| 2026-07-01 | Trial | New trial registered: Postprandial Regulation of Bone Perfusion in Healthy Individuals | Trial register ClinicalTrials.gov |
| 2026-04-01 | Trial | New trial registered: Pancreatic Polypeptide as a Modulator of Amylin- Induced Satiety in Healthy Humans | Trial register ClinicalTrials.gov |
| 2026-03-05 | Results | Results posted: Two Way Crossover Closed Loop Study Insulin vs Insulin and Pramlintide | Trial register ClinicalTrials.gov |
| 2026-01-05 | Trial | New trial registered: Hypersensitivity to Amylin in Post-Traumatic Headache | Trial register ClinicalTrials.gov |
| 2026-01-05 | Trial | New trial registered: Amylin-Induced Migraine Attacks Without Aura | Trial register ClinicalTrials.gov |
| 2025-10-27 | Shortage | FDA shortage status to be discontinued: SymlinPen® 60 , Injection, 1000 ug/1 mL (NDC 0310-6615-02) | Regulator FDA drug shortages |
| 2025-10-27 | Shortage | FDA shortage status to be discontinued: SymlinPen® 120 , Injection, 1000 ug/1 mL (NDC 0310-6627-02) | Regulator FDA drug shortages |
| 2024-10-01 | Trial | New trial registered: Tailoring Obesity Treatment Trial | Trial register ClinicalTrials.gov |
| 2024-05-20 | Trial | New trial registered: Two Way Crossover Closed Loop Study Insulin vs Insulin and Pramlintide | Trial register ClinicalTrials.gov |
| 2024-03-27 | Results | Results posted: Phase 2, Randomized, Open-Label, Crossover, PD/PK Study of a Novel Pram-Insulin Co-Formulation in Adults With T1D | Trial register ClinicalTrials.gov |
| 2023-12-29 | Trial | New trial registered: The Role of Amylin in Bone Metabolism | Trial register ClinicalTrials.gov |
| 2023-09-21 | Trial | New trial registered: A Fully Automated Lyumjev and Pramlintide Delivery System for Adults With Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2022-05-26 | Results | Results posted: Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery | Trial register ClinicalTrials.gov |
| 2022-01-20 | Trial | New trial registered: A Fully-closed Loop, Pramlintide and Insulin, Artificial Pancreas Clinical Trial for Adults With Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2021-07-15 | Trial | New trial registered: Safety and Efficacy of BC LisPram | Trial register ClinicalTrials.gov |
| 2020-10-20 | Results | Results posted: Safety Study of Using Symlin Alongside Insulin in a Multiple Injection Port | Trial register ClinicalTrials.gov |
| 2020-02-05 | Trial | New trial registered: Biological Outcomes of Pramlintide in Resectable Cutaneous Squamous Cell Carcinoma: A Pilot Study | Trial register ClinicalTrials.gov |
| 2020-01-28 | Trial | New trial registered: Co-administration of Pramlintide and Insulin Via an Automated Dual-hormone Artificial Pancreas System in Adults With Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2019-12-18 | Label | FDA label revised: SymlinPen (NDA021332) | Regulator FDA drug label register |
| 2019-11-15 | Trial | New trial registered: Alleviating Carbohydrate Counting for Patients With Type 1 Diabetes Using a Novel Insulin-plus-pramlintide Artificial Pancreas | Trial register ClinicalTrials.gov |
| 2019-08-30 | Trial | New trial registered: Phase 2, Randomized, Open-Label, Crossover, PD/PK Study of a Novel Pram-Insulin Co-Formulation in Adults With T1D | Trial register ClinicalTrials.gov |
| 2019-06-20 | Trial | New trial registered: Pramlintide and Fiasp Closed-Loop With a Simple Meal Announcement | Trial register ClinicalTrials.gov |
| 2019-06-07 | Trial | New trial registered: A Trial to Assess Safety and Efficacy of ADO09 Versus Insulin Aspart in Subjects With Type 1 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2019-04-16 | Trial | New trial registered: A Trial to Assess a Co-formulation of an Insulin Analog and Pramlintide in Subjects With Type 1 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2019-01-11 | Trial | New trial registered: Insulin-plus-pramlintide Closed-loop Strategy to Regulate Glucose Levels Without Carbohydrate Counting | Trial register ClinicalTrials.gov |
| 2018-11-16 | Results | Results posted: Demonstrate the Effects of Pramlintide on Weight Reduction in Schizophrenia | Trial register ClinicalTrials.gov |
| 2018-11-02 | Results | Results posted: Effect of a Fixed Pramlintide: Insulin Dose Ratio on Postprandial Glucose in Type 1 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2018-07-26 | Trial | New trial registered: Amylin and CGRP Head to Head Provocation in Migraine Without Aura Patients | Trial register ClinicalTrials.gov |
| 2018-07-10 | Results | Results posted: Post-meal Insulin Dosing With Adjuvant Pre-meal Pramlintide in Children With Type 1 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2018-06-19 | Trial | New trial registered: Multi-Center Development of a Novel Diagnostic Test for Alzheimer's Disease | Trial register ClinicalTrials.gov |
| 2018-06-06 | Trial | New trial registered: Glucagon Counterregulation in Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2018-04-30 | Trial | New trial registered: A Trial to Investigate Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BioChaperone® Pramlintide Insulin in Patients With Type 1 Diab | Trial register ClinicalTrials.gov |
| 2018-02-08 | Results | Results posted: Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia | Trial register ClinicalTrials.gov |
| 2016-06-27 | Trial | New trial registered: Effect of Basal-Bolus Closed-Loop Co-Administration of Insulin and Pramlintide on Improving the Glycemic Control in Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2015-07-17 | Trial | New trial registered: Effect of a Fixed Pramlintide: Insulin Dose Ratio on Postprandial Glucose in Type 1 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2014-02-28 | Results | Results posted: A Study to Evaluate the Effect on Body Weight of Leptin Administered in Conjunction With Pramlintide in Overweight and Obese Subjects | Trial register ClinicalTrials.gov |
| 2013-12-09 | Results | Results posted: A Study To Examine The Efficacy And Safety Of Pramlintide+Metreleptin In Obese Subjects | Trial register ClinicalTrials.gov |
| 2013-12-05 | Results | Results posted: Extension Study of Protocol DFA102 to Examine the Long-Term Safety, Tolerability, and Effect on Body Weight of Pramlintide Administered in Combination Wit | Trial register ClinicalTrials.gov |
| 2013-11-14 | Results | Results posted: Study to Examine Safety, Tolerability, and Effect on Body Weight of Metreleptin Administered in Conjunction With Pramlintide in Obese and Overweight Subje | Trial register ClinicalTrials.gov |
| 2013-04-26 | Trial | New trial registered: Pramlintide (Symlin) for the Treatment of Hypoglycemia Following Gastric Bypass Surgery | Trial register ClinicalTrials.gov |
| 2013-04-24 | Trial | New trial registered: Phase 2 Study of Adaptive Insulin Meal Supervisor (AIMS) in Adults With Type 1 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2012-10-19 | Results | Results posted: Pramlintide in Adolescents With Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2012-10-16 | Trial | New trial registered: Effect of Different Fixed Pramlintide:Insulin Dose Ratios on Postprandial Glucose in T1DM | Trial register ClinicalTrials.gov |
| 2011-09-15 | Trial | New trial registered: Pramlintide Combined With Model Predictive Control Algorithm | Trial register ClinicalTrials.gov |
| 2011-01-04 | Trial | New trial registered: Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia | Trial register ClinicalTrials.gov |
| 2011-01-04 | Trial | New trial registered: Closed Loop System With Pramlintide Versus Exenatide | Trial register ClinicalTrials.gov |
| 2010-11-08 | Trial | New trial registered: A Study To Examine The Efficacy And Safety Of Pramlintide+Metreleptin In Obese Subjects | Trial register ClinicalTrials.gov |
| 2010-07-20 | Trial | New trial registered: Effectiveness Study of Pramlintide to Treat Post-Transplant Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2010-06-04 | Trial | New trial registered: Efficacy Study of High Dose Symlin to Treat Type 2 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2009-08-03 | Trial | New trial registered: The Effect of Byetta and Symlin on Post-meal Meal Blood Sugar Levels in Children With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2009-06-24 | Results | Results posted: An Observational Study Evaluating SYMLIN® (Pramlintide Acetate) Injection Use in Insulin Using Patients With Type 2 and Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2009-06-04 | Results | Results posted: A Study to Characterize Regimens of Basal Insulin Intensified With Either Symlin® or Rapid Acting Insulin in Patients With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2009-02-12 | Trial | New trial registered: Pramlintide in Adolescents With Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2009-01-08 | Trial | New trial registered: Extension Study of Protocol DFA102 to Examine the Long-Term Safety, Tolerability, and Effect on Body Weight of Pramlintide Administered in Combinati | Trial register ClinicalTrials.gov |
| 2008-11-10 | Trial | New trial registered: Safety Study of Using Symlin Alongside Insulin in a Multiple Injection Port | Trial register ClinicalTrials.gov |
| 2008-08-11 | Trial | New trial registered: Effects of Pramlintide on Endogenous Production of Very-low-density-lipoprotein (VLDL)-Triglyceride and Glucose in the Post Prandial State in T2DM | Trial register ClinicalTrials.gov |
| 2008-06-05 | Trial | New trial registered: A Study of the Functional Magnetic Resonance Imaging Response to Leptin and Pramlintide | Trial register ClinicalTrials.gov |
| 2008-06-04 | Trial | New trial registered: Demonstrate the Effects of Pramlintide on Weight Reduction in Schizophrenia | Trial register ClinicalTrials.gov |
| 2008-05-07 | Trial | New trial registered: Study to Examine Safety, Tolerability, and Effect on Body Weight of Metreleptin Administered in Conjunction With Pramlintide in Obese and Overweight | Trial register ClinicalTrials.gov |
| 2007-07-25 | Trial | New trial registered: Efficacy of Pramlintide on Prevention of Weight Gain Early Onset of Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2007-07-17 | Trial | New trial registered: A Pilot Study of Continuous Subcutaneous Pramlintide Infusion Therapy in Patients With Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2007-06-21 | Trial | New trial registered: Effect of Hyperglycemia on Gastric Emptying Interactions With Pramlintide | Trial register ClinicalTrials.gov |
| 2007-05-01 | Trial | New trial registered: A Study to Characterize Regimens of Basal Insulin Intensified With Either Symlin® or Rapid Acting Insulin in Patients With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2007-04-13 | Trial | New trial registered: The Effect of Pramlintide on Meal Time Insulin Bolus | Trial register ClinicalTrials.gov |
| 2007-03-08 | Trial | New trial registered: Exploratory Study to Evaluate Various Pharmacodynamic Effects of Subcutaneously Infused or Injected Pramlintide in Obese Subjects | Trial register ClinicalTrials.gov |
| 2007-03-02 | Trial | New trial registered: Post-meal Insulin Dosing With Adjuvant Pre-meal Pramlintide in Children With Type 1 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2006-11-22 | Trial | New trial registered: A Study to Examine the Safety, Tolerability, and Body Weight Effect of Pramlintide Alone and in Combination With Oral Antiobesity Agents in Overweig | Trial register ClinicalTrials.gov |
| 2006-10-26 | Trial | New trial registered: A Study to Evaluate the Effect on Body Weight of Leptin Administered in Conjunction With Pramlintide in Overweight and Obese Subjects | Trial register ClinicalTrials.gov |
| 2006-06-16 | Federal Register | Federal Register notice: Determination of Regulatory Review Period for Purposes of Patent Extension; SYMLIN | Regulator Federal Register |
| 2006-04-12 | Trial | New trial registered: A Study to Evaluate Symlin in Adolescent Subjects With Type 1 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2006-02-15 | Trial | New trial registered: Continuous Subcutaneous Infusion of Pramlintide and Insulin | Trial register ClinicalTrials.gov |
| 2005-10-18 | Trial | New trial registered: A Study Evaluating the Efficacy and Safety of Adding Symlin® to Lantus® (Insulin Glargine) in Subjects With Type 2 Diabetes | Trial register ClinicalTrials.gov |
| 2005-09-30 | Trial | New trial registered: An Observational Study Evaluating SYMLIN® (Pramlintide Acetate) Injection Use in Insulin Using Patients With Type 2 and Type 1 Diabetes | Trial register ClinicalTrials.gov |
| 2005-09-21 | Trial | New trial registered: The Role of Amylin and Glucagon in T1DM | Trial register ClinicalTrials.gov |
| 2005-09-21 | Trial | New trial registered: The Effect of Prolonged Pramlintide Infusion in Pediatric Diabetes | Trial register ClinicalTrials.gov |
| 2005-09-19 | Trial | New trial registered: A Study to Examine the Long Term Effect of Pramlintide on Body Weight and Its Safety and Tolerability in Obese Subjects | Trial register ClinicalTrials.gov |
| 2005-05-30 | Trial | New trial registered: A Study to Examine the Effect of Pramlintide on Body Weight and Its Safety and Tolerability in Obese Subjects | Trial register ClinicalTrials.gov |
| 2005-04-13 | Trial | New trial registered: Clinical Utility and Safety of Pramlintide in Subjects With Type 1 and Type 2 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2005-04-06 | Trial | New trial registered: Study of the Long-Term Safety of Pramlintide in Subjects With Type 1 Diabetes Mellitus | Trial register ClinicalTrials.gov |
| 2002-09-05 | Trial | New trial registered: Evaluation of an Orally Administered Medication When Taken in Conjunction With Pramlintide | Trial register ClinicalTrials.gov |
| 2002-08-05 | Trial | New trial registered: Evaluation of the Effect of Pramlintide on Satiety and Food Intake | Trial register ClinicalTrials.gov |
| 2002-08-01 | Trial | New trial registered: Evaluation of Dose-titration of Pramlintide During Initiation of Therapy in Patients Trying to Improve Glucose Control | Trial register ClinicalTrials.gov |
| 2002-08-01 | Trial | New trial registered: Evaluation of the Bioavailability of Pramlintide | Trial register ClinicalTrials.gov |
| 2001-06-08 | Federal Register | Federal Register notice: Endocrinologic and Metabolic Drugs Advisory Committe; Notice of Meeting | Regulator Federal Register |