synthetic tetrapeptide
SS-31 (elamipretide) clinical trials
Answer
SS-31 (elamipretide) has 30 registered trials: 3 running, 22 completed, 4 stopped early. 14 posted results.
Trial registerClinicalTrials.gov, read 2026-08-31
| Trial | Title | Status | Phase | Registered | Results |
|---|---|---|---|---|---|
| NCT07531251 Trial register | Clinical Trial in Patients With Barth Syndrome- 4TAZPower | currently recruiting participants | - | 2026-03-12 | - |
| NCT06373731 Trial register | ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects With Dry Age-Related Macular Degeneration (Dry | running, but no longer enrolling | - | 2024-04-16 | - |
| NCT05168774 Trial register | FRDA Investigator Initiated Study (IIS) With Elamipretide | completed | - | 2021-12-09 | Posted |
| NCT07275424 Trial register | Study of Healthy Aging and Physical Function With Elamipretide | currently recruiting participants | - | 2025-10-15 | - |
| NCT05162768 Trial register | Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD) | completed | - | 2021-12-08 | - |
| NCT04689360 Trial register | An Intermediate Size Expanded Access Protocol of Elamipretide | available | - | 2020-12-23 | - |
| NCT03891875 Trial register | ReCLAIM-2 Study to Evaluate Safety,Efficacy & Pharmacokinetics of Elamipretide in Subjects With AMD With Non-central GA | completed | - | 2019-03-25 | Posted |
| NCT03098797 Trial register | A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth Syndrome | completed | - | 2017-03-21 | Posted |
| NCT03323749 Trial register | A Trial to Evaluate Safety and Efficacy of Elamipretide Primary Mitochondrial Myopathy Followed by Open-Label Extension | terminated before completion | - | 2017-10-12 | Posted |
| NCT02976038 Trial register | Open-Label Extension Trial to Characterize the Long-term Safety and Tolerability of Elamipretide in Subjects With Genetically Confirmed Primary Mitochondrial My | terminated before completion | - | 2016-11-18 | Posted |
| NCT02693119 Trial register | A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for Treatment of Leber's Hereditary Optic Neuropathy | completed | - | 2016-02-15 | Posted |
| NCT02653391 Trial register | A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrop | completed | - | 2015-12-20 | Posted |
| NCT02848313 Trial register | An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects With Intermediate Age-Related Macular Deg | completed | - | 2016-07-25 | Posted |
| NCT01755858 Trial register | Effects of Intravenous Bendavia™ on Reperfusion Injury in Patients Undergoing Angioplasty of the Renal Artery | terminated before completion | - | 2012-12-19 | Posted |
| NCT02914665 Trial register | A Phase 2 Study to Evaluate the Cardiac and Renal Effects of Short Term Treatment With Elamipretide in Patients Hospitalized With Congestion Due to Heart Failur | completed | - | 2016-09-14 | - |
| NCT02805790 Trial register | Safety, Tolerability, Efficacy of MTP-131 for Treatment of Mitochondrial Disease in Subjects From the MMPOWER Study | completed | - | 2016-06-13 | Posted |
| NCT02245620 Trial register | A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendavia™) on Skeletal Muscle Function in Elderly | completed | - | 2014-09-17 | Posted |
| NCT01572909 Trial register | Evaluation of Myocardial Effects of MTP-131 for Reducing Reperfusion Injury in Patients With Acute Coronary Events | completed | - | 2012-03-28 | Posted |
| NCT02788747 Trial register | Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection Fraction | completed | - | 2016-05-27 | Posted |
| NCT02367014 Trial register | Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial Myopathy | completed | - | 2015-02-09 | Posted |
| NCT02814097 Trial register | A Study to Evaluate the Effects of 4 Weeks Treatment With Subcutaneous Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Pres | completed | - | 2016-06-08 | - |
| NCT02436447 Trial register | A Phase 1 Study Investigating the Safety and Pharmacokinetics of Repeat-dose Intravenous Infusion of MTP-131 in Subjects With Impaired Renal Function | completed | - | 2015-04-30 | - |
| NCT02314299 Trial register | A Study of MTP-131 Topical Ophthalmic Solution in Subjects With Diabetic Macular Edema and Non-Exudative Intermediate Age-related Macular Degeneration | completed | - | 2014-12-02 | - |
| NCT02388529 Trial register | A Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of Bendavia™ (MTP-131) in Patients With Heart Failure | withdrawn before enrolling anyone | - | 2015-03-01 | - |
| NCT02388464 Trial register | A Study Investigating the Safety, Tolerability, and Pharmacokinetics of MTP-131 in Subjects With Congestive Heart Failure | completed | - | 2015-03-01 | - |
| NCT01786915 Trial register | Safety and Pharmacokinetic (PK) Study of Oral Bendavia Administered for 7 Days | completed | - | 2013-02-06 | - |
| NCT01754818 Trial register | A Phase 1 Study Examining the Pharmacokinetics and Tolerability of a Single Oral Dose of Bendavia (MTP-131) | completed | - | 2012-12-18 | - |
| NCT01513200 Trial register | Study to Assess the Pharmacodynamic Effects of Unfractionated Heparin (UFH) in Healthy Volunteers With and Without Bendavia | completed | - | 2012-01-06 | - |
| NCT01518985 Trial register | The Impact of Intravenous Bendavia™ on Endothelial Reactivity Dysfunction in Cigarette Smoking | completed | - | 2012-01-23 | - |
| NCT01115920 Trial register | Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of Intravenous (IV) Infusion of MTP-131 (Bendavia™) in Healthy Adults | completed | - | 2010-04-30 | - |
Source: ClinicalTrials.gov, read 2026-08-31. Not medical advice.
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