GLP-1 receptor agonist
Semaglutide dose
Answer
FDA label for Ozempic: Recommended dosage is 2 mg once weekly. Half-life on the label: approximately 1 week. Trials with posted results tested 25 doses, most often 1 mg, 2.4 mg, 14 mg.
Not dosing advice.
FDA LABEL
What the approved labels state
Ozempic NDA209637 · label of 2026-07-30 Regulator
Recommended dosage is 2 mg once weekly.
The maximum recommended dosage is 2 mg once weekly.
Half-life: approximately 1 week (section 12.3).
WEGOVY NDA215256 · label of 2024-04-23 Regulator
Half-life: approximately 1 week (section 12.3).
IN TRIALS
Doses tested in 109 trials with posted results
| Dose in the arm title | Trials | People on it | Phases |
|---|---|---|---|
| 1 mg | 18 | 4,507 | 1/2/3 |
| 2.4 mg | 18 | 3,648 | 2/3/4 |
| 14 mg | 12 | 3,306 | 3 |
| 0.5 mg | 8 | 2,378 | 3 |
| 7 mg | 8 | 1,915 | 3 |
| 3 mg | 7 | 1,496 | 3 |
| 7.2 mg | 2 | 1,311 | 3 |
| 50 mg | 3 | 1,002 | 3 |
| 25 mg | 2 | 738 | 3 |
| 2 mg | 2 | 539 | 2/3 |
| 0.4 mg | 3 | 334 | 2 |
| 0.1 mg | 4 | 292 | 2 |
| 0.2 mg | 4 | 289 | 2 |
| 0.3 mg | 2 | 268 | 2 |
| 40 mg | 1 | 211 | 2 |
| 0.05 mg | 2 | 167 | 2 |
| 1.7 mg | 1 | 100 | 3 |
| 0.8 mg | 1 | 85 | 2 |
| 2.5 mg | 1 | 70 | 2 |
| 20 mg | 1 | 70 | 2 |
| 5 mg | 1 | 70 | 2 |
| 10 mg | 1 | 69 | 2 |
| 16 mg | 1 | 62 | 2 |
| 8 mg | 1 | 60 | 2 |
| 1.6 mg | 1 | 47 | 2 |
Trial register Read from the titles of arms that received Semaglutide (n ≥ 20). An arm naming several doses counts under each; a schedule or escalation is on the trial record. All trials.
WEEKLY
Register Watch, weekly
New trials, approvals and enforcement actions. One email a week.