial register ClinicalTrials.gov
2015-07-09	Trial	New trial registered: Second Plecanatide Study In Irritable Bowel Syndrome With Constipation (IBS-C)	Trial register ClinicalTrials.gov
2015-03-13	Trial	New trial registered: The Plecanatide Irritable Bowel Syndrome With Constipation Study (IBS-C)	Trial register ClinicalTrials.gov
2014-04-24	Trial	New trial registered: 12-Week Study of Plecanatide for CIC (The National CIC3 Study)	Trial register ClinicalTrials.gov
2013-11-13	Trial	New trial registered: 12-Week Study of Plecanatide for CIC (The CIC3 Study)	Trial register ClinicalTrials.gov
2013-08-09	Trial	New trial registered: Open-label Extension (OLE) Study of Plecanatide for Chronic Idiopathic Constipation (CIC)	Trial register ClinicalTrials.gov
2012-11-06	Trial	New trial registered: The Plecanatide Irritable Bowel Syndrome With Constipation Study (IBS-C)	Trial register ClinicalTrials.gov
2011-09-07	Trial	New trial registered: The Plecanatide Chronic Idiopathic Constipation (CIC) Study	Trial register ClinicalTrials.gov
2010-01-12	Trial	New trial registered: SP-304 Dose Ranging Study in Patients With Chronic Idiopathic Constipation	Trial register ClinicalTrials.gov

From ClinicalTrials.gov, EU CTIS, FDA labels, recalls, shortages and warning letters, the Federal Register, and regulators' published actions. Not medical advice.

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