GLP-1 receptor agonist
Semaglutide clinical trials
Answer
Semaglutide has 861 registered trials: 348 running, 347 completed, 24 stopped early. 109 posted results.
Trial registerClinicalTrials.gov and EU CTIS, read 2026-10-03
| Trial | Title | Status | Phase | Registered | Results |
|---|---|---|---|---|---|
| NCT06856291 Trial register | Response to Semaglutide in Non-diabetic Obese Patients With Varying Degrees of Insulin Resistance | completed | - | 2025-03-04 | - |
| NCT06977438 Trial register | GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward | not yet recruiting participants | - | 2025-05-18 | - |
| NCT07855133 Trial register | A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From | not yet recruiting participants | 1 | 2026-10-02 | - |
| 2022-502922-41-00 Trial register | Long-term safety and efficacy of semaglutide s.c. once-weekly on weight management in children and adolescents (aged 6 to <18 years) with obesity or overweight | Not stated | 3 | - | - |
| NCT05254314 Trial register | Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3) | running, but no longer enrolling | - | 2022-02-24 | - |
| NCT06184633 Trial register | DUTCH Weight Control in Atrial Fibrillation Study | running, but no longer enrolling | - | 2023-12-28 | - |
| NCT07112872 Trial register | A Study to Compare Different Doses of RO7795081 With Placebo or Semaglutide in People With Type 2 Diabetes | running, but no longer enrolling | - | 2025-08-08 | - |
| NCT07249554 Trial register | Combination Therapy for Alcohol Use Disorder | not yet recruiting participants | - | 2025-11-25 | - |
| NCT07820358 Trial register | Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer | not yet recruiting participants | 2 | 2026-09-15 | - |
| 2026-527373-11-00 Trial register | SEMAGONA: A randomized four-arm parallel group double-blind double dummy 52-week clinical trial comparing the effects of s.c. Semaglutide 2.4 mg once-weekly, i. | Not stated | 2 | - | - |
| NCT03596450 Trial register | Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized P | completed | - | 2018-07-23 | Posted |
| NCT05567796 Trial register | A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight | running, but no longer enrolling | - | 2022-10-05 | - |
| NCT06323174 Trial register | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Diet and Exercise | completed | - | 2024-03-21 | - |
| NCT06854614 Trial register | Sequential Therapy Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial) | running, but no longer enrolling | 4 | 2025-03-03 | - |
| NCT07011667 Trial register | A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term | running, but no longer enrolling | - | 2025-06-09 | - |
| NCT07253285 Trial register | A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight | currently recruiting participants | - | 2025-11-28 | - |
| NCT07280221 Trial register | WEgovy Real World Assessment of Weight Loss in Korea | enrolling by invitation only | - | 2025-12-12 | - |
| NCT07564414 Trial register | A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Los | currently recruiting participants | - | 2026-05-04 | - |
| NCT07817251 Trial register | Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema | currently recruiting participants | 3 | 2026-09-14 | - |
| NCT07849348 Trial register | Study on the Efficacy and Safety of Initial Combination of Finerenone and Semaglutide in Non-Diabetic Adult Patients With Obesity Complicated by Chronic Kidney | not yet recruiting participants | - | 2026-09-30 | - |
| NCT07850765 Trial register | Real-World Patient and Physician Experience With Semaglutide Across Six Emerging Markets | completed | - | 2026-09-30 | - |
| 2023-506827-26-00 Trial register | Long-term effects of semaglutide on diabetic retinopathy in subjects with type 2 diabetes (FOCUS) | Not stated | 3 | - | - |
| NCT05305794 Trial register | Effect of Weekly GLP1 Agonist Treatment in "Double Diabetes" | currently recruiting participants | - | 2022-03-31 | - |
| NCT06771115 Trial register | Phase 2a Placebo-Controlled Study of VTX3232 Alone or in Combination With Semaglutide in Obesity | completed | - | 2025-01-13 | Posted |
| NCT07171723 Trial register | Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment | completed | - | 2025-09-12 | - |
| NCT07724340 Trial register | A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweigh | running, but no longer enrolling | - | 2026-07-24 | - |
| NCT07845500 Trial register | A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity | not yet recruiting participants | 3 | 2026-09-29 | - |
| NCT07845578 Trial register | A Research Study Looking Into How a High Dose of s.c. Semaglutide Works With Emptying of the Stomach in People With Excess Body Weight | not yet recruiting participants | 1 | 2026-09-29 | - |
| NCT07845994 Trial register | SEMAFORCRANIO : Multicenter, Double-blind, Parallel, Randomized Controlled Trial of the Efficacy of Semaglutide in Hypothalamic Obesity Secondary to Craniophary | not yet recruiting participants | 3 | 2026-09-29 | - |
| NCT06260722 Trial register | Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 | running, but no longer enrolling | 3 | 2024-02-15 | - |
| NCT07668414 Trial register | A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide | currently recruiting participants | - | 2026-06-25 | - |
| NCT07797036 Trial register | Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes Mellitus | not yet recruiting participants | 2 | 2026-09-01 | - |
| NCT07819227 Trial register | Optimizing Albuminuria Treatment in CKD With Finerenone and Semaglutide | completed | 2 | 2026-09-14 | - |
| NCT06738979 Trial register | A Clinical Study Comparing Semaglutide Injection and Wegovy® for Weight Management in Obese Subjects | completed | - | 2024-12-18 | - |
| NCT07254715 Trial register | Effect of Itopride on Semaglutide Gastroparesis | completed | - | 2025-11-28 | - |
| NCT07840729 Trial register | Evaluate the Safety and Tolerability of Multiple Doses of JMT206 Injection in Obese Participants | not yet recruiting participants | 1 | 2026-09-25 | - |
| NCT06131372 Trial register | A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema | completed | - | 2023-11-14 | - |
| NCT07511543 Trial register | Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy | not yet recruiting participants | - | 2026-04-06 | - |
| 2024-514906-30-00 Trial register | TOLEDDO: Effect of weekly GLP1 agonist treatment in "double diabetes": a randomized, open-label study | Not stated | 3 | - | - |
| NCT07651319 Trial register | Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease | currently recruiting participants | - | 2026-06-16 | - |
| NCT07836140 Trial register | A Study Comparing the Effects of BGM0504 Injection and Semaglutide Injection on Obese Subjects. | completed | 2 | 2026-09-23 | - |
| 2023-506289-29-00 Trial register | eHealth Based treatment of AdolescenT obesiTy with Low energy diet and sEmaglutide (eBATTLE Obesity) | Not stated | 4 | - | - |
| 2024-513168-24-00 Trial register | A randomised, controlled, parallel group, open-label trial evaluating the impact of treatment with the GLP-1 analogue semaglutide on weight loss in people livin | Not stated | 2 | - | - |
| NCT06050577 Trial register | The Effect of Oral Semaglutide on Bone Turnover in Patients With T2D: a Randomized Placebo-controlled Clinical Trial | running, but no longer enrolling | - | 2023-09-22 | - |
| NCT06173778 Trial register | Semaglutide for Post-Smoking Cessation Weight Management | currently recruiting participants | - | 2023-12-18 | - |
| NCT07163624 Trial register | UBT251 Injection Phase II (Type 2 Diabetes Mellitus) Study | completed | - | 2025-09-09 | - |
| NCT07218354 Trial register | Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized Controlled Trial for Alcohol Use Disorder (CRAVE) | currently recruiting participants | - | 2025-10-20 | - |
| NCT07390110 Trial register | Comparative Effectiveness of Oral Semaglutide vs Sitagliptin Among Individuals With Heart Failure With Preserved Ejection Fraction (STEP-HFpEF DM ORAL) | completed | - | 2026-02-05 | - |
| NCT05714683 Trial register | Regulatory Post Marketing Surveillance (rPMS) Study of Rybelsus (Oral Semaglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitu | not yet recruiting participants | - | 2023-02-06 | - |
| NCT06779929 Trial register | Comparative Study of Tirzepatide Versus Dulaglutide (SURPASS CVOT) or Semaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes | completed | - | 2025-01-17 | - |
| NCT07169136 Trial register | Effects of Glucagon-like Peptide-1 (GLP-1) Agonist in Neuro-reproductive Function in Obese Adolescent Females With Polycystic Ovary Syndrome (PCOS) | currently recruiting participants | - | 2025-09-11 | - |
| NCT07423481 Trial register | Weight Trajectories and Predictive Factors After Semaglutide in Patients With Grade 3 and Complicated Obesity | not yet recruiting participants | - | 2026-02-20 | - |
| NCT07627191 Trial register | GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular Cancer | currently recruiting participants | - | 2026-06-04 | - |
| NCT07220629 Trial register | Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2) | completed | - | 2025-10-24 | - |
| NCT06913023 Trial register | Semaglutide for the Prevention Of Post-Transplant Diabetes Mellitus | not yet recruiting participants | - | 2025-04-06 | - |
| NCT07639021 Trial register | A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity | running, but no longer enrolling | - | 2026-06-10 | - |
| NCT05569772 Trial register | Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational Diabetes | currently recruiting participants | - | 2022-10-06 | - |
| NCT06045221 Trial register | A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin | completed | - | 2023-09-21 | Posted |
| NCT07820111 Trial register | Comparative Study of Different Weekly GLP-1 Receptor Agonists Among Diabetic and Non-Diabetic Patients: Clinical Trial | completed | 3 | 2026-09-15 | - |
| NCT06897475 Trial register | A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide | currently recruiting participants | 2 | 2025-03-27 | - |
| NCT06908694 Trial register | Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy | running, but no longer enrolling | - | 2025-04-03 | - |
| NCT07653477 Trial register | Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGU | currently recruiting participants | - | 2026-06-17 | - |
| NCT07415954 Trial register | A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes | currently recruiting participants | - | 2026-02-17 | - |
| NCT07668388 Trial register | A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes | currently recruiting participants | - | 2026-06-25 | - |
| NCT06691243 Trial register | Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV | running, but no longer enrolling | - | 2024-11-15 | - |
| NCT06797869 Trial register | A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy | completed | - | 2025-01-29 | - |
| NCT06836284 Trial register | The Evira Study: Additional Support During Obesity Treatment | currently recruiting participants | - | 2025-02-20 | - |
| NCT07010432 Trial register | The Role of the Amylin Analogue Cagrilintide in Bone Metabolism | currently recruiting participants | - | 2025-06-08 | - |
| NCT07184086 Trial register | A Study to See How Metabolism is Influenced by Weight Loss Due to Intervention With Cagrilintide and Semaglutide Compared to Diet | running, but no longer enrolling | - | 2025-09-19 | - |
| NCT07223983 Trial register | Semaglutide (SEMA) for Alcohol Use Disorder (AUD) After Metabolic and Bariatric Surgery (MBS) | running, but no longer enrolling | - | 2025-11-03 | - |
| NCT07812597 Trial register | A Study Evaluating Safety and Tolerability of Switching From Semaglutide to Zovaglutide in Adults With Obesity (HORIZON-SWITCH-SZ) | not yet recruiting participants | 2 | 2026-09-10 | - |
| 2026-526951-79-00 Trial register | A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Efficacy and Safety of Semaglutide Subcutaneous Depot (CAM2056) in People with Obes | Not stated | 2 | - | - |
| NCT03811561 Trial register | A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes | running, but no longer enrolling | - | 2019-01-22 | - |
| NCT05202353 Trial register | A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver | running, but no longer enrolling | - | 2022-01-21 | - |
| NCT05726227 Trial register | A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight | running, but no longer enrolling | - | 2023-02-13 | - |
| NCT06323161 Trial register | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Once-daily Basal I | completed | - | 2024-03-21 | - |
| NCT06534411 Trial register | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGL | completed | 3 | 2024-08-02 | - |
| NCT07282613 Trial register | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes | currently recruiting participants | - | 2025-12-15 | - |
| NCT07662213 Trial register | A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat | currently recruiting participants | - | 2026-06-23 | - |
| NCT07770841 Trial register | Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight | currently recruiting participants | - | 2026-08-18 | - |
| NCT07801820 Trial register | Phase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes Mellitus | currently recruiting participants | 2 | 2026-09-03 | - |
| 2023-506924-94-00 Trial register | The cardiovascular safety and efficacy of cagrilintide 2.4 mg s.c. in combination with semaglutide 2.4 mg s.c. (CagriSema 2.4 mg/2.4 mg s.c.) once-weekly in par | Not stated | 3 | - | - |
| 2023-509176-42-00 Trial register | Efficacy, safety and pharmacokinetics of cagrilintide s.c. 2.4 mg as monotherapy and in combination with semaglutide s.c. 2.4 mg (CagriSema) once weekly for wei | Not stated | 3 | - | - |
| 2025-523414-89-00 Trial register | Effects of semaglutide as add-on therapy to sulfonylurea on plasma glucose in individuals with HNF1A- and HNF4A-MODY - A Steno MODERN-MODY project (MM-SEMA) | Not stated | 2 | - | - |
| 2026-527538-29-00 Trial register | SemenGlutide: A randomized double-blinded, placebo-controlled, single-center, clinical trial comparing the effects of s.c. Semaglutide 2.4 mg once-weekly versus | Not stated | 2 | - | - |
| NCT07059377 Trial register | Semaglutide for Smoking Cessation in Patients With Diabetes | currently recruiting participants | - | 2025-07-10 | - |
| 2026-526083-20-00 Trial register | A research study looking into how a high dose of s.c. semaglutide works with emptying of the stomach in people with excess body weight | Not stated | 1 | - | - |
| NCT04822181 Trial register | Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) | running, but no longer enrolling | - | 2021-03-30 | - |
| NCT06221969 Trial register | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With | completed | 3 | 2024-01-24 | - |
| NCT06851962 Trial register | Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes. | completed | - | 2025-02-28 | - |
| NCT07446998 Trial register | Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss | running, but no longer enrolling | - | 2026-03-03 | - |
| NCT07627074 Trial register | Weight Loss in Adults Using Semaglutide (Real-world Study) | completed | - | 2026-06-04 | - |
| NCT07745504 Trial register | A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight | currently recruiting participants | - | 2026-08-04 | - |
| NCT07767175 Trial register | A First-in-human Research Study on How NNC0721-8060 Works in People Living With Overweight or Obesity | currently recruiting participants | - | 2026-08-17 | - |
| 2023-503753-35-01 Trial register | FIT-HF - Effect of weight loss on physical and cardiac performance in patients with heart failure and obesity | Not stated | 2 | - | - |
| NCT06803888 Trial register | Bariatric Surgery vs. Semaglutide vs. Tirzepatide | running, but no longer enrolling | 4 | 2025-01-31 | - |
| 2026-525465-42-00 Trial register | Efficacy and safety of once-weekly subcutaneous UBT251 in participants with type 2 diabetes - a dose-finding study | Not stated | 2 | - | - |
| NCT06015893 Trial register | Semaglutide Therapy for Alcohol Reduction (STAR) | running, but no longer enrolling | - | 2023-08-29 | - |
| NCT06762314 Trial register | Efficacy and Safety of Empagliflozin or Semaglutide in Overweight/Obese Patients With Type 1 Diabetes | completed | - | 2025-01-07 | - |
| NCT06934655 Trial register | Early Reinitiation of Semaglutide Post-Sleeve Gastrectomy in Youth | currently recruiting participants | - | 2025-04-18 | - |
| NCT06299098 Trial register | A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weig | running, but no longer enrolling | - | 2024-03-07 | - |
| NCT07284979 Trial register | Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes | currently recruiting participants | - | 2025-12-16 | - |
| NCT07677995 Trial register | Free Fatty Acid Effects In Type 2 Diabetes | enrolling by invitation only | - | 2026-07-01 | - |
| NCT05669755 Trial register | REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels | running, but no longer enrolling | - | 2023-01-03 | - |
| NCT05819853 Trial register | Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome | currently recruiting participants | - | 2023-04-19 | - |
| NCT06401746 Trial register | Body Surface Gastric Mapping in Patients on Semaglutide | completed | - | 2024-05-07 | Posted |
| NCT06716307 Trial register | A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Single Doses of Different Versions of Injectable CagriSema in Adults With Overwei | completed | - | 2024-12-04 | - |
| NCT06548490 Trial register | GLP-1R Agonist Treatment for Opioid Use Disorder | currently recruiting participants | - | 2024-08-12 | - |
| NCT07760948 Trial register | HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide | not yet recruiting participants | - | 2026-08-12 | - |
| 2023-504159-29-01 Trial register | Safety and efficacy of oral semaglutide in hyperglycaemic patients after renal transplantation | Not stated | 2 | - | - |
| NCT07787936 Trial register | GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry | not yet recruiting participants | - | 2026-08-18 | - |
| 2024-520446-31-00 Trial register | Efficacy and safety of NNC0487-0111 s.c. once-weekly compared to semaglutide s.c. once-weekly in participants with overweight or obesity, and type 2 diabetes (A | Not stated | 3 | - | - |
| NCT07783854 Trial register | A Randomized Controlled Study of Dose-tapering Regimen of Semaglutide for Weight-Loss Maintenance in Adults With Overweight or Obesity | not yet recruiting participants | - | 2026-08-25 | - |
| NCT07781371 Trial register | A Retrospective Real-World Cohort Study | not yet recruiting participants | - | 2026-08-19 | - |
| 2025-523260-20-00 Trial register | Protocol Title: Efficacy and safety of once-weekly subcutaneous NNC0662-0419 in participants with type 2 diabetes - a dose-finding study | Not stated | 2 | - | - |
| NCT04596631 Trial register | A Research Study to Compare a New Medicine Oral Semaglutide to a Dummy Medicine in Children and Teenagers With Type 2 Diabetes | completed | - | 2020-10-22 | Posted |
| NCT07779343 Trial register | OBESIAL: A Prospective Interventional Real-world Study of a Multidisciplinary Obesity Management Programme | currently recruiting participants | - | 2026-08-21 | - |
| 2024-518682-95-00 Trial register | SIGNAL - Body fluid proteome SIGnatures for persoNALised intervention to prevent cardiovascular and renal complications in diabetes | Not stated | 4 | - | - |
| NCT07485062 Trial register | Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes | not yet recruiting participants | - | 2026-03-20 | - |
| NCT07563699 Trial register | Safety, Tolerability and Efficacy of Semaglutide Depot in Subjects With Type-2 Diabetes Mellitus | currently recruiting participants | - | 2026-05-04 | - |
| NCT06546384 Trial register | GLP-1 RA on Alcohol Consumption, Metabolism and Liver Parameters in Patients With Obesity and Fatty Liver Disease | not yet recruiting participants | - | 2024-08-09 | - |
| NCT06807970 Trial register | Optimization of Obesity for Total Knee Replacement With Glucagon-like Peptide-1 Receptor Agonist | running, but no longer enrolling | - | 2025-02-04 | - |
| NCT07213323 Trial register | Probiotic Intervention for Digestive Health in Obese Patients Initiating GLP-RA Treatment | currently recruiting participants | NA | 2025-09-18 | - |
| NCT07772960 Trial register | Semaglutide Dose Effects on Metabolic and Stress Hormone, Craving and Alcohol Use Outcomes | not yet recruiting participants | - | 2026-08-19 | - |
| 2025-523511-11-00 Trial register | A Phase 3, Randomized, Active- and Placebo-Controlled, Partially-Blinded Study to Compare the Efficacy and Safety of KAI-9531 Administered Once Weekly Versus Se | Not stated | 3 | - | - |
| 2026-526016-36-00 Trial register | A neuropsychobiological approach to optimize patient selection for GLP-1-based pharmacotherapy for weight management across the binge eating spectrum | Not stated | 4 | - | - |
| NCT05891496 Trial register | A Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease | completed | - | 2023-06-07 | Posted |
| NCT07770152 Trial register | Semaglutide in Youth With Autism Spectrum Disorder | not yet recruiting participants | - | 2026-08-18 | - |
| NCT07770282 Trial register | Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome | not yet recruiting participants | - | 2026-08-18 | - |
| NCT07202247 Trial register | Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients Du | currently recruiting participants | 2 | 2025-10-01 | - |
| NCT07769047 Trial register | Semaglutide and Structured Lifestyle Support to Improve Heart and Blood Vessel Health in Postmenopausal Obese Breast Cancer Survivors Taking Aromatase Inhibitor | not yet recruiting participants | - | 2026-08-17 | - |
| NCT05132088 Trial register | Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in East Asian People Who Are Overweight or Living With Obesity | completed | - | 2021-11-24 | Posted |
| NCT05371496 Trial register | Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction | completed | - | 2022-05-12 | - |
| 2023-506962-30-00 Trial register | The effect of semaglutide in subjects with non-cirrhotic non-alcoholic steatohepatitis | Not stated | 3 | - | - |
| 2025-524626-18-00 Trial register | Efficacy and safety of once daily oral semaglutide in adults with overweight or obesity | Not stated | 3 | - | - |
| NCT05220917 Trial register | Comparative Effectiveness and Safety of Four Second Line Pharmacological Strategies in Type 2 Diabetes Study | running, but no longer enrolling | - | 2021-12-22 | - |
| NCT06269120 Trial register | SEMA-CardioDiab HUNGARY: A Research Study to Understand the Effects of Oral Semaglutide on Blood Sugar Levels, Weight, and Cardiovascular Risk in People With Ty | completed | - | 2024-02-21 | - |
| NCT07087795 Trial register | A Study to See the Effect of NNC0194-0499 Alone or in Combination With Semaglutide on Blood Sugar Control in People Living With Type 1 Diabetes | running, but no longer enrolling | - | 2025-07-28 | - |
| NCT07271251 Trial register | A Research Study to See if Two Different Formulations of Oral Semaglutide Are Equally Safe and Effective in Reducing the Blood Sugar Level in Japanese People Wi | completed | - | 2025-12-09 | - |
| NCT05040087 Trial register | Changing the Natural History of Type 2 Diabetes ("CHANGE" Study) | running, but no longer enrolling | - | 2021-08-27 | - |
| NCT07760532 Trial register | Comparing Facial Aging Between Identical Twins With 3D Imaging | not yet recruiting participants | - | 2026-08-07 | - |
| NCT07178145 Trial register | Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction | currently recruiting participants | - | 2025-07-23 | - |
| NCT07728669 Trial register | Digital Dietary Intervention for Patients Receiving GLP-1 Receptor Agonist Therapy | currently recruiting participants | - | 2026-07-22 | - |
| NCT03884075 Trial register | Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES) | currently recruiting participants | - | 2019-03-21 | - |
| NCT05035082 Trial register | A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE) | completed | - | 2021-09-05 | Posted |
| NCT07275697 Trial register | Waiting on Atrial Fibrillation Intervention Therapy (WAIT) Study | currently recruiting participants | - | 2025-12-10 | - |
| NCT07466017 Trial register | A Study of CS060380 Tablets in Patients With MASH and Obesity | running, but no longer enrolling | - | 2026-03-12 | - |
| NCT07754045 Trial register | Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults | not yet recruiting participants | - | 2026-08-10 | - |
| NCT07755085 Trial register | GLP-1s in Hip and Knee Arthroplasty | not yet recruiting participants | - | 2026-08-03 | - |
| 2025-523933-24-00 Trial register | A Randomized, Open-label, Parallel-group Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Elecoglipron Compared with Oral Semaglutide in Ad | Not stated | 3 | - | - |
| NCT05984238 Trial register | A Trial to Evaluate Safety, Feasibility and Efficacy of Endoscopic Duodenal PEF Therapy | completed | - | 2023-08-09 | - |
| 2025-522488-14-00 Trial register | A clinical study to compare efficacy and safety of two different doses of CagriSema and semaglutide in participants with obesity with or without type 2 diabetes | Not stated | 3 | - | - |
| NCT06411210 Trial register | Obesity Complicating Type 1 Diabetes: GLP-1 Analogue Anti-obesity Treatment | currently recruiting participants | - | 2024-05-13 | - |
| NCT06715514 Trial register | Menopausal Hormone Therapy, GLP-1 Agonists, and Glucose and Energy Homeostasis in Postmenopausal Women With Diabetes | running, but no longer enrolling | - | 2024-11-28 | - |
| NCT07055607 Trial register | A Two-year Prospective, Observational Study of Wegovy in Real-world Clinical Practice | enrolling by invitation only | - | 2025-07-09 | - |
| NCT07743983 Trial register | A Study of BGM0504 in Early T2DM With Obesity | currently recruiting participants | - | 2026-08-04 | - |
| 2023-509600-15-00 Trial register | Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) 1.0 mg/1.0 mg s.c. once weekly versus tirzepatide 5 mg s.c. once weekly in parti | Not stated | 3 | - | - |
| NCT05548647 Trial register | Semaglutide Treatment, Appetite, and Eating Behavior: Long-term Effects | completed | - | 2022-09-21 | Posted |
| NCT07428746 Trial register | Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes | currently recruiting participants | - | 2026-02-24 | - |
| NCT06374875 Trial register | Fibrosis Lessens After Metabolic Surgery | currently recruiting participants | 4 | 2024-04-16 | - |
| NCT07478653 Trial register | MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease | not yet recruiting participants | - | 2026-03-12 | - |
| NCT07673900 Trial register | Semaglutide Delivered Epi-Intradermally by Microarray Patch (VX-201) Versus Subcutaneous Administration in Healthy Overweight and Obese Participants | currently recruiting participants | - | 2026-06-29 | - |
| NCT07740291 Trial register | Tirzepatide Impact Assessment Study | currently recruiting participants | NA | 2026-07-31 | - |
| NCT06649344 Trial register | A Study of HRS9531 Versus Semaglutide Once Weekly as Add-on Therapy to Metformin Monotherapy or in Combination With SGLT2 Inhibitors in Participants With Type 2 | completed | - | 2024-10-18 | - |
| NCT07737522 Trial register | Myocardial Metabolic Flux in Pulmonary Arterial Hypertension | not yet recruiting participants | - | 2026-07-27 | - |
| NCT07732738 Trial register | Bariatric Surgery Combined With GLP-1RA: A Multicenter Study. | currently recruiting participants | - | 2026-07-19 | - |
| NCT07731256 Trial register | Semaglutide for Low Back Pain | not yet recruiting participants | - | 2026-07-28 | - |
| NCT07732218 Trial register | Efficacy of Once Weekly Semaglutide in Patients With Type 2 Diabetes: a Non Randomized Clinical Trial | completed | - | 2026-07-28 | - |
| NCT07732426 Trial register | Effects of Semaglutide on Brain Dopamine Responses to Food Cues in Adults With Obesity and Food Addiction Tendencies | currently recruiting participants | - | 2026-07-28 | - |
| 2022-501392-81-00 Trial register | DUTCH Weight Control in Atrial Fibrillation Study | Not stated | 4 | - | - |
| 2024-519533-38-00 Trial register | A study to see the effect of NNC0194-0499 alone or in combination with semaglutide on blood sugar control in people living with type 1 diabetes. | Not stated | 1 | - | - |
| NCT05071898 Trial register | Pharmacogenetics of Response to GLP1R Agonists | currently recruiting participants | - | 2021-10-08 | - |
| NCT05173714 Trial register | Sit Less, Interact and Move More (SLIMM) 2 Study | currently recruiting participants | - | 2021-12-30 | - |
| NCT06072963 Trial register | COMMETS- Combination MCI Metabolic Syndrome | currently recruiting participants | - | 2023-10-10 | - |
| NCT07727473 Trial register | Preoperative Semaglutide Prior to Radical Prostatectomy | not yet recruiting participants | - | 2026-07-27 | - |
| NCT07728383 Trial register | A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity | currently recruiting participants | - | 2026-07-27 | - |
| NCT07728812 Trial register | Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity Pharmacotherapy | not yet recruiting participants | NA | 2026-07-10 | - |
| 2023-508055-40-00 Trial register | Weight Maintenance in Adolescents With Obesity; Long-Term Treatment With Semaglutide s.c. 2.4 mg Once-weekly | Not stated | 4 | - | - |
| NCT07702461 Trial register | Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists | currently recruiting participants | - | 2026-07-14 | - |
| NCT07621640 Trial register | Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study) | not yet recruiting participants | - | 2026-06-02 | - |
| NCT07720414 Trial register | Effects of GLP-1 RAs on Human Lactation Outcomes | currently recruiting participants | - | 2026-07-17 | - |
| NCT07720466 Trial register | Salivary Function and Dental Changes During GLP-1 Therapy | not yet recruiting participants | - | 2026-07-14 | - |
| 2024-513958-29-00 Trial register | Semaglutide for people with obesity and resistant hypertension (SUPPORT): a pilot, randomized, parallel-group, integrated, multicentre clinical trial. | Not stated | 3 | - | - |
| NCT05503927 Trial register | A Study to Evaluate the Safety of Exposure to Wegovy During Pregnancy | enrolling by invitation only | - | 2022-08-10 | - |
| NCT06497595 Trial register | Lifestyle Intervention to Reduce the Risk of Sarcopenia in Adults With Diabetes & Obesity Treated With Semaglutide | currently recruiting participants | - | 2024-07-12 | - |
| NCT06967389 Trial register | Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity | currently recruiting participants | - | 2025-02-25 | - |
| NCT06975111 Trial register | Focusing on the Menopausal Transition to Improve Mid-Life Women's Health | currently recruiting participants | - | 2025-05-16 | - |
| NCT07225816 Trial register | Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide | currently recruiting participants | - | 2025-11-10 | - |
| NCT07057310 Trial register | Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women | enrolling by invitation only | 4 | 2025-07-09 | - |
| NCT07711548 Trial register | Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity? | not yet recruiting participants | - | 2026-07-14 | - |
| NCT07713992 Trial register | Efficacy and Safety of Mazdutide in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Nonalcoholic Fatty Liver Disease Previously Treated With Semag | not yet recruiting participants | - | 2026-07-20 | - |
| 2023-507449-27-01 Trial register | A biomarker-targeted clinical trial to optimize treatment for patients with chronic kidney disease | Not stated | 4 | - | - |
| NCT06005012 Trial register | Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM | running, but no longer enrolling | - | 2023-08-22 | - |
| NCT07272837 Trial register | Impact of Semaglutide (Ozempic/Wegovy®) on Heart and Muscle Mass | currently recruiting participants | - | 2025-12-09 | - |
| 2023-509662-38-00 Trial register | Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) once weekly versus placebo in participants with type 2 diabetes and painful diab | Not stated | 2 | - | - |
| NCT06814938 Trial register | A Study of a Novel Precision Medicine Approach For Obesity | running, but no longer enrolling | - | 2025-02-07 | - |
| NCT06982859 Trial register | A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus | running, but no longer enrolling | 1 | 2025-05-21 | - |
| NCT07539415 Trial register | A Phase 1 Clinical Trial to Assess the Safety of DWRX5003 and Relative Bioavailability to DWC202502 and DWC202503 in Healthy Adult Volunteers | currently recruiting participants | - | 2026-02-09 | - |
| NCT06575738 Trial register | Physiologic Response to Bariatric Surgery and the Impact of Adjunct Semaglutide in Adolescents | currently recruiting participants | 1 | 2024-08-28 | - |
| NCT07701005 Trial register | Non-Invasive Hepatic and Metabolic Index Changes After Incretin Therapy in Overweight/Obesity | completed | - | 2026-07-14 | - |
| NCT07115069 Trial register | Comparison of Body Composition Changes With Weight Loss Interventions | running, but no longer enrolling | - | 2025-07-25 | - |
| NCT07297238 Trial register | Effect of GLP-1 on Intestinal Barrier Function in SBS-IF Patients: A Preliminary Exploration. | completed | - | 2025-09-19 | - |
| NCT07091500 Trial register | Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Therapy and Exercise Training in People With Obesity | currently recruiting participants | - | 2025-07-29 | - |
| NCT07653412 Trial register | Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists. | currently recruiting participants | - | 2026-06-17 | - |
| NCT07695454 Trial register | Imaging in Semaglutide Study | not yet recruiting participants | - | 2026-07-10 | - |
| NCT07357740 Trial register | A Research Study to Compare Two Different Versions of Injectable CagriSema in People With Type 2 Diabetes | withdrawn before enrolling anyone | - | 2026-01-21 | - |
| NCT07357766 Trial register | A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight | withdrawn before enrolling anyone | - | 2026-01-21 | - |
| NCT07417618 Trial register | INcreTin-based thERapies for Cardiovascular Event PrevenTion in Patients With and Without ASCVD (INTERCEPT-ASCVD) | completed | - | 2026-02-18 | - |
| NCT07619495 Trial register | Injectable Semaglutide vs Dulaglutide in Individuals at Cardiovascular Risk | completed | - | 2026-06-02 | - |
| NCT07619508 Trial register | Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes. | completed | - | 2026-06-02 | - |
| 2023-506929-11-00 Trial register | Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c.) once-weekly in participants with overweight or obesity | Not stated | 3 | - | - |
| NCT04639414 Trial register | Combined Active Treatment in Type 2 Diabetes With NASH | completed | - | 2020-11-20 | - |
| NCT05574439 Trial register | Young Adults With Early-onset Obesity Treated With Semaglutide | completed | - | 2022-10-10 | - |
| NCT05616013 Trial register | Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or Obese | completed | - | 2022-11-14 | Posted |
| NCT06003153 Trial register | GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH | currently recruiting participants | - | 2023-08-21 | - |
| NCT06065540 Trial register | A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes T | completed | - | 2023-10-04 | - |
| 2024-520328-27-00 Trial register | J1R-MC-GZFD: A Parallel-Group Treatment, Phase 2, Double-Blind study of Once-Weekly Subcutaneous LY3457263 Compared to Placebo in Participants with Type 2 Diabe | Not stated | 2 | - | - |
| NCT04777396 Trial register | A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE) | completed | - | 2021-03-02 | - |
| NCT04873245 Trial register | Lifestyle Counseling and Medication for Adolescent Weight Management | completed | - | 2021-05-05 | - |
| NCT06640972 Trial register | Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 Agonists | completed | 2 | 2024-10-08 | Posted |
| NCT07021937 Trial register | Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity | not yet recruiting participants | - | 2025-06-15 | - |
| NCT07444073 Trial register | Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock | not yet recruiting participants | - | 2026-02-12 | - |
| NCT07677865 Trial register | GLP-1 Receptor Agonists and Alzheimer's Disease: A Multi-National Target Trial Emulation | completed | - | 2026-06-24 | - |
| 2024-510846-15-00 Trial register | Efficacy, safety, and pharmacokinetics of NNC0519-0130 once weekly s.c. versus semaglutide 1.0 mg and placebo in people with chronic kidney disease, with or wit | Not stated | 2 | - | - |
| NCT07430059 Trial register | Safety, Tolerability and Pharmacokinetics of a Subcutaneous Semaglutide Implant | not yet recruiting participants | - | 2026-02-24 | - |
| NCT06396416 Trial register | Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2 | currently recruiting participants | - | 2024-05-02 | - |
| 2024-511114-20-00 Trial register | SEMAFORCRANIO : Multicenter, double-blind, parallel, randomized controlled trial of the efficacy of semaglutide in hypothalamic obesity secondary to craniophary | Not stated | 3 | - | - |
| NCT04777409 Trial register | A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus) | completed | - | 2021-03-02 | - |
| NCT07017270 Trial register | Glucagon-like-peptide-1 Receptor Agonists in Patients Receiving Maintenance Dialysis | currently recruiting participants | - | 2025-06-12 | - |
| NCT07509112 Trial register | Semaglutide for Treatment of People With Methamphetamine Use Disorder: the SHIFT Study | not yet recruiting participants | - | 2026-04-03 | - |
| NCT07592546 Trial register | Translational Health Research Into Vascular and Neurocognitive Effects of Weight Loss | not yet recruiting participants | - | 2026-05-18 | - |
| NCT07597018 Trial register | A Research Study to Compare Blood Levels of Cagrilintide After Multiple Doses of Different Versions of Cagrilintide in Adults With Overweight or Obesity | currently recruiting participants | - | 2026-05-19 | - |
| NCT07505303 Trial register | MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial | running, but no longer enrolling | - | 2026-04-01 | - |
| NCT07668765 Trial register | GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity | not yet recruiting participants | - | 2026-06-04 | - |
| NCT06380426 Trial register | A Multicenter Pharmacoepidemiological Cohort on Real Life Use of Semaglutide in Adolescents or Adults With Monogenic Obesity | currently recruiting participants | - | 2024-04-23 | - |
| NCT05441267 Trial register | A Study of Cardiovascular Events iN Diabetes Plus | running, but no longer enrolling | - | 2022-07-01 | - |
| NCT06423599 Trial register | Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure | currently recruiting participants | - | 2024-05-21 | - |
| 2025-523374-17-03 Trial register | Insulin resistance in type 2 diabetes: evaluating the pathogenic mechanisms of insulin resistance in the myocardium and the effects of the treatments with GLP-1 | Not stated | 4 | - | - |
| 2024-520322-11-00 Trial register | A Randomized, Double-Blind, Placebo- and Open-Label Active Comparator- Controlled, Parallel-Group, Multi-Center Phase II Study to Evaluate the Efficacy, Safety, | Not stated | 2 | - | - |
| NCT07502508 Trial register | Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy | currently recruiting participants | - | 2026-03-26 | - |
| 2025-522326-13-00 Trial register | Obesity and Semaglutide in Type 1 Diabetes Therapy (OBES1TY): A Multicentre, Randomised, Double-Blinded, Placebo-Controlled, Investigator-Initiated Trial | Not stated | 3 | - | - |
| NCT05259033 Trial register | A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People | completed | - | 2022-02-28 | Posted |
| NCT04572165 Trial register | Epidemiological Assessment of the Risk for Pancreatic Cancer Associated With the Use of Semaglutide in Patients With Type 2 Diabetes - A Cohort Study Based on N | completed | - | 2020-10-01 | - |
| NCT06184568 Trial register | A Study Comparing IBI362 vs Semaglutide in Chinese Adults With Early Type 2 Diabetes and Obesity | completed | - | 2023-12-28 | - |
| NCT07642635 Trial register | Glucagon-Like Peptide-1 Receptor Agonists to Attenuate Metabolic Risk in Individuals With Duchenne Muscular Dystrophy | not yet recruiting participants | - | 2026-06-11 | - |
| NCT07282769 Trial register | Semaglutide (Wegovy) Treatment for Trichotillomania | not yet recruiting participants | - | 2025-12-15 | - |
| NCT07462663 Trial register | SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer | not yet recruiting participants | - | 2025-11-23 | - |
| NCT07640139 Trial register | Estimating the Impact of Obesity Medications on Clinical and Economic Outcomes | enrolling by invitation only | - | 2026-06-03 | - |
| NCT05622045 Trial register | Does Personality Predict Patient Adherence, Health Behaviors, and Weight Loss Outcomes During the Latino Crossover Semaglutide Study (LCSS)? (Story-LCSS Project | running, but no longer enrolling | - | 2022-11-18 | - |
| NCT07107334 Trial register | A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients Wit | currently recruiting participants | 2 | 2025-08-06 | - |
| NCT07633639 Trial register | GLP-1 Therapy After Bariatric Surgery in Chinese Patients With Obesity | currently recruiting participants | NA | 2026-06-08 | - |
| NCT04560998 Trial register | A Research Study to Compare a Medicine Called Semaglutide Against Placebo in People With Peripheral Arterial Disease and Type 2 Diabetes | completed | - | 2020-09-23 | Posted |
| NCT05356104 Trial register | GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD) | currently recruiting participants | - | 2022-04-08 | - |
| NCT06269107 Trial register | A Research Study to See How Well New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Levels in People Wi | completed | - | 2024-02-21 | - |
| NCT07628985 Trial register | BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes | not yet recruiting participants | - | 2026-06-05 | - |
| NCT05424003 Trial register | Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant | currently recruiting participants | - | 2022-06-21 | - |
| NCT06584916 Trial register | A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MA | completed | 3 | 2024-09-03 | - |
| NCT05813912 Trial register | A Research Study to See How a New Weekly Insulin, Insulin Icodec When Given Along With Semaglutide Helps in Reducing the Blood Sugar Level in Patients With Type | completed | - | 2023-04-14 | Posted |
| NCT07204249 Trial register | Glutide for Ending Methamphetamine | currently recruiting participants | - | 2025-10-02 | - |
| NCT07622810 Trial register | BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or Obesity | not yet recruiting participants | - | 2026-06-03 | - |
| NCT05822609 Trial register | Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes | currently recruiting participants | - | 2023-04-21 | - |
| NCT06571383 Trial register | STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss | running, but no longer enrolling | - | 2024-08-26 | - |
| NCT07605572 Trial register | Impact of GLP-1 Receptor Agonists on Dry Eye Disease in Patients With Type 2 Diabetes Mellitus and Obesity | currently recruiting participants | - | 2026-05-11 | - |
| NCT07621419 Trial register | Study of Adult Patients Residing in Argentina Diagnosed With Type 2 Diabetes Treated With a New Formulation of Semaglutide, Both Oral and Subcutaneous, in a Rea | currently recruiting participants | - | 2026-06-02 | - |
| NCT07617155 Trial register | GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute Pancreatitis | not yet recruiting participants | - | 2026-06-01 | - |
| NCT03899402 Trial register | Triple Therapy in T1DM | running, but no longer enrolling | - | 2019-04-02 | - |
| NCT07610174 Trial register | Effects of Dapagliflozin, Semaglutide, and Their Combination in Heart Failure Patients With Prosthetic Heart Valves | completed | - | 2026-05-27 | - |
| NCT07613437 Trial register | GLP-1 Receptor Agonist in Primary Intracerebral Hemorrhage: A Phase 2 Randomized Trial | not yet recruiting participants | - | 2026-05-29 | - |
| NCT07614412 Trial register | SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes. | not yet recruiting participants | - | 2026-05-29 | - |
| NCT05333003 Trial register | Semaglutide in Comorbid Schizophrenia Spectrum Disorder and Obesity | running, but no longer enrolling | - | 2022-04-18 | - |
| NCT07221214 Trial register | GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV | currently recruiting participants | - | 2025-10-27 | - |
| 2025-524612-11-00 Trial register | Effect of an adjunctive intervention on the tolerability of semaglutide in overweight adults without diabetes: a prospective, randomised, double-blind, single-c | Not stated | 4 | - | - |
| NCT07456774 Trial register | A Two-armed Real-world Study of Ozempic (OW Semaglutide) to Evaluate Its Adherence and Persistence Compared With Other Anti-diabetic Drugs Among Adult T2DM Pati | enrolling by invitation only | - | 2026-03-06 | - |
| NCT07599046 Trial register | Fecal Microbiota Transplantation (FMT) Combined With Calorie-Restricted Diet and Semaglutide in Patients With Obesity and Type 2 Diabetes | not yet recruiting participants | - | 2026-05-20 | - |
| 2025-524738-24-00 Trial register | Healing Diabetic Foot Ulcers with Semaglutide | Not stated | 4 | - | - |
| NCT04469855 Trial register | Post-Marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Ozempic® | completed | - | 2020-07-14 | - |
| NCT06289504 Trial register | A Study on How CagriSema Affects Levels of Atorvastatin and Warfarin in the Blood of Participants With Excess Body Weight | completed | - | 2024-03-04 | - |
| NCT07317115 Trial register | Side-to-Side Duodeno-ileostomy Versus Semaglutide in Adults With Obesity and Type 2 Diabetes | currently recruiting participants | - | 2026-01-05 | - |
| NCT06041217 Trial register | A Research Study to See How Well Semaglutide Helps People Who Have a Body Weight Above the Healthy Weight Range | completed | - | 2023-09-18 | Posted |
| NCT06790160 Trial register | Study of Patients Being Treated With Anti-obesity Medication | currently recruiting participants | - | 2025-01-17 | - |
| NCT06827002 Trial register | Effect of Aqueous Extracts of Cissus Quadrangularis and Dichrostachys Glomerata on GLP-1 Concentration and DPP-4 Activity in Overweight and Obese Adults | running, but no longer enrolling | - | 2025-02-14 | - |
| NCT06980623 Trial register | Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction | running, but no longer enrolling | - | 2025-05-20 | - |
| NCT07457424 Trial register | Direct Measurement of Microstructure of Ingestive Behaviour After Initiation of GLP-1 Receptor Agonist Treatment at Maximum Dose (DIGRAT) | running, but no longer enrolling | - | 2026-03-09 | - |
| NCT07588984 Trial register | GLP-1 Medication & Behavioral Health Programs on Weight & Metabolic Outcomes: FLOURISH and THRIVE Prospective Cohort Study | not yet recruiting participants | - | 2026-05-15 | - |
| NCT07589322 Trial register | Comparative Observation of Metabolic and Pharmacologic Adipose Remodeling With Enhanced Incretin AgonisTs | currently recruiting participants | NA | 2026-05-15 | - |
| NCT07523633 Trial register | Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder | currently recruiting participants | - | 2026-04-13 | - |
| NCT07586150 Trial register | Personalized Pharmaco-Lifestyle Interventions for Severe Mental Illnesses (LIFETRAIN) | not yet recruiting participants | - | 2026-05-14 | - |
| NCT06745284 Trial register | A Study to Test Whether Survodutide Improves How the Body Uses Energy and Breaks Down Fat in People With Obesity | running, but no longer enrolling | - | 2024-12-20 | - |
| NCT06884293 Trial register | A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease （MAFLD） | running, but no longer enrolling | - | 2025-03-19 | - |
| NCT07581145 Trial register | Effect of Semaglutide on Healing of Foot Ulcers in Type 2 Diabetes Patients | currently recruiting participants | - | 2026-05-12 | - |
| NCT05514535 Trial register | A Research Study to Look Into How Semaglutide, Together With a Lower Dose of Insulin Glargine, Compares to a Higher Dose of Insulin Glargine Alone in People Wit | completed | - | 2022-08-24 | Posted |
| NCT05586802 Trial register | Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome | currently recruiting participants | - | 2022-10-19 | - |
| NCT07187830 Trial register | Visceral Adipose Tissue and Liver Changes Associated With Semaglutide in CKD | currently recruiting participants | - | 2025-09-23 | - |
| NCT07547878 Trial register | Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) | not yet recruiting participants | - | 2026-04-23 | - |
| NCT05035095 Trial register | Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1) | completed | - | 2021-09-05 | Posted |
| NCT07527195 Trial register | Understanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health) | currently recruiting participants | - | 2026-04-14 | - |
| 2023-506109-20-00 Trial register | An interventional, multi-center, randomized, double blinded, placebo controlled study to investigate semaglutide add-on treatment for metabolic control in antip | Not stated | 3 | - | - |
| NCT07570810 Trial register | Efficacy, Safety, and Tolerability of CS0159 Combined With Semaglutide in MAFLD Patients With Obesity and T2DM | not yet recruiting participants | - | 2026-05-06 | - |
| 2024-512144-39-00 Trial register | Long-term efficacy and safety of cagrilintide s.c. 2.4 mg in combination with semaglutide s.c. 2.4 mg (CagriSema 2.4 mg/2.4 mg) once weekly versus placebo in pa | Not stated | 3 | - | - |
| NCT05689372 Trial register | Regulatory Post Marketing Surveillance (rPMS) Study of Ozempic (Semaglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitus in R | enrolling by invitation only | - | 2023-01-19 | - |
| NCT06388187 Trial register | A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight | completed | - | 2024-04-29 | - |
| NCT07041983 Trial register | 24-h Energy Expenditure and Anti-obesity Medication | enrolling by invitation only | - | 2025-05-28 | - |
| NCT04019197 Trial register | Effects of Semaglutide in HIV-Associated Lipohypertrophy | running, but no longer enrolling | - | 2019-07-15 | Posted |
| NCT05938712 Trial register | The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplan | currently recruiting participants | - | 2023-07-10 | - |
| NCT06613854 Trial register | Effect of Early Combination Antihyperglycemic Treatment on Metabolic Control in Individuals With Type 2 Diabetes | currently recruiting participants | - | 2024-09-26 | - |
| NCT07065383 Trial register | Rebalancing the Fat Content of the Heart and Muscles | currently recruiting participants | - | 2025-07-15 | - |
| NCT07558863 Trial register | Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 Diabetes | currently recruiting participants | - | 2026-04-14 | - |
| NCT04174755 Trial register | Semaglutide's Efficacy in Achieving Weight Loss for Those With HIV | currently recruiting participants | - | 2019-11-22 | - |
| NCT06263595 Trial register | Semaglutide and Preoperative Residual Gastric Volumes | completed | - | 2024-02-16 | - |
| NCT06754163 Trial register | Evaluating the Effect of the STEP@STAH Semaglutide Protocol on the Physical Health Measures of Atypical Antipsychotic-Treated Patients | running, but no longer enrolling | - | 2024-12-31 | - |
| NCT07229170 Trial register | Changes in Taste and Eating Habits Associated With GLP-1 Agonists in Weight Loss Patients | currently recruiting participants | - | 2025-11-13 | - |
| NCT07487103 Trial register | Efficacy and Safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 Diabetes | not yet recruiting participants | - | 2026-03-17 | - |
| NCT07554417 Trial register | Combatting Muscle Loss in Obese Adult Patients on GLP-1 Medications Through Dietary Counseling and Exercise During Treatment Evaluates Whether a 12-week Exercis | not yet recruiting participants | - | 2026-04-28 | - |
| 2024-516542-19-00 Trial register | Searching simple biomarkers to phenotype type 2 diabetic patients and personalize their treatment | Not stated | 4 | - | - |
| NCT05649137 Trial register | A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight | completed | - | 2022-12-13 | Posted |
| NCT07081178 Trial register | A Non-interventional Study Investigating Semaglutide in Combination With Lifestyle-based Modifications for the Management of Obesity in Real-World Clinical Prac | terminated before completion | - | 2025-07-23 | - |
| 2025-522486-29-01 Trial register | Impact of Oral Semaglutide on Platelet Reactivity in Patients with Diabetes Mellitus or Overweight with High Risk or established Cardiovascular Disease: the SEM | Not stated | 3 | - | - |
| NCT05646706 Trial register | A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP) | completed | - | 2022-12-12 | Posted |
| NCT07336862 Trial register | Bariatric Surgery Combined With GLP-1 Receptor Agonists Study | currently recruiting participants | - | 2025-09-29 | - |
| NCT06283667 Trial register | Special Use - Results Surveillance on Long-term Use With Wegovy® | running, but no longer enrolling | - | 2024-02-28 | - |
| NCT07539584 Trial register | Adiponectin in Patients With Metabolic Disorders | completed | - | 2026-04-13 | - |
| 2025-524177-16-00 Trial register | An open-label, single-center, non-controlled pilot clinical trial to assess the efficacy of weekly semaglutide in combination with regular counselling sessions | Not stated | 2 | - | - |
| NCT05746039 Trial register | Feasibility of Semaglutide in Advanced Lung Disease | currently recruiting participants | - | 2023-02-27 | - |
| NCT06333080 Trial register | The Effect of Adherence to Oral Semaglutide on Glycaemic Control in People With Type 2 Diabetes Treated With Metformin | terminated before completion | - | 2024-03-27 | - |
| NCT06885736 Trial register | LEAN Mass Preservation With Resistance Exercise and Protein During Semaglutide/Tirzepatide Therapy | currently recruiting participants | NA | 2025-03-20 | - |
| NCT07281196 Trial register | Semaglutide Effects on Sleep Apnea in Patients With Type 2 Diabetes/Obesity and Comorbid Obstructive Sleep Apnea | completed | - | 2025-12-15 | - |
| NCT07446439 Trial register | A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use | currently recruiting participants | - | 2026-02-10 | - |
| NCT06619015 Trial register | Tailoring Obesity Treatment Trial | withdrawn before enrolling anyone | - | 2024-10-01 | - |
| NCT06903923 Trial register | Bone Metabolism in 12-21 Year Olds Undergoing Glucagon Like Peptide (GLP)-1 Receptor Agonist Therapy | currently recruiting participants | - | 2025-04-01 | - |
| NCT07027969 Trial register | Metabolic Surgery for Atrial Fibrillation Elimination | not yet recruiting participants | 4 | 2025-06-11 | - |
| 2024-518086-99-00 Trial register | Young adults with early-onset obesity treated with semaglutide -The RESETTLE study - a randomized double blind placebo-controlled clinical trial | Not stated | 4 | - | - |
| NCT05067621 Trial register | Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease | running, but no longer enrolling | - | 2021-10-05 | - |
| NCT06467604 Trial register | CRAVE Study: Comparing Craving Responses and Diet Quality of GLP1 Receptor Agonist Users | running, but no longer enrolling | - | 2024-06-11 | - |
| NCT05390892 Trial register | PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes | currently recruiting participants | - | 2022-05-19 | - |
| NCT06605703 Trial register | A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepat | completed | 4 | 2024-09-20 | - |
| NCT06706284 Trial register | Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes | currently recruiting participants | - | 2024-11-26 | - |
| NCT06751589 Trial register | A Study of a Weight Loss Intervention in People With Endometrial Cancer | currently recruiting participants | EARLY_1 | 2024-12-30 | - |
| NCT07073417 Trial register | A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH) | running, but no longer enrolling | - | 2025-07-18 | - |
| NCT05144984 Trial register | A Research Study Looking at How Well a Combination of the Medicines Semaglutide and NNC0480-0389 Works in People With Type 2 Diabetes | completed | - | 2021-12-06 | Posted |
| NCT05195944 Trial register | Semaglutide vs Sitagliptin | enrolling by invitation only | - | 2022-01-19 | - |
| NCT06604624 Trial register | Semaglutide in Treatment of Obesity | completed | - | 2024-09-19 | - |
| NCT06830343 Trial register | The Safety, Tolerability, and Pharmacokinetics of of SYH9017 in Chinese Participants With Overweight and Obesity | currently recruiting participants | - | 2025-02-11 | - |
| NCT07513168 Trial register | Low-Dose Semaglutide for Weight Loss in Obese Non-Diabetic Pakistani Adults | currently recruiting participants | - | 2026-04-06 | - |
| NCT07272343 Trial register | The Impact of Semaglutide Compared to Energy Restriction on Type 2 Diabetes | currently recruiting participants | - | 2025-12-09 | - |
| 2025-524163-21-00 Trial register | A randomized, double-blind, placebo-controlled trial of semaglutide for reducing cannabis use in adults with cannabis use disorder | Not stated | 2 | - | - |
| 2025-524819-37-00 Trial register | TheRapeutic StrAtegies for Obstructive SleeP Apnea in Older Adults with OverweigHt or Obesity: A RandomizEd Clinical TriaL (RAPHAEL study) | Not stated | 4 | - | - |
| NCT06118203 Trial register | Semaglutide Use in Acute Pulmonary Embolism | completed | - | 2023-11-07 | - |
| NCT07361874 Trial register | IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion | currently recruiting participants | - | 2026-01-23 | - |
| 2022-500311-39-00 Trial register | Prevention of postoperative endoscopic recurrence with endoscopy-driven versus systematic biological therapy: a randomized, multicentre, parallel group pragmati | Not stated | 4 | - | - |
| NCT07040592 Trial register | Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide | currently recruiting participants | - | 2025-06-27 | - |
| NCT05925959 Trial register | Preoperative Weight Loss for Open Abdominal Wall Reconstruction | currently recruiting participants | - | 2023-06-14 | - |
| NCT06222437 Trial register | Semaglutide and Polycystic Ovarian Syndrome: an Emerging Treatment Strategy | withdrawn before enrolling anyone | - | 2024-01-24 | - |
| NCT07216651 Trial register | WeDosify Real World Evidence (RWE) Study: Personalized Semaglutide Dosing in U.S. Adults | completed | - | 2025-10-14 | - |
| NCT07227948 Trial register | Repurposing Semaglutide for the Treatment of Cocaine Use Disorder | currently recruiting participants | - | 2025-11-13 | - |
| NCT07483801 Trial register | DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies | not yet recruiting participants | 4 | 2026-03-19 | - |
| NCT05119179 Trial register | Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes | currently recruiting participants | - | 2021-11-15 | - |
| NCT06989177 Trial register | Probiotic Intervention on Body Weight | currently recruiting participants | - | 2025-05-25 | - |
| NCT06989203 Trial register | Protein Supplementation Intervention on Body Weight | currently recruiting participants | - | 2025-05-25 | - |
| NCT07207148 Trial register | People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists | currently recruiting participants | - | 2025-09-17 | - |
| NCT07195994 Trial register | A Clinical Trial to Examine the Efficacy and Safety of an Investigational Product With and Without Use of Semaglutide on Glycemic Response in Adults With Predia | currently recruiting participants | - | 2025-09-29 | - |
| NCT06409130 Trial register | Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver Disease | completed | - | 2024-05-10 | - |
| NCT07400107 Trial register | AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose | not yet recruiting participants | - | 2026-02-10 | - |
| NCT07465965 Trial register | A Clinical Study of Semaglutide Nasal Spray in Overweight or Obese Adults | currently recruiting participants | - | 2026-03-12 | - |
| NCT06717698 Trial register | A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease | currently recruiting participants | - | 2024-12-05 | - |
| NCT07213466 Trial register | Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder | currently recruiting participants | - | 2025-10-09 | - |
| 2025-522920-28-00 Trial register | Understanding the effect of CagriSema, cagrilintide, and semaglutide on muscle health | Not stated | 1 | - | - |
| 2023-509273-24-00 Trial register | Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c. 1.0 mg/1.0 mg and 1.7 mg/1.7 mg) once-weekly in participants with | Not stated | 3 | - | - |
| NCT05819138 Trial register | Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes | currently recruiting participants | - | 2023-04-19 | - |
| NCT06027567 Trial register | The Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Di | completed | - | 2023-09-07 | - |
| NCT06403761 Trial register | Investigating How CagriSema, Semaglutide and Cagrilintide Regulate Insulin Effects in the Body of People With Type 2 Diabetes | completed | - | 2024-05-08 | - |
| NCT07285902 Trial register | A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With Obesity | running, but no longer enrolling | - | 2025-12-16 | - |
| NCT05564117 Trial register | Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in People Who Have a Body Weight Above the Healthy Range | completed | - | 2022-10-03 | Posted |
| NCT07172867 Trial register | A Ph2 Study to Evaluate the Safety, Efficacy and Tolerability of HT-6184 and Semaglutide in Obese Participants With T2DM | withdrawn before enrolling anyone | - | 2025-09-15 | - |
| NCT07430332 Trial register | GLP-1 RA for Stage 1 Type 1 Diabetes | not yet recruiting participants | - | 2026-02-24 | - |
| NCT07424430 Trial register | Real-world Canadian Retrospective Study Evaluating Longitudinal Semaglutide Use on Cardio-Kidney-Metabolic Outcomes | not yet recruiting participants | - | 2026-02-20 | - |
| NCT07280403 Trial register | Effect of a Low-carbohydrate Diet on Weight Loss in People Using the Injectable GLP-1 Agonist Semaglutide for Weight Loss | completed | - | 2025-12-12 | - |
| NCT07325500 Trial register | Incretin Microdosing for Cardiometabolic Health in People With HIV | currently recruiting participants | - | 2026-01-08 | - |
| NCT07101939 Trial register | A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2) | currently recruiting participants | - | 2025-08-03 | - |
| NCT07411378 Trial register | Testing the Efficacy, Safety, and PK of 20E in Patients With Obesity Who Are Starting Treatment With the GLP-1 Agonist Semaglutide for Weight Loss. | not yet recruiting participants | - | 2026-02-13 | - |
| NCT04972721 Trial register | SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial | completed | - | 2021-07-22 | - |
| NCT06478550 Trial register | A Research Study to Understand How People With Type 2 Diabetes Take Ozempic® and if the Ozempic®App Helps Them Stay on This Treatment | completed | - | 2024-06-27 | - |
| NCT06608433 Trial register | Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal Function | completed | - | 2024-09-23 | - |
| NCT07294950 Trial register | Impact of Semaglutide Withdrawal on Cardiometabolic Profile and Physiology of Energy Balance: Recovery Effects After Semaglutide Termination | currently recruiting participants | - | 2025-12-19 | - |
| NCT07389941 Trial register | Semaglutide PrIor to CathEeter Ablation in Patients With Atrial Fibrillation | not yet recruiting participants | - | 2026-02-05 | - |
| NCT07401992 Trial register | Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in Psoriasis | currently recruiting participants | - | 2026-02-11 | - |
| NCT04779697 Trial register | GLP-1 Analogue Effects on Food Cues, Stress, Motivation for Highly Palatable Foods, and Weight | completed | - | 2021-03-03 | Posted |
| NCT04865770 Trial register | A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Tr | completed | - | 2021-04-29 | Posted |
| 2023-506919-18-00 Trial register | A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease ( | Not stated | 3 | - | - |
| NCT06131437 Trial register | A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight | completed | 3 | 2023-11-14 | - |
| NCT07136714 Trial register | Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity | currently recruiting participants | - | 2025-08-22 | - |
| NCT07392151 Trial register | Reversal to Normoglycemia by Treating Prediabetes | not yet recruiting participants | - | 2026-01-23 | - |
| 2023-506918-45-00 Trial register | A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease ( | Not stated | 3 | - | - |
| NCT07391267 Trial register | Pathogenesis of Chronic Kidney Disease Associated With Metabolic Dysfunction- Associated Fatty Liver Disease (MAFLD) and Treatment Response of Oral Semaglutide. | not yet recruiting participants | - | 2026-02-05 | - |
| NCT03498001 Trial register | Effects of GLP-1 Agonists on CArdiac Steatosis Evaluated by Magnetic Resonance Imaging | completed | - | 2018-03-30 | - |
| NCT07382388 Trial register | A Real-World Study on the Impact of Weight Loss on Treatment Efficacy in Overweight/Obese Patients With Plaque Psoriasis | not yet recruiting participants | - | 2026-01-20 | - |
| 2022-502484-38-00 Trial register | A 40-week study comparing the efficacy and safety of once weekly IcoSema and daily insulin glargine 100 units/mL in participants with type 2 diabetes inadequate | Not stated | 3 | - | - |
| 2023-509483-20-00 Trial register | Investigating how CagriSema, semaglutide and cagrilintide regulate insulin effects in the body of people with type 2 diabetes. | Not stated | 1 | - | - |
| NCT06914102 Trial register | Emulation of the STEP-HFpEF DM Heart Failure Trial in Healthcare Claims Data | completed | - | 2025-04-06 | - |
| NCT06914141 Trial register | Comparative Effectiveness of Tirzepatide Versus Semaglutide in Individuals With Heart Failure With Preserved Ejection Fraction | completed | - | 2025-04-06 | - |
| NCT04251156 Trial register | Research Study of How Well Semaglutide Works in People Living With Overweight or Obesity. | completed | - | 2020-01-31 | Posted |
| NCT05040971 Trial register | Research Study Looking at How Well Semaglutide Works in People Living With Obesity and Prediabetes | completed | - | 2021-09-10 | Posted |
| 2022-502677-42-00 Trial register | Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4 mg/2.4 mg and 1.0 mg/1.0 mg once weekly versus placebo in part | Not stated | 3 | - | - |
| 2022-502678-18-00 Trial register | Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4/2.4 mg and 1.0/1.0 mg once weekly versus semaglutide 2.4 mg an | Not stated | 3 | - | - |
| 2025-523977-40-00 Trial register | Changes in Coronary Plaque Composition By Semaglutide Use in Diabetic Patients With Acute Coronary Syndrome: A Randomized Optical Coherence Tomography Trial - A | Not stated | 4 | - | - |
| NCT05394519 Trial register | A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight | completed | - | 2022-05-27 | - |
| NCT07374328 Trial register | Triple Hypoglycemic Regimens In Patients With Newly Diagnosed Type 2 Diabetes Mellitus | currently recruiting participants | - | 2026-01-28 | - |
| NCT07141914 Trial register | A Master Protocol for Semaglutide Effects on Cardiovascular and Obesity-related Outcomes in People With Overweight or Obesity in the Real World | completed | - | 2025-08-26 | - |
| 2022-502679-43-00 Trial register | Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema) s.c. in doses 2.4 mg/2.4 mg and 1.0 mg/1.0 mg once weekly versus placebo in part | Not stated | 3 | - | - |
| NCT05813925 Trial register | A Research Study to See How Well CagriSema Helps People in East Asia With Excess Body Weight Lose Weight | completed | - | 2023-04-14 | - |
| NCT05890976 Trial register | Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in Chinese Adults Who Are Above a Healthy Weight Range (OASIS 3) | completed | - | 2023-06-06 | - |
| NCT06132477 Trial register | Impact GLP-1 Agonists Following Bariatric | currently recruiting participants | - | 2023-11-02 | - |
| NCT06390501 Trial register | The Effect of Weekly Semaglutide Treatment on Energy Expenditure | completed | - | 2024-04-30 | - |
| NCT05788965 Trial register | Semaglutide in CFRD | completed | - | 2023-03-29 | Posted |
| NCT07242534 Trial register | Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization. | currently recruiting participants | - | 2025-11-21 | - |
| NCT06780449 Trial register | A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity | running, but no longer enrolling | - | 2025-01-17 | - |
| NCT06500143 Trial register | Residual Gastric Content After Holding of Glucagon-like Peptide-1 Receptor Agonists Before Elective Surgery | completed | - | 2024-07-15 | - |
| NCT05579249 Trial register | A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America | completed | - | 2022-10-13 | Posted |
| NCT05872022 Trial register | A Study to Evaluate Safety of Exposure to Wegovy During Pregnancy | enrolling by invitation only | - | 2023-04-26 | - |
| NCT06577090 Trial register | Study to Evaluate the Effect on Obesity of QW Nimacimab and QW Nimacimab Co-administered With Semaglutide vs Placebo | running, but no longer enrolling | - | 2024-08-29 | - |
| NCT06852391 Trial register | JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity | currently recruiting participants | - | 2025-02-28 | - |
| 2023-505857-42-00 Trial register | Efficacy and safety of co-administered cagrilintide and semaglutide (CagriSema 2.4 mg/2.4 mg) once weekly versus semaglutide 2.4 mg, cagrilintide 2.4 mg and pla | Not stated | 2 | - | - |
| NCT06042153 Trial register | DIALYSIS-TIR Study | running, but no longer enrolling | - | 2023-09-18 | - |
| NCT06579105 Trial register | Efficacy, Safety, and Tolerability of Once Daily Oral Administration of AZD5004 Versus Placebo for 26 Weeks in Adults With Type 2 Diabetes Mellitus. | completed | - | 2024-08-30 | - |
| NCT05829460 Trial register | Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia | withdrawn before enrolling anyone | - | 2023-04-25 | - |
| NCT05877547 Trial register | A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013) | completed | - | 2023-05-26 | - |
| NCT06648031 Trial register | Comparison of the Safety, Efficacy and Pharmacokinetics of DehydraTECH -CBD and DehydraTECH-GLP1 Agonists Alone or in Combination, in Overweight or Obese, Pre- | completed | 1 | 2024-10-18 | - |
| NCT05996848 Trial register | A Research Study to See How Well CagriSema Helps People in China With Excess Body Weight Lose Weight | completed | - | 2023-08-18 | - |
| NCT04969939 Trial register | A Research Study to Investigate How Well NNC0165-1875 in Combination With Semaglutide Works in People With Obesity | completed | - | 2021-07-21 | Posted |
| NCT06207877 Trial register | A Research Study to Look at How CagriSema Influences Food Intake, Appetite and Emptying of the Stomach in People With Excess Body Weight | completed | - | 2024-01-17 | - |
| NCT06267092 Trial register | A Study of How CagriSema Works on Appetite in People With Excess Body Weight | completed | - | 2024-02-20 | - |
| NCT07302802 Trial register | Efficacy of Semaglutide s.c. Once-weekly on Weight Loss and Management in Adolescents With Monogenic Obesity in Clinical Practice | currently recruiting participants | - | 2025-12-24 | - |
| NCT07325435 Trial register | Beta Cell Function in Type 2 Diabetes: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists | running, but no longer enrolling | - | 2025-12-18 | - |
| NCT07323134 Trial register | The Effect of Semaglutide on the Intestinal Flora in Obesity | not yet recruiting participants | - | 2026-01-07 | - |
| NCT07319975 Trial register | Effect of Semaglutide and Tirzepatide Combined With Exercise in Obesity | not yet recruiting participants | NA | 2026-01-06 | - |
| NCT07295223 Trial register | Effect of Glp-1 and Antidiabetic sgLT2 Agents for myoCardial infarcTion and Ultrasensitive Inflammatory Surveillance (GALACTUS Trial) | currently recruiting participants | - | 2025-12-19 | - |
| NCT07297589 Trial register | Epicardial Cardiac Fat-CT (EPIC-CT) | currently recruiting participants | - | 2025-12-22 | - |
| NCT07314684 Trial register | GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM | currently recruiting participants | - | 2026-01-02 | - |
| NCT04998136 Trial register | Research Study Investigating How Well Semaglutide Works in People From Thailand and South Korea Living With Obesity | completed | - | 2021-08-10 | Posted |
| NCT05443191 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Finland, as Part of Local Clinical Practice | completed | - | 2022-07-05 | - |
| NCT06507475 Trial register | Real World Effectiveness of Oral Semaglutide in Thailand Participants With Type 2 Diabetes | completed | - | 2024-07-18 | - |
| NCT07309094 Trial register | Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD | currently recruiting participants | - | 2025-12-30 | - |
| NCT05702931 Trial register | Semaglutide Treatment for Hyperglycaemia After Renal Transplantation | currently recruiting participants | - | 2023-01-27 | - |
| NCT05892432 Trial register | Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder (AUD) | completed | - | 2023-06-07 | - |
| NCT06801015 Trial register | Effects of Long-Acting GLP-1 (Glucagon-like Peptide-1) or Dual Incretin (GLP-1 and GIP [Glucose-dependent Insulinotropic Peptide]) Modulation on Gastric Motor F | running, but no longer enrolling | 4 | 2025-01-30 | - |
| 2024-511734-13-04 Trial register | Is the glucagon-like peptide-1 receptor agonist semaglutide able to alleviate mood in patients with major depressive disorder and overweight or obesity? Sema-Mo | Not stated | 3 | - | - |
| 2025-523374-17-01 Trial register | Insulin resistance in type 2 diabetes: evaluating the pathogenic mechanisms of insulin resistance in the myocardium and the effects of the treatments with GLP-1 | Not stated | 4 | - | - |
| NCT04982575 Trial register | Research Study to Look at How Well Cagrilintide Together With Semaglutide Works in People With Type 2 Diabetes | completed | - | 2021-07-29 | Posted |
| NCT07058155 Trial register | Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease | currently recruiting participants | 4 | 2025-06-27 | - |
| NCT06954090 Trial register | Urinary Proteomics to Guide Early Intervention to Prevent Complications in Type 2 Diabetes - a Feasibility Study | enrolling by invitation only | - | 2025-05-01 | - |
| NCT06983171 Trial register | Semaglutide Effectiveness in Patients With Metabolic Dysfunction-Associated Fatty Liver Disease in the Real World Practice | running, but no longer enrolling | - | 2025-05-21 | - |
| NCT06468748 Trial register | The Effects of Semaglutide on Body Composition and Performance in Military Personnel | withdrawn before enrolling anyone | - | 2024-06-21 | - |
| NCT07293325 Trial register | Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity | currently recruiting participants | NA | 2025-12-19 | - |
| 2023-508170-28-00 Trial register | Effects of NNC0194-0499 alone and in combination with semaglutide, of semaglutide alone, and of cagrilintide alone and in combination with semaglutide on liver | Not stated | 2 | - | - |
| NCT06338553 Trial register | GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab | currently recruiting participants | - | 2024-03-29 | - |
| NCT06972992 Trial register | A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC47 in Combination With Semaglutide | completed | - | 2025-05-15 | - |
| 2025-524182-25-00 Trial register | Waiting on Atrial fibrillation Intervention Therapy (WAIT) Study | Not stated | 4 | - | - |
| NCT05891587 Trial register | Semaglutide Therapy for Alcohol Reduction - Tulsa | completed | - | 2023-06-07 | - |
| NCT04940078 Trial register | A Research Study to Compare Blood Levels of Cagrilintide and Semaglutide After Combined Versus Separate Injections in People With Overweight or Obesity | completed | - | 2021-06-25 | - |
| NCT05478252 Trial register | A Research Study to Compare Two Semaglutide Medicines in People With Type 2 Diabetes | completed | - | 2022-07-28 | Posted |
| NCT05486065 Trial register | A Research Study to Look Into How Well Semaglutide Medicine Works at Different Doses in People With Type 2 Diabetes and Overweight | completed | - | 2022-08-03 | Posted |
| NCT03914326 Trial register | A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes | completed | - | 2019-04-16 | Posted |
| NCT04102189 Trial register | A Research Study on How Well Semaglutide Works in Adolescents With Overweight or Obesity | completed | - | 2019-09-25 | Posted |
| NCT07276763 Trial register | Impact of Discontinuing GLP-1 Receptor Agonists for Two Weeks Prior to Upper Endoscopy on the Risk of Gastric Retention | not yet recruiting participants | - | 2025-11-29 | - |
| 2022-502647-35-00 Trial register | A Phase 2b Randomized, Double-Blind Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Efinopegdutide (MK-6024) in Adults with Precirr | Not stated | 2 | - | - |
| NCT06069622 Trial register | Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment | currently recruiting participants | - | 2023-10-06 | - |
| 2025-521748-39-00 Trial register | SGLT-2i, Heart, Improvement of Cardiovascular Autonomic Neuropathy | Not stated | 4 | - | - |
| NCT04707469 Trial register | Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes | completed | - | 2021-01-13 | Posted |
| NCT07096739 Trial register | Tolerance of a High Protein Nutrition Shake in Individuals on GLP-1 | completed | - | 2025-07-24 | - |
| NCT04559815 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Canada, as Part of Local Clinical Practice | completed | - | 2020-09-23 | - |
| NCT04788511 Trial register | Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity | completed | - | 2021-03-09 | Posted |
| NCT06533527 Trial register | Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy | completed | 4 | 2024-06-27 | Posted |
| NCT05352815 Trial register | A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People | completed | - | 2022-04-29 | Posted |
| NCT05013229 Trial register | A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People | completed | - | 2021-08-19 | - |
| NCT05784402 Trial register | A Research Study to Compare How Much Semaglutide is Found in the Blood With Different Tablets of Oral Semaglutide in Healthy Participants | completed | - | 2023-03-24 | - |
| NCT07251556 Trial register | GLP-1 Receptor Agonists in Non-diabetic Patients With Psoriatic Arthritis | not yet recruiting participants | - | 2025-11-26 | - |
| NCT07254572 Trial register | Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes | currently recruiting participants | - | 2025-11-28 | - |
| NCT04916470 Trial register | Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes | completed | - | 2021-06-07 | - |
| NCT04971785 Trial register | Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) | completed | - | 2021-07-21 | Posted |
| NCT05822830 Trial register | A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities | completed | 3 | 2023-04-21 | Posted |
| NCT06410352 Trial register | Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome | currently recruiting participants | - | 2024-05-13 | - |
| 2024-513416-98-00 Trial register | Adipose Tissue Heterogeneity and Its Link to Type 2 Diabetes: A Randomized Open Intervention Study That Compares Empagliflozin, Pioglitazone and Semaglutide (Di | Not stated | 2 | - | - |
| 2024-515417-17-00 Trial register | A study in people with obesity to test the effects of different doses of BI 456906 compared with semaglutide on glucagon receptor activity in the liver | Not stated | 1 | - | - |
| 2025-520802-37-00 Trial register | Impact of GLP1-RAs on inflammation and endothelial biomarkerS in Type 2 diABetes meLlitus patiEnts: STABLE-GLP1 trial. | Not stated | 4 | - | - |
| NCT03919929 Trial register | Treating PCOS With Semaglutide vs Active Lifestyle Intervention | completed | - | 2019-04-18 | Posted |
| NCT06778967 Trial register | A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus | running, but no longer enrolling | - | 2025-01-16 | - |
| NCT07150975 Trial register | Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects | currently recruiting participants | - | 2025-09-02 | - |
| NCT07154238 Trial register | Characteristics and Treatment Experiences of Individuals Using Injectable Semaglutide for Weight Management, a Cross-sectional Time-series Analysis, Multi-count | enrolling by invitation only | - | 2025-09-04 | - |
| 2025-522970-35-00 Trial register | REVERsal to normoglycemia by Treating PREDIABETES: the REVERT-PREDIABETES trial | Not stated | 3 | - | - |
| NCT06420739 Trial register | The Semaglutide Study | running, but no longer enrolling | - | 2024-05-20 | - |
| NCT07239570 Trial register | A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease | currently recruiting participants | - | 2025-11-20 | - |
| 2022-502082-22-00 Trial register | Semaglutide for the treatment of glucose intolerance in women with prior gestational diabetes: a double blind RCT | Not stated | 3 | - | - |
| NCT05016882 Trial register | Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH) | completed | - | 2021-08-23 | - |
| NCT05064735 Trial register | Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis | completed | - | 2021-10-01 | Posted |
| NCT06499857 Trial register | Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation | currently recruiting participants | - | 2024-07-15 | - |
| 2023-505959-45-00 Trial register | The effect of oral Semaglutide on bone turnover in patients with T2D: a randomized placebo-controlled clinical trial (SOBER II) | Not stated | 2 | - | - |
| NCT06446531 Trial register | Prevention of Progression of Prediabetes, Obesity and CV Risk | currently recruiting participants | - | 2024-05-31 | - |
| NCT06804603 Trial register | A Study to Measure the Effects of Using Tradipitant on Nausea and Vomiting After GLP-1R Agonist Use | completed | - | 2025-01-09 | - |
| NCT05768945 Trial register | Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Semaglutide v DPP4 Inhibitors | completed | - | 2023-03-15 | Posted |
| NCT07223242 Trial register | Tailored Exercise Training Study Among Adults With HFpEF | currently recruiting participants | 2/3 | 2025-10-06 | - |
| NCT07064486 Trial register | A Study of BGM0504 in Participants With Type 2 Diabetes in Indonesia | currently recruiting participants | - | 2025-07-14 | - |
| 2023-506923-27-00 Trial register | PIONEER TEENS Efficacy and safety of oral semaglutide versus placebo both in combination with metformin and/or basal insulin in children and adolescents with ty | Not stated | 3 | - | - |
| 2025-522525-34-00 Trial register | Effect of Semaglutide on embryo quality in overweight and obese patients undergoing In Vitro Fertilization. A Randomized Controlled Trial | Not stated | 4 | - | - |
| NCT06642584 Trial register | A Research Study Looking at New Protein-based Tablets in Healthy Men - Oral Formulation IV | completed | - | 2024-10-15 | - |
| NCT06659744 Trial register | Emulation of the SUSTAIN6 Diabetes Trial Using Healthcare Claims | completed | - | 2024-10-26 | - |
| NCT07096063 Trial register | Comparative Effectiveness of Tirzepatide and Semaglutide in Individuals at Cardiovascular Risk | completed | - | 2025-07-31 | - |
| NCT05443568 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Israel, as Part of Local Clinical Practice | completed | - | 2022-07-05 | - |
| NCT04466345 Trial register | Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder | completed | - | 2020-07-10 | - |
| NCT05755360 Trial register | DOORS: A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes Who Change From Dipeptidyl Peptidase-4 Inhibitor (DPP4i) Treatme | completed | - | 2023-03-06 | - |
| NCT07200622 Trial register | Oral Semaglutide in Patients With Alzheimer's Disease | not yet recruiting participants | - | 2025-10-01 | - |
| 2023-504913-65-01 Trial register | The SEMAFOOT2 Pilot. Effect of semaglutide on healing of foot ulcers in type 2 diabetes patients. A Pilot study. | Not stated | 2 | - | - |
| NCT06639464 Trial register | Semaglutide for Helping Opioid Recovery | currently recruiting participants | - | 2024-10-15 | - |
| NCT04537637 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Denmark, as Part of Local Clinical Practice | completed | - | 2020-09-03 | - |
| NCT04601740 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in The Netherlands, as Part of Local Clinical Practice | completed | - | 2020-10-26 | - |
| NCT04601753 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Sweden, as Part of Local Clinical Practice | completed | - | 2020-10-26 | - |
| NCT04862923 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in the United Kingdom, as Part of Local Clinical Practice | completed | - | 2021-04-28 | - |
| NCT04878393 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Japan, as Part of Local Clinical Practice | completed | - | 2021-05-07 | - |
| NCT05230589 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Saudi Arabia, as Part of Local Clinical Practice | completed | - | 2022-02-09 | - |
| NCT05230615 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Italy, as Part of Local Clinical Practice | completed | - | 2022-02-09 | - |
| NCT05316662 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Mexico, as Part of Local Clinical Practice | completed | - | 2022-04-07 | - |
| NCT05443334 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Spain, as Part of Local Clinical Practice | completed | - | 2022-07-05 | - |
| NCT05533632 Trial register | Safety Study of Weekly Semaglutide in Chilean Participants With Type 2 Diabetes | completed | - | 2022-09-09 | Posted |
| NCT05996874 Trial register | A Research Study Comparing the Effect of Different Dosing Conditions on Blood Levels of Semaglutide in a New Tablet Composition in Healthy Participants | completed | - | 2023-08-18 | - |
| NCT07190144 Trial register | Coronary Flow Reserve Changes After Semaglutide Treatment | completed | - | 2025-09-24 | - |
| NCT05670379 Trial register | Assessment of Safety, Tolerability and Drug Levels of Exenatide Implant | completed | - | 2023-01-04 | - |
| NCT07187856 Trial register | Phase 2 Randomized Study of PG-102 vs Placebo and Semaglutide in Type 2 Diabetes Mellitus | not yet recruiting participants | - | 2025-09-23 | - |
| NCT07188545 Trial register | Using Secondary Data to Evaluate Sex-based Heterogeneity of GLP-1 Agonists and SGLT2 Inhibitors on Cardiovascular-Kidney-Metabolic Health (CKMH) Outcomes in Rea | running, but no longer enrolling | - | 2025-09-16 | - |
| 2023-506931-13-00 Trial register | Efficacy and safety of cagrilintide s.c. in combination with semaglutide s.c. (CagriSema s.c.) once-weekly in participants with overweight or obesity and type 2 | Not stated | 3 | - | - |
| NCT06282458 Trial register | Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight Mgmt | completed | - | 2024-02-28 | - |
| NCT07165158 Trial register | The Effect of Semaglutide on Bone Health | not yet recruiting participants | - | 2025-09-10 | - |
| NCT07179120 Trial register | Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health | not yet recruiting participants | 2 | 2025-09-17 | - |
| NCT07042672 Trial register | Behavioral Therapy and GLP-1 Analogue Effects on Binge Eating, Weight, and Coping in Obesity | currently recruiting participants | - | 2025-04-03 | - |
| 2025-522503-18-00 Trial register | Semaglutide and Finerenone for Kidney and Vascular Protection in CKD | Not stated | 4 | - | - |
| NCT04126603 Trial register | Impact of Semaglutide on CD34+ EPC and Fat Derived MSC | completed | - | 2019-10-15 | Posted |
| NCT05756764 Trial register | Anti-obesity Pharmacotherapy and Inflammation | running, but no longer enrolling | - | 2023-03-06 | - |
| NCT07156331 Trial register | Research on Effects of Drugs on Body Composition and Function With Imaging in Diabetes | not yet recruiting participants | - | 2025-08-07 | - |
| NCT07156591 Trial register | Impact of Neuropathy on the Risk of Semaglutide-Induced Gastric Retention | not yet recruiting participants | - | 2025-09-05 | - |
| NCT06500429 Trial register | A Study to Evaluate the Safety and Efficacy of NG101 in Adult Participants Receiving a Glucagon-like Peptide-1 (GLP-1) Agonist | completed | - | 2024-07-15 | - |
| NCT05537233 Trial register | ADJUnct Semaglutide Treatment in Type 1 Diabetes | completed | - | 2022-09-13 | Posted |
| NCT06292065 Trial register | Gastric Ultrasound To Assess Gastric Contents In Patients On Semaglutide Therapy | completed | - | 2024-03-04 | - |
| NCT07152756 Trial register | Impact of a One-Week Discontinuation of Semaglutide on Gastric Retention and Endoscopic Mucosal Visibility Scores | not yet recruiting participants | - | 2025-09-03 | - |
| NCT05897398 Trial register | SEMASEARCH, Retrospective/Prospective Cohort Nested at ATUc/AP2 WEGOVY® | completed | - | 2023-05-31 | - |
| 2023-508525-27-00 Trial register | A multiarm, randomized, open label Clinical study comparing AntiatheroSClerotic efficacy of selected Antidiabetic agents in patients with coronary artery diseas | Not stated | 4 | - | - |
| NCT06986993 Trial register | Impact of Semaglutide on Tobacco Use and Related Health Behaviors | currently recruiting participants | - | 2025-05-23 | - |
| NCT07139548 Trial register | A Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 Diabetes | not yet recruiting participants | - | 2025-08-24 | - |
| NCT05530577 Trial register | Effects of Semaglutide on Nicotine Intake | completed | - | 2022-09-07 | Posted |
| NCT07135245 Trial register | Improved Treatment and Monitoring of Alzheimer's Disease | not yet recruiting participants | - | 2025-08-22 | - |
| NCT06909006 Trial register | Semaglutide Treatment in Type 1 Diabetes | not yet recruiting participants | - | 2025-04-03 | - |
| NCT05895643 Trial register | Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity? | completed | - | 2023-06-08 | - |
| NCT06118008 Trial register | A Study of HS-20094 in T2DM Participants | completed | - | 2023-05-25 | - |
| NCT06634927 Trial register | Pharmacokinetic Similarity, Safety, and Immunogenicity of Semaglutide Injection and Ozempic ® Injection in Healthy Subjects. | completed | - | 2024-10-10 | - |
| NCT07092605 Trial register | Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures | enrolling by invitation only | - | 2024-12-18 | - |
| NCT07092618 Trial register | Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation | currently recruiting participants | - | 2024-12-18 | - |
| NCT07090343 Trial register | Semaglutide in Patients Undergoing Transcatether Aortic Valve Replacement | not yet recruiting participants | - | 2025-07-29 | - |
| NCT06739044 Trial register | Efficacy and Safety of Semaglutide Injection vs Ozempic® in Patients With Type 2 Diabetes | completed | - | 2024-12-18 | - |
| NCT07073053 Trial register | The Role of Glucagon-Like Peptide-1 Receptor Agonists in Coronary Artery Diseases and Their Potential Mechanisms | not yet recruiting participants | - | 2025-07-18 | - |
| NCT06097390 Trial register | A Research Study Looking at New Protein-based Tablets in Healthy Men - Oral Formulation III | completed | - | 2023-10-24 | - |
| NCT07056803 Trial register | Oral vs. Subcutaneous Semaglutide in Type 2 Diabetes Mellitus | completed | - | 2025-07-09 | - |
| NCT04451837 Trial register | Semaglutide and Dapagliflozin in Diabetic Patients With Different Pathophysiology | running, but no longer enrolling | - | 2020-06-30 | - |
| NCT06161844 Trial register | Efficacy and Safety of Semaglutide Injection (HD1916) in Patients With Type 2 Diabetes Mellitus | completed | - | 2023-12-08 | - |
| NCT07043361 Trial register | Efficacy of Semaglutide in Glycemic Control, Weight Loss, and Improving Lipidogram- Role of Baseline Vitamin D Levels | completed | - | 2025-06-29 | - |
| 2023-503371-25-00 Trial register | Does the Glucagon-like Peptide 1 (GLP-1) receptor agonist semaglutide reduce alcohol intake in patients with Alcohol Use Disorder and comorbid obesity? | Not stated | 2 | - | - |
| NCT07046273 Trial register | Phase III Clinical Study on the Efficacy and Safety of Semaglutide and Ozempic® in Patients With Type 2 Diabetes | not yet recruiting participants | - | 2025-07-01 | - |
| NCT07035704 Trial register | Prevent and Reverse Obesity in Children, Adolescents and Young Adults | not yet recruiting participants | - | 2025-06-10 | - |
| NCT07036172 Trial register | Efficacy and Safety of Semaglutide Injection Vs WEGOVY® in Chinese Obese Patients | currently recruiting participants | - | 2025-06-25 | - |
| NCT07030621 Trial register | Efficacy of Semaglutide in Improving Neurological Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke: A Randomized Double-Blind Controlled Trial | not yet recruiting participants | - | 2025-06-22 | - |
| 2022-502139-20-00 Trial register | Semaglutide Treatment for Prevention of Toxicity in High-dose Chemotherapy with Autologous Hematopoietic Stem Cell Transplantation - a randomized, double-blind, | Not stated | 2 | - | - |
| NCT06060392 Trial register | Effect of Oral Semaglutide on Liver Fat and Body Composition in Liver Transplant Recipients With Diabetes Mellitus | currently recruiting participants | - | 2023-09-29 | - |
| NCT07018544 Trial register | A Multicentre, Prospective, Single-arm, Non-interventional Regulatory Post-marketing Surveillance (rPMS) Study to Investigate the Safety and Effectiveness of We | enrolling by invitation only | - | 2025-06-12 | - |
| NCT05303857 Trial register | Analyse the Effect of Semaglutide on Vascular Structure and Function in Patients With Early Type 2 Diabetes | completed | - | 2022-03-31 | - |
| NCT06363487 Trial register | Semaglutide and Cognition in Healthy Volunteers | completed | - | 2024-04-12 | - |
| 2024-517120-19-02 Trial register | Glucagone Like Peptide-1 Receptor (GLP-1R) Analogue Assisted Rapid Weight Loss Program as treatment of Idiopathic Intracranial Hypertension | Not stated | 4 | - | - |
| NCT06492330 Trial register | Efficacy and Safety of CS0159 Combined With Semaglutide in MASH Patients With Obesity and T2DM | completed | - | 2024-07-09 | - |
| NCT06924697 Trial register | Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients | enrolling by invitation only | - | 2025-04-11 | - |
| 2023-504988-16-00 Trial register | The effect of semaglutide therapy on hepatic fat content and on the acute reponse of liver fat to high-fat load in obese MASLD patients | Not stated | 3 | - | - |
| NCT06659679 Trial register | Emulating the PIONEER6 Diabetes Trial Using Healthcare Claims | completed | - | 2024-10-26 | - |
| NCT06659718 Trial register | Emulation of the SOUL Diabetes Trial in Healthcare Claims | completed | - | 2024-10-26 | - |
| 2022-502717-28-00 Trial register | A single arm study investigating the glycaemic control and safety of adding semaglutide to insulin icodec in participants with type 2 diabetes qualifying for tr | Not stated | 3 | - | - |
| NCT06987669 Trial register | Gastric Emptying in Healthy Volunteers and GLP-1 Agonist Users | not yet recruiting participants | - | 2025-05-08 | - |
| NCT06874751 Trial register | Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity in the Real World | completed | - | 2025-03-13 | - |
| NCT06974825 Trial register | A Study of BGM0504 in Chinese Patients With Type 2 Diabetes | completed | - | 2025-05-16 | - |
| NCT06937060 Trial register | Effect of Semaglutide in Patients With Psoriasis and Obesity | currently recruiting participants | - | 2025-04-20 | - |
| NCT05419726 Trial register | Brown Adipose Tissue Activity in Response to Semaglutide Administered to Obese Subjects. | currently recruiting participants | - | 2022-06-15 | - |
| 2024-518040-21-00 Trial register | A Phase 1 Trial Assessing Pharmacokinetics and Safety of CAM2056 (Semaglutide Subcutaneous Depot) | Not stated | 1 | - | - |
| NCT06959784 Trial register | Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study) | enrolling by invitation only | - | 2025-05-07 | - |
| NCT05786521 Trial register | Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults | completed | - | 2023-03-27 | Posted |
| NCT04032197 Trial register | A Research Study of How Semaglutide Works in People With Disease Affecting the Heart and/or Blood Vessels and Type 2 Diabetes | completed | - | 2019-07-25 | - |
| NCT06946628 Trial register | New Triple Therapy in Newly Diagnosed Type 2 Diabetes | not yet recruiting participants | - | 2025-03-03 | - |
| NCT04889183 Trial register | SeMaglutide and Albuminuria Reduction Trial in Obese Individuals Without Diabetes | completed | - | 2021-05-17 | - |
| NCT05302596 Trial register | Semaglutide Use in Elderly Obese Patients | completed | - | 2022-03-31 | Posted |
| NCT06351748 Trial register | Real-world Study of CHina Ozempic cLinicAl pRactice in Patients With Type 2 Diabetes (SCHOLAR) | completed | - | 2024-04-08 | - |
| NCT05520775 Trial register | Semaglutide for Alcohol Use Disorder | completed | - | 2022-08-30 | Posted |
| NCT06896981 Trial register | Semaglutide in Women With Polycystic Ovary Syndrome and Obesity | currently recruiting participants | - | 2025-03-26 | - |
| NCT06487832 Trial register | Effect of GLP1 Receptor Agonist on Brain Insulin Responsiveness | currently recruiting participants | - | 2024-06-27 | - |
| NCT06894784 Trial register | A Clinical Trial to Evaluate The Effects of Semaglutide and Empagliflozin Combined to Automated Insulin Delivery on Diabetes Control in Adults Living With Type | currently recruiting participants | - | 2025-03-25 | - |
| NCT05340868 Trial register | Genetics of the Acute Response to Oral Semaglutide | currently recruiting participants | - | 2022-04-22 | - |
| NCT05435677 Trial register | A Research Study to Look at How Insulin Icodec and Semaglutide Work in the Body of People From China With Type 2 Diabetes When Given Alone or Together | completed | - | 2022-06-28 | - |
| NCT06734312 Trial register | MAINTAIN (Mucosal AblatIoN Therapy After INcretins) | currently recruiting participants | NA | 2024-12-10 | - |
| NCT03819153 Trial register | A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease | completed | - | 2019-01-28 | Posted |
| NCT04979130 Trial register | Comparing Semaglutide Versus Placebo on Intestinal Barrier Function in Type 2 Diabetes Mellitus (SIB) | completed | - | 2021-07-28 | - |
| NCT05078255 Trial register | The Separate and Combined Effects of Long-term GIP and GLP-1 Receptor Activation in Patients with Type 2 Diabetes | completed | - | 2021-10-14 | - |
| NCT04873050 Trial register | Treatment to Regress to Normoglycemia in Women with a Recent History of GDM | currently recruiting participants | - | 2021-05-05 | - |
| 2024-510612-75-00 Trial register | Efficacy and safety of once-weekly semaglutide s.c. 2.0 mg as add-on to dose-reduced insulin glargine vs titrated insuline glargine in participants with type 2 | Not stated | 3 | - | - |
| NCT04817644 Trial register | A Research Study to See How Much Semaglutide and SNAC is in the Milk of Healthy, Breastfeeding Women Taking Semaglutide Tablets | completed | - | 2021-03-26 | - |
| NCT05920889 Trial register | Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke Treated by Reperfusion Therapies | completed | - | 2023-06-27 | - |
| NCT06863363 Trial register | PEG-rhGH and Semaglutide Combination Therapy in Non-Diabetic Obese Adults | not yet recruiting participants | - | 2025-03-07 | - |
| 2022-502164-20-01 Trial register | Semaglutide 2.4mg for low responders after bariatric surgery | Not stated | 4 | - | - |
| NCT06856928 Trial register | Impact of Antiobesity Medications on Appetite and Appetite-related Hormones and Metabolites. | not yet recruiting participants | - | 2025-02-13 | - |
| NCT05501483 Trial register | Adipose Tissue Heterogeneity and Its Link to Type 2 Diabetes | currently recruiting participants | - | 2022-08-15 | - |
| NCT06400615 Trial register | Study That Tests AD109 in Patients Taking GLP-1 Drugs | completed | 2 | 2024-04-12 | - |
| NCT04538352 Trial register | Transition From Basal/Bolus to Once-weekly Subcutaneous Semaglutide and Basal Insulin in Patients With T2D | completed | - | 2020-09-04 | Posted |
| 2023-506825-13-00 Trial register | A randomised double-blind placebo-controlled clinical study investigating the effects of semaglutide s.c. once-weekly versus placebo on central and peripheral i | Not stated | 3 | - | - |
| NCT05812183 Trial register | Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity | withdrawn before enrolling anyone | 4 | 2023-03-31 | - |
| NCT06825793 Trial register | Semaglutide's Weight Loss Effects in Obesity | not yet recruiting participants | - | 2025-02-13 | - |
| NCT06821919 Trial register | Impact of Antiglycemic & Immunosuppressive Therapies on NETosis in Diabetes & Kidney Disease (NETs - Neutrophil Traps) | currently recruiting participants | - | 2025-01-26 | - |
| NCT06820047 Trial register | Sleeve Gastrectomy vs. Lifestyle & Medications: Impact on BMI Trajectory and Target Attainment in a Matched Cohort Study | completed | - | 2025-01-27 | - |
| NCT06363747 Trial register | The Medically Reproducing Bariatric Surgery (MRB) II Study | running, but no longer enrolling | - | 2024-04-09 | - |
| NCT06716216 Trial register | A Study of BGM0504 in Participants with Type 2 Diabetes | currently recruiting participants | - | 2024-12-04 | - |
| NCT05700877 Trial register | Screening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes | currently recruiting participants | - | 2023-01-05 | - |
| NCT06792422 Trial register | A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma | currently recruiting participants | - | 2025-01-24 | - |
| NCT06788626 Trial register | Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular Treatment | not yet recruiting participants | - | 2025-01-23 | - |
| 2023-506961-74-00 Trial register | Efficacy and safety investigation of NNC0194-0499 co-administered with semaglutide in subjects with non-alcoholic steatohepatitis: a dose-ranging, placebo-contr | Not stated | 2 | - | - |
| NCT05205928 Trial register | Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care | completed | - | 2022-01-25 | - |
| NCT05751226 Trial register | A Study in People With Overweight or Obesity to Test How Well Different Doses of BI 1820237 Are Tolerated When Given Alone or in Combination With Either Semaglu | completed | - | 2023-03-02 | - |
| 2024-517463-23-00 Trial register | Weight management with orismilast alone or in combination with s.c. semaglutide (WELOSITI) | Not stated | 2 | - | - |
| NCT04515849 Trial register | A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus | completed | - | 2020-08-17 | Posted |
| NCT05671653 Trial register | A Study to Evaluate the Effect of the Experimental GLP-1 Drug PF-07081532 on Blood Levels of Common Birth Control Pills, and Drugs Omeprazole and Midazolam, and | terminated before completion | - | 2023-01-05 | Posted |
| NCT06761703 Trial register | A Study to Determine the Feasibility of Online Recruitment of People Using an Anti-Obesity Medication for Weight Loss | completed | - | 2025-01-01 | - |
| NCT06082063 Trial register | Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes | currently recruiting participants | - | 2023-10-13 | - |
| NCT06764056 Trial register | Characterization and Management of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) | not yet recruiting participants | - | 2025-01-08 | - |
| NCT06387199 Trial register | Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide | currently recruiting participants | - | 2024-04-26 | - |
| NCT06234111 Trial register | Semaglutide and Physical Activity for Obesity and Multimorbidity | running, but no longer enrolling | - | 2024-01-31 | - |
| NCT05073835 Trial register | Semaglutide 2.4 mg in Patients With Poor Weight-loss | running, but no longer enrolling | - | 2021-10-12 | - |
| NCT06629688 Trial register | Semaglutide and Intestinal Iron Absorption | completed | - | 2024-10-08 | - |
| 2024-510802-10-00 Trial register | The impact of pramlintide on top of semaglutide in obese people with prediabetes | Not stated | 2/3 | - | - |
| NCT06699329 Trial register | A Study of Enlicitide Decanoate (MK-0616) and Semaglutide in Healthy Adult Participants (MK-0616-023) | completed | - | 2024-11-21 | - |
| 2024-518510-87-00 Trial register | Additive Benefits of Semaglutide for open-AngLe glaucoma - an Opportunity for Neuroprotection (ABSALON) | Not stated | 4 | - | - |
| NCT06686134 Trial register | Comprehensive Clinical Evaluation Study of GLP-1RA | currently recruiting participants | - | 2024-11-01 | - |
| NCT03789578 Trial register | A Research Study to Look at How Insulin 287 and Semaglutide Work in the Body of People With Type 2 Diabetes When Taken Alone or Together | completed | - | 2018-12-28 | - |
| NCT06581120 Trial register | GLP_1 RA Ultrasound Study | enrolling by invitation only | - | 2024-09-03 | - |
| 2024-518746-24-00 Trial register | Does the glucagon-like peptide-1 receptor agonist semaglutide prevent deterioration of metabolic state in prediabetic or diabetic patients with schizophrenia tr | Not stated | 2 | - | - |
| NCT05087342 Trial register | Latino Semaglutide Study | completed | - | 2021-10-21 | - |
| NCT05689099 Trial register | A Research Trial Looking at the Comparability of 2 Different Concentrations of Semaglutide for the 0.5 Milligram (mg) Dose | completed | - | 2023-01-18 | - |
| NCT06633783 Trial register | A Phase III Study Comparing the Weight Loss Effects of Semaglutide Injection and Wegovy® | not yet recruiting participants | - | 2024-10-09 | - |
| NCT06318442 Trial register | The GAPSID Study - How GLP-1 Analogues Prevent Steroid-Induced Diabetes | currently recruiting participants | - | 2024-03-19 | - |
| NCT04017832 Trial register | A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 Diabetes | completed | - | 2019-07-12 | Posted |
| NCT04216589 Trial register | Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardio | completed | - | 2020-01-02 | Posted |
| NCT06616961 Trial register | Efficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes Mellitus | not yet recruiting participants | - | 2024-09-27 | - |
| NCT04892199 Trial register | Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication? | last verified some time ago; the register no longer confirms its status | - | 2021-05-19 | - |
| NCT05577728 Trial register | Prediction of the SEPRA Diabetes Trial in Healthcare Claims Data | completed | - | 2022-10-13 | - |
| NCT05897372 Trial register | Feasibility of Aggressive Albuminuria Reduction in Biopsy-Proven Diabetic Nephropathy - a Pilot Study | terminated before completion | - | 2023-06-09 | - |
| NCT04109547 Trial register | A Research Study Comparing a New Medicine Oral Semaglutide to Placebo in People With Type 2 Diabetes | completed | - | 2019-09-30 | Posted |
| NCT04537624 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Switzerland, as Part of Local Clinical Practice | completed | - | 2020-09-03 | - |
| NCT05227196 Trial register | A Research Study Looking at the Comparability of 2 Different Forms of Oral Semaglutide in Healthy People | completed | - | 2022-02-07 | - |
| NCT05236517 Trial register | A Research Study Looking at How 50 mg Semaglutide Daily Affects Food Intake and Emptying of the Stomach in People With Obesity | completed | - | 2022-02-11 | - |
| NCT05502562 Trial register | A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes in India | completed | - | 2022-08-16 | - |
| NCT03574597 Trial register | Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity | completed | - | 2018-07-02 | Posted |
| 2023-506434-69-00 Trial register | FINESSE; Optimization of albuminuria lowering therapies to individual patients with CKD using FINErenone and SEmaglutide (FINESSE-CKD) | Not stated | 2 | - | - |
| NCT06557811 Trial register | Effect of Oral Semaglutide on Epicardial and Pericoronary Adipose Tissues in Type 2 Diabetes After Myocardial Infarction | last verified some time ago; the register no longer confirms its status | - | 2024-08-16 | - |
| NCT06555146 Trial register | Semaglutide's Effect on Renal Hemodynamics and Function in Patients With Type 2 Diabetes Mellitus and Nephropathy | last verified some time ago; the register no longer confirms its status | - | 2024-08-15 | - |
| NCT05429593 Trial register | A Research Study Investigating How Semaglutide and Dapagliflozin Act in Your Body When Dosed in One Tablet | completed | - | 2022-06-23 | - |
| NCT06541509 Trial register | Mechanisms of Semaglutide Therapy in Heart Failure Patients | last verified some time ago; the register no longer confirms its status | - | 2024-08-07 | - |
| NCT04990024 Trial register | The Effect of Different Diets on Arterial Stiffness in Obese Patients on Semaglutide | last verified some time ago; the register no longer confirms its status | - | 2021-08-04 | - |
| NCT05579977 Trial register | Trial to Learn About the Study Medicine (PF-07081532) and Rybelsus in People With Type 2 Diabetes and Separately PF-07081532 in People With Obesity | terminated before completion | - | 2022-10-11 | Posted |
| NCT06449235 Trial register | Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in Bangladesh | last verified some time ago; the register no longer confirms its status | - | 2024-06-07 | - |
| NCT04016974 Trial register | A Research Study of How Oral Semaglutide Tablets Work in Healthy People Who Are Chinese | completed | - | 2019-07-12 | - |
| NCT06497049 Trial register | Open Randomized Study of Comparative Pharmacokinetics and Biosimilarity of GP40221 (GEROPHARM LLC, Russia) and Ozempic®. | completed | - | 2024-07-04 | - |
| NCT05193578 Trial register | Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes | completed | - | 2022-01-18 | - |
| NCT06489457 Trial register | The Effects of Semaglutide vs Testosterone Replacement Therapy on Functional Hypogonadism and Sperm Quality in Men With Type 2 Diabetes Mellitus and Obesity | completed | - | 2024-07-08 | - |
| NCT06475586 Trial register | Effect of Semaglutide on the Psoriatic Lesions in Patients With Type 2 Diabetes Mellitus | completed | - | 2024-06-26 | - |
| 2024-510885-17-01 Trial register | Defining the Glucagon Unit: Investigating the Impact on Energy Expenditure and Glucose Level Deviation in healthy volunteers | Not stated | 1 | - | - |
| NCT06461377 Trial register | The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy | currently recruiting participants | - | 2024-06-17 | - |
| NCT06449625 Trial register | Semaglutide in Auto-HSCT | not yet recruiting participants | - | 2024-06-10 | - |
| NCT05780905 Trial register | Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes | currently recruiting participants | - | 2023-03-23 | - |
| NCT03987451 Trial register | A Research Study on How Semaglutide Works in People With Fatty Liver Disease and Liver Damage | completed | - | 2019-06-17 | Posted |
| NCT05129891 Trial register | A Research Study Looking at New Protein-based Tablets in Healthy Male Participants | completed | - | 2021-11-22 | - |
| NCT06426446 Trial register | Monitoring Patients With Severe Obesity Treated With Wegovy® Using Connected Device: Real-world Data | last verified some time ago; the register no longer confirms its status | - | 2024-05-13 | - |
| NCT06422624 Trial register | A Study to Evaluate Safety, Tolerability and pK of Semaglutide ER Injectable Suspension in Healthy, Adult Human Subjects | last verified some time ago; the register no longer confirms its status | - | 2024-05-21 | - |
| NCT05646199 Trial register | Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS) | last verified some time ago; the register no longer confirms its status | - | 2022-12-12 | - |
| NCT06361823 Trial register | Exploratory Study on the Efficacy and Safety of Semaglutide for Idiopathic Intracranial Hypertension Treatment | last verified some time ago; the register no longer confirms its status | - | 2024-04-12 | - |
| NCT06354101 Trial register | The Purpose of This Registry Study is to Learn More About Metabolic Health: Approximately 15,000 Participants Who Are Overweight or Have Obesity With or Without | withdrawn before enrolling anyone | - | 2024-04-09 | - |
| NCT06344247 Trial register | Comparison of the Efficacy and Safety of SGLT2i and GLP-1 Receptor Agonists in Obese Patients With Kidney Disease | last verified some time ago; the register no longer confirms its status | - | 2024-03-17 | - |
| NCT05813249 Trial register | Semaglutide in Nonalcoholic Fatty Liver Disease | completed | - | 2023-04-14 | - |
| NCT06339086 Trial register | Efficacy and Safety of Semaglutide Injection in Subjects With Type 2 Diabetes | last verified some time ago; the register no longer confirms its status | - | 2024-04-01 | - |
| NCT05702905 Trial register | Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome | last verified some time ago; the register no longer confirms its status | - | 2023-01-27 | - |
| NCT06301191 Trial register | The Effect of Semaglutide on Cardiovascular Markers and Liver Function | last verified some time ago; the register no longer confirms its status | - | 2024-03-08 | - |
| NCT06298799 Trial register | GENETIC VARIABILITY TO GLP1 TREATMENT | last verified some time ago; the register no longer confirms its status | - | 2024-03-01 | - |
| NCT06149260 Trial register | Subcutaneous Semaglutide in Systemic Scleroderma | last verified some time ago; the register no longer confirms its status | - | 2023-11-28 | - |
| NCT06287307 Trial register | Semaglutide 2.4mg for Low Responders After Bariatric Surgery | last verified some time ago; the register no longer confirms its status | - | 2024-03-01 | - |
| NCT05766709 Trial register | A Research Study Comparing Blood Levels of Medicines NNC0194-0499 and Semaglutide Administered as a Combination Formulation Versus Two Separate Formulations | completed | - | 2023-03-13 | - |
| NCT05136287 Trial register | SEMAGLUTIDE VERSUS GLP-1 RECEPTOR AGONISTS. EFFECTIVENESS , SAFETY AND QUALITY OF LIFE IN PATIENTS WITH DIABETES MELLITUS 2. OBSERVATIONAL, PROSPECTIVE AND MULT | completed | - | 2021-11-29 | - |
| NCT05390307 Trial register | Obesity Treatment to Improve Diabetes | completed | - | 2022-05-25 | - |
| NCT06083675 Trial register | Research Study to Compare Semaglutide Tablets With Empagliflozin or Metformin Tablets in People With Type 2 Diabetes | withdrawn before enrolling anyone | - | 2023-10-16 | - |
| NCT06256549 Trial register | A Study of GZR18 Injection in Chinese Patients With Type 2 Diabetes Mellitus | last verified some time ago; the register no longer confirms its status | - | 2024-02-13 | - |
| NCT06221696 Trial register | Preventing Weight Regain Post-Semaglutide Treatment With Active Fiber Supplement (Soloways) | completed | - | 2024-01-24 | - |
| NCT04741074 Trial register | Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy | terminated before completion | - | 2021-02-05 | Posted |
| NCT06243536 Trial register | The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients | last verified some time ago; the register no longer confirms its status | - | 2024-02-06 | - |
| NCT06120556 Trial register | Efficacy of Glucagon-like Peptide-1 Receptor Agonists According to Type 2 Diabetes Subtypes | completed | - | 2023-11-07 | - |
| NCT05232708 Trial register | A Clinical Trial Looking at the Comparability of 2 Different Forms of Semaglutide | completed | - | 2022-02-10 | - |
| NCT06215196 Trial register | Effectiveness and Safety of Semaglutide Combined With Dietary Fiber (Soloways) in Adults With Overweight or Obesity | completed | - | 2024-01-22 | - |
| NCT05751720 Trial register | Effect on Non-Alcoholic Fatty Liver Disease in Patients With Type 2 Diabetes Mellitus With Gastric Inhibitory Polypeptide/Glucagon Like Peptide-1 Analogue | last verified some time ago; the register no longer confirms its status | 1/2 | 2023-03-02 | - |
| NCT05716724 Trial register | O-SEMA-Fast: A Research Study to Understand How Oral Semaglutide Works in People With Type 2 Diabetes Who Plan to Fast During Ramadan in the United Arab Emirate | completed | - | 2023-02-08 | - |
| NCT05816057 Trial register | A Study of the Efficacy and Safety of Semaglutide Injection in the Treatment of Type 2 Diabetes Mellitus | completed | - | 2023-04-18 | - |
| NCT06182618 Trial register | Retrospective Analysis for Patients With Metabolic Syndrome | last verified some time ago; the register no longer confirms its status | - | 2023-12-27 | - |
| NCT05498610 Trial register | A Research Study of How the Medicine NNC0480-0389 Taken With Semaglutide Works in the Body of Healthy Chinese Men | completed | - | 2022-08-12 | - |
| 2023-503949-65-00 Trial register | A research study comparing the effect of different dosing conditions on blood levels of semaglutide in a new tablet composition in healthy participants | Not stated | 1 | - | - |
| NCT06154486 Trial register | Evaluation of Gastric Content of Volunteers Fasting and Using Semaglutide: an Observational and Cross-sectional Study | completed | - | 2023-12-04 | - |
| NCT04944992 Trial register | A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001) | completed | - | 2021-06-30 | Posted |
| NCT04624672 Trial register | Treatment of GLP-1 for Diabetic Bariatric Patients | terminated before completion | - | 2020-11-12 | Posted |
| NCT04259801 Trial register | First Research Study to Look at How Two Medicines, NNC0480-0389 and Semaglutide, Work Together in Healthy People, in People With High Body Weight and in People | completed | - | 2020-02-06 | - |
| NCT05153564 Trial register | A Research Study Looking Into the Effect of Semaglutide and NNC0480 0389 on Blood Levels of a Birth Control Pill in Woman After Menopause | completed | - | 2021-12-10 | - |
| NCT04885634 Trial register | Semaglutide for the Reduction of Arrhythmia Burden in Overweight AF Patients | withdrawn before enrolling anyone | - | 2021-05-13 | - |
| NCT04524832 Trial register | Research Study Comparing New Tablets of Semaglutide in New Doses, in Healthy People | completed | - | 2020-08-24 | - |
| NCT03985384 Trial register | Semaglutide Treatment On Coronary Progression | completed | - | 2019-06-13 | - |
| NCT06057077 Trial register | Semaglutide GLP1 Agonists With Degludec Basal-bolus Insulin in Early Type 1 Diabetes to Basal-bolus | last verified some time ago; the register no longer confirms its status | - | 2023-09-28 | - |
| NCT04263415 Trial register | The Effects of Semaglutide on Taste, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Response in Women With PCOS and Obesity | completed | - | 2020-02-10 | - |
| NCT05990374 Trial register | Therapeutic Effects and Effects on Body Fat of GLP-1 Receptor Agonists in Patients With Type 2 Diabetes for 1-4 Years | last verified some time ago; the register no longer confirms its status | NA | 2023-08-14 | - |
| NCT05870462 Trial register | Semaglutide and Vascular Regeneration | last verified some time ago; the register no longer confirms its status | - | 2023-05-23 | - |
| NCT05950516 Trial register | Efficacy and Safety of Semaglutide Ingection in Subjects With Type 2 Diabetes | last verified some time ago; the register no longer confirms its status | - | 2023-07-18 | - |
| 2023-504159-29-00 Trial register | Safety and efficacy of oral semaglutide in hyperglycaemic patients after renal transplantation | Not stated | 2 | - | - |
| NCT03693430 Trial register | Two-year Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity | completed | - | 2018-10-03 | Posted |
| NCT05046873 Trial register | A Research Study Looking Into Blood Levels of Semaglutide and NNC0480-0389 When Given in the Same Injection or in Two Separate Injections in Healthy People | completed | - | 2021-09-16 | - |
| NCT05161429 Trial register | BESTMED: Observational Evaluation of Second Line Therapy Medications in Diabetes | last verified some time ago; the register no longer confirms its status | - | 2021-11-23 | - |
| 2022-501072-25-02 Trial register | The safety and efficacy of acute subcutaneous administration of semaglutide in non-diabetic patients with acute ischemic stroke: a multicentre, phase 2, prospec | Not stated | 2 | - | - |
| NCT01511393 Trial register | An Active Surveillance Program for Cases of Medullary Thyroid Carcinoma (MTC) | enrolling by invitation only | - | 2011-11-30 | - |
| NCT04938388 Trial register | Comparison of Oral Semaglutide w/ Placebo- Treatment for Latino Adults w/T2 Diabetes Receiving Enhanced Lifestyle Care | terminated before completion | - | 2021-06-24 | - |
| NCT04074161 Trial register | Research Study to Investigate How Well Semaglutide Works Compared to Liraglutide in People Living With Overweight or Obesity | completed | - | 2019-08-29 | Posted |
| NCT04878406 Trial register | A Research Study of How the Medicine NNC0480-0389 Taken With Semaglutide Works in the Body of Healthy Japanese Men | completed | - | 2021-05-07 | - |
| NCT05779644 Trial register | Effects of GLP-1RA on Body Weight, Metabolism and Fat Distribution in Overweight/Obese Patients With Type 2 Diabetes Mellitus | last verified some time ago; the register no longer confirms its status | - | 2023-03-22 | - |
| NCT04513704 Trial register | A Clinical Trial Comparing Semaglutide in Healthy People Who Eat and Take the Medicine at Different Times | completed | - | 2020-08-14 | - |
| NCT05857085 Trial register | Novel Therapeutics and Endothelial Dysfunction in T1DM Patients | completed | - | 2023-05-12 | - |
| NCT04200625 Trial register | Semaglutide vs Dulaglutide on Epicardial Adipose Tissue | completed | - | 2019-12-16 | - |
| NCT05597202 Trial register | Does the Hematopoietic Stem Cell Govern Residual Inflammatory Cardiovascular Risk in Type 2 Diabetes | last verified some time ago; the register no longer confirms its status | - | 2022-10-27 | - |
| NCT05630586 Trial register | Acute Subcutaneous SemaglutidE in Acute Ischemic sTroke | currently recruiting participants | - | 2022-11-29 | - |
| 2022-500007-52-00 Trial register | A study comparing exposure of semaglutide and dapagliflozin dosed orally as mono-components versus in a fixed-dose combination | Not stated | 1 | - | - |
| NCT04083820 Trial register | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in France, as Part of Local Clinical Practice (SURE FRANCE) | completed | - | 2019-09-10 | - |
| NCT04261933 Trial register | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Germany, as Part of Local Clinical Practice (SURE GERMANY) | completed | - | 2020-02-10 | - |
| NCT03951753 Trial register | A Study of Tirzepatide in Participants With Type 2 Diabetes Mellitus (T2DM) | completed | 1 | 2019-05-15 | Posted |
| NCT03292315 Trial register | Once Weekly GLP-1 in Persons With Spinal Cord Injury | completed | - | 2017-09-25 | - |
| NCT04094415 Trial register | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Italy, as Part of Local Clinical Practice | completed | - | 2019-09-19 | - |
| NCT04865744 Trial register | The Effect of Semaglutide on Pituitary Function | completed | - | 2021-04-29 | - |
| NCT05468632 Trial register | A Study in North Macedonia Investigating Retrospective Data of Glucagon-like Peptide-1 (GLP-1) Participants With Type 2 Diabetes (T2D) in Real World Environment | completed | - | 2022-07-21 | - |
| NCT03989232 Trial register | A Research Study to Compare Two Doses of Semaglutide Taken Once Weekly in People With Type 2 Diabetes | completed | - | 2019-06-18 | Posted |
| 2022-501106-35-00 Trial register | I8F-MC-GPHJ: A Phase 3b, Randomized Controlled Study to Evaluate the Efficacy and Safety of Tirzepatide Compared to Semaglutide 2.4 mg in Adults Who Have Obesit | Not stated | 3 | - | - |
| NCT03929679 Trial register | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in The Netherlands, as Part of Local Clinical Practice (SURE NETHERLANDS) | completed | - | 2019-04-29 | - |
| NCT04153929 Trial register | A Study to Test Whether Different Doses of BI 456906 Are Effective in Treating Adults With Type 2 Diabetes. | completed | - | 2019-11-06 | Posted |
| NCT05616052 Trial register | Comparison of Body Weight Change Through Different Smeglutide Administration Methods | last verified some time ago; the register no longer confirms its status | - | 2022-11-15 | - |
| NCT03689374 Trial register | A Research Study to Compare Semaglutide to Insulin Aspart, When Taken Together With Metformin and Insulin Glargine, in People With Type 2 Diabetes | completed | - | 2018-09-28 | Posted |
| NCT05444153 Trial register | Research Study to Compare Semaglutide Tablets With Empagliflozin Tablets Taken Once Daily in People With Type 2 Diabetes and Obesity | withdrawn before enrolling anyone | - | 2022-07-05 | - |
| NCT04189848 Trial register | Comparison of Injection Site Pain Experience for Semaglutide and Dulaglutide sc | completed | - | 2019-12-06 | Posted |
| NCT05606471 Trial register | Glucagon-like Peptide-1 Agonism With Very Low Calorie Diets | last verified some time ago; the register no longer confirms its status | - | 2022-11-04 | - |
| NCT05209165 Trial register | Semaglutide to Reduce Atrial Fibrillation Burden | suspended | - | 2022-01-26 | - |
| NCT05322200 Trial register | The POST-ACS Study | last verified some time ago; the register no longer confirms its status | - | 2022-02-11 | - |
| NCT05473286 Trial register | A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Germany, as Part of Local Clinical Practice | withdrawn before enrolling anyone | - | 2022-07-25 | - |
| NCT05492305 Trial register | Glucagon-like Peptide 1 (GLP1) Receptor Agonists and Mental Health | last verified some time ago; the register no longer confirms its status | - | 2022-08-08 | - |
| NCT04097600 Trial register | A Research Study Comparing Active Drug in the Blood in Healthy Participants Following Dosing of the Current and a New Formulation (D) Semaglutide Tablets | completed | - | 2019-09-20 | - |
| NCT05249881 Trial register | "Efficacy of Once Weekly GLP 1 Analogue: Semaglutide. A Multicenter Experience From Pakistan." | last verified some time ago; the register no longer confirms its status | - | 2022-02-22 | - |
| NCT02607865 Trial register | Efficacy and Long-term Safety of Oral Semaglutide Versus Sitagliptin in Subjects With Type 2 Diabetes | completed | - | 2015-11-18 | Posted |
| NCT02692716 Trial register | A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes | completed | - | 2016-02-26 | Posted |
| NCT02849080 Trial register | Efficacy and Safety of Oral Semaglutide Using a Flexible Dose Adjustment Based on Clinical Evaluation Versus Sitagliptin in Subjects With Type 2 Diabetes Mellit | completed | - | 2016-07-29 | Posted |
| NCT02863328 Trial register | Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus | completed | - | 2016-08-11 | Posted |
| NCT02863419 Trial register | Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus | completed | - | 2016-08-11 | Posted |
| NCT02906930 Trial register | Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Diet and Exercise Only | completed | - | 2016-09-20 | Posted |
| NCT05442450 Trial register | Efficacy of Oral Semaglutide in Overweight or Obesity | last verified some time ago; the register no longer confirms its status | - | 2022-07-05 | - |
| NCT05147896 Trial register | Semaglutide Anti-Atherosclerotic Mechanisms of Action Study in Type 2 Diabetes Patients | last verified some time ago; the register no longer confirms its status | - | 2021-12-07 | - |
| NCT04854083 Trial register | Semaglutide as an Adjunct to Dieting in the Treatment of Type 2 Diabetes | last verified some time ago; the register no longer confirms its status | - | 2021-04-22 | - |
| NCT03811574 Trial register | STEP 6: Research Study Investigating How Well Semaglutide Works in People Living With Overweight or Obesity | completed | - | 2019-01-22 | Posted |
| NCT03987919 Trial register | A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes | completed | 3 | 2019-06-17 | Posted |
| NCT04615871 Trial register | Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19 | last verified some time ago; the register no longer confirms its status | - | 2020-11-04 | - |
| NCT04287179 Trial register | SUSTAIN SWITCH: A Research Study to Compare Two Dose Schedules of Semaglutide Taken Once Weekly in People With Type 2 Diabetes | withdrawn before enrolling anyone | - | 2020-02-27 | - |
| NCT03548987 Trial register | Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity | completed | - | 2018-06-07 | Posted |
| NCT04228354 Trial register | A Research Study Looking at the Comparability (Bioequivalence) of Two Versions of Semaglutide | completed | - | 2020-01-14 | - |
| NCT03357380 Trial register | A Study on How Semaglutide Works on Early Stages of Scar Tissue in the Liver Assessed by Pictures of the Liver | completed | - | 2017-11-29 | - |
| NCT03548935 Trial register | STEP 1: Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity | completed | - | 2018-06-07 | Posted |
| NCT03600480 Trial register | A Research Study of How NNC0174-0833 Taken With Semaglutide Works in People Who Are Overweight or Obese | completed | - | 2018-07-26 | - |
| NCT02970942 Trial register | Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis. | completed | - | 2016-11-22 | Posted |
| NCT03648281 Trial register | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Denmark and Sweden, as Part of Local Clinical Practice (SURE DENMARK/SWEDEN) | completed | - | 2018-08-27 | - |
| NCT03611582 Trial register | Research Study to Look at How Well Semaglutide is at Lowering Weight When Taken Together With an Intensive Lifestyle Program | completed | - | 2018-08-02 | Posted |
| NCT04187300 Trial register | A Research Study Looking at the Comparability (Bioequivalence) of Two Forms of Semaglutide in Two Different Pen-injectors in People With Overweight or Obesity | completed | - | 2019-12-05 | - |
| NCT04152915 Trial register | A Research Study Looking at Similarity Between Once-weekly Semaglutide Versions for Different Injection Pens | completed | - | 2019-11-05 | - |
| NCT03552757 Trial register | Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity | completed | - | 2018-06-12 | Posted |
| NCT05071417 Trial register | Effect Of Semaglutide In Coronary Atheroma Plaque | last verified some time ago; the register no longer confirms its status | - | 2021-10-08 | - |
| NCT04067999 Trial register | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Spain, as Part of Local Clinical Practice | completed | - | 2019-08-28 | - |
| NCT03457012 Trial register | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Canada, as Part of Local Clinical Practice | completed | - | 2018-03-07 | - |
| NCT03631186 Trial register | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in Switzerland, as Part of Local Clinical Practice (SURE SWITZERLAND) | completed | - | 2018-08-15 | - |
| NCT03987074 Trial register | Safety, Tolerability, and Efficacy of Monotherapy and Combination Regimens in Participants With Nonalcoholic Steatohepatitis (NASH) | completed | - | 2019-06-14 | Posted |
| NCT03086330 Trial register | Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus | completed | - | 2017-03-22 | Posted |
| NCT03574584 Trial register | A Research Study of NNC0165-1562 and Semaglutide in People Who Are Overweight or Obese | completed | - | 2018-07-02 | - |
| NCT04702516 Trial register | The Effect of Semaglutide on Bone Turnover in Patients With Increased Risk of Bone Fracture | last verified some time ago; the register no longer confirms its status | - | 2021-01-11 | - |
| NCT03015220 Trial register | Safety and Efficacy of Oral Semaglutide Versus Dulaglutide Both in Combination With One OAD (Oral Antidiabetic Drug) in Japanese Subjects With Type 2 Diabetes | completed | - | 2017-01-09 | Posted |
| NCT03061214 Trial register | Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin in Subjects With Type 2 Diabetes (SUSTAIN - CHINA MRCT) | completed | - | 2017-02-23 | Posted |
| NCT03288740 Trial register | A Trial to Assess the Pharmacokinetics, Safety and Tolerability of Semaglutide in Healthy Chinese Subjects | completed | - | 2017-09-20 | - |
| NCT04383197 Trial register | Exercise and GLP-1 RA on Insulin Secretion | last verified some time ago; the register no longer confirms its status | - | 2020-05-12 | - |
| NCT04109508 Trial register | A Research Study Comparing Active Drug in the Blood in Healthy Participants Following Dosing of the Current and a New Formulation (C) Semaglutide Tablets | completed | - | 2019-09-30 | - |
| NCT04143945 Trial register | A Study Comparing the Injection Site Pain Experience After the Injection of Semaglutide B and Semaglutide D With 2 Different Injection Pens, a Compound for the | completed | - | 2019-10-30 | Posted |
| NCT03876015 Trial register | A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in United Kingdom, as Part of Local Clinical Practice (SURE UK) | completed | - | 2019-03-15 | - |
| NCT01923181 Trial register | Multiple Dose Trial Examining Dose Range, Escalation and Efficacy of Oral Semaglutide in Subjects With Type 2 Diabetes | completed | - | 2013-08-15 | Posted |
| NCT03018028 Trial register | Dose-response, Safety and Efficacy of Oral Semaglutide Versus Placebo and Versus Liraglutide, All as Monotherapy in Japanese Subjects With Type 2 Diabetes | completed | - | 2017-01-11 | Posted |
| NCT03842202 Trial register | A Research Study to Look at How Semaglutide Affects Gastric Emptying in People With Obesity | completed | - | 2019-02-15 | - |
| NCT02773381 Trial register | A Trial Investigating the Effect of Oral Semaglutide Compared With Placebo on Postprandial Glucose and Triglyceride Metabolism, Energy Intake, Appetite Sensatio | completed | - | 2016-05-16 | - |
| NCT04238962 Trial register | A Research Study to Compare Two Different Forms of Once-weekly Semaglutide in Two Different Injection Pens | completed | - | 2020-01-23 | - |
| NCT04007107 Trial register | A Study Comparing the Injection Site Pain Experience After the Injection of 2 Different Solutions of Semaglutide With 2 Different Injection Pens, a Compound for | completed | - | 2019-07-05 | Posted |
| NCT04447859 Trial register | 16-week Flexible vs. 8-week Semaglutide Titration | last verified some time ago; the register no longer confirms its status | - | 2020-06-25 | - |
| NCT03724981 Trial register | A Study Comparing the Dulaglutide Pen and the Semaglutide Pen | completed | - | 2018-10-30 | Posted |
| NCT02453711 Trial register | Investigation of Safety and Efficacy of Once-daily Semaglutide in Obese Subjects Without Diabetes Mellitus | completed | - | 2015-05-25 | Posted |
| NCT03021187 Trial register | Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin | completed | - | 2017-01-13 | Posted |
| NCT04175665 Trial register | Real-world Health Outcomes in Canadian Patients Using Semaglutide | completed | - | 2019-11-25 | - |
| NCT02070510 Trial register | A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy Subjects | completed | - | 2014-02-25 | - |
| NCT02249910 Trial register | Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects | completed | - | 2014-09-26 | - |
| NCT02827708 Trial register | Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes and Moderate Renal Impairment | completed | - | 2016-07-11 | Posted |
| NCT03136484 Trial register | Efficacy and Safety of Semaglutide Versus Canagliflozin as add-on to Metformin in Subjects With Type 2 Diabetes | completed | - | 2017-05-02 | Posted |
| NCT03598621 Trial register | A Research Study to Look at Similarity Between Semaglutide Versions in Different Injection Tools | completed | - | 2018-07-26 | - |
| NCT03611322 Trial register | A Trial to Compare Blood Concentration Levels of Semaglutide Following Subcutaneous Injections of Semaglutide 1 mg by 2 Different Devices (the DV3372 Device and | completed | - | 2018-08-02 | - |
| NCT03638778 Trial register | Research Study Comparing Different Tablets With the Study Medicine Semaglutide in Healthy Men | completed | - | 2018-08-20 | - |
| NCT04012255 Trial register | A Research Study to Compare Two Forms of Semaglutide in Two Different Pen-injectors in People With Overweight or Obesity | terminated before completion | - | 2019-07-09 | - |
| NCT02648204 Trial register | Efficacy and Safety of Semaglutide Versus Dulaglutide as add-on to Metformin in Subjects With Type 2 Diabetes. | completed | - | 2016-01-06 | Posted |
| NCT03191396 Trial register | Research Study Comparing a New Medicine Semaglutide to Liraglutide in People With Type 2 Diabetes | completed | - | 2017-06-19 | Posted |
| NCT03707990 Trial register | A Research Study of NNC0165-1875 Alone or Together With Semaglutide in People Who Are Overweight or Obese | completed | - | 2018-10-16 | - |
| NCT04061200 Trial register | Renal Effects of Treatment With Empagliflozin Alone or in Combination With Semaglutide in Patients With Type 2 Diabetes and Albuminuria | last verified some time ago; the register no longer confirms its status | - | 2019-08-19 | - |
| NCT00696657 Trial register | A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and Liraglutide | completed | - | 2008-06-13 | Posted |
| NCT02461589 Trial register | Dose-finding of Semaglutide Administered Subcutaneously Once Daily Versus Placebo and Liraglutide in Subjects With Type 2 Diabetes | completed | - | 2015-06-03 | Posted |
| NCT01720446 Trial register | Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes | completed | - | 2012-11-02 | Posted |
| NCT03466567 Trial register | A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects | completed | - | 2018-03-15 | - |
| NCT01885208 Trial register | Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Di | completed | - | 2013-06-24 | Posted |
| NCT01930188 Trial register | Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 Diabetes | completed | - | 2013-08-28 | Posted |
| NCT02128932 Trial register | Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects | completed | - | 2014-05-01 | Posted |
| NCT02054897 Trial register | Efficacy and Safety of Semaglutide Once-weekly Versus Placebo in Drug-naïve Subjects With Type 2 Diabetes | completed | - | 2014-02-04 | Posted |
| NCT02305381 Trial register | Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With T | completed | - | 2014-12-02 | Posted |
| NCT02877355 Trial register | Investigation of the Effect of Upper Gastrointestinal Disease on the Pharmacokinetics of Oral Semaglutide in Subjects With Type 2 Diabetes. | completed | - | 2016-08-24 | - |
| NCT02207374 Trial register | A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly in Monotherapy or in Combination With One OAD in Japanese Subjects With Type 2 Diabetes | completed | - | 2014-08-04 | Posted |
| NCT01686945 Trial register | Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of a Long-acting GLP-1 Analogue in Healthy Male Subjects and Male | completed | - | 2012-09-18 | - |
| NCT02254291 Trial register | A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly Versus Sitagliptin Once Daily in Japanese Subjects With Type 2 Diabetes | completed | - | 2014-10-01 | Posted |
| NCT03659682 Trial register | GLP1R in Parkinson's Disease | last verified some time ago; the register no longer confirms its status | - | 2018-09-06 | - |
| NCT02147431 Trial register | A Trial Investigating the Effect of Semaglutide on Hypoglycaemic Counterregulation Compared to Placebo in Subjects With Type 2 Diabetes | completed | - | 2014-05-26 | - |
| NCT02249871 Trial register | Investigating the Influence of Omeprazole on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects | completed | - | 2014-09-26 | - |
| NCT02064348 Trial register | A Thorough QTc Evaluation of the Effect of Semaglutide on Cardiac Repolarisation in Healthy Subjects | completed | - | 2014-02-17 | - |
| NCT02016911 Trial register | Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment | completed | - | 2013-12-20 | - |
| NCT02014259 Trial register | Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Various Degrees of Impaired Renal Function | completed | - | 2013-12-18 | - |
| NCT02146079 Trial register | A Trial to Assess the Pharmacokinetics, Pharmacodynamics, and the Safety and Tolerability of Semaglutide in Healthy Male Japanese and Caucasian Subjects | completed | - | 2014-05-23 | - |
| NCT02212067 Trial register | A Trial Investigating the Effects of Semaglutide on ß-cell Function in Subjects With Type 2 Diabetes | completed | - | 2014-08-08 | - |
| NCT02210871 Trial register | Investigating the Pharmacokinetics, Safety and Tolerability After a Single Subcutaneous Injection of Semaglutide in Subjects With Mild, Moderate or Severe Hepat | completed | - | 2014-08-07 | - |
| NCT03010475 Trial register | A Trial Investigating the Effect of Oral Semaglutide on the Pharmacokinetics of Furosemide and Rosuvastatin in Healthy Subjects | completed | - | 2017-01-05 | - |
| NCT02920385 Trial register | A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokin | completed | - | 2016-09-30 | - |
| NCT02079870 Trial register | Trial Investigating the Effect of Semaglutide on Energy Intake, Appetite Sensations, Postprandial Glucose and Triglyceride Metabolism and Gastric Emptying in Ob | completed | - | 2014-03-06 | - |
| NCT02845219 Trial register | A Trial Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Ethinylestradiol and Levonorgestrel in an Oral Contraceptive Combination Drug in | completed | - | 2016-07-27 | - |
| NCT03144271 Trial register | Dose Escalation Trial of Single Subcutaneous Doses of NNC 0113-0217 to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Male Subjec | completed | - | 2017-05-08 | - |
| NCT00833716 Trial register | Effect of Renal Impairment on the Pharmacokinetics of NN9535 | completed | - | 2009-02-02 | - |
| NCT02022254 Trial register | Influence of Semaglutide on Pharmacokinetics and Pharmacodynamics of Warfarin and Pharmacokinetics of Metformin in Healthy Subjects | completed | - | 2013-12-27 | - |
| NCT02243098 Trial register | Investigating the Influence of Semaglutide on the Pharmacokinetics of Single Doses of Atorvastatin and Digoxin in Healthy Subjects | completed | - | 2014-09-17 | - |
| NCT02060266 Trial register | Trial Investigating the Absorption, Metabolism and Excretion After a Single Subcutaneous Dose of [3H]-Semaglutide in Healthy Male Subjects | completed | - | 2014-02-12 | - |
| NCT01572753 Trial register | Investigation of Optimal Dosing Conditions for a Long Acting GLP-1 Analogue in Healthy Male Subjects | completed | - | 2012-04-06 | - |
| NCT01324505 Trial register | Effect of Oral Contraceptives After Administration of Semaglutide in Subjects With Type 2 Diabetes | completed | - | 2011-03-29 | - |
| NCT02557620 Trial register | Comparing Semaglutide Administered Subcutaneously Once Daily to Semaglutide Administered Subcutaneously Once Weekly | completed | - | 2015-09-23 | - |
| NCT00813020 Trial register | A Clinical Trial Investigating the Comparison of Three Different Concentrations of NN9535 in Healthy Male Subjects | completed | - | 2008-12-22 | - |
| NCT00851773 Trial register | Safety, Tolerability, and Profile of Action of Drug in the Body of NN9535 in Healthy Male Japanese and Caucasian Subjects | completed | - | 2009-02-26 | - |
| NCT01272973 Trial register | Investigation on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of NN9924 in Healthy Male Subjects | completed | - | 2011-01-10 | - |
| NCT01619345 Trial register | Pharmacoscintigraphic Investigation of NN9924 in Healthy Male Subjects | completed | - | 2012-06-14 | - |
| NCT02231684 Trial register | Investigating the Pharmacokinetics of Subcutaneous Injections With 1 mg/mL, 3 mg/mL, and 10 mg/mL Semaglutide Strengths and the Absolute Bioavailability of Sema | completed | - | 2014-09-04 | - |
| NCT02161588 Trial register | A Trial to Assess the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Oral Semaglutide in Healthy Male Japanese and Caucasian Subjects | completed | - | 2014-06-11 | - |
| NCT02172313 Trial register | Effect of Food on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects | completed | - | 2014-06-24 | - |
| NCT01766245 Trial register | A Randomised, Single Centre, Double-blind, Two-period, Cross-over Trial in Healthy Subjects Investigating the Bioequivalence Between Subcutaneous Injections of | completed | - | 2013-01-11 | - |
| NCT01866748 Trial register | Investigation on Safety, Tolerability and Pharmacokinetics of Single and Multiple Doses of a Long-acting GLP-1 Analogue (Semaglutide) in an Oral Formulation in | completed | - | 2013-05-31 | - |
Source: ClinicalTrials.gov and EU CTIS, read 2026-10-03. Not medical advice.
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